Detail Information

Basic Information:


  VIRBase ID:  

HHID00065529

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           ZBTB25:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p ZBTB25
miRBase
Accession/Entrez ID		 MIMAT0004570 7597
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C14orf51//KUP//ZNF46

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZBTB25
chr14:64955808(-) A-I      intronic
chr14:64965160(-) A-I      intronic
chr14:64965204(-) A-I      intronic
chr14:64956900(-) A-I      intronic
chr14:64965153(-) A-I      intronic
chr14:64965189(-) A-I      intronic
chr14:64958102(-) A-I      intronic
chr14:64965156(-) A-I      intronic
chr14:64965169(-) A-I      intronic
chr14:64965176(-) A-I      intronic
chr14:64965198(-) A-I      intronic
chr14:64958803(-) A-I      intronic
chr14:64966122(-) A-I      intronic
chr14:64966059(-) A-I      intronic
chr14:64955739(-) A-I      intronic
chr14:64955711(-) A-I      intronic
chr14:64965624(-) A-I      intronic
chr14:64965581(-) A-I      intronic
chr14:64955706(-) A-I      intronic
chr14:64965484(-) A-I      intronic
chr14:64965301(-) A-I      intronic
chr14:64965280(-) A-I      intronic
chr14:64962551(-) A-I      intronic
chr14:64965211(-) A-I      intronic
chr14:64965136(-) A-I      intronic
chr14:64965098(-) A-I      intronic
chr14:64962632(-) A-I      intronic
chr14:64961314(-) A-I      intronic
chr14:64967335(-) A-I      intronic
chr14:64965619(-) A-I      intronic
chr14:64956846(-) A-I      intronic
chr14:64958754(-) A-I      intronic
chr14:64956760(-) A-I      intronic
chr14:64956447(-) A-I      intronic
chr14:64956418(-) A-I      intronic
chr14:64956414(-) A-I      intronic
chr14:64956386(-) A-I      intronic
chr14:64955922(-) A-I      intronic
chr14:64955903(-) A-I      intronic
chr14:64955802(-) A-I      intronic
chr14:64955844(-) A-I      intronic
chr14:64963175(-) A-I      intronic
chr14:64956804(-) A-I      intronic
chr14:64966136(-) A-I      intronic
chr14:64955720(-) A-I      intronic
chr14:64956843(-) A-I      intronic
chr14:64956746(-) A-I      intronic
chr14:64965107(-) A-I      intronic
chr14:64965621(-) A-I      intronic
chr14:64956283(-) A-I      intronic
chr14:64956887(-) A-I      intronic
chr14:64955850(-) A-I      intronic
chr14:64965170(-) A-I      intronic
chr14:64967717(-) A-I      intronic
chr14:64966119(-) A-I      intronic
chr14:64956350(-) A-I      intronic
chr14:64962621(-) A-I      intronic
chr14:64963207(-) A-I      intronic
chr14:64956287(-) A-I      intronic
chr14:64956850(-) A-I      intronic
chr14:64955782(-) A-I      intronic
chr14:64955914(-) A-I      intronic
chr14:64965123(-) A-I      intronic
chr14:64963146(-) A-I      intronic
chr14:64963133(-) A-I      intronic
chr14:64955975(-) A-I      intronic
chr14:64956743(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZBTB25
chr14:64962621(-) A-G intron -    22484847
chr14:64966161(-) T-C intron -    22484847
chr14:64966232(-) A-G intron -    22484847
chr14:64966238(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZBTB25
chr14:64915903-64915904(-) m6A 3'UTR       24284625//24981863//22608085
chr14:64916012-64916013(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr14:64916057-64916058(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr14:64916087-64916088(-) m6A 3'UTR       24284625//24981863
chr14:64916114-64916115(-) m6A 3'UTR       24284625
chr14:64944816-64944817(-) m6A 3'UTR//intron       27773535
chr14:64944941-64944942(-) m6A 3'UTR//intron       27773535
chr14:64948401-64948402(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:64948422-64948423(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:64948453-64948454(-) m6A 3'UTR//intron       24981863//22608085
chr14:64948477-64948478(-) m6A 3'UTR//intron       24981863//22608085
chr14:64948488-64948489(-) m6A 3'UTR//intron       24981863//22608085
chr14:64950189-64950190(-) m6A 3'UTR//intron       -
chr14:64950212-64950213(-) m6A 3'UTR//intron       -
chr14:64952566-64952567(-) m6A 3'UTR//intron       22608085
chr14:64952605-64952606(-) m6A 3'UTR//intron       22608085
chr14:64952621-64952622(-) m6A 3'UTR//intron       22608085
chr14:64952632-64952633(-) m6A 3'UTR//intron       24981863//22608085
chr14:64952638-64952639(-) m6A 3'UTR//intron       24981863//22608085
chr14:64952678-64952679(-) m6A 3'UTR//intron       24981863
chr14:64953482-64953483(-) m6A 3'UTR//intron       27773535
chr14:64953704-64953705(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr14:64953712-64953713(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr14:64953850-64953851(-) m6A CDS//intron       24284625//24981863//28052920//27773535//27371828//22608085
chr14:64953935-64953936(-) m6A CDS//intron       24284625//24981863//28052920//27773535//27371828//22608085
chr14:64953956-64953957(-) m6A CDS//intron       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr14:64954019-64954020(-) m6A CDS//intron       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr14:64954030-64954031(-) m6A CDS//intron       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr14:64954085-64954086(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr14:64954250-64954251(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr14:64954403-64954404(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr14:64954478-64954479(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr14:64954516-64954517(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr14:64954522-64954523(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:64954533-64954534(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:64954584-64954585(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:64954687-64954688(-) m6A CDS//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr14:64957082-64957083(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22608085
chr14:64957207-64957208(-) m6A CDS       27773535
chr14:64957246-64957247(-) m6A CDS       27773535
chr14:64966255-64966256(-) m6A 5'UTR//intron       27773536
chr14:64969744-64969745(-) m6A 5'UTR//intron       -
chr14:64970536-64970537(-) m6A 5'UTR//intron       27773536
chr14:64971481-64971482(-) m6A 5'UTR       24981863
chr14:64971499-64971500(-) m6A 5'UTR       24981863
chr14:64971649-64971650(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ZBTB25
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: ZBTB25

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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