Basic Information:

  VIRBase ID:  

HHID00065549

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          ADNP:  NM_001282531     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	ADNP
miRBase Accession/Entrez ID	MIMAT0004570	23394
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ADNP1//HVDAS//MRD28

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ADNP	chr20:49511833(-) A-I      intronic chr20:49512047(-) A-I      intronic chr20:49512068(-) A-I      intronic chr20:49523681(-) A-I      intronic chr20:49513211(-) A-I      intronic chr20:49523682(-) A-I      intronic chr20:49523932(-) A-I      intronic chr20:49523936(-) A-I      intronic chr20:49528792(-) A-I      intronic chr20:49512059(-) A-I      intronic chr20:49512251(-) A-I      intronic chr20:49512218(-) A-I      intronic chr20:49512250(-) A-I      intronic chr20:49512249(-) A-I      intronic chr20:49536714(-) A-I      intronic chr20:49511834(-) A-I      intronic chr20:49512019(-) A-I      intronic chr20:49513238(-) A-I      intronic chr20:49511839(-) A-I      intronic chr20:49539195(-) A-I      intronic chr20:49539177(-) A-I      intronic chr20:49525248(-) A-I      intronic chr20:49525259(-) A-I      intronic chr20:49528780(-) A-I      intronic chr20:49528900(-) A-I      intronic chr20:49528976(-) A-I      intronic chr20:49529631(-) A-I      intronic chr20:49536790(-) A-I      intronic chr20:49525211(-) A-I      intronic chr20:49525167(-) A-I      intronic chr20:49525153(-) A-I      intronic chr20:49525147(-) A-I      intronic chr20:49524031(-) A-I      intronic chr20:49523974(-) A-I      intronic chr20:49529636(-) A-I      intronic chr20:49529666(-) A-I      intronic chr20:49523693(-) A-I      intronic chr20:49523684(-) A-I      intronic chr20:49523637(-) A-I      intronic chr20:49512298(-) A-I      intronic chr20:49523570(-) A-I      intronic chr20:49512126(-) A-I      intronic chr20:49512175(-) A-I      intronic chr20:49512183(-) A-I      intronic chr20:49512338(-) A-I      intronic chr20:49512590(-) A-I      intronic chr20:49520891(-) A-I      intronic chr20:49522568(-) A-I      intronic chr20:49522582(-) A-I      intronic chr20:49522591(-) A-I      intronic chr20:49525216(-) A-I      intronic chr20:49522692(-) A-I      intronic chr20:49523572(-) A-I      intronic chr20:49523573(-) A-I      intronic chr20:49523601(-) A-I      intronic chr20:49523602(-) A-I      intronic chr20:49523633(-) A-I      intronic chr20:49529680(-) A-I      intronic chr20:49529681(-) A-I      intronic chr20:49529714(-) A-I      intronic chr20:49535895(-) A-I      intronic chr20:49535898(-) A-I      intronic chr20:49535929(-) A-I      intronic chr20:49544199(-) A-I      intronic chr20:49544160(-) A-I      intronic chr20:49540306(-) A-I      intronic chr20:49540273(-) A-I      intronic chr20:49540248(-) A-I      intronic chr20:49540166(-) A-I      intronic chr20:49540157(-) A-I      intronic chr20:49539400(-) A-I      intronic chr20:49536648(-) A-I      intronic chr20:49539299(-) A-I      intronic chr20:49539257(-) A-I      intronic chr20:49539215(-) A-I      intronic chr20:49520831(-) A-I      5'UTR chr20:49520845(-) A-I      5'UTR chr20:49540234(-) A-I      intronic chr20:49529622(-) A-I      intronic chr20:49525203(-) A-I      intronic chr20:49536938(-) A-I      intronic chr20:49522493(-) A-I      intronic chr20:49522585(-) A-I      intronic chr20:49528960(-) A-I      intronic chr20:49535776(-) A-I      intronic chr20:49542359(-) A-I      intronic chr20:49523901(-) A-I      intronic chr20:49520873(-) A-I      intronic chr20:49536571(-) A-I      intronic chr20:49528919(-) A-I      intronic chr20:49511175(-) A-I      intronic chr20:49511188(-) A-I      intronic chr20:49529721(-) A-I      intronic chr20:49522649(-) A-I      intronic chr20:49529668(-) A-I      intronic chr20:49522742(-) A-I      intronic chr20:49528821(-) A-I      intronic chr20:49528769(-) A-I      intronic chr20:49535762(-) A-I      intronic chr20:49515908(-) A-I      intronic chr20:49528852(-) A-I      intronic chr20:49523832(-) A-I      intronic chr20:49536657(-) A-I      intronic chr20:49529707(-) A-I      intronic chr20:49529625(-) A-I      intronic chr20:49525067(-) A-I      intronic chr20:49523678(-) A-I      intronic chr20:49535970(-) A-I      intronic chr20:49544205(-) A-I      intronic chr20:49540233(-) A-I      intronic chr20:49523687(-) A-I      intronic chr20:49513016(-) A-I      intronic chr20:49522702(-) A-I      intronic chr20:49520863(-) A-I      intronic chr20:49523643(-) A-I      intronic chr20:49523928(-) A-I      intronic chr20:49528767(-) A-I      intronic chr20:49527254(-) A-I      intronic chr20:49523952(-) A-I      intronic chr20:49536873(-) A-I      intronic chr20:49527417(-) A-I      intronic chr20:49540336(-) A-I      intronic chr20:49512558(-) A-I      intronic chr20:49523968(-) A-I      intronic chr20:49529706(-) A-I      intronic chr20:49523532(-) A-I      intronic chr20:49523700(-) A-I      intronic chr20:49539254(-) A-I      intronic chr20:49539355(-) A-I      intronic chr20:49527482(-) A-I      intronic chr20:49525189(-) A-I      intronic chr20:49512326(-) A-I      intronic chr20:49512545(-) A-I      intronic chr20:49528853(-) A-I      intronic chr20:49512961(-) A-I      intronic chr20:49524375(-) A-I      intronic chr20:49526892(-) A-I      intronic chr20:49525297(-) A-I      intronic chr20:49539200(-) A-I      intronic chr20:49539241(-) A-I      intronic chr20:49528866(-) A-I      intronic chr20:49529596(-) A-I      intronic chr20:49512174(-) A-I      intronic chr20:49524188(-) A-I      intronic chr20:49522637(-) A-I      intronic chr20:49542445(-) A-I      intronic chr20:49522601(-) A-I      intronic chr20:49527077(-) A-I      intronic chr20:49529678(-) A-I      intronic chr20:49540115(-) A-I      intronic chr20:49513058(-) A-I      intronic chr20:49524354(-) A-I      intronic chr20:49535956(-) A-I      intronic chr20:49523594(-) A-I      intronic chr20:49544157(-) A-I      intronic chr20:49528943(-) A-I      intronic chr20:49523675(-) A-I      intronic chr20:49523668(-) A-I      intronic chr20:49540310(-) A-I      intronic chr20:49520954(-) A-I      intronic chr20:49540219(-) A-I      intronic chr20:49536629(-) A-I      intronic chr20:49525202(-) A-I      intronic chr20:49527390(-) A-I      intronic chr20:49529620(-) A-I      intronic chr20:49512244(-) A-I      intronic chr20:49522686(-) A-I      intronic chr20:49528851(-) A-I      intronic chr20:49522627(-) A-I      intronic chr20:49512679(-) A-I      intronic chr20:49524384(-) A-I      intronic chr20:49539184(-) A-I      intronic chr20:49542475(-) A-I      intronic chr20:49535912(-) A-I      intronic chr20:49544165(-) A-I      intronic chr20:49523942(-) A-I      intronic chr20:49524268(-) A-I      intronic chr20:49523723(-) A-I      intronic chr20:49536751(-) A-I      intronic chr20:49536572(-) A-I      intronic chr20:49529641(-) A-I      intronic chr20:49527330(-) A-I      intronic chr20:49525122(-) A-I      intronic chr20:49512270(-) A-I      intronic chr20:49536728(-) A-I      intronic chr20:49512284(-) A-I      intronic chr20:49523909(-) A-I      intronic chr20:49523999(-) A-I      intronic chr20:49529697(-) A-I      intronic chr20:49528959(-) A-I      intronic chr20:49529570(-) A-I      intronic chr20:49535940(-) A-I      intronic chr20:49525055(-) A-I      intronic chr20:49528966(-) A-I      intronic chr20:49524007(-) A-I      intronic chr20:49528982(-) A-I      intronic chr20:49522667(-) A-I      intronic chr20:49528789(-) A-I      intronic chr20:49523915(-) A-I      intronic chr20:49529544(-) A-I      intronic chr20:49520855(-) A-I      intronic chr20:49542421(-) A-I      intronic chr20:49522744(-) A-I      intronic chr20:49540305(-) A-I      intronic chr20:49528822(-) A-I      intronic chr20:49511187(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ADNP	chr20:49524975(-) A-I intron -    19478186 chr20:49512058(-) A-I intron -    22327324 chr20:49522737(-) A-I intron -    21960545   //22327324 chr20:49523643(-) A-I intron -    22327324 chr20:49527482(-) A-I intron -    22327324 chr20:49528769(-) A-I intron -    22327324 chr20:49529596(-) A-I intron -    22327324 chr20:49511798(-) A-I intron -    21960545 chr20:49513194(-) A-I intron -    21960545 chr20:49516203(-) A-I intron -    21960545 chr20:49516557(-) A-I intron -    21960545 chr20:49516624(-) A-I intron -    21960545 chr20:49516777(-) A-I intron -    21960545 chr20:49522637(-) A-I intron -    21960545 chr20:49528848(-) A-I intron -    21960545 chr20:49544205(-) A-I intron -    21960545 chr20:49544228(-) A-I intron -    21960545 chr20:49512058(-) A-G intron -    22484847 chr20:49513248(-) A-G intron -    22484847 chr20:49516151(-) A-G intron -    22484847 chr20:49516203(-) A-G intron -    22484847 chr20:49520917(-) A-G intron -    22484847 chr20:49520954(-) A-G intron -    22484847 chr20:49522508(-) T-C intron -    22484847 chr20:49523643(-) A-G intron -    22484847 chr20:49523668(-) A-G intron -    22484847 chr20:49523687(-) A-G intron -    22484847 chr20:49523998(-) A-G intron -    22484847 chr20:49524292(-) C-A intron -    22484847 chr20:49524354(-) A-G intron -    22484847 chr20:49527252(-) A-G intron -    22484847 chr20:49527264(-) A-G intron -    22484847 chr20:49528769(-) A-G intron -    22484847 chr20:49528848(-) A-G intron -    22484847 chr20:49528880(-) A-G intron -    22484847 chr20:49529596(-) A-G intron -    22484847 chr20:49529721(-) A-G intron -    22484847 chr20:49536571(-) A-G intron -    22484847 chr20:49536572(-) A-G intron -    22484847 chr20:49539241(-) A-G intron -    22484847 chr20:49539254(-) A-G intron -    22484847 chr20:49544228(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ADNP	chr20:49505785-49505786(-) m6A 3'UTR       22575960 chr20:49505796-49505797(-) m6A 3'UTR       22575960 chr20:49505805-49505806(-) m6A 3'UTR       22575960 chr20:49507540-49507541(-) m6A 3'UTR       24981863//27773535//22608085 chr20:49507600-49507601(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr20:49507720-49507721(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49507742-49507743(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49507756-49507757(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49507777-49507778(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49507833-49507834(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49507899-49507900(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49507962-49507963(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508025-49508026(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508122-49508123(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508267-49508268(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508274-49508275(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508293-49508294(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508302-49508303(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508409-49508410(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508418-49508419(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508438-49508439(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508467-49508468(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508520-49508521(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508550-49508551(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508620-49508621(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49508669-49508670(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49509152-49509153(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr20:49509173-49509174(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr20:49509351-49509352(-) m6A CDS       24284625//24981863//26404942//27773535 chr20:49509386-49509387(-) m6A CDS       24284625//24981863//26404942//27773535 chr20:49509620-49509621(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49509627-49509628(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:49509846-49509847(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr20:49509969-49509970(-) m6A CDS       24284625//24981863//27773535 chr20:49510206-49510207(-) m6A CDS       26404942 chr20:49510261-49510262(-) m6A CDS       24284625//26404942 chr20:49510404-49510405(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr20:49510420-49510421(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr20:49510428-49510429(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr20:49510452-49510453(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr20:49510522-49510523(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr20:49510689-49510690(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr20:49510791-49510792(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr20:49510810-49510811(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22608085 chr20:49510883-49510884(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22608085 chr20:49510892-49510893(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr20:49510900-49510901(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr20:49510951-49510952(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr20:49511034-49511035(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr20:49511039-49511040(-) m6A CDS       24284625//27773535//22608085 chr20:49518557-49518558(-) m6A CDS       24284625//27773535//22608085 chr20:49518575-49518576(-) m6A CDS       24284625//27773535 chr20:49518583-49518584(-) m6A CDS       24284625//27773535 chr20:49518605-49518606(-) m6A CDS       24284625//27773535 chr20:49518628-49518629(-) m6A CDS       24284625//27773535 chr20:49518637-49518638(-) m6A CDS       27773535 chr20:49520434-49520435(-) m6A CDS       27773535 chr20:49520481-49520482(-) m6A CDS       27773535 chr20:49541751-49541752(-) Tm intron       - chr20:49545234-49545235(-) m6A 5'UTR//intron       27773535 chr20:49547716-49547717(-) m6A 5'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ADNP	Chromatin K562 cells     - Cytosol HeLa-S3 cells|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: ADNP

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.