Basic Information:

  VIRBase ID:  

HHID00065541

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          TMED2:  NM_001321445     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	TMED2
miRBase Accession/Entrez ID	MIMAT0004570	10959
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	p24//P24A//p24b1//p24beta1//RNP24

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMED2	chr12:124079669(+) A-I      intronic chr12:124078482(+) A-I      intronic chr12:124079098(+) A-I      intronic chr12:124078484(+) A-I      intronic chr12:124078775(+) A-I      intronic chr12:124078924(+) A-I      intronic chr12:124079295(+) A-I      intronic chr12:124079270(+) A-I      intronic chr12:124078223(+) A-I      intronic chr12:124079354(+) A-I      intronic chr12:124079319(+) A-I      intronic chr12:124079359(+) A-I      intronic chr12:124079249(+) A-I      intronic chr12:124078479(+) A-I      intronic chr12:124077592(+) A-I      intronic chr12:124079355(+) A-I      intronic chr12:124079110(+) A-I      intronic chr12:124078460(+) A-I      intronic chr12:124079649(+) A-I      intronic chr12:124079656(+) A-I      intronic chr12:124079665(+) A-I      intronic chr12:124078442(+) A-I      intronic chr12:124077737(+) A-I      intronic chr12:124077498(+) A-I      intronic chr12:124074354(+) A-I      intronic chr12:124078811(+) A-I      intronic chr12:124077497(+) A-I      intronic chr12:124075276(+) A-I      intronic chr12:124079072(+) A-I      intronic chr12:124079314(+) A-I      intronic chr12:124078443(+) A-I      intronic chr12:124078307(+) A-I      intronic chr12:124079177(+) A-I      intronic chr12:124079144(+) A-I      intronic chr12:124077736(+) A-I      intronic chr12:124077384(+) A-I      intronic chr12:124078229(+) A-I      intronic chr12:124078955(+) A-I      intronic chr12:124079323(+) A-I      intronic chr12:124079049(+) A-I      intronic chr12:124077749(+) A-I      intronic chr12:124079180(+) A-I      intronic chr12:124079034(+) A-I      intronic chr12:124077621(+) A-I      intronic chr12:124078821(+) A-I      intronic chr12:124079076(+) A-I      intronic chr12:124078232(+) A-I      intronic chr12:124077900(+) A-I      intronic chr12:124074677(+) A-I      intronic chr12:124080394(+) A-I      intronic chr12:124079248(+) A-I      intronic chr12:124078606(+) A-I      intronic chr12:124078555(+) A-I      intronic chr12:124079287(+) A-I      intronic chr12:124076355(+) A-I      intronic chr12:124079245(+) A-I      intronic chr12:124079179(+) A-I      intronic chr12:124078888(+) A-I      intronic chr12:124079340(+) A-I      intronic chr12:124071077(+) A-I      5'UTR chr12:124071080(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMED2	chr12:124079049(+) A-G intron -    22484847 chr12:124079245(+) A-G intron -    22484847 chr12:124079248(+) A-G intron -    22484847 chr12:124077749(+) A-G intron -    22484847 chr12:124077924(+) T-C intron -    22484847 chr12:124078555(+) A-G intron -    22484847 chr12:124078606(+) A-G intron -    22484847 chr12:124079034(+) A-G intron -    22484847 chr12:124079076(+) A-G intron -    22484847 chr12:124079177(+) A-G intron -    22484847 chr12:124080354(+) T-C intron -    22484847 chr12:124080383(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMED2	chr12:124069200-124069201(+) m6A CDS//exon       24209618//22575960 chr12:124069349-124069350(+) m6A CDS//exon       22575960 chr12:124071301-124071302(+) m6A 5'UTR//CDS//exon       26404942 chr12:124071330-124071331(+) m6A 5'UTR//CDS//exon       26404942//27773535 chr12:124071377-124071378(+) m6A CDS//exon       26404942//27773535 chr12:124071466-124071467(+) m6A CDS//exon       24981863//26404942//27773535 chr12:124071479-124071480(+) m6A CDS//exon       24981863//26404942//27773535 chr12:124071495-124071496(+) m6A exon//intron       24981863//26404942//27773535 chr12:124074897-124074898(+) m6A CDS//exon       24981863//26404942//27773535//22575960 chr12:124074955-124074956(+) m6A CDS//exon       24981863//26404942//27773535//22575960 chr12:124074969-124074970(+) Am CDS//exon       - chr12:124081166-124081167(+) m6A CDS//exon       24981863//26404942//27773535 chr12:124081227-124081228(+) m6A CDS//exon       26404942//27773535 chr12:124081322-124081323(+) m6A 3'UTR//exon       26404942//27773535 chr12:124081371-124081372(+) m6A 3'UTR//exon       26404942//27773535 chr12:124081518-124081519(+) m6A 3'UTR//exon       26404942 chr12:124081524-124081525(+) m6A 3'UTR//exon       26404942 chr12:124081833-124081834(+) m6A 3'UTR//exon       26404942 chr12:124081885-124081886(+) m6A 3'UTR//exon       26404942 chr12:124082429-124082430(+) m6A 3'UTR       26404942 chr12:124082493-124082494(+) m6A 3'UTR       27773535 chr12:124082517-124082518(+) m6A 3'UTR       27773535 chr12:124082559-124082560(+) m6A 3'UTR       27773535 chr12:124082595-124082596(+) m6A 3'UTR       27773535 chr12:124082605-124082606(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TMED2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: TMED2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.