Detail Information

Basic Information:


  VIRBase ID:  

HHID00065560

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           TDP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p TDP2
miRBase
Accession/Entrez ID		 MIMAT0004570 51567
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AD022//dJ30M3.3//EAP2//EAPII//hTDP2//TTRAP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TDP2
chr6:24655118(-) A-I      intronic
chr6:24652088(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TDP2
chr6:24651076-24651077(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24651081-24651082(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24651100-24651101(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24651123-24651124(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24651168-24651169(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24651199-24651200(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24651231-24651232(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24651237-24651238(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr6:24658939-24658940(-) m6A CDS//exon//intron       27773535
chr6:24659115-24659116(-) m6A exon//intron       24981863
chr6:24666437-24666438(-) m6A 5'UTR//exon//intron       24981863
chr6:24666456-24666457(-) m6A 5'UTR//exon//intron       24981863
chr6:24666553-24666554(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828//22608085
chr6:24666679-24666680(-) m6A 5'UTR//exon//intron       25456834//27371828
chr6:24666757-24666758(-) m6A 5'UTR//CDS//exon       24284625//24209618//27773535//27371828//27773536
chr6:24666775-24666776(-) m6A 5'UTR//CDS//exon       24284625//24209618//27773535//27371828//27773536
chr6:24666828-24666829(-) m6A CDS//exon       24284625//24209618//25456834//27773535//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TDP2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: TDP2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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