Basic Information:

  VIRBase ID:  

HHID00065535

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          CRIPT:  NM_014171     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	CRIPT
miRBase Accession/Entrez ID	MIMAT0004570	9419
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC139//SSMDF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CRIPT	chr2:46852400(+) A-I      3'UTR chr2:46852390(+) A-I      3'UTR chr2:46852393(+) A-I      3'UTR chr2:46852384(+) A-I      3'UTR chr2:46849302(+) A-I      intronic chr2:46847425(+) A-I      intronic chr2:46847436(+) A-I      intronic chr2:46852377(+) A-I      3'UTR chr2:46852420(+) A-I      3'UTR chr2:46852340(+) A-I      3'UTR chr2:46852336(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CRIPT	chr2:46844405-46844406(+) m6A 5'UTR//intron       24209618//24981863 chr2:46845921-46845922(+) m6A CDS//exon       24209618//24981863 chr2:46852113-46852114(+) m6A 3'UTR//exon       24981863 chr2:46852118-46852119(+) m6A 3'UTR//exon       24981863 chr2:46852177-46852178(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CRIPT	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: CRIPT

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.