Detail Information

Basic Information:


  VIRBase ID:  

HHID00065513

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:           HIVEP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-5p HIVEP1
miRBase
Accession/Entrez ID		 MIMAT0004570 3096
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CIRIP//CRYBP1//GAAP//MBP-1//PRDII-BF1//Schnurri-1//ZAS1//ZNF40//ZNF40A

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-5p
rs1240009384 chrX:66018913    A/T
rs1397275461 chrX:66018904    G/T
rs1464475149 chrX:66018916    T/C
rs761701581 chrX:66018906    C/G
rs772305537 chrX:66018909    G/A
rs774279244 chrX:66018895    C/T
rs890919635 chrX:66018896    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HIVEP1
chr6:12038019(+) A-I      NonSyn:Gln->Arg
chr6:12155510(+) A-I      intronic
chr6:12047561(+) A-I      intronic
chr6:12046803(+) A-I      intronic
chr6:12046851(+) A-I      intronic
chr6:12046856(+) A-I      intronic
chr6:12046907(+) A-I      intronic
chr6:12046921(+) A-I      intronic
chr6:12047144(+) A-I      intronic
chr6:12047168(+) A-I      intronic
chr6:12047260(+) A-I      intronic
chr6:12068506(+) A-I      intronic
chr6:12068473(+) A-I      intronic
chr6:12047344(+) A-I      intronic
chr6:12041495(+) A-I      intronic
chr6:12026086(+) A-I      intronic
chr6:12041391(+) A-I      intronic
chr6:12041399(+) A-I      intronic
chr6:12041426(+) A-I      intronic
chr6:12041996(+) A-I      intronic
chr6:12042033(+) A-I      intronic
chr6:12042080(+) A-I      intronic
chr6:12042081(+) A-I      intronic
chr6:12038614(+) A-I      3'UTR
chr6:12038612(+) A-I      3'UTR
chr6:12038743(+) A-I      3'UTR
chr6:12038744(+) A-I      3'UTR
chr6:12038745(+) A-I      3'UTR
chr6:12038755(+) A-I      3'UTR
chr6:12038758(+) A-I      3'UTR
chr6:12038794(+) A-I      3'UTR
chr6:12038855(+) A-I      3'UTR
chr6:12038830(+) A-I      3'UTR
chr6:12038224(+) A-I      3'UTR
chr6:12038646(+) A-I      3'UTR
chr6:12038657(+) A-I      3'UTR
chr6:12059471(+) A-I      intronic
chr6:12042034(+) A-I      intronic
chr6:12037020(+) A-I      intronic
chr6:12046750(+) A-I      intronic
chr6:12047268(+) A-I      intronic
chr6:12026174(+) A-I      intronic
chr6:12046847(+) A-I      intronic
chr6:12046852(+) A-I      intronic
chr6:12041918(+) A-I      intronic
chr6:12059454(+) A-I      intronic
chr6:12042032(+) A-I      intronic
chr6:12041400(+) A-I      intronic
chr6:12041508(+) A-I      intronic
chr6:12038753(+) A-I      3'UTR
chr6:12038083(+) A-I      3'UTR
chr6:12038652(+) A-I      3'UTR
chr6:12038210(+) A-I      3'UTR
chr6:12038217(+) A-I      3'UTR
chr6:12038213(+) A-I      3'UTR
chr6:12038695(+) A-I      3'UTR
chr6:12038696(+) A-I      3'UTR
chr6:12038089(+) A-I      3'UTR
chr6:12038778(+) A-I      3'UTR
chr6:12038222(+) A-I      3'UTR
chr6:12038660(+) A-I      3'UTR
chr6:12038073(+) A-I      3'UTR
chr6:12046854(+) A-I      intronic
chr6:12047366(+) A-I      intronic
chr6:12041534(+) A-I      intronic
chr6:12041492(+) A-I      intronic
chr6:12046891(+) A-I      intronic
chr6:12047274(+) A-I      intronic
chr6:12068588(+) A-I      intronic
chr6:12022533(+) A-I      intronic
chr6:12047198(+) A-I      intronic
chr6:12047259(+) A-I      intronic
chr6:12047194(+) A-I      intronic
chr6:12046759(+) A-I      intronic
chr6:12070765(+) A-I      intronic
chr6:12041491(+) A-I      intronic
chr6:12047277(+) A-I      intronic
chr6:12130650(+) A-I      intronic
chr6:12041997(+) A-I      intronic
chr6:12038003(+) A-I      NonSyn:Ser->Gly
chr6:12037989(+) A-I      NonSyn:Gln->Arg
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HIVEP1
chr6:12038222(+) A-I intron -    21960545
chr6:12058165(+) A-G intron -    22484847
chr6:12021142(+) G-T intron -    22484847
chr6:12022024(+) G-A intron -    22484847
chr6:12026173(+) T-C intron -    22484847
chr6:12037989(+) A-G intron -    22484847
chr6:12038003(+) A-G intron -    22484847
chr6:12038089(+) A-G intron -    22484847
chr6:12038176(+) A-G intron -    22484847
chr6:12038209(+) A-G intron -    22484847
chr6:12038210(+) A-G intron -    22484847
chr6:12038213(+) A-G intron -    22484847
chr6:12038217(+) A-G intron -    22484847
chr6:12038222(+) A-G intron -    22484847
chr6:12038651(+) A-G intron -    22484847
chr6:12038652(+) A-G intron -    22484847
chr6:12038660(+) A-G intron -    22484847
chr6:12038695(+) A-G intron -    22484847
chr6:12038696(+) A-G intron -    22484847
chr6:12038778(+) A-G intron -    22484847
chr6:12038784(+) A-G intron -    22484847
chr6:12041491(+) A-G intron -    22484847
chr6:12041492(+) A-G intron -    22484847
chr6:12041493(+) A-G intron -    22484847
chr6:12041918(+) A-G intron -    22484847
chr6:12041920(+) A-G intron -    22484847
chr6:12041990(+) A-G intron -    22484847
chr6:12041997(+) A-G intron -    22484847
chr6:12042022(+) A-G intron -    22484847
chr6:12042032(+) A-G intron -    22484847
chr6:12042034(+) A-G intron -    22484847
chr6:12046750(+) A-G intron -    22484847
chr6:12046758(+) A-G intron -    22484847
chr6:12046759(+) A-G intron -    22484847
chr6:12046850(+) A-G intron -    22484847
chr6:12046852(+) A-G intron -    22484847
chr6:12046854(+) A-G intron -    22484847
chr6:12046891(+) A-G intron -    22484847
chr6:12047194(+) A-G intron -    22484847
chr6:12047197(+) A-G intron -    22484847
chr6:12047198(+) A-G intron -    22484847
chr6:12047223(+) A-G intron -    22484847
chr6:12047268(+) A-G intron -    22484847
chr6:12047274(+) A-G intron -    22484847
chr6:12047277(+) A-G intron -    22484847
chr6:12047291(+) A-G intron -    22484847
chr6:12047366(+) A-G intron -    22484847
chr6:12055550(+) G-A intron -    22484847
chr6:12059191(+) C-T intron -    22484847
chr6:12059198(+) G-T intron -    22484847
chr6:12059454(+) A-G intron -    22484847
chr6:12059471(+) A-G intron -    22484847
chr6:12068588(+) A-G intron -    22484847
chr6:12070695(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HIVEP1
chr6:12120148-12120149(+) m6A 5'UTR//CDS       24981863
chr6:12120357-12120358(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12120370-12120371(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12120453-12120454(+) m6A 5'UTR//CDS//intron       24284625//24981863//22575960//22608085
chr6:12120510-12120511(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr6:12120541-12120542(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr6:12120547-12120548(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr6:12120605-12120606(+) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12120645-12120646(+) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12120688-12120689(+) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12120696-12120697(+) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12120712-12120713(+) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12120740-12120741(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr6:12120766-12120767(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr6:12120891-12120892(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12120990-12120991(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12120996-12120997(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12121073-12121074(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863
chr6:12121233-12121234(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22608085
chr6:12121360-12121361(+) m6A 5'UTR//CDS//intron       24284625//24981863//22575960//22608085
chr6:12121410-12121411(+) m6A 5'UTR//CDS//intron       24284625//24981863//22575960//22608085
chr6:12121499-12121500(+) m6A 5'UTR//CDS//intron       24284625//24981863//22575960//22608085
chr6:12121539-12121540(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12121606-12121607(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12121673-12121674(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22608085
chr6:12121750-12121751(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr6:12121785-12121786(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22608085
chr6:12121811-12121812(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12121879-12121880(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12121934-12121935(+) m6A 5'UTR//CDS//intron       24981863//22608085
chr6:12122080-12122081(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122127-12122128(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122132-12122133(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122151-12122152(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122434-12122435(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122673-12122674(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122721-12122722(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122738-12122739(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122775-12122776(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12122896-12122897(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12122914-12122915(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22608085
chr6:12122924-12122925(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22608085
chr6:12122937-12122938(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22608085
chr6:12122988-12122989(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12122995-12122996(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12123015-12123016(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12123096-12123097(+) m6A 5'UTR//CDS//intron       24981863//22608085
chr6:12123153-12123154(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123175-12123176(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123296-12123297(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123334-12123335(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123366-12123367(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123392-12123393(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123402-12123403(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123411-12123412(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123690-12123691(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123702-12123703(+) m6A 5'UTR//CDS//intron       24981863
chr6:12123753-12123754(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12123764-12123765(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12123829-12123830(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12123855-12123856(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12123897-12123898(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12123995-12123996(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12124134-12124135(+) m6A 5'UTR//CDS//intron       24284625//22608085
chr6:12124219-12124220(+) m6A 5'UTR//CDS//intron       24284625//24981863
chr6:12124334-12124335(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12124483-12124484(+) m6A 5'UTR//CDS//intron       24284625
chr6:12124510-12124511(+) m6A 5'UTR//CDS//intron       24284625
chr6:12124517-12124518(+) m6A 5'UTR//CDS//intron       24284625
chr6:12125291-12125292(+) m6A 5'UTR//CDS//intron       24981863
chr6:12125361-12125362(+) m6A 5'UTR//CDS//intron       24981863//22608085
chr6:12125403-12125404(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12125427-12125428(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12125577-12125578(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12125606-12125607(+) m6A 5'UTR//CDS//intron       24284625//24981863//22608085
chr6:12125696-12125697(+) m6A 5'UTR//CDS//intron       24284625//24981863//26404942//22608085
chr6:12125750-12125751(+) m6A 5'UTR//CDS//intron       24284625//24981863//26404942//22608085
chr6:12125807-12125808(+) m6A 5'UTR//CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085
chr6:12125839-12125840(+) m6A 5'UTR//CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085
chr6:12125903-12125904(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085
chr6:12125911-12125912(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085
chr6:12125932-12125933(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085
chr6:12126003-12126004(+) m6A 5'UTR//CDS//intron       24284625//24981863//26404942//22608085
chr6:12126008-12126009(+) m6A 5'UTR//CDS//intron       24284625//24981863//26404942//22608085
chr6:12126059-12126060(+) m6A 5'UTR//CDS//intron       24284625//24981863//26404942//22608085
chr6:12161678-12161679(+) m6A 3'UTR//CDS       24981863
chr6:12161770-12161771(+) m6A 3'UTR//CDS       24981863//27773535//22608085
chr6:12161854-12161855(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085
chr6:12161914-12161915(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12161994-12161995(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22575960//22608085
chr6:12162061-12162062(+) m6A 3'UTR//CDS       25456834//24981863//22608085
chr6:12162097-12162098(+) m6A 3'UTR//CDS       25456834//24981863//22608085
chr6:12163532-12163533(+) m6A 3'UTR//CDS       24284625
chr6:12163566-12163567(+) m6A 3'UTR//CDS       24284625//24981863
chr6:12163616-12163617(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr6:12163716-12163717(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr6:12163802-12163803(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr6:12163845-12163846(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12163894-12163895(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22575960//22608085
chr6:12163972-12163973(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085
chr6:12164019-12164020(+) m6A 3'UTR//CDS       24284625//25456834//24981863
chr6:12164078-12164079(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22575960//22608085
chr6:12164099-12164100(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12164119-12164120(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12164179-12164180(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr6:12164277-12164278(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr6:12164292-12164293(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr6:12164311-12164312(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12164325-12164326(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12164437-12164438(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr6:12164483-12164484(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr6:12164574-12164575(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12164587-12164588(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:12164671-12164672(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr6:12164751-12164752(+) m6A 3'UTR       24209618//24981863//22608085
chr6:12164787-12164788(+) m6A 3'UTR       24209618//24981863//22608085
chr6:12164816-12164817(+) m6A 3'UTR       24981863//22608085
chr6:12164877-12164878(+) m6A 3'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-5p
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
HIVEP1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-5p
Interactor2: HIVEP1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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