Basic Information:

  VIRBase ID:  

HHID00065527

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          UGCG:  NM_003358     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	UGCG
miRBase Accession/Entrez ID	MIMAT0004570	7357
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCS//GLCT1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UGCG	chr9:114681170(+) A-I      intronic chr9:114681745(+) A-I      intronic chr9:114684204(+) A-I      intronic chr9:114683370(+) A-I      intronic chr9:114684244(+) A-I      intronic chr9:114684221(+) A-I      intronic chr9:114684217(+) A-I      intronic chr9:114683772(+) A-I      intronic chr9:114678907(+) A-I      intronic chr9:114665293(+) A-I      intronic chr9:114663017(+) A-I      intronic chr9:114662866(+) A-I      intronic chr9:114681817(+) A-I      intronic chr9:114681839(+) A-I      intronic chr9:114681843(+) A-I      intronic chr9:114681750(+) A-I      intronic chr9:114683764(+) A-I      intronic chr9:114682879(+) A-I      intronic chr9:114682906(+) A-I      intronic chr9:114682918(+) A-I      intronic chr9:114682920(+) A-I      intronic chr9:114683371(+) A-I      intronic chr9:114683668(+) A-I      intronic chr9:114683749(+) A-I      intronic chr9:114683765(+) A-I      intronic chr9:114683773(+) A-I      intronic chr9:114683886(+) A-I      intronic chr9:114684122(+) A-I      intronic chr9:114684166(+) A-I      intronic chr9:114675279(+) A-I      intronic chr9:114684178(+) A-I      intronic chr9:114674642(+) A-I      intronic chr9:114665077(+) A-I      intronic chr9:114665079(+) A-I      intronic chr9:114665192(+) A-I      intronic chr9:114665197(+) A-I      intronic chr9:114665199(+) A-I      intronic chr9:114665203(+) A-I      intronic chr9:114665310(+) A-I      intronic chr9:114665341(+) A-I      intronic chr9:114665595(+) A-I      intronic chr9:114665635(+) A-I      intronic chr9:114665643(+) A-I      intronic chr9:114665692(+) A-I      intronic chr9:114665693(+) A-I      intronic chr9:114665694(+) A-I      intronic chr9:114665725(+) A-I      intronic chr9:114665745(+) A-I      intronic chr9:114665979(+) A-I      intronic chr9:114666059(+) A-I      intronic chr9:114666926(+) A-I      intronic chr9:114666931(+) A-I      intronic chr9:114666954(+) A-I      intronic chr9:114666955(+) A-I      intronic chr9:114666980(+) A-I      intronic chr9:114666985(+) A-I      intronic chr9:114667031(+) A-I      intronic chr9:114667063(+) A-I      intronic chr9:114667125(+) A-I      intronic chr9:114667310(+) A-I      intronic chr9:114667326(+) A-I      intronic chr9:114667799(+) A-I      intronic chr9:114667835(+) A-I      intronic chr9:114667836(+) A-I      intronic chr9:114667853(+) A-I      intronic chr9:114667936(+) A-I      intronic chr9:114670022(+) A-I      intronic chr9:114670109(+) A-I      intronic chr9:114670171(+) A-I      intronic chr9:114673125(+) A-I      intronic chr9:114673152(+) A-I      intronic chr9:114673155(+) A-I      intronic chr9:114673248(+) A-I      intronic chr9:114673923(+) A-I      intronic chr9:114673944(+) A-I      intronic chr9:114673945(+) A-I      intronic chr9:114673982(+) A-I      intronic chr9:114674021(+) A-I      intronic chr9:114674029(+) A-I      intronic chr9:114674059(+) A-I      intronic chr9:114674142(+) A-I      intronic chr9:114674611(+) A-I      intronic chr9:114674625(+) A-I      intronic chr9:114674649(+) A-I      intronic chr9:114678980(+) A-I      intronic chr9:114678998(+) A-I      intronic chr9:114679008(+) A-I      intronic chr9:114679223(+) A-I      intronic chr9:114679224(+) A-I      intronic chr9:114680425(+) A-I      intronic chr9:114680958(+) A-I      intronic chr9:114681022(+) A-I      intronic chr9:114681023(+) A-I      intronic chr9:114665931(+) A-I      intronic chr9:114665976(+) A-I      intronic chr9:114680488(+) A-I      intronic chr9:114681613(+) A-I      intronic chr9:114681723(+) A-I      intronic chr9:114681068(+) A-I      intronic chr9:114681094(+) A-I      intronic chr9:114665969(+) A-I      intronic chr9:114683427(+) A-I      intronic chr9:114681571(+) A-I      intronic chr9:114673940(+) A-I      intronic chr9:114673289(+) A-I      intronic chr9:114682029(+) A-I      intronic chr9:114681090(+) A-I      intronic chr9:114684191(+) A-I      intronic chr9:114683458(+) A-I      intronic chr9:114679170(+) A-I      intronic chr9:114665666(+) A-I      intronic chr9:114665683(+) A-I      intronic chr9:114683324(+) A-I      intronic chr9:114681055(+) A-I      intronic chr9:114680386(+) A-I      intronic chr9:114670098(+) A-I      intronic chr9:114682692(+) A-I      intronic chr9:114681636(+) A-I      intronic chr9:114679169(+) A-I      intronic chr9:114679020(+) A-I      intronic chr9:114683404(+) A-I      intronic chr9:114681918(+) A-I      intronic chr9:114678981(+) A-I      intronic chr9:114674596(+) A-I      intronic chr9:114682685(+) A-I      intronic chr9:114667914(+) A-I      intronic chr9:114665724(+) A-I      intronic chr9:114684192(+) A-I      intronic chr9:114667081(+) A-I      intronic chr9:114682828(+) A-I      intronic chr9:114682905(+) A-I      intronic chr9:114681541(+) A-I      intronic chr9:114683247(+) A-I      intronic chr9:114680378(+) A-I      intronic chr9:114680421(+) A-I      intronic chr9:114674025(+) A-I      intronic chr9:114682706(+) A-I      intronic chr9:114684171(+) A-I      intronic chr9:114682845(+) A-I      intronic chr9:114680375(+) A-I      intronic chr9:114678769(+) A-I      intronic chr9:114684142(+) A-I      intronic chr9:114683707(+) A-I      intronic chr9:114681640(+) A-I      intronic chr9:114684354(+) A-I      intronic chr9:114679215(+) A-I      intronic chr9:114681602(+) A-I      intronic chr9:114683262(+) A-I      intronic chr9:114681996(+) A-I      intronic chr9:114680451(+) A-I      intronic chr9:114684195(+) A-I      intronic chr9:114663009(+) A-I      intronic chr9:114678862(+) A-I      intronic chr9:114678993(+) A-I      intronic chr9:114681981(+) A-I      intronic chr9:114681712(+) A-I      intronic chr9:114683348(+) A-I      intronic chr9:114680469(+) A-I      intronic chr9:114683655(+) A-I      intronic chr9:114680448(+) A-I      intronic chr9:114681084(+) A-I      intronic chr9:114684231(+) A-I      intronic chr9:114665805(+) A-I      intronic chr9:114665832(+) A-I      intronic chr9:114679243(+) A-I      intronic chr9:114684253(+) A-I      intronic chr9:114667875(+) A-I      intronic chr9:114683364(+) A-I      intronic chr9:114678776(+) A-I      intronic chr9:114665137(+) A-I      intronic chr9:114674088(+) A-I      intronic chr9:114694219(+) A-I      intronic chr9:114678967(+) A-I      intronic chr9:114666063(+) A-I      intronic chr9:114684302(+) A-I      intronic chr9:114663047(+) A-I      intronic chr9:114681954(+) A-I      intronic chr9:114674024(+) A-I      intronic chr9:114681024(+) A-I      intronic chr9:114681555(+) A-I      intronic chr9:114678773(+) A-I      intronic chr9:114678768(+) A-I      intronic chr9:114680477(+) A-I      intronic chr9:114665833(+) A-I      intronic chr9:114683676(+) A-I      intronic chr9:114683784(+) A-I      intronic chr9:114683406(+) A-I      intronic chr9:114673901(+) A-I      intronic chr9:114680385(+) A-I      intronic chr9:114683677(+) A-I      intronic chr9:114683393(+) A-I      intronic chr9:114665919(+) A-I      intronic chr9:114670089(+) A-I      intronic chr9:114678843(+) A-I      intronic chr9:114680361(+) A-I      intronic chr9:114681702(+) A-I      intronic chr9:114683769(+) A-I      intronic chr9:114670046(+) A-I      intronic chr9:114667021(+) A-I      intronic chr9:114679178(+) A-I      intronic chr9:114665988(+) A-I      intronic chr9:114681620(+) A-I      intronic chr9:114684373(+) A-I      intronic chr9:114681605(+) A-I      intronic chr9:114680487(+) A-I      intronic chr9:114679147(+) A-I      intronic chr9:114674081(+) A-I      intronic chr9:114683852(+) A-I      intronic chr9:114666995(+) A-I      intronic chr9:114665899(+) A-I      intronic chr9:114681133(+) A-I      intronic chr9:114681883(+) A-I      intronic chr9:114682888(+) A-I      intronic chr9:114680383(+) A-I      intronic chr9:114683774(+) A-I      intronic chr9:114681642(+) A-I      intronic chr9:114683704(+) A-I      intronic chr9:114684196(+) A-I      intronic chr9:114681718(+) A-I      intronic chr9:114681995(+) A-I      intronic chr9:114681167(+) A-I      intronic chr9:114667048(+) A-I      intronic chr9:114683917(+) A-I      intronic chr9:114681683(+) A-I      intronic chr9:114673119(+) A-I      intronic chr9:114682785(+) A-I      intronic chr9:114674023(+) A-I      intronic chr9:114681847(+) A-I      intronic chr9:114680450(+) A-I      intronic chr9:114683833(+) A-I      intronic chr9:114686089(+) A-I      intronic chr9:114673247(+) A-I      intronic chr9:114667986(+) A-I      intronic chr9:114681816(+) A-I      intronic chr9:114682705(+) A-I      intronic chr9:114681058(+) A-I      intronic chr9:114673976(+) A-I      intronic chr9:114683384(+) A-I      intronic chr9:114673931(+) A-I      intronic chr9:114665223(+) A-I      intronic chr9:114674815(+) A-I      intronic chr9:114666042(+) A-I      intronic chr9:114683349(+) A-I      intronic chr9:114666886(+) A-I      intronic chr9:114684233(+) A-I      intronic chr9:114694244(+) A-I      intronic chr9:114682763(+) A-I      intronic chr9:114683837(+) A-I      intronic chr9:114674603(+) A-I      intronic chr9:114682771(+) A-I      intronic chr9:114684146(+) A-I      intronic chr9:114663316(+) A-I      intronic chr9:114682772(+) A-I      intronic chr9:114674080(+) A-I      intronic chr9:114683775(+) A-I      intronic chr9:114686246(+) A-I      intronic chr9:114684134(+) A-I      intronic chr9:114671316(+) A-I      intronic chr9:114683786(+) A-I      intronic chr9:114684321(+) A-I      intronic chr9:114680422(+) A-I      intronic chr9:114681508(+) A-I      intronic chr9:114665751(+) A-I      intronic chr9:114666017(+) A-I      intronic chr9:114665953(+) A-I      intronic chr9:114678895(+) A-I      intronic chr9:114683300(+) A-I      intronic chr9:114681524(+) A-I      intronic chr9:114674068(+) A-I      intronic chr9:114683283(+) A-I      intronic chr9:114681125(+) A-I      intronic chr9:114694289(+) A-I      intronic chr9:114674682(+) A-I      intronic chr9:114673968(+) A-I      intronic chr9:114674000(+) A-I      intronic chr9:114678946(+) A-I      intronic chr9:114681964(+) A-I      intronic chr9:114665138(+) A-I      intronic chr9:114666021(+) A-I      intronic chr9:114681928(+) A-I      intronic chr9:114683734(+) A-I      intronic chr9:114668014(+) A-I      intronic chr9:114683658(+) A-I      intronic chr9:114684154(+) A-I      intronic chr9:114681117(+) A-I      intronic chr9:114681190(+) A-I      intronic chr9:114682814(+) A-I      intronic chr9:114681920(+) A-I      intronic chr9:114665934(+) A-I      intronic chr9:114683760(+) A-I      intronic chr9:114683763(+) A-I      intronic chr9:114682750(+) A-I      intronic chr9:114681126(+) A-I      intronic chr9:114682695(+) A-I      intronic chr9:114683282(+) A-I      intronic chr9:114680494(+) A-I      intronic chr9:114665943(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UGCG	chr9:114678768(+) A-I intron -    15342557 chr9:114678776(+) A-I intron -    15342557 chr9:114678843(+) A-I intron -    15342557 chr9:114678895(+) A-I intron -    15342557 chr9:114678946(+) A-I intron -    15342557 chr9:114678967(+) A-I intron -    15342557 chr9:114678981(+) A-I intron -    15342557 chr9:114678985(+) A-I intron -    15342557 chr9:114678993(+) A-I intron -    15342557 chr9:114679170(+) A-I intron -    15342557   //15258596 chr9:114679215(+) A-I intron -    15342557   //15258596 chr9:114679292(+) A-I intron -    15342557   //15258596 chr9:114679642(+) A-I intron -    15342557 chr9:114680375(+) A-I intron -    15342557 chr9:114680378(+) A-I intron -    15342557 chr9:114680383(+) A-I intron -    15342557 chr9:114680385(+) A-I intron -    15342557 chr9:114680386(+) A-I intron -    15342557 chr9:114680422(+) A-I intron -    15342557 chr9:114680426(+) A-I intron -    15342557 chr9:114680439(+) A-I intron -    15342557 chr9:114680450(+) A-I intron -    15342557 chr9:114680451(+) A-I intron -    15342557 chr9:114680494(+) A-I intron -    15342557   //15258596   //22327324 chr9:114680496(+) A-I intron -    15342557   //15258596 chr9:114680584(+) A-I intron -    15342557   //15258596 chr9:114681024(+) A-I intron -    15342557 chr9:114681055(+) A-I intron -    15342557 chr9:114681058(+) A-I intron -    15342557 chr9:114681084(+) A-I intron -    15342557 chr9:114681090(+) A-I intron -    15342557 chr9:114681111(+) A-I intron -    15342557 chr9:114681125(+) A-I intron -    15342557 chr9:114681126(+) A-I intron -    15342557 chr9:114681133(+) A-I intron -    15342557 chr9:114681167(+) A-I intron -    15342557 chr9:114681190(+) A-I intron -    15342557 chr9:114680341(+) A-I intron -    22327324 chr9:114683349(+) A-I intron -    22327324 chr9:114673210(+) A-I intron -    21960545 chr9:114678889(+) A-I intron -    21960545 chr9:114667829(+) A-G intron -    22484847 chr9:114679170(+) A-G intron -    22484847 chr9:114680341(+) A-G intron -    22484847 chr9:114680375(+) A-G intron -    22484847 chr9:114680385(+) A-G intron -    22484847 chr9:114680487(+) A-G intron -    22484847 chr9:114680494(+) A-G intron -    22484847 chr9:114681571(+) A-G intron -    22484847 chr9:114681607(+) A-G intron -    22484847 chr9:114681616(+) A-G intron -    22484847 chr9:114681636(+) A-G intron -    22484847 chr9:114681642(+) A-G intron -    22484847 chr9:114681692(+) A-G intron -    22484847 chr9:114681888(+) A-G intron -    22484847 chr9:114681925(+) A-G intron -    22484847 chr9:114682695(+) A-G intron -    22484847 chr9:114683348(+) A-G intron -    22484847 chr9:114683349(+) A-G intron -    22484847 chr9:114683427(+) A-G intron -    22484847 chr9:114683774(+) A-G intron -    22484847 chr9:114683778(+) A-G intron -    22484847 chr9:114683851(+) A-G intron -    22484847 chr9:114683852(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UGCG	chr9:114659212-114659213(+) m6A 5'UTR       24209618//27773536 chr9:114659225-114659226(+) m6A 5'UTR       24209618//27773536 chr9:114659254-114659255(+) m6A 5'UTR       24209618//27773536 chr9:114659291-114659292(+) m6A 5'UTR       24209618//24981863 chr9:114695200-114695201(+) m6A CDS       24981863 chr9:114695220-114695221(+) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	UGCG	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: UGCG

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.