Detail Information

Basic Information:


  VIRBase ID:  

HHID00065525

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           PSMB7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p PSMB7
miRBase
Accession/Entrez ID		 MIMAT0004570 5695
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Z

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PSMB7
chr9:127168139(-) A-I      intronic
chr9:127168131(-) A-I      intronic
chr9:127168126(-) A-I      intronic
chr9:127169203(-) A-I      intronic
chr9:127166939(-) A-I      intronic
chr9:127166913(-) A-I      intronic
chr9:127166396(-) A-I      intronic
chr9:127166388(-) A-I      intronic
chr9:127149519(-) A-I      intronic
chr9:127149462(-) A-I      intronic
chr9:127149358(-) A-I      intronic
chr9:127149344(-) A-I      intronic
chr9:127144724(-) A-I      intronic
chr9:127144714(-) A-I      intronic
chr9:127144711(-) A-I      intronic
chr9:127144703(-) A-I      intronic
chr9:127144583(-) A-I      intronic
chr9:127144516(-) A-I      intronic
chr9:127144405(-) A-I      intronic
chr9:127144333(-) A-I      intronic
chr9:127144321(-) A-I      intronic
chr9:127144280(-) A-I      intronic
chr9:127137656(-) A-I      intronic
chr9:127137646(-) A-I      intronic
chr9:127137644(-) A-I      intronic
chr9:127137621(-) A-I      intronic
chr9:127168237(-) A-I      intronic
chr9:127137312(-) A-I      intronic
chr9:127166463(-) A-I      intronic
chr9:127168659(-) A-I      intronic
chr9:127173488(-) A-I      intronic
chr9:127170441(-) A-I      intronic
chr9:127170318(-) A-I      intronic
chr9:127170223(-) A-I      intronic
chr9:127170221(-) A-I      intronic
chr9:127170208(-) A-I      intronic
chr9:127170205(-) A-I      intronic
chr9:127172360(-) A-I      intronic
chr9:127136907(-) A-I      intronic
chr9:127144584(-) A-I      intronic
chr9:127144381(-) A-I      intronic
chr9:127166279(-) A-I      intronic
chr9:127168100(-) A-I      intronic
chr9:127144293(-) A-I      intronic
chr9:127166263(-) A-I      intronic
chr9:127144760(-) A-I      intronic
chr9:127166377(-) A-I      intronic
chr9:127168216(-) A-I      intronic
chr9:127168610(-) A-I      intronic
chr9:127172546(-) A-I      intronic
chr9:127137715(-) A-I      intronic
chr9:127144461(-) A-I      intronic
chr9:127168537(-) A-I      intronic
chr9:127137564(-) A-I      intronic
chr9:127165769(-) A-I      intronic
chr9:127168059(-) A-I      intronic
chr9:127136995(-) A-I      intronic
chr9:127173501(-) A-I      intronic
chr9:127136921(-) A-I      intronic
chr9:127166914(-) A-I      intronic
chr9:127168699(-) A-I      intronic
chr9:127169258(-) A-I      intronic
chr9:127144645(-) A-I      intronic
chr9:127144559(-) A-I      intronic
chr9:127168142(-) A-I      intronic
chr9:127144410(-) A-I      intronic
chr9:127166303(-) A-I      intronic
chr9:127168086(-) A-I      intronic
chr9:127165682(-) A-I      intronic
chr9:127137235(-) A-I      intronic
chr9:127137578(-) A-I      intronic
chr9:127168135(-) A-I      intronic
chr9:127166309(-) A-I      intronic
chr9:127144404(-) A-I      intronic
chr9:127168681(-) A-I      intronic
chr9:127166246(-) A-I      intronic
chr9:127170196(-) A-I      intronic
chr9:127144317(-) A-I      intronic
chr9:127144320(-) A-I      intronic
chr9:127169252(-) A-I      intronic
chr9:127144326(-) A-I      intronic
chr9:127144762(-) A-I      intronic
chr9:127136869(-) A-I      intronic
chr9:127144705(-) A-I      intronic
chr9:127144294(-) A-I      intronic
chr9:127168718(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PSMB7
chr9:127144293(-) A-I intron -    21960545
chr9:127144294(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PSMB7
chr9:127115760-127115761(-) m6A 3'UTR//exon       24284625//28052920//27773535
chr9:127115766-127115767(-) m6A 3'UTR//exon       24284625//28052920//27773535
chr9:127115783-127115784(-) m6A 3'UTR//exon       24284625//28052920//27773535
chr9:127115814-127115815(-) m6A 3'UTR//exon       24284625//28052920//27773535//22575960
chr9:127115886-127115887(-) m6A CDS//exon       24284625//28052920//27773535//22575960
chr9:127115893-127115894(-) m6A CDS//exon       24284625//27773535//22575960
chr9:127115902-127115903(-) m6A CDS//exon       24284625//26404942//27773535//22575960
chr9:127115959-127115960(-) m6A CDS//exon       24284625//26404942//22575960
chr9:127118901-127118902(-) m6A intron       24284625
chr9:127119046-127119047(-) m6A CDS//exon       27773535
chr9:127119093-127119094(-) m6A CDS//exon       27773535//22575960
chr9:127174738-127174739(-) m6A CDS//exon       26404942
chr9:127174744-127174745(-) m6A CDS//exon       26404942
chr9:127174754-127174755(-) m6A CDS//exon       26404942
chr9:127176222-127176223(-) m6A CDS//exon       26404942
chr9:127177152-127177153(-) m6A CDS//exon       26404942//22575960
chr9:127177720-127177721(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
PSMB7
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: PSMB7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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