Basic Information:

  VIRBase ID:  

HHID00065542

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          DSTN:  NM_001011546     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	DSTN
miRBase Accession/Entrez ID	MIMAT0004570	11034
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACTDP//ADF//bA462D18.2//HEL32

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DSTN	chr20:17587851(+) A-I      3'UTR chr20:17587853(+) A-I      3'UTR chr20:17587854(+) A-I      3'UTR chr20:17587881(+) A-I      3'UTR chr20:17578791(+) A-I      intronic chr20:17578788(+) A-I      intronic chr20:17578739(+) A-I      intronic chr20:17578733(+) A-I      intronic chr20:17579579(+) A-I      intronic chr20:17578750(+) A-I      intronic chr20:17587873(+) A-I      3'UTR chr20:17587868(+) A-I      3'UTR chr20:17587829(+) A-I      3'UTR chr20:17587834(+) A-I      3'UTR chr20:17587845(+) A-I      3'UTR chr20:17587847(+) A-I      3'UTR chr20:17571497(+) A-I      intronic chr20:17554686(+) A-I      intronic chr20:17554595(+) A-I      intronic chr20:17561925(+) A-I      intronic chr20:17561308(+) A-I      intronic chr20:17556219(+) A-I      intronic chr20:17556211(+) A-I      intronic chr20:17561313(+) A-I      intronic chr20:17556207(+) A-I      intronic chr20:17565040(+) A-I      intronic chr20:17561314(+) A-I      intronic chr20:17554581(+) A-I      intronic chr20:17555603(+) A-I      intronic chr20:17555602(+) A-I      intronic chr20:17561923(+) A-I      intronic chr20:17554702(+) A-I      intronic chr20:17556179(+) A-I      intronic chr20:17569995(+) A-I      intronic chr20:17570124(+) A-I      intronic chr20:17570102(+) A-I      intronic chr20:17569997(+) A-I      intronic chr20:17554726(+) A-I      intronic chr20:17569985(+) A-I      intronic chr20:17568012(+) A-I      intronic chr20:17565080(+) A-I      intronic chr20:17565075(+) A-I      intronic chr20:17564482(+) A-I      intronic chr20:17562032(+) A-I      intronic chr20:17559991(+) A-I      intronic chr20:17570036(+) A-I      intronic chr20:17562083(+) A-I      intronic chr20:17555601(+) A-I      intronic chr20:17561944(+) A-I      intronic chr20:17560212(+) A-I      intronic chr20:17555251(+) A-I      intronic chr20:17554685(+) A-I      intronic chr20:17562824(+) A-I      intronic chr20:17571660(+) A-I      intronic chr20:17562053(+) A-I      intronic chr20:17554616(+) A-I      intronic chr20:17559965(+) A-I      intronic chr20:17556139(+) A-I      intronic chr20:17555614(+) A-I      intronic chr20:17554661(+) A-I      intronic chr20:17570113(+) A-I      intronic chr20:17571673(+) A-I      intronic chr20:17564618(+) A-I      intronic chr20:17554583(+) A-I      intronic chr20:17564410(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DSTN	chr20:17554595(+) A-I intron -    21960545 chr20:17554661(+) A-I intron -    21960545 chr20:17561138(+) A-I intron -    21960545 chr20:17578693(+) A-I intron -    21960545 chr20:17578741(+) A-I intron -    21960545 chr20:17578750(+) A-I intron -    21960545 chr20:17554583(+) A-G intron -    22484847 chr20:17570036(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DSTN	chr20:17550523-17550524(+) m6A 5'UTR       24981863 chr20:17550551-17550552(+) m6A 5'UTR       24981863 chr20:17550570-17550571(+) m6A 5'UTR       24981863 chr20:17550616-17550617(+) m6A 5'UTR       24981863 chr20:17572669-17572670(+) m1A 5'UTR//intron       26863410 chr20:17585837-17585838(+) m6A 3'UTR//intron       26404942 chr20:17588073-17588074(+) m6A 3'UTR       26404942 chr20:17588551-17588552(+) m6A 3'UTR       27773535//22575960 chr20:17588572-17588573(+) m6A 3'UTR       27773535 chr20:17588676-17588677(+) m6A 3'UTR       27773535 chr20:17588826-17588827(+) m6A 3'UTR       27773535//22575960 chr20:17588834-17588835(+) m6A 3'UTR       27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	DSTN	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: DSTN

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.