Detail Information

Basic Information:


  VIRBase ID:  

HHID00065518

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           LCP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p LCP1
miRBase
Accession/Entrez ID		 MIMAT0004570 3936
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CP64//HEL-S-37//L-PLASTIN//LC64P//LPL//PLS2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LCP1
chr13:46751828(-) A-I      intronic
chr13:46711592(-) A-I      intronic
chr13:46779098(-) A-I      intronic
chr13:46709021(-) A-I      intronic
chr13:46711612(-) A-I      intronic
chr13:46711588(-) A-I      intronic
chr13:46711575(-) A-I      intronic
chr13:46713019(-) A-I      intronic
chr13:46711599(-) A-I      intronic
chr13:46712878(-) A-I      intronic
chr13:46712849(-) A-I      intronic
chr13:46715500(-) A-I      intronic
chr13:46702257(-) A-I      intronic
chr13:46711510(-) A-I      intronic
chr13:46712946(-) A-I      intronic
chr13:46712942(-) A-I      intronic
chr13:46702255(-) A-I      intronic
chr13:46719800(-) A-I      intronic
chr13:46711548(-) A-I      intronic
chr13:46711451(-) A-I      intronic
chr13:46718089(-) A-I      intronic
chr13:46702248(-) A-I      intronic
chr13:46712858(-) A-I      intronic
chr13:46702729(-) A-I      intronic
chr13:46711469(-) A-I      intronic
chr13:46712938(-) A-I      intronic
chr13:46702249(-) A-I      intronic
chr13:46727717(-) A-I      intronic
chr13:46709993(-) A-I      intronic
chr13:46711593(-) A-I      intronic
chr13:46711670(-) A-I      intronic
chr13:46711550(-) A-I      intronic
chr13:46751675(-) A-I      intronic
chr13:46702549(-) A-I      intronic
chr13:46702477(-) A-I      intronic
chr13:46711524(-) A-I      intronic
chr13:46702203(-) A-I      intronic
chr13:46702175(-) A-I      intronic
chr13:46711615(-) A-I      intronic
chr13:46748725(-) A-I      intronic
chr13:46711623(-) A-I      intronic
chr13:46712871(-) A-I      intronic
chr13:46702221(-) A-I      intronic
chr13:46709998(-) A-I      intronic
chr13:46712850(-) A-I      intronic
chr13:46712957(-) A-I      intronic
chr13:46711468(-) A-I      intronic
chr13:46709135(-) A-I      intronic
chr13:46713055(-) A-I      intronic
chr13:46711456(-) A-I      intronic
chr13:46712844(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LCP1
chr13:46702175(-) A-I intron -    15258596
chr13:46702203(-) A-I intron -    15258596
chr13:46702255(-) A-I intron -    15258596
chr13:46702257(-) A-I intron -    15258596
chr13:46711451(-) A-G intron -    22484847
chr13:46711456(-) A-G intron -    22484847
chr13:46711550(-) A-G intron -    22484847
chr13:46711592(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LCP1
chr13:46700177-46700178(-) m6A 3'UTR       28052920//27773535
chr13:46700269-46700270(-) m6A 3'UTR       28052920//26404942//27773535
chr13:46700329-46700330(-) m6A 3'UTR       28052920//26404942//27773535
chr13:46700406-46700407(-) m6A 3'UTR       24981863//28052920//26404942//27773535
chr13:46700442-46700443(-) m6A 3'UTR       24981863//28052920//26404942//27773535
chr13:46700490-46700491(-) m6A 3'UTR       28052920//26404942//27773535
chr13:46700496-46700497(-) m6A 3'UTR       28052920//26404942//27773535
chr13:46700516-46700517(-) m6A 3'UTR       28052920//26404942//27773535
chr13:46700544-46700545(-) m6A 3'UTR       28052920//26404942//27773535
chr13:46700642-46700643(-) m6A 3'UTR       26404942//27773535
chr13:46700654-46700655(-) m6A 3'UTR       26404942//27773535
chr13:46700974-46700975(-) m6A 3'UTR       26404942
chr13:46701009-46701010(-) m6A 3'UTR       26404942
chr13:46701206-46701207(-) m6A 3'UTR       27773535
chr13:46701306-46701307(-) m6A 3'UTR       27773535
chr13:46701324-46701325(-) m6A 3'UTR       27773535
chr13:46701786-46701787(-) m6A CDS       26404942
chr13:46701801-46701802(-) m6A CDS       26404942
chr13:46704962-46704963(-) m6A CDS       26404942
chr13:46704988-46704989(-) m6A CDS       26404942
chr13:46718615-46718616(-) m6A CDS       -
chr13:46718624-46718625(-) m6A CDS       -
chr13:46718634-46718635(-) m6A CDS       -
chr13:46721065-46721066(-) m6A CDS//exon       27773535
chr13:46721071-46721072(-) m6A CDS//exon       27773535
chr13:46721079-46721080(-) m6A CDS//exon       27773535
chr13:46721128-46721129(-) m6A CDS//exon       26404942//27773535
chr13:46721140-46721141(-) m6A CDS//exon       26404942//27773535
chr13:46722492-46722493(-) m6A CDS//exon       -
chr13:46742619-46742620(-) m6A 5'UTR//intron       24981863//28052920//26404942//27371828
chr13:46756263-46756264(-) m6A 5'UTR//exon       24981863//28052920//26404942//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
LCP1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: LCP1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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