Basic Information:

  VIRBase ID:  

HHID00065553

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          WSB1:  NR_145520     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	WSB1
miRBase Accession/Entrez ID	MIMAT0004570	26118
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SWIP1//WSB-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WSB1	chr17:25625514(+) A-I      intronic chr17:25639900(+) A-I      3'UTR chr17:25639899(+) A-I      3'UTR chr17:25639872(+) A-I      3'UTR chr17:25624704(+) A-I      intronic chr17:25624703(+) A-I      intronic chr17:25626443(+) A-I      intronic chr17:25627795(+) A-I      intronic chr17:25631617(+) A-I      intronic chr17:25631623(+) A-I      intronic chr17:25639914(+) A-I      3'UTR chr17:25639902(+) A-I      3'UTR chr17:25631663(+) A-I      intronic chr17:25638756(+) A-I      intronic chr17:25639915(+) A-I      3'UTR chr17:25627802(+) A-I      intronic chr17:25631611(+) A-I      intronic chr17:25631612(+) A-I      intronic chr17:25624624(+) A-I      intronic chr17:25639952(+) A-I      3'UTR chr17:25639916(+) A-I      3'UTR chr17:25624309(+) A-I      intronic chr17:25628162(+) A-I      intronic chr17:25625513(+) A-I      intronic chr17:25624981(+) A-I      intronic chr17:25624977(+) A-I      intronic chr17:25624948(+) A-I      intronic chr17:25624933(+) A-I      intronic chr17:25624932(+) A-I      intronic chr17:25624691(+) A-I      intronic chr17:25624630(+) A-I      intronic chr17:25624597(+) A-I      intronic chr17:25624455(+) A-I      intronic chr17:25624434(+) A-I      intronic chr17:25624328(+) A-I      intronic chr17:25624271(+) A-I      intronic chr17:25624247(+) A-I      intronic chr17:25628160(+) A-I      intronic chr17:25628139(+) A-I      intronic chr17:25624235(+) A-I      intronic chr17:25628134(+) A-I      intronic chr17:25628127(+) A-I      intronic chr17:25628120(+) A-I      intronic chr17:25627833(+) A-I      intronic chr17:25627826(+) A-I      intronic chr17:25626384(+) A-I      intronic chr17:25626383(+) A-I      intronic chr17:25626373(+) A-I      intronic chr17:25629648(+) A-I      intronic chr17:25629694(+) A-I      intronic chr17:25626328(+) A-I      intronic chr17:25625815(+) A-I      intronic chr17:25625796(+) A-I      intronic chr17:25625691(+) A-I      intronic chr17:25640022(+) A-I      3'UTR chr17:25640038(+) A-I      3'UTR chr17:25639897(+) A-I      3'UTR chr17:25640012(+) A-I      3'UTR chr17:25639833(+) A-I      3'UTR chr17:25640016(+) A-I      3'UTR chr17:25639898(+) A-I      3'UTR chr17:25639940(+) A-I      3'UTR chr17:25639917(+) A-I      3'UTR chr17:25639992(+) A-I      3'UTR chr17:25639973(+) A-I      3'UTR chr17:25624974(+) A-I      intronic chr17:25624538(+) A-I      intronic chr17:25625139(+) A-I      intronic chr17:25624878(+) A-I      intronic chr17:25629633(+) A-I      intronic chr17:25626446(+) A-I      intronic chr17:25638062(+) A-I      intronic chr17:25627841(+) A-I      intronic chr17:25629727(+) A-I      intronic chr17:25624373(+) A-I      intronic chr17:25625565(+) A-I      intronic chr17:25624457(+) A-I      intronic chr17:25633384(+) A-I      intronic chr17:25627817(+) A-I      intronic chr17:25629173(+) A-I      intronic chr17:25633378(+) A-I      intronic chr17:25624333(+) A-I      intronic chr17:25628078(+) A-I      intronic chr17:25627809(+) A-I      intronic chr17:25628008(+) A-I      intronic chr17:25624519(+) A-I      intronic chr17:25624655(+) A-I      intronic chr17:25625811(+) A-I      intronic chr17:25628059(+) A-I      intronic chr17:25624647(+) A-I      intronic chr17:25626400(+) A-I      intronic chr17:25625023(+) A-I      intronic chr17:25622944(+) A-I      intronic chr17:25628039(+) A-I      intronic chr17:25627844(+) A-I      intronic chr17:25624702(+) A-I      intronic chr17:25624517(+) A-I      intronic chr17:25624938(+) A-I      intronic chr17:25626476(+) A-I      intronic chr17:25624574(+) A-I      intronic chr17:25625072(+) A-I      intronic chr17:25638060(+) A-I      intronic chr17:25625980(+) A-I      intronic chr17:25628037(+) A-I      intronic chr17:25638066(+) A-I      intronic chr17:25624983(+) A-I      intronic chr17:25628097(+) A-I      intronic chr17:25628087(+) A-I      intronic chr17:25631687(+) A-I      intronic chr17:25624725(+) A-I      intronic chr17:25626376(+) A-I      intronic chr17:25625548(+) A-I      intronic chr17:25626457(+) A-I      intronic chr17:25625690(+) A-I      intronic chr17:25624456(+) A-I      intronic chr17:25623127(+) A-I      intronic chr17:25624429(+) A-I      intronic chr17:25624278(+) A-I      intronic chr17:25629734(+) A-I      intronic chr17:25639979(+) A-I      3'UTR chr17:25639848(+) A-I      3'UTR chr17:25624471(+) A-I      intronic chr17:25639877(+) A-I      3'UTR chr17:25624331(+) A-I      intronic chr17:25625537(+) A-I      intronic chr17:25639857(+) A-I      3'UTR chr17:25638797(+) A-I      intronic chr17:25628176(+) A-I      intronic chr17:25624729(+) A-I      intronic chr17:25625743(+) A-I      intronic chr17:25627855(+) A-I      intronic chr17:25625960(+) A-I      intronic chr17:25639905(+) A-I      3'UTR chr17:25625747(+) A-I      intronic chr17:25639956(+) A-I      3'UTR chr17:25624927(+) A-I      intronic chr17:25629212(+) A-I      intronic chr17:25624530(+) A-I      intronic chr17:25625491(+) A-I      intronic chr17:25628121(+) A-I      intronic chr17:25625751(+) A-I      intronic chr17:25624593(+) A-I      intronic chr17:25625560(+) A-I      intronic chr17:25624988(+) A-I      intronic chr17:25626471(+) A-I      intronic chr17:25624292(+) A-I      intronic chr17:25625083(+) A-I      intronic chr17:25625769(+) A-I      intronic chr17:25625071(+) A-I      intronic chr17:25624217(+) A-I      intronic chr17:25625624(+) A-I      intronic chr17:25626273(+) A-I      intronic chr17:25639946(+) A-I      3'UTR chr17:25624666(+) A-I      intronic chr17:25624673(+) A-I      intronic chr17:25624716(+) A-I      intronic chr17:25625030(+) A-I      intronic chr17:25628135(+) A-I      intronic chr17:25627816(+) A-I      intronic chr17:25637984(+) A-I      intronic chr17:25624349(+) A-I      intronic chr17:25638851(+) A-I      intronic chr17:25626318(+) A-I      intronic chr17:25626525(+) A-I      intronic chr17:25627842(+) A-I      intronic chr17:25626378(+) A-I      intronic chr17:25639987(+) A-I      3'UTR chr17:25624321(+) A-I      intronic chr17:25625700(+) A-I      intronic chr17:25624914(+) A-I      intronic chr17:25639871(+) A-I      3'UTR chr17:25624272(+) A-I      intronic chr17:25627857(+) A-I      intronic chr17:25624984(+) A-I      intronic chr17:25625029(+) A-I      intronic chr17:25638848(+) A-I      intronic chr17:25639896(+) A-I      3'UTR chr17:25624469(+) A-I      intronic chr17:25624400(+) A-I      intronic chr17:25624606(+) A-I      intronic chr17:25626323(+) A-I      intronic chr17:25624291(+) A-I      intronic chr17:25625877(+) A-I      intronic chr17:25627819(+) A-I      intronic chr17:25624919(+) A-I      intronic chr17:25638909(+) A-I      intronic chr17:25624972(+) A-I      intronic chr17:25639988(+) A-I      3'UTR chr17:25625878(+) A-I      intronic chr17:25623133(+) A-I      intronic chr17:25624717(+) A-I      intronic chr17:25628190(+) A-I      intronic chr17:25639834(+) A-I      3'UTR chr17:25626519(+) A-I      intronic chr17:25624367(+) A-I      intronic chr17:25627940(+) A-I      intronic chr17:25629660(+) A-I      intronic chr17:25628012(+) A-I      intronic chr17:25629713(+) A-I      intronic chr17:25625676(+) A-I      intronic chr17:25625039(+) A-I      intronic chr17:25625701(+) A-I      intronic chr17:25628064(+) A-I      intronic chr17:25625662(+) A-I      intronic chr17:25624975(+) A-I      intronic chr17:25626312(+) A-I      intronic chr17:25626382(+) A-I      intronic chr17:25629281(+) A-I      intronic chr17:25624405(+) A-I      intronic chr17:25625939(+) A-I      intronic chr17:25628081(+) A-I      intronic chr17:25624261(+) A-I      intronic chr17:25625532(+) A-I      intronic chr17:25626381(+) A-I      intronic chr17:25628063(+) A-I      intronic chr17:25628072(+) A-I      intronic chr17:25625770(+) A-I      intronic chr17:25626379(+) A-I      intronic chr17:25625617(+) A-I      intronic chr17:25628109(+) A-I      intronic chr17:25629179(+) A-I      intronic chr17:25625976(+) A-I      intronic chr17:25627989(+) A-I      intronic chr17:25627741(+) A-I      intronic chr17:25626390(+) A-I      intronic chr17:25626497(+) A-I      intronic chr17:25626275(+) A-I      intronic chr17:25624640(+) A-I      intronic chr17:25624594(+) A-I      intronic chr17:25624295(+) A-I      intronic chr17:25625667(+) A-I      intronic chr17:25629181(+) A-I      intronic chr17:25624648(+) A-I      intronic chr17:25624879(+) A-I      intronic chr17:25624378(+) A-I      intronic chr17:25626426(+) A-I      intronic chr17:25625699(+) A-I      intronic chr17:25627815(+) A-I      intronic chr17:25622964(+) A-I      intronic chr17:25626524(+) A-I      intronic chr17:25625133(+) A-I      intronic chr17:25625623(+) A-I      intronic chr17:25626042(+) A-I      intronic chr17:25625718(+) A-I      intronic chr17:25626045(+) A-I      intronic chr17:25629725(+) A-I      intronic chr17:25625629(+) A-I      intronic chr17:25625615(+) A-I      intronic chr17:25624250(+) A-I      intronic chr17:25624438(+) A-I      intronic chr17:25624973(+) A-I      intronic chr17:25624947(+) A-I      intronic chr17:25624979(+) A-I      intronic chr17:25625510(+) A-I      intronic chr17:25624721(+) A-I      intronic chr17:25625509(+) A-I      intronic chr17:25626050(+) A-I      intronic chr17:25625640(+) A-I      intronic chr17:25626391(+) A-I      intronic chr17:25624358(+) A-I      intronic chr17:25639882(+) A-I      3'UTR chr17:25639963(+) A-I      3'UTR chr17:25639880(+) A-I      3'UTR chr17:25639843(+) A-I      3'UTR chr17:25639924(+) A-I      3'UTR chr17:25639881(+) A-I      3'UTR chr17:25640011(+) A-I      3'UTR chr17:25639920(+) A-I      3'UTR chr17:25639870(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WSB1	chr17:25624250(+) A-I intron -    22327324 chr17:25624292(+) A-I intron -    21960545   //22327324 chr17:25624717(+) A-I intron -    22327324 chr17:25624972(+) A-I intron -    22327324 chr17:25624974(+) A-I intron -    22327324 chr17:25624984(+) A-I intron -    22327324 chr17:25625072(+) A-I intron -    22327324 chr17:25625509(+) A-I intron -    22327324 chr17:25625747(+) A-I intron -    22327324 chr17:25626390(+) A-I intron -    21960545   //22327324 chr17:25627817(+) A-I intron -    22327324 chr17:25629179(+) A-I intron -    21960545   //22327324 chr17:25624291(+) A-I intron -    21960545 chr17:25625491(+) A-I intron -    21960545 chr17:25622944(+) A-G intron -    22484847 chr17:25622964(+) A-G intron -    22484847 chr17:25624250(+) A-G intron -    22484847 chr17:25624291(+) A-G intron -    22484847 chr17:25624292(+) A-G intron -    22484847 chr17:25624295(+) A-G intron -    22484847 chr17:25624331(+) A-G intron -    22484847 chr17:25624333(+) A-G intron -    22484847 chr17:25624400(+) A-G intron -    22484847 chr17:25624405(+) A-G intron -    22484847 chr17:25624593(+) A-G intron -    22484847 chr17:25624594(+) A-G intron -    22484847 chr17:25624702(+) A-G intron -    22484847 chr17:25624716(+) A-G intron -    22484847 chr17:25624717(+) A-G intron -    22484847 chr17:25624878(+) A-G intron -    22484847 chr17:25624914(+) A-G intron -    22484847 chr17:25624919(+) A-G intron -    22484847 chr17:25624938(+) A-G intron -    22484847 chr17:25624972(+) A-G intron -    22484847 chr17:25624973(+) A-G intron -    22484847 chr17:25624974(+) A-G intron -    22484847 chr17:25624983(+) A-G intron -    22484847 chr17:25624984(+) A-G intron -    22484847 chr17:25625071(+) A-G intron -    22484847 chr17:25625072(+) A-G intron -    22484847 chr17:25625133(+) A-G intron -    22484847 chr17:25625509(+) A-G intron -    22484847 chr17:25625617(+) A-G intron -    22484847 chr17:25625623(+) A-G intron -    22484847 chr17:25625690(+) A-G intron -    22484847 chr17:25625747(+) A-G intron -    22484847 chr17:25625877(+) A-G intron -    22484847 chr17:25625893(+) G-A intron -    22484847 chr17:25625939(+) A-G intron -    22484847 chr17:25625960(+) A-G intron -    22484847 chr17:25626318(+) A-G intron -    22484847 chr17:25626323(+) A-G intron -    22484847 chr17:25626381(+) A-G intron -    22484847 chr17:25626382(+) A-G intron -    22484847 chr17:25626390(+) A-G intron -    22484847 chr17:25626400(+) A-G intron -    22484847 chr17:25626457(+) A-G intron -    22484847 chr17:25626476(+) A-G intron -    22484847 chr17:25626497(+) A-G intron -    22484847 chr17:25626519(+) A-G intron -    22484847 chr17:25627809(+) A-G intron -    22484847 chr17:25627815(+) A-G intron -    22484847 chr17:25627816(+) A-G intron -    22484847 chr17:25627817(+) A-G intron -    22484847 chr17:25627819(+) A-G intron -    22484847 chr17:25627842(+) A-G intron -    22484847 chr17:25627940(+) A-G intron -    22484847 chr17:25628037(+) A-G intron -    22484847 chr17:25628059(+) A-G intron -    22484847 chr17:25628087(+) A-G intron -    22484847 chr17:25628109(+) A-G intron -    22484847 chr17:25629173(+) A-G intron -    22484847 chr17:25629179(+) A-G intron -    22484847 chr17:25629456(+) G-A intron -    22484847 chr17:25629660(+) A-G intron -    22484847 chr17:25629713(+) A-G intron -    22484847 chr17:25639834(+) A-G intron -    22484847 chr17:25639848(+) A-G intron -    22484847 chr17:25639871(+) A-G intron -    22484847 chr17:25639903(+) C-A intron -    22484847 chr17:25640011(+) A-G intron -    22484847 chr17:25640065(+) T-A intron -    22484847 chr17:25640066(+) C-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WSB1	chr17:25621171-25621172(+) m6A 5'UTR//exon       24981863 chr17:25628934-25628935(+) m6A CDS//exon//intron       27773535 chr17:25628978-25628979(+) m6A CDS//exon//intron       27773535 chr17:25628987-25628988(+) m6A exon//intron       27773535 chr17:25630446-25630447(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr17:25630485-25630486(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr17:25630496-25630497(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr17:25630548-25630549(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr17:25630593-25630594(+) m6A CDS//exon//intron       24284625//24981863//27773535 chr17:25635292-25635293(+) m6A 3'UTR//exon//intron       26404942 chr17:25635320-25635321(+) m6A 3'UTR//exon//intron       26404942 chr17:25635330-25635331(+) m6A 3'UTR//exon//intron       26404942 chr17:25635401-25635402(+) m6A 3'UTR//exon//intron       26404942 chr17:25635421-25635422(+) m6A 3'UTR//exon//intron       26404942 chr17:25635962-25635963(+) m6A exon//intron       26404942 chr17:25639422-25639423(+) m6A 3'UTR//exon       26404942 chr17:25639446-25639447(+) m6A 3'UTR//exon       26404942 chr17:25639557-25639558(+) Y 3'UTR//exon       25219674 chr17:25639562-25639563(+) m6A 3'UTR//exon       26404942 chr17:25639581-25639582(+) m6A 3'UTR//exon       26404942 chr17:25639622-25639623(+) m6A 3'UTR//exon       26404942 chr17:25639671-25639672(+) m6A 3'UTR//exon       26404942 chr17:25639776-25639777(+) m6A 3'UTR//exon       26404942 chr17:25639858-25639859(+) m6A 3'UTR//exon       26404942 chr17:25639871-25639872(+) m6A 3'UTR//exon       26404942 chr17:25640043-25640044(+) m6A 3'UTR//exon       27773535 chr17:25640056-25640057(+) m6A 3'UTR//exon       27773535 chr17:25640129-25640130(+) m6A 3'UTR//exon       27773535 chr17:25640146-25640147(+) m6A 3'UTR//exon       27773535 chr17:25642058-25642059(+) m6A 3'UTR       - chr17:25642112-25642113(+) m6A 3'UTR       22608085 chr17:25642168-25642169(+) m6A 3'UTR       22608085 chr17:25642176-25642177(+) m6A 3'UTR       22608085 chr17:25642209-25642210(+) m6A 3'UTR       22608085 chr17:25642287-25642288(+) m6A 3'UTR       22608085 chr17:25642445-25642446(+) m6A 3'UTR       22608085 chr17:25642530-25642531(+) m6A 3'UTR       25456834//22608085 chr17:25642545-25642546(+) m6A 3'UTR       24284625//25456834//22608085 chr17:25642593-25642594(+) m6A 3'UTR       24284625//25456834//22608085 chr17:25642657-25642658(+) m6A 3'UTR       - chr17:25642666-25642667(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	WSB1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: WSB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.