Basic Information:

  VIRBase ID:  

HHID00065543

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          SYNPO:  NM_001109974     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	SYNPO
miRBase Accession/Entrez ID	MIMAT0004570	11346
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SYNPO	chr5:150008324(+) A-I      intronic chr5:150008363(+) A-I      intronic chr5:150008376(+) A-I      intronic chr5:150008749(+) A-I      intronic chr5:150008755(+) A-I      intronic chr5:150008758(+) A-I      intronic chr5:150008784(+) A-I      intronic chr5:150013442(+) A-I      intronic chr5:150015148(+) A-I      intronic chr5:150034602(+) A-I      intronic chr5:150015158(+) A-I      intronic chr5:150015301(+) A-I      intronic chr5:150023177(+) A-I      intronic chr5:150023222(+) A-I      intronic chr5:150023284(+) A-I      intronic chr5:150023678(+) A-I      intronic chr5:150034433(+) A-I      intronic chr5:150034523(+) A-I      intronic chr5:150034536(+) A-I      intronic chr5:150034540(+) A-I      intronic chr5:150034556(+) A-I      intronic chr5:150034567(+) A-I      intronic chr5:150034576(+) A-I      intronic chr5:150034607(+) A-I      intronic chr5:150034619(+) A-I      intronic chr5:150034621(+) A-I      intronic chr5:150034622(+) A-I      intronic chr5:150034639(+) A-I      intronic chr5:150035630(+) A-I      intronic chr5:150035633(+) A-I      intronic chr5:150035675(+) A-I      intronic chr5:150008315(+) A-I      intronic chr5:150035402(+) A-I      intronic chr5:150008295(+) A-I      intronic chr5:150008238(+) A-I      intronic chr5:150008287(+) A-I      intronic chr5:150035422(+) A-I      intronic chr5:150035393(+) A-I      intronic chr5:150008309(+) A-I      intronic chr5:150035487(+) A-I      intronic chr5:150035447(+) A-I      intronic chr5:150035396(+) A-I      intronic chr5:150035387(+) A-I      intronic chr5:150035379(+) A-I      intronic chr5:150035354(+) A-I      intronic chr5:150035344(+) A-I      intronic chr5:150035332(+) A-I      intronic chr5:150035314(+) A-I      intronic chr5:150035276(+) A-I      intronic chr5:150037038(+) A-I      3'UTR chr5:150037036(+) A-I      3'UTR chr5:150037034(+) A-I      3'UTR chr5:150037026(+) A-I      3'UTR chr5:150008350(+) A-I      intronic chr5:150023579(+) A-I      intronic chr5:150035238(+) A-I      intronic chr5:150014311(+) A-I      intronic chr5:150008285(+) A-I      intronic chr5:150008809(+) A-I      intronic chr5:150008701(+) A-I      intronic chr5:150008349(+) A-I      intronic chr5:150023487(+) A-I      intronic chr5:150023676(+) A-I      intronic chr5:150008700(+) A-I      intronic chr5:150008786(+) A-I      intronic chr5:150008740(+) A-I      intronic chr5:150015170(+) A-I      intronic chr5:150023616(+) A-I      intronic chr5:150008714(+) A-I      intronic chr5:150008681(+) A-I      intronic chr5:150023652(+) A-I      intronic chr5:150008764(+) A-I      intronic chr5:150035315(+) A-I      intronic chr5:150023630(+) A-I      intronic chr5:150008327(+) A-I      intronic chr5:150023147(+) A-I      intronic chr5:150023614(+) A-I      intronic chr5:150008693(+) A-I      intronic chr5:150008390(+) A-I      intronic chr5:150035435(+) A-I      intronic chr5:150023482(+) A-I      intronic chr5:150023555(+) A-I      intronic chr5:150023665(+) A-I      intronic chr5:150015186(+) A-I      intronic chr5:150023116(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SYNPO	chr5:150037290(+) A-I exon 3'UTR    19478186 chr5:150035238(+) A-I intron -    21960545 chr5:150035315(+) A-I intron -    21960545 chr5:150035632(+) A-I intron -    21960545 chr5:150008285(+) A-G intron -    22484847 chr5:150008350(+) A-G intron -    22484847 chr5:150008390(+) A-G intron -    22484847 chr5:150008700(+) A-G intron -    22484847 chr5:150008701(+) A-G intron -    22484847 chr5:150008714(+) A-G intron -    22484847 chr5:150008764(+) A-G intron -    22484847 chr5:150023555(+) A-G intron -    22484847 chr5:150023614(+) A-G intron -    22484847 chr5:150023616(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SYNPO	chr5:149980694-149980695(+) m6A 5'UTR       - chr5:149997743-149997744(+) m6A 5'UTR       - chr5:149997765-149997766(+) m6A 5'UTR       - chr5:149997842-149997843(+) m6A 5'UTR       - chr5:149997921-149997922(+) m6A 5'UTR       - chr5:149998154-149998155(+) m6A CDS       - chr5:149998210-149998211(+) m6A CDS       - chr5:149998248-149998249(+) m6A CDS       - chr5:149998324-149998325(+) m6A CDS       - chr5:150020351-150020352(+) m6A 5'UTR//intron       24284625 chr5:150020406-150020407(+) m6A 5'UTR//intron       24284625 chr5:150027683-150027684(+) m6A 5'UTR//CDS//intron       24284625 chr5:150027976-150027977(+) m6A CDS//intron       24284625//24981863 chr5:150028051-150028052(+) m6A CDS//intron       24284625//24981863//26404942 chr5:150028132-150028133(+) m6A CDS//exon       24284625//24981863//26404942 chr5:150028235-150028236(+) m6A CDS//exon       24284625//24981863//26404942 chr5:150028672-150028673(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr5:150028694-150028695(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr5:150028777-150028778(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr5:150028806-150028807(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr5:150029017-150029018(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr5:150029037-150029038(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr5:150029065-150029066(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr5:150029240-150029241(+) m6A CDS       24284625//24209618//24981863 chr5:150029251-150029252(+) m6A CDS       24284625//24209618//24981863 chr5:150029451-150029452(+) m6A CDS       24284625//24209618//24981863 chr5:150029626-150029627(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr5:150029725-150029726(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr5:150029898-150029899(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr5:150030110-150030111(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960 chr5:150030149-150030150(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960 chr5:150030269-150030270(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr5:150030282-150030283(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr5:150030441-150030442(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr5:150030524-150030525(+) m6A 3'UTR//intron       24284625//24209618//25456834 chr5:150031021-150031022(+) m6A 3'UTR//intron       24284625//24209618 chr5:150031068-150031069(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr5:150031195-150031196(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr5:150031250-150031251(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr5:150031286-150031287(+) m6A 3'UTR//intron       24284625//24209618 chr5:150031293-150031294(+) m6A 3'UTR//intron       24284625//24209618 chr5:150031309-150031310(+) m6A 3'UTR//intron       24209618 chr5:150031383-150031384(+) m6A 3'UTR//intron       24209618 chr5:150031642-150031643(+) m6A 3'UTR//intron       24284625 chr5:150032410-150032411(+) m6A 3'UTR//intron       24284625//24981863 chr5:150032479-150032480(+) m6A 3'UTR//intron       24981863 chr5:150032551-150032552(+) m6A 3'UTR//intron       24981863 chr5:150032731-150032732(+) m6A 3'UTR//intron       24284625 chr5:150033052-150033053(+) m6A 3'UTR//intron       24284625 chr5:150033101-150033102(+) m6A 3'UTR//intron       24284625//24981863 chr5:150033218-150033219(+) m6A 3'UTR//intron       24284625 chr5:150033244-150033245(+) m6A 3'UTR//intron       24284625 chr5:150033719-150033720(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr5:150033734-150033735(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr5:150033786-150033787(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr5:150036166-150036167(+) m6A CDS       24209618 chr5:150036215-150036216(+) m6A CDS       24209618 chr5:150036272-150036273(+) m6A CDS       24209618 chr5:150036506-150036507(+) m6A CDS       24284625//24209618//24981863//22575960 chr5:150036533-150036534(+) m6A CDS       24284625//24209618//24981863//22575960 chr5:150036703-150036704(+) m6A 3'UTR       24981863 chr5:150036712-150036713(+) m6A 3'UTR       - chr5:150037542-150037543(+) m6A 3'UTR       24209618 chr5:150037626-150037627(+) m6A 3'UTR       24209618//24981863 chr5:150038241-150038242(+) m6A 3'UTR       24284625//24981863 chr5:150038257-150038258(+) m6A 3'UTR       24284625//24981863 chr5:150038284-150038285(+) m6A 3'UTR       24284625//24981863 chr5:150038337-150038338(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SYNPO	Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: SYNPO

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.