Basic Information:

  VIRBase ID:  

HHID00065506

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          BTF3:  NM_001207     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	BTF3
miRBase Accession/Entrez ID	MIMAT0004570	689
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BETA-NAC//BTF3a//BTF3b//NACB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BTF3	chr5:72794328-72794329(+) m6A 5'UTR//exon       24981863//22575960 chr5:72794456-72794457(+) m6A 5'UTR//exon//intron       25456834//24981863//22575960 chr5:72794466-72794467(+) m6A 5'UTR//exon//intron       25456834//24981863//22575960 chr5:72794501-72794502(+) m6A CDS//exon//intron       24209618//25456834//24981863 chr5:72794603-72794604(+) m6A CDS//exon//intron       24209618//24981863 chr5:72794611-72794612(+) m6A CDS//exon//intron       24209618//24981863 chr5:72794967-72794968(+) m6A CDS//exon//intron       24981863//27773535 chr5:72794977-72794978(+) m6A CDS//exon//intron       24981863//27773535 chr5:72794987-72794988(+) m6A CDS//exon//intron       24981863//27773535 chr5:72794996-72794997(+) m6A CDS//exon//intron       24981863//27773535 chr5:72795086-72795087(+) m6A exon//intron       24981863//27773535 chr5:72795124-72795125(+) m6A exon//intron       24981863//27773535 chr5:72795408-72795409(+) m6A exon//intron       24981863 chr5:72795430-72795431(+) m6A exon//intron       24981863 chr5:72798315-72798316(+) m6A CDS//exon//intron       24981863 chr5:72798348-72798349(+) m6A CDS//exon//intron       24981863//27773535 chr5:72798371-72798372(+) m6A CDS//exon//intron       24981863//27773535 chr5:72798403-72798404(+) m6A CDS//exon//intron       24981863//27773535 chr5:72798455-72798456(+) m6A exon//intron       27773535 chr5:72798525-72798526(+) m6A exon//intron       27773535 chr5:72798879-72798880(+) m6A CDS//exon       27773535 chr5:72798916-72798917(+) m6A CDS//exon       27773535 chr5:72798937-72798938(+) m6A CDS//exon       27773535 chr5:72800298-72800299(+) m6A exon//intron       27773535 chr5:72800333-72800334(+) m6A exon//intron       27773535 chr5:72801058-72801059(+) m6A CDS//exon       27773535 chr5:72801087-72801088(+) m6A 3'UTR//exon       27773535 chr5:72801203-72801204(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	BTF3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: BTF3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.