Basic Information:

  VIRBase ID:  

HHID00065507

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          CDC27:  NR_148340     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	CDC27
miRBase Accession/Entrez ID	MIMAT0004570	996
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ANAPC3//APC3//CDC27Hs//D0S1430E//D17S978E//H-NUC//HNUC//NUC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	CDC27	chr17: 45221300     chr17: 45232815

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC27	chr17:45221300(-) A-I      Syn:Ala->Ala chr17:45246478(-) A-I      intronic chr17:45237761(-) A-I      intronic chr17:45239004(-) A-I      intronic chr17:45246466(-) A-I      intronic chr17:45246450(-) A-I      intronic chr17:45244422(-) A-I      intronic chr17:45244414(-) A-I      intronic chr17:45244398(-) A-I      intronic chr17:45246527(-) A-I      intronic chr17:45246503(-) A-I      intronic chr17:45244390(-) A-I      intronic chr17:45213293(-) A-I      intronic chr17:45213322(-) A-I      intronic chr17:45213325(-) A-I      intronic chr17:45233237(-) A-I      intronic chr17:45233272(-) A-I      intronic chr17:45233297(-) A-I      intronic chr17:45246534(-) A-I      intronic chr17:45246528(-) A-I      intronic chr17:45244306(-) A-I      intronic chr17:45241978(-) A-I      intronic chr17:45233903(-) A-I      intronic chr17:45256424(-) A-I      intronic chr17:45242020(-) A-I      intronic chr17:45211892(-) A-I      intronic chr17:45211953(-) A-I      intronic chr17:45212045(-) A-I      intronic chr17:45242071(-) A-I      intronic chr17:45233951(-) A-I      intronic chr17:45233200(-) A-I      intronic chr17:45242131(-) A-I      intronic chr17:45233970(-) A-I      intronic chr17:45233978(-) A-I      intronic chr17:45233990(-) A-I      intronic chr17:45234007(-) A-I      intronic chr17:45234009(-) A-I      intronic chr17:45234032(-) A-I      intronic chr17:45237731(-) A-I      intronic chr17:45233607(-) A-I      intronic chr17:45233637(-) A-I      intronic chr17:45237760(-) A-I      intronic chr17:45237795(-) A-I      intronic chr17:45237811(-) A-I      intronic chr17:45233112(-) A-I      intronic chr17:45237865(-) A-I      intronic chr17:45233709(-) A-I      intronic chr17:45212046(-) A-I      intronic chr17:45213301(-) A-I      intronic chr17:45223148(-) A-I      intronic chr17:45232679(-) A-I      intronic chr17:45232714(-) A-I      intronic chr17:45232884(-) A-I      intronic chr17:45211296(-) A-I      intronic chr17:45209304(-) A-I      intronic chr17:45209255(-) A-I      intronic chr17:45209250(-) A-I      intronic chr17:45237824(-) A-I      intronic chr17:45233099(-) A-I      intronic chr17:45209118(-) A-I      intronic chr17:45208180(-) A-I      intronic chr17:45246594(-) A-I      intronic chr17:45246652(-) A-I      intronic chr17:45246841(-) A-I      intronic chr17:45246845(-) A-I      intronic chr17:45246863(-) A-I      intronic chr17:45246911(-) A-I      intronic chr17:45246924(-) A-I      intronic chr17:45247738(-) A-I      intronic chr17:45247740(-) A-I      intronic chr17:45247746(-) A-I      intronic chr17:45248287(-) A-I      intronic chr17:45248402(-) A-I      intronic chr17:45211396(-) A-I      intronic chr17:45256221(-) A-I      intronic chr17:45256229(-) A-I      intronic chr17:45256265(-) A-I      intronic chr17:45256280(-) A-I      intronic chr17:45256307(-) A-I      intronic chr17:45256338(-) A-I      intronic chr17:45256375(-) A-I      intronic chr17:45256400(-) A-I      intronic chr17:45246485(-) A-I      intronic chr17:45208160(-) A-I      intronic chr17:45233724(-) A-I      intronic chr17:45246545(-) A-I      intronic chr17:45242183(-) A-I      intronic chr17:45246533(-) A-I      intronic chr17:45208167(-) A-I      intronic chr17:45244472(-) A-I      intronic chr17:45244393(-) A-I      intronic chr17:45240850(-) A-I      intronic chr17:45241198(-) A-I      intronic chr17:45241216(-) A-I      intronic chr17:45241246(-) A-I      intronic chr17:45241309(-) A-I      intronic chr17:45241394(-) A-I      intronic chr17:45241425(-) A-I      intronic chr17:45241972(-) A-I      intronic chr17:45253144(-) A-I      intronic chr17:45204519(-) A-I      intronic chr17:45211799(-) A-I      intronic chr17:45255817(-) A-I      intronic chr17:45207663(-) A-I      intronic chr17:45233119(-) A-I      intronic chr17:45233281(-) A-I      intronic chr17:45244349(-) A-I      intronic chr17:45241405(-) A-I      intronic chr17:45233236(-) A-I      intronic chr17:45233824(-) A-I      intronic chr17:45255818(-) A-I      intronic chr17:45255757(-) A-I      intronic chr17:45248284(-) A-I      intronic chr17:45255832(-) A-I      intronic chr17:45212233(-) A-I      intronic chr17:45255771(-) A-I      intronic chr17:45241980(-) A-I      intronic chr17:45247744(-) A-I      intronic chr17:45238528(-) A-I      intronic chr17:45237764(-) A-I      intronic chr17:45238951(-) A-I      intronic chr17:45241926(-) A-I      intronic chr17:45209067(-) A-I      intronic chr17:45246556(-) A-I      intronic chr17:45242035(-) A-I      intronic chr17:45211896(-) A-I      intronic chr17:45253016(-) A-I      intronic chr17:45211491(-) A-I      intronic chr17:45233267(-) A-I      intronic chr17:45233149(-) A-I      intronic chr17:45246576(-) A-I      intronic chr17:45237732(-) A-I      intronic chr17:45241223(-) A-I      intronic chr17:45256317(-) A-I      intronic chr17:45242182(-) A-I      intronic chr17:45232744(-) A-I      intronic chr17:45246928(-) A-I      intronic chr17:45241306(-) A-I      intronic chr17:45248339(-) A-I      intronic chr17:45204527(-) A-I      intronic chr17:45233073(-) A-I      intronic chr17:45209309(-) A-I      intronic chr17:45254553(-) A-I      intronic chr17:45232756(-) A-I      intronic chr17:45242139(-) A-I      intronic chr17:45242100(-) A-I      intronic chr17:45242017(-) A-I      intronic chr17:45247636(-) A-I      intronic chr17:45210028(-) A-I      intronic chr17:45233305(-) A-I      intronic chr17:45248355(-) A-I      intronic chr17:45210943(-) A-I      intronic chr17:45246396(-) A-I      intronic chr17:45241267(-) A-I      intronic chr17:45254857(-) A-I      intronic chr17:45234087(-) A-I      intronic chr17:45253176(-) A-I      intronic chr17:45241307(-) A-I      intronic chr17:45207605(-) A-I      intronic chr17:45208019(-) A-I      intronic chr17:45247743(-) A-I      intronic chr17:45233520(-) A-I      intronic chr17:45206204(-) A-I      intronic chr17:45255806(-) A-I      intronic chr17:45237691(-) A-I      intronic chr17:45238994(-) A-I      intronic chr17:45210681(-) A-I      intronic chr17:45247780(-) A-I      intronic chr17:45244399(-) A-I      intronic chr17:45246755(-) A-I      intronic chr17:45207996(-) A-I      intronic chr17:45207538(-) A-I      intronic chr17:45252964(-) A-I      intronic chr17:45232815(-) A-I      intronic chr17:45256332(-) A-I      intronic chr17:45239072(-) A-I      intronic chr17:45240875(-) A-I      intronic chr17:45234064(-) A-I      intronic chr17:45242061(-) A-I      intronic chr17:45209132(-) A-I      intronic chr17:45255825(-) A-I      intronic chr17:45241268(-) A-I      intronic chr17:45233219(-) A-I      intronic chr17:45256340(-) A-I      intronic chr17:45213252(-) A-I      intronic chr17:45256391(-) A-I      intronic chr17:45213432(-) A-I      intronic chr17:45253119(-) A-I      intronic chr17:45199219(-) A-I      intronic chr17:45233676(-) A-I      intronic chr17:45204537(-) A-I      intronic chr17:45244400(-) A-I      intronic chr17:45236123(-) A-I      intronic chr17:45252278(-) A-I      intronic chr17:45205236(-) A-I      intronic chr17:45239008(-) A-I      intronic chr17:45211766(-) A-I      intronic chr17:45248464(-) A-I      intronic chr17:45247685(-) A-I      intronic chr17:45242137(-) A-I      intronic chr17:45242003(-) A-I      intronic chr17:45236154(-) A-I      intronic chr17:45242147(-) A-I      intronic chr17:45242136(-) A-I      intronic chr17:45213313(-) A-I      intronic chr17:45204577(-) A-I      intronic chr17:45247594(-) A-I      intronic chr17:45246481(-) A-I      intronic chr17:45254549(-) A-I      intronic chr17:45246600(-) A-I      intronic chr17:45246821(-) A-I      intronic chr17:45212270(-) A-I      intronic chr17:45252210(-) A-I      intronic chr17:45248462(-) A-I      intronic chr17:45207997(-) A-I      intronic chr17:45246959(-) A-I      intronic chr17:45246495(-) A-I      intronic chr17:45241403(-) A-I      intronic chr17:45213302(-) A-I      intronic chr17:45232688(-) A-I      intronic chr17:45233633(-) A-I      intronic chr17:45246472(-) A-I      intronic chr17:45247708(-) A-I      intronic chr17:45209103(-) A-I      intronic chr17:45238541(-) A-I      intronic chr17:45246584(-) A-I      intronic chr17:45210021(-) A-I      intronic chr17:45233125(-) A-I      intronic chr17:45242176(-) A-I      intronic chr17:45212250(-) A-I      intronic chr17:45237809(-) A-I      intronic chr17:45209127(-) A-I      intronic chr17:45233170(-) A-I      intronic chr17:45233262(-) A-I      intronic chr17:45232758(-) A-I      intronic chr17:45213360(-) A-I      intronic chr17:45248459(-) A-I      intronic chr17:45210642(-) A-I      intronic chr17:45213386(-) A-I      intronic chr17:45210683(-) A-I      intronic chr17:45238488(-) A-I      intronic chr17:45241998(-) A-I      intronic chr17:45253120(-) A-I      intronic chr17:45248384(-) A-I      intronic chr17:45244394(-) A-I      intronic chr17:45204297(-) A-I      intronic chr17:45233224(-) A-I      intronic chr17:45246998(-) A-I      intronic chr17:45211320(-) A-I      intronic chr17:45211321(-) A-I      intronic chr17:45242101(-) A-I      intronic chr17:45241323(-) A-I      intronic chr17:45233151(-) A-I      intronic chr17:45233124(-) A-I      intronic chr17:45246972(-) A-I      intronic chr17:45241245(-) A-I      intronic chr17:45211980(-) A-I      intronic chr17:45236149(-) A-I      intronic chr17:45232749(-) A-I      intronic chr17:45233207(-) A-I      intronic chr17:45212223(-) A-I      intronic chr17:45233868(-) A-I      intronic chr17:45247686(-) A-I      intronic chr17:45233066(-) A-I      intronic chr17:45210636(-) A-I      intronic chr17:45246810(-) A-I      intronic chr17:45244318(-) A-I      intronic chr17:45247741(-) A-I      intronic chr17:45241303(-) A-I      intronic chr17:45232709(-) A-I      intronic chr17:45239033(-) A-I      intronic chr17:45233288(-) A-I      intronic chr17:45254831(-) A-I      intronic chr17:45256337(-) A-I      intronic chr17:45204324(-) A-I      intronic chr17:45209143(-) A-I      intronic chr17:45237858(-) A-I      intronic chr17:45246903(-) A-I      intronic chr17:45257485(-) A-I      intronic chr17:45242181(-) A-I      intronic chr17:45237887(-) A-I      intronic chr17:45206387(-) A-I      intronic chr17:45256306(-) A-I      intronic chr17:45232708(-) A-I      intronic chr17:45233910(-) A-I      intronic chr17:45246455(-) A-I      intronic chr17:45247767(-) A-I      intronic chr17:45248249(-) A-I      intronic chr17:45242000(-) A-I      intronic chr17:45253130(-) A-I      intronic chr17:45212190(-) A-I      intronic chr17:45237757(-) A-I      intronic chr17:45233072(-) A-I      intronic chr17:45254867(-) A-I      intronic chr17:45247858(-) A-I      intronic chr17:45253050(-) A-I      intronic chr17:45205459(-) A-I      intronic chr17:45239108(-) A-I      intronic chr17:45234086(-) A-I      intronic chr17:45236077(-) A-I      intronic chr17:45210987(-) A-I      intronic chr17:45241409(-) A-I      intronic chr17:45241402(-) A-I      intronic chr17:45211949(-) A-I      intronic chr17:45233669(-) A-I      intronic chr17:45248458(-) A-I      intronic chr17:45213317(-) A-I      intronic chr17:45242114(-) A-I      intronic chr17:45246769(-) A-I      intronic chr17:45247728(-) A-I      intronic chr17:45246539(-) A-I      intronic chr17:45233710(-) A-I      intronic chr17:45246575(-) A-I      intronic chr17:45209264(-) A-I      intronic chr17:45239077(-) A-I      intronic chr17:45211894(-) A-I      intronic chr17:45236345(-) A-I      intronic chr17:45242107(-) A-I      intronic chr17:45233171(-) A-I      intronic chr17:45244424(-) A-I      intronic chr17:45211403(-) A-I      intronic chr17:45204582(-) A-I      intronic chr17:45211336(-) A-I      intronic chr17:45242097(-) A-I      intronic chr17:45253106(-) A-I      intronic chr17:45211806(-) A-I      intronic chr17:45237771(-) A-I      intronic chr17:45213339(-) A-I      intronic chr17:45246638(-) A-I      intronic chr17:45253100(-) A-I      intronic chr17:45195951(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC27	chr17:45212233(-) A-I intron -    15342557 chr17:45212250(-) A-I intron -    15342557 chr17:45212270(-) A-I intron -    15342557 chr17:45213302(-) A-I intron -    15342557 chr17:45213313(-) A-I intron -    15342557 chr17:45213317(-) A-I intron -    15342557 chr17:45213339(-) A-I intron -    15342557 chr17:45213360(-) A-I intron -    15342557 chr17:45213386(-) A-I intron -    15342557 chr17:45195951(-) A-I exon 3'UTR    22327324 chr17:45238528(-) A-I intron -    22327324 chr17:45205459(-) A-G intron -    22484847 chr17:45211799(-) A-G intron -    22484847 chr17:45211949(-) A-G intron -    22484847 chr17:45233710(-) A-G intron -    22484847 chr17:45237732(-) A-G intron -    22484847 chr17:45238528(-) A-G intron -    22484847 chr17:45238994(-) A-G intron -    22484847 chr17:45241223(-) A-G intron -    22484847 chr17:45242035(-) A-G intron -    22484847 chr17:45242107(-) A-G intron -    22484847 chr17:45244400(-) A-G intron -    22484847 chr17:45246600(-) A-G intron -    22484847 chr17:45247594(-) A-G intron -    22484847 chr17:45247636(-) A-G intron -    22484847 chr17:45248384(-) A-G intron -    22484847 chr17:45256332(-) A-G intron -    22484847 chr17:45256391(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC27	chr17:45196181-45196182(-) Y 3'UTR       26075521 chr17:45197017-45197018(-) m6A 3'UTR       27773535 chr17:45197725-45197726(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:45197748-45197749(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:45197768-45197769(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:45197828-45197829(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:45197890-45197891(-) m6A 3'UTR       24284625//27773535 chr17:45197950-45197951(-) m6A 3'UTR       24209618//27773535 chr17:45197977-45197978(-) m6A 3'UTR       24284625//24209618//27773535//22608085 chr17:45198056-45198057(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:45198107-45198108(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:45198159-45198160(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:45198285-45198286(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr17:45198377-45198378(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27371828//22575960//22608085 chr17:45199816-45199817(-) m6A 3'UTR//CDS       24981863//22608085 chr17:45214531-45214532(-) m6A 3'UTR//CDS//intron       22575960 chr17:45219674-45219675(-) m6A 3'UTR//CDS//intron       24981863//27773535 chr17:45219735-45219736(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr17:45219747-45219748(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr17:45219755-45219756(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr17:45229175-45229176(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22575960//22608085 chr17:45229196-45229197(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22575960 chr17:45229256-45229257(-) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr17:45229262-45229263(-) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr17:45234307-45234308(-) m6A 3'UTR//CDS//exon//intron       22575960 chr17:45234330-45234331(-) m6A 3'UTR//CDS//exon//intron       22575960 chr17:45234337-45234338(-) m6A 3'UTR//CDS//exon//intron       22575960 chr17:45234352-45234353(-) m6A 3'UTR//CDS//exon//intron       22575960 chr17:45234369-45234370(-) m6A 3'UTR//CDS//exon//intron       22575960 chr17:45234375-45234376(-) m6A 3'UTR//CDS//exon//intron       22575960 chr17:45235664-45235665(-) m6A CDS//exon//intron       22575960 chr17:45239258-45239259(-) m6A intron       27773535 chr17:45239280-45239281(-) m6A intron       27773535 chr17:45239373-45239374(-) m6A intron       27773535 chr17:45239414-45239415(-) m6A intron       27773535 chr17:45247293-45247294(-) m6A CDS//exon//intron       22575960 chr17:45247392-45247393(-) m6A CDS//exon//intron       22575960 chr17:45249344-45249345(-) m6A CDS//exon//intron       22575960 chr17:45249356-45249357(-) m6A CDS//exon//intron       22575960 chr17:45258980-45258981(-) m6A CDS//exon       24284625//24981863//27371828//22575960//22608085 chr17:45266520-45266521(-) m6A CDS//exon//intron       24284625//24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CDC27	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: CDC27

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.