Detail Information

Basic Information:


  VIRBase ID:  

HHID00065522

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           PFN1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p PFN1
miRBase
Accession/Entrez ID		 MIMAT0004570 5216
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ALS18

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PFN1
chr17:4848998-4848999(-) m6A 3'UTR       24284625
chr17:4849044-4849045(-) m6A 3'UTR       24284625//24981863//27773535//22575960
chr17:4849075-4849076(-) m6A 3'UTR       24284625//24981863//27773535//22575960
chr17:4849124-4849125(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960
chr17:4849931-4849932(-) m6A CDS       26404942//22575960
chr17:4850020-4850021(-) m6A CDS       26404942//22575960
chr17:4850083-4850084(-) m6A CDS       24284625//27773535//27773536//22575960
chr17:4850172-4850173(-) m6A 5'UTR//intron       24284625//27773535//27773536//22575960
chr17:4850191-4850192(-) m6A 5'UTR//intron       24284625//27773535//27773536//22575960
chr17:4850544-4850545(-) m6A 5'UTR//intron       -
chr17:4850578-4850579(-) m6A 5'UTR//intron       -
chr17:4850596-4850597(-) m6A 5'UTR//intron       -
chr17:4850713-4850714(-) m6A 5'UTR//intron       22575960
chr17:4851609-4851610(-) m6A CDS       24284625//24209618//26404942//27371828//27773536//22575960
chr17:4851643-4851644(-) m6A CDS       24284625//24209618//28052920//26404942//27371828//27773536//22575960
chr17:4852010-4852011(-) m6A 5'UTR//intron       27773535
chr17:4852068-4852069(-) m6A 5'UTR//intron       27773535
chr17:4852193-4852194(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
PFN1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: PFN1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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