Detail Information

Basic Information:


  VIRBase ID:  

HHID00065545

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           DIS3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p DIS3
miRBase
Accession/Entrez ID		 MIMAT0004570 22894
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 2810028N01Rik//dis3p//EXOSC11//KIAA1008//RRP44

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DIS3
chr13:73353306(-) A-I      intronic
chr13:73353379(-) A-I      intronic
chr13:73354240(-) A-I      intronic
chr13:73354292(-) A-I      intronic
chr13:73353472(-) A-I      intronic
chr13:73353404(-) A-I      intronic
chr13:73354222(-) A-I      intronic
chr13:73354442(-) A-I      intronic
chr13:73353288(-) A-I      intronic
chr13:73353474(-) A-I      intronic
chr13:73354438(-) A-I      intronic
chr13:73353425(-) A-I      intronic
chr13:73353354(-) A-I      intronic
chr13:73354387(-) A-I      intronic
chr13:73353390(-) A-I      intronic
chr13:73353311(-) A-I      intronic
chr13:73354431(-) A-I      intronic
chr13:73353296(-) A-I      intronic
chr13:73354316(-) A-I      intronic
chr13:73353437(-) A-I      intronic
chr13:73353386(-) A-I      intronic
chr13:73354417(-) A-I      intronic
chr13:73353469(-) A-I      intronic
chr13:73353431(-) A-I      intronic
chr13:73353460(-) A-I      intronic
chr13:73353332(-) A-I      intronic
chr13:73354221(-) A-I      intronic
chr13:73353528(-) A-I      intronic
chr13:73354315(-) A-I      intronic
chr13:73353326(-) A-I      intronic
chr13:73353324(-) A-I      intronic
chr13:73354450(-) A-I      intronic
chr13:73353498(-) A-I      intronic
chr13:73353406(-) A-I      intronic
chr13:73353360(-) A-I      intronic
chr13:73353459(-) A-I      intronic
chr13:73353452(-) A-I      intronic
chr13:73353422(-) A-I      intronic
chr13:73353331(-) A-I      intronic
chr13:73354381(-) A-I      intronic
chr13:73354352(-) A-I      intronic
chr13:73353464(-) A-I      intronic
chr13:73353488(-) A-I      intronic
chr13:73353289(-) A-I      intronic
chr13:73353483(-) A-I      intronic
chr13:73354294(-) A-I      intronic
chr13:73353450(-) A-I      intronic
chr13:73354231(-) A-I      intronic
chr13:73354332(-) A-I      intronic
chr13:73354407(-) A-I      intronic
chr13:73354272(-) A-I      intronic
chr13:73353529(-) A-I      intronic
chr13:73354209(-) A-I      intronic
chr13:73353344(-) A-I      intronic
chr13:73331393(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DIS3
chr13:73353344(-) A-I intron -    22327324
chr13:73353406(-) A-I intron -    22327324
chr13:73353324(-) A-G intron -    22484847
chr13:73353326(-) A-G intron -    22484847
chr13:73353331(-) A-G intron -    22484847
chr13:73353332(-) A-G intron -    22484847
chr13:73353344(-) A-G intron -    22484847
chr13:73353360(-) A-G intron -    22484847
chr13:73353386(-) A-G intron -    22484847
chr13:73353406(-) A-G intron -    22484847
chr13:73353422(-) A-G intron -    22484847
chr13:73353452(-) A-G intron -    22484847
chr13:73354231(-) A-G intron -    22484847
chr13:73354352(-) A-G intron -    22484847
chr13:73354381(-) A-G intron -    22484847
chr13:73354417(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DIS3
chr13:73329347-73329348(-) m6A 3'UTR       -
chr13:73329390-73329391(-) m6A 3'UTR       -
chr13:73329554-73329555(-) m6A 3'UTR       27773535
chr13:73329601-73329602(-) m6A 3'UTR       27773535
chr13:73329694-73329695(-) m6A 3'UTR       27773535
chr13:73330125-73330126(-) m6A 3'UTR       24981863//27773535
chr13:73330948-73330949(-) m6A 3'UTR       24981863//22608085
chr13:73330980-73330981(-) m6A 3'UTR       24981863//22608085
chr13:73331016-73331017(-) m6A 3'UTR       24981863
chr13:73333077-73333078(-) m6A 3'UTR       27773535
chr13:73333119-73333120(-) m6A 3'UTR       27773535
chr13:73333133-73333134(-) m6A 3'UTR       27773535
chr13:73333144-73333145(-) m6A 3'UTR       27773535
chr13:73333201-73333202(-) m6A 3'UTR       27773535
chr13:73333247-73333248(-) m6A 3'UTR       27773535
chr13:73333277-73333278(-) m6A 3'UTR       27773535
chr13:73333682-73333683(-) m6A 3'UTR       24981863//26404942//27773535//22608085
chr13:73333742-73333743(-) m6A 3'UTR       24981863//26404942//27773535//22608085
chr13:73333789-73333790(-) m6A 3'UTR       24981863//26404942//27773535//22575960//22608085
chr13:73333808-73333809(-) m6A 3'UTR       24981863//26404942//27773535//22575960//22608085
chr13:73333871-73333872(-) m6A 3'UTR       24981863//27773535//22608085
chr13:73333881-73333882(-) m6A 3'UTR       24981863//27773535//22608085
chr13:73333906-73333907(-) m6A 3'UTR       24981863//27773535//22608085
chr13:73333965-73333966(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr13:73333975-73333976(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr13:73333981-73333982(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr13:73334672-73334673(-) m6A 3'UTR//CDS       24284625//22608085
chr13:73334718-73334719(-) m6A 3'UTR//CDS       22608085
chr13:73336109-73336110(-) Y 3'UTR//CDS//intron       26075521
chr13:73348122-73348123(-) m6A CDS       24981863//22575960
chr13:73348190-73348191(-) m6A CDS       24981863//22575960
chr13:73349359-73349360(-) m6A CDS       24981863//22575960
chr13:73349484-73349485(-) m6A CDS       27773535
chr13:73349492-73349493(-) m6A CDS       27773535
chr13:73349498-73349499(-) m6A CDS       27773535
chr13:73350136-73350137(-) m6A CDS       27773535
chr13:73351593-73351594(-) m6A CDS       27773535
chr13:73352365-73352366(-) m6A CDS       24981863//27773535
chr13:73352407-73352408(-) m6A CDS       24981863//27773535
chr13:73352430-73352431(-) m6A 5'UTR//CDS       24981863//27773535
chr13:73352496-73352497(-) m6A 5'UTR//CDS       24981863//27773535
chr13:73352502-73352503(-) m6A 5'UTR//CDS       24981863//27773535
chr13:73352513-73352514(-) m6A 5'UTR//CDS       24981863//27773535
chr13:73355092-73355093(-) m6A 5'UTR//CDS//exon//intron       27773535
chr13:73355124-73355125(-) m6A 5'UTR//CDS//exon//intron       27773535
chr13:73355469-73355470(-) m6A 5'UTR//CDS//exon//intron       27773535
chr13:73355939-73355940(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//27371828
chr13:73356053-73356054(-) m6A 5'UTR//exon       25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
DIS3
Chromatin K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: DIS3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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