Basic Information:

  VIRBase ID:  

HHID00065526

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          RPS6KA3:  NM_004586     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	RPS6KA3
miRBase Accession/Entrez ID	MIMAT0004570	6197
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CLS//HU-3//ISPK-1//MAPKAPK1B//MRX19//p90-RSK2//pp90RSK2//RSK//RSK2//S6K-alpha3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RPS6KA3	chrX:20196742(-) A-I      intronic chrX:20261879(-) A-I      intronic chrX:20261849(-) A-I      intronic chrX:20261825(-) A-I      intronic chrX:20261819(-) A-I      intronic chrX:20261815(-) A-I      intronic chrX:20252481(-) A-I      intronic chrX:20250608(-) A-I      intronic chrX:20250607(-) A-I      intronic chrX:20250590(-) A-I      intronic chrX:20249205(-) A-I      intronic chrX:20233089(-) A-I      intronic chrX:20233059(-) A-I      intronic chrX:20233049(-) A-I      intronic chrX:20233017(-) A-I      intronic chrX:20233009(-) A-I      intronic chrX:20230553(-) A-I      intronic chrX:20230381(-) A-I      intronic chrX:20230371(-) A-I      intronic chrX:20230359(-) A-I      intronic chrX:20211370(-) A-I      intronic chrX:20252469(-) A-I      intronic chrX:20211349(-) A-I      intronic chrX:20211344(-) A-I      intronic chrX:20211320(-) A-I      intronic chrX:20211313(-) A-I      intronic chrX:20211284(-) A-I      intronic chrX:20210938(-) A-I      intronic chrX:20210929(-) A-I      intronic chrX:20210786(-) A-I      intronic chrX:20198205(-) A-I      intronic chrX:20198203(-) A-I      intronic chrX:20198163(-) A-I      intronic chrX:20198107(-) A-I      intronic chrX:20197991(-) A-I      intronic chrX:20196836(-) A-I      intronic chrX:20265810(-) A-I      intronic chrX:20194848(-) A-I      intronic chrX:20194830(-) A-I      intronic chrX:20194821(-) A-I      intronic chrX:20192563(-) A-I      intronic chrX:20182776(-) A-I      intronic chrX:20182754(-) A-I      intronic chrX:20182233(-) A-I      intronic chrX:20182223(-) A-I      intronic chrX:20182217(-) A-I      intronic chrX:20182186(-) A-I      intronic chrX:20182161(-) A-I      intronic chrX:20182018(-) A-I      intronic chrX:20181924(-) A-I      intronic chrX:20181919(-) A-I      intronic chrX:20181902(-) A-I      intronic chrX:20181711(-) A-I      intronic chrX:20176414(-) A-I      intronic chrX:20176400(-) A-I      intronic chrX:20176371(-) A-I      intronic chrX:20176335(-) A-I      intronic chrX:20176334(-) A-I      intronic chrX:20176328(-) A-I      intronic chrX:20176327(-) A-I      intronic chrX:20175510(-) A-I      intronic chrX:20174926(-) A-I      intronic chrX:20174746(-) A-I      intronic chrX:20174739(-) A-I      intronic chrX:20265859(-) A-I      intronic chrX:20265465(-) A-I      intronic chrX:20265448(-) A-I      intronic chrX:20265422(-) A-I      intronic chrX:20265419(-) A-I      intronic chrX:20265410(-) A-I      intronic chrX:20176420(-) A-I      intronic chrX:20182759(-) A-I      intronic chrX:20182767(-) A-I      intronic chrX:20182770(-) A-I      intronic chrX:20198123(-) A-I      intronic chrX:20221486(-) A-I      intronic chrX:20221491(-) A-I      intronic chrX:20221492(-) A-I      intronic chrX:20221517(-) A-I      intronic chrX:20221520(-) A-I      intronic chrX:20249235(-) A-I      intronic chrX:20249241(-) A-I      intronic chrX:20249245(-) A-I      intronic chrX:20249253(-) A-I      intronic chrX:20249258(-) A-I      intronic chrX:20264203(-) A-I      intronic chrX:20264174(-) A-I      intronic chrX:20262350(-) A-I      intronic chrX:20261884(-) A-I      intronic chrX:20261878(-) A-I      intronic chrX:20264160(-) A-I      intronic chrX:20174721(-) A-I      intronic chrX:20176470(-) A-I      intronic chrX:20266739(-) A-I      intronic chrX:20187040(-) A-I      intronic chrX:20261650(-) A-I      intronic chrX:20204154(-) A-I      intronic chrX:20210816(-) A-I      intronic chrX:20210857(-) A-I      intronic chrX:20210975(-) A-I      intronic chrX:20266757(-) A-I      intronic chrX:20210981(-) A-I      intronic chrX:20176339(-) A-I      intronic chrX:20182775(-) A-I      intronic chrX:20266771(-) A-I      intronic chrX:20230775(-) A-I      intronic chrX:20189098(-) A-I      intronic chrX:20210787(-) A-I      intronic chrX:20251060(-) A-I      intronic chrX:20205171(-) A-I      intronic chrX:20249188(-) A-I      intronic chrX:20205517(-) A-I      intronic chrX:20198006(-) A-I      intronic chrX:20182596(-) A-I      intronic chrX:20211139(-) A-I      intronic chrX:20182147(-) A-I      intronic chrX:20181963(-) A-I      intronic chrX:20269364(-) A-I      intronic chrX:20266709(-) A-I      intronic chrX:20211350(-) A-I      intronic chrX:20198095(-) A-I      intronic chrX:20249180(-) A-I      intronic chrX:20220095(-) A-I      intronic chrX:20198173(-) A-I      intronic chrX:20201477(-) A-I      intronic chrX:20196696(-) A-I      intronic chrX:20249275(-) A-I      intronic chrX:20182182(-) A-I      intronic chrX:20210843(-) A-I      intronic chrX:20265378(-) A-I      intronic chrX:20261885(-) A-I      intronic chrX:20201441(-) A-I      intronic chrX:20264070(-) A-I      intronic chrX:20197952(-) A-I      intronic chrX:20174751(-) A-I      intronic chrX:20182059(-) A-I      intronic chrX:20198091(-) A-I      intronic chrX:20175537(-) A-I      intronic chrX:20182060(-) A-I      intronic chrX:20197964(-) A-I      intronic chrX:20182749(-) A-I      intronic chrX:20176388(-) A-I      intronic chrX:20265485(-) A-I      intronic chrX:20182038(-) A-I      intronic chrX:20261672(-) A-I      intronic chrX:20264053(-) A-I      intronic chrX:20251753(-) A-I      intronic chrX:20211274(-) A-I      intronic chrX:20251838(-) A-I      intronic chrX:20249222(-) A-I      intronic chrX:20204224(-) A-I      intronic chrX:20181925(-) A-I      intronic chrX:20233121(-) A-I      intronic chrX:20210907(-) A-I      intronic chrX:20263981(-) A-I      intronic chrX:20274116(-) A-I      intronic chrX:20194929(-) A-I      intronic chrX:20194982(-) A-I      intronic chrX:20261671(-) A-I      intronic chrX:20211309(-) A-I      intronic chrX:20264124(-) A-I      intronic chrX:20251774(-) A-I      intronic chrX:20264154(-) A-I      intronic chrX:20176279(-) A-I      intronic chrX:20175536(-) A-I      intronic chrX:20196848(-) A-I      intronic chrX:20261689(-) A-I      intronic chrX:20176361(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RPS6KA3	chrX:20272981(-) A-I intron -    15342557 chrX:20272992(-) A-I intron -    15342557 chrX:20273019(-) A-I intron -    15342557 chrX:20273092(-) A-I intron -    15342557 chrX:20273127(-) A-I intron -    15342557 chrX:20273168(-) A-I intron -    15342557 chrX:20273169(-) A-I intron -    15342557 chrX:20171749(-) G-A exon 3'UTR    22484847 chrX:20209914(-) G-A intron -    22484847 chrX:20261689(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPS6KA3	chrX:20168721-20168722(-) m6A 3'UTR       26404942 chrX:20168739-20168740(-) m6A 3'UTR       26404942 chrX:20168760-20168761(-) m6A 3'UTR       26404942 chrX:20168797-20168798(-) m6A 3'UTR       26404942 chrX:20168906-20168907(-) m6A 3'UTR       26404942 chrX:20168917-20168918(-) m6A 3'UTR       26404942 chrX:20169405-20169406(-) m6A 3'UTR       26404942 chrX:20169441-20169442(-) m6A 3'UTR       26404942 chrX:20169984-20169985(-) m6A 3'UTR       - chrX:20170033-20170034(-) m6A 3'UTR       - chrX:20170098-20170099(-) m6A 3'UTR       - chrX:20171113-20171114(-) m6A 3'UTR       27773535 chrX:20171120-20171121(-) m6A 3'UTR       27773535 chrX:20171175-20171176(-) m6A 3'UTR       27773535 chrX:20171186-20171187(-) m6A 3'UTR       27773535 chrX:20171833-20171834(-) m6A 3'UTR       24981863 chrX:20172887-20172888(-) m6A 3'UTR       27773535 chrX:20172915-20172916(-) m6A 3'UTR       27773535 chrX:20173051-20173052(-) m6A 3'UTR       27773535 chrX:20173113-20173114(-) m6A 3'UTR       24981863//26404942//27773535//22608085 chrX:20173140-20173141(-) m6A 3'UTR       24981863//26404942//27773535//22608085 chrX:20173249-20173250(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:20173293-20173294(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:20173434-20173435(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chrX:20173581-20173582(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chrX:20173606-20173607(-) m6A CDS//exon       24284625 chrX:20187538-20187539(-) m6A CDS//exon       26404942 chrX:20187549-20187550(-) m6A CDS//exon       26404942 chrX:20187586-20187587(-) m6A CDS//exon       26404942 chrX:20227441-20227442(-) m6A CDS//exon       27773535 chrX:20227471-20227472(-) m6A CDS//exon       24981863//27773535 chrX:20227517-20227518(-) m1A CDS//exon       26863196 chrX:20237037-20237038(-) m6A 5'UTR//intron       24981863 chrX:20237054-20237055(-) m6A 5'UTR//intron       24981863 chrX:20252877-20252878(-) m6A CDS//exon       24981863 chrX:20252908-20252909(-) m6A CDS//exon       24981863 chrX:20252926-20252927(-) m6A 5'UTR//CDS//exon       24981863 chrX:20259732-20259733(-) m6A intron       24981863 chrX:20259762-20259763(-) m6A intron       24981863 chrX:20259774-20259775(-) m6A intron       24981863 chrX:20284727-20284728(-) m6A 5'UTR//CDS//intron       24981863 chrX:20285159-20285160(-) m6A exon       24209618//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	RPS6KA3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: RPS6KA3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.