Basic Information:

  VIRBase ID:  

HHID00065505

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          ATR:  NM_001184     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	ATR
miRBase Accession/Entrez ID	MIMAT0004570	545
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FCTCS//FRP1//MEC1//SCKL//SCKL1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATR	chr3:142228858(-) A-I      intronic chr3:142262644(-) A-I      intronic chr3:142200910(-) A-I      intronic chr3:142208993(-) A-I      intronic chr3:142228179(-) A-I      intronic chr3:142228194(-) A-I      intronic chr3:142209069(-) A-I      intronic chr3:142209068(-) A-I      intronic chr3:142208093(-) A-I      intronic chr3:142228218(-) A-I      intronic chr3:142228225(-) A-I      intronic chr3:142208143(-) A-I      intronic chr3:142200881(-) A-I      intronic chr3:142192562(-) A-I      intronic chr3:142192552(-) A-I      intronic chr3:142192516(-) A-I      intronic chr3:142208138(-) A-I      intronic chr3:142208067(-) A-I      intronic chr3:142208054(-) A-I      intronic chr3:142206252(-) A-I      intronic chr3:142206251(-) A-I      intronic chr3:142206246(-) A-I      intronic chr3:142205776(-) A-I      intronic chr3:142205768(-) A-I      intronic chr3:142205753(-) A-I      intronic chr3:142205728(-) A-I      intronic chr3:142202649(-) A-I      intronic chr3:142202612(-) A-I      intronic chr3:142202539(-) A-I      intronic chr3:142202513(-) A-I      intronic chr3:142202487(-) A-I      intronic chr3:142201976(-) A-I      intronic chr3:142201945(-) A-I      intronic chr3:142201932(-) A-I      intronic chr3:142291367(-) A-I      intronic chr3:142291186(-) A-I      intronic chr3:142291183(-) A-I      intronic chr3:142291175(-) A-I      intronic chr3:142291081(-) A-I      intronic chr3:142291040(-) A-I      intronic chr3:142290779(-) A-I      intronic chr3:142290778(-) A-I      intronic chr3:142290091(-) A-I      intronic chr3:142289509(-) A-I      intronic chr3:142289505(-) A-I      intronic chr3:142289503(-) A-I      intronic chr3:142289321(-) A-I      intronic chr3:142289294(-) A-I      intronic chr3:142289226(-) A-I      intronic chr3:142288604(-) A-I      intronic chr3:142288346(-) A-I      intronic chr3:142288331(-) A-I      intronic chr3:142288201(-) A-I      intronic chr3:142285784(-) A-I      intronic chr3:142285754(-) A-I      intronic chr3:142285694(-) A-I      intronic chr3:142285653(-) A-I      intronic chr3:142285273(-) A-I      intronic chr3:142285226(-) A-I      intronic chr3:142285204(-) A-I      intronic chr3:142283829(-) A-I      intronic chr3:142283815(-) A-I      intronic chr3:142283763(-) A-I      intronic chr3:142283758(-) A-I      intronic chr3:142283631(-) A-I      intronic chr3:142277243(-) A-I      intronic chr3:142277225(-) A-I      intronic chr3:142277210(-) A-I      intronic chr3:142277185(-) A-I      intronic chr3:142277139(-) A-I      intronic chr3:142277108(-) A-I      intronic chr3:142276679(-) A-I      intronic chr3:142276642(-) A-I      intronic chr3:142276542(-) A-I      intronic chr3:142201644(-) A-I      intronic chr3:142201641(-) A-I      intronic chr3:142201617(-) A-I      intronic chr3:142270277(-) A-I      intronic chr3:142270211(-) A-I      intronic chr3:142269880(-) A-I      intronic chr3:142269879(-) A-I      intronic chr3:142269768(-) A-I      intronic chr3:142201470(-) A-I      intronic chr3:142201430(-) A-I      intronic chr3:142200914(-) A-I      intronic chr3:142263292(-) A-I      intronic chr3:142263256(-) A-I      intronic chr3:142262764(-) A-I      intronic chr3:142262762(-) A-I      intronic chr3:142262726(-) A-I      intronic chr3:142262646(-) A-I      intronic chr3:142252042(-) A-I      intronic chr3:142229294(-) A-I      intronic chr3:142229146(-) A-I      intronic chr3:142229121(-) A-I      intronic chr3:142228939(-) A-I      intronic chr3:142228931(-) A-I      intronic chr3:142228914(-) A-I      intronic chr3:142228911(-) A-I      intronic chr3:142228901(-) A-I      intronic chr3:142228882(-) A-I      intronic chr3:142228544(-) A-I      intronic chr3:142227703(-) A-I      intronic chr3:142227584(-) A-I      intronic chr3:142227576(-) A-I      intronic chr3:142223884(-) A-I      intronic chr3:142223882(-) A-I      intronic chr3:142223880(-) A-I      intronic chr3:142223823(-) A-I      intronic chr3:142209072(-) A-I      intronic chr3:142209070(-) A-I      intronic chr3:142209039(-) A-I      intronic chr3:142208979(-) A-I      intronic chr3:142209148(-) A-I      intronic chr3:142200580(-) A-I      intronic chr3:142269997(-) A-I      intronic chr3:142208108(-) A-I      intronic chr3:142290788(-) A-I      intronic chr3:142288260(-) A-I      intronic chr3:142208969(-) A-I      intronic chr3:142228107(-) A-I      intronic chr3:142208081(-) A-I      intronic chr3:142270215(-) A-I      intronic chr3:142270120(-) A-I      intronic chr3:142283726(-) A-I      intronic chr3:142229081(-) A-I      intronic chr3:142285654(-) A-I      intronic chr3:142205793(-) A-I      intronic chr3:142223824(-) A-I      intronic chr3:142200785(-) A-I      intronic chr3:142270035(-) A-I      intronic chr3:142262640(-) A-I      intronic chr3:142228896(-) A-I      intronic chr3:142289423(-) A-I      intronic chr3:142228538(-) A-I      intronic chr3:142201980(-) A-I      intronic chr3:142191728(-) A-I      intronic chr3:142228101(-) A-I      intronic chr3:142263096(-) A-I      intronic chr3:142207948(-) A-I      intronic chr3:142201614(-) A-I      intronic chr3:142263211(-) A-I      intronic chr3:142209016(-) A-I      intronic chr3:142285427(-) A-I      intronic chr3:142192520(-) A-I      intronic chr3:142228513(-) A-I      intronic chr3:142285244(-) A-I      intronic chr3:142283729(-) A-I      intronic chr3:142191612(-) A-I      intronic chr3:142200935(-) A-I      intronic chr3:142263182(-) A-I      intronic chr3:142270036(-) A-I      intronic chr3:142206178(-) A-I      intronic chr3:142247942(-) A-I      intronic chr3:142285707(-) A-I      intronic chr3:142251949(-) A-I      intronic chr3:142262650(-) A-I      intronic chr3:142262740(-) A-I      intronic chr3:142201578(-) A-I      intronic chr3:142290791(-) A-I      intronic chr3:142201456(-) A-I      intronic chr3:142200540(-) A-I      intronic chr3:142292181(-) A-I      intronic chr3:142263117(-) A-I      intronic chr3:142202642(-) A-I      intronic chr3:142192525(-) A-I      intronic chr3:142209061(-) A-I      intronic chr3:142229095(-) A-I      intronic chr3:142277114(-) A-I      intronic chr3:142201667(-) A-I      intronic chr3:142229094(-) A-I      intronic chr3:142201908(-) A-I      intronic chr3:142202593(-) A-I      intronic chr3:142207933(-) A-I      intronic chr3:142187722(-) A-I      intronic chr3:142201457(-) A-I      intronic chr3:142206055(-) A-I      intronic chr3:142206243(-) A-I      intronic chr3:142228292(-) A-I      intronic chr3:142202623(-) A-I      intronic chr3:142228830(-) A-I      intronic chr3:142209012(-) A-I      intronic chr3:142228701(-) A-I      intronic chr3:142201633(-) A-I      intronic chr3:142192615(-) A-I      intronic chr3:142231614(-) A-I      intronic chr3:142283691(-) A-I      intronic chr3:142292122(-) A-I      intronic chr3:142270011(-) A-I      intronic chr3:142200885(-) A-I      intronic chr3:142262566(-) A-I      intronic chr3:142270049(-) A-I      intronic chr3:142229093(-) A-I      intronic chr3:142228111(-) A-I      intronic chr3:142288414(-) A-I      intronic chr3:142208175(-) A-I      intronic chr3:142263056(-) A-I      intronic chr3:142263207(-) A-I      intronic chr3:142262763(-) A-I      intronic chr3:142291009(-) A-I      intronic chr3:142229239(-) A-I      intronic chr3:142270009(-) A-I      intronic chr3:142269741(-) A-I      intronic chr3:142290142(-) A-I      intronic chr3:142228106(-) A-I      intronic chr3:142247888(-) A-I      intronic chr3:142202557(-) A-I      intronic chr3:142228461(-) A-I      intronic chr3:142206254(-) A-I      intronic chr3:142228564(-) A-I      intronic chr3:142228204(-) A-I      intronic chr3:142191649(-) A-I      intronic chr3:142209129(-) A-I      intronic chr3:142201986(-) A-I      intronic chr3:142227509(-) A-I      intronic chr3:142290826(-) A-I      intronic chr3:142270174(-) A-I      intronic chr3:142202436(-) A-I      intronic chr3:142284555(-) A-I      intronic chr3:142231653(-) A-I      intronic chr3:142201596(-) A-I      intronic chr3:142290120(-) A-I      intronic chr3:142228134(-) A-I      intronic chr3:142201452(-) A-I      intronic chr3:142263097(-) A-I      intronic chr3:142201920(-) A-I      intronic chr3:142291412(-) A-I      intronic chr3:142201888(-) A-I      intronic chr3:142263134(-) A-I      intronic chr3:142252101(-) A-I      intronic chr3:142291443(-) A-I      intronic chr3:142262792(-) A-I      intronic chr3:142277177(-) A-I      intronic chr3:142292249(-) A-I      intronic chr3:142228875(-) A-I      intronic chr3:142209065(-) A-I      intronic chr3:142262717(-) A-I      intronic chr3:142248008(-) A-I      intronic chr3:142289367(-) A-I      intronic chr3:142191754(-) A-I      intronic chr3:142270221(-) A-I      intronic chr3:142228568(-) A-I      intronic chr3:142228205(-) A-I      intronic chr3:142228301(-) A-I      intronic chr3:142285714(-) A-I      intronic chr3:142208028(-) A-I      intronic chr3:142200581(-) A-I      intronic chr3:142187666(-) A-I      intronic chr3:142292141(-) A-I      intronic chr3:142237174(-) A-I      intronic chr3:142201439(-) A-I      intronic chr3:142206094(-) A-I      intronic chr3:142205698(-) A-I      intronic chr3:142192466(-) A-I      intronic chr3:142208076(-) A-I      intronic chr3:142202496(-) A-I      intronic chr3:142290225(-) A-I      intronic chr3:142191542(-) A-I      intronic chr3:142228185(-) A-I      intronic chr3:142292173(-) A-I      intronic chr3:142192907(-) A-I      intronic chr3:142289409(-) A-I      intronic chr3:142208114(-) A-I      intronic chr3:142201950(-) A-I      intronic chr3:142262676(-) A-I      intronic chr3:142285425(-) A-I      intronic chr3:142192526(-) A-I      intronic chr3:142192847(-) A-I      intronic chr3:142200781(-) A-I      intronic chr3:142292176(-) A-I      intronic chr3:142206187(-) A-I      intronic chr3:142252020(-) A-I      intronic chr3:142209171(-) A-I      intronic chr3:142206117(-) A-I      intronic chr3:142276613(-) A-I      intronic chr3:142209015(-) A-I      intronic chr3:142291505(-) A-I      intronic chr3:142206225(-) A-I      intronic chr3:142228138(-) A-I      intronic chr3:142228895(-) A-I      intronic chr3:142228846(-) A-I      intronic chr3:142201444(-) A-I      intronic chr3:142201415(-) A-I      intronic chr3:142208171(-) A-I      intronic chr3:142223829(-) A-I      intronic chr3:142228786(-) A-I      intronic chr3:142285365(-) A-I      intronic chr3:142229120(-) A-I      intronic chr3:142229195(-) A-I      intronic chr3:142209170(-) A-I      intronic chr3:142201562(-) A-I      intronic chr3:142201595(-) A-I      intronic chr3:142200550(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATR	chr3:142169290(-) A-I intron -    22327324 chr3:142169319(-) A-I intron -    22327324 chr3:142169336(-) A-I intron -    22327324 chr3:142169354(-) A-I intron -    22327324 chr3:142169363(-) A-I intron -    22327324 chr3:142169397(-) A-I intron -    22327324 chr3:142169515(-) A-I intron -    22327324 chr3:142201986(-) A-I intron -    22327324 chr3:142206243(-) A-I intron -    22327324 chr3:142208969(-) A-I intron -    22327324 chr3:142262566(-) A-I intron -    22327324 chr3:142201457(-) A-I intron -    21960545 chr3:142201898(-) A-I intron -    21960545 chr3:142201931(-) A-I intron -    21960545 chr3:142209101(-) A-I intron -    21960545 chr3:142209116(-) A-I intron -    21960545 chr3:142171396(-) T-C intron -    22484847 chr3:142191618(-) A-G intron -    22484847 chr3:142192525(-) A-G intron -    22484847 chr3:142192526(-) A-G intron -    22484847 chr3:142192615(-) A-G intron -    22484847 chr3:142192907(-) A-G intron -    22484847 chr3:142200785(-) A-G intron -    22484847 chr3:142200864(-) A-G intron -    22484847 chr3:142201452(-) A-G intron -    22484847 chr3:142201456(-) A-G intron -    22484847 chr3:142201457(-) A-G intron -    22484847 chr3:142201482(-) A-G intron -    22484847 chr3:142201494(-) A-G intron -    22484847 chr3:142201502(-) A-G intron -    22484847 chr3:142201508(-) A-G intron -    22484847 chr3:142201562(-) A-G intron -    22484847 chr3:142201566(-) A-G intron -    22484847 chr3:142201578(-) A-G intron -    22484847 chr3:142201595(-) A-G intron -    22484847 chr3:142201596(-) A-G intron -    22484847 chr3:142201980(-) A-G intron -    22484847 chr3:142201986(-) A-G intron -    22484847 chr3:142202436(-) A-G intron -    22484847 chr3:142202496(-) A-G intron -    22484847 chr3:142202557(-) A-G intron -    22484847 chr3:142202642(-) A-G intron -    22484847 chr3:142205693(-) A-G intron -    22484847 chr3:142205698(-) A-G intron -    22484847 chr3:142205793(-) A-G intron -    22484847 chr3:142205898(-) A-G intron -    22484847 chr3:142206070(-) A-G intron -    22484847 chr3:142206117(-) A-G intron -    22484847 chr3:142206159(-) A-T intron -    22484847 chr3:142206187(-) A-G intron -    22484847 chr3:142206243(-) A-G intron -    22484847 chr3:142206254(-) A-G intron -    22484847 chr3:142207948(-) A-G intron -    22484847 chr3:142207987(-) A-G intron -    22484847 chr3:142208028(-) A-G intron -    22484847 chr3:142208032(-) A-G intron -    22484847 chr3:142208076(-) A-G intron -    22484847 chr3:142208081(-) A-G intron -    22484847 chr3:142208114(-) A-G intron -    22484847 chr3:142208969(-) A-G intron -    22484847 chr3:142208985(-) A-G intron -    22484847 chr3:142209012(-) A-G intron -    22484847 chr3:142209015(-) A-G intron -    22484847 chr3:142209016(-) A-G intron -    22484847 chr3:142209017(-) A-G intron -    22484847 chr3:142209041(-) A-G intron -    22484847 chr3:142209057(-) A-G intron -    22484847 chr3:142209061(-) A-G intron -    22484847 chr3:142209077(-) A-G intron -    22484847 chr3:142209129(-) A-G intron -    22484847 chr3:142209179(-) A-G intron -    22484847 chr3:142209193(-) A-G intron -    22484847 chr3:142223824(-) A-G intron -    22484847 chr3:142223829(-) A-G intron -    22484847 chr3:142225295(-) T-C intron -    22484847 chr3:142228107(-) A-G intron -    22484847 chr3:142228111(-) A-G intron -    22484847 chr3:142228146(-) A-G intron -    22484847 chr3:142228292(-) A-G intron -    22484847 chr3:142228301(-) A-G intron -    22484847 chr3:142228477(-) A-G intron -    22484847 chr3:142228564(-) A-G intron -    22484847 chr3:142228830(-) A-G intron -    22484847 chr3:142228895(-) A-G intron -    22484847 chr3:142228896(-) A-G intron -    22484847 chr3:142228957(-) C-T intron -    22484847 chr3:142229120(-) A-G intron -    22484847 chr3:142229239(-) A-G intron -    22484847 chr3:142230326(-) G-A intron -    22484847 chr3:142231614(-) A-G intron -    22484847 chr3:142231653(-) A-G intron -    22484847 chr3:142248008(-) A-G intron -    22484847 chr3:142251893(-) A-G intron -    22484847 chr3:142251949(-) A-G intron -    22484847 chr3:142252021(-) A-G intron -    22484847 chr3:142262566(-) A-G intron -    22484847 chr3:142262636(-) A-G intron -    22484847 chr3:142262640(-) A-G intron -    22484847 chr3:142262650(-) A-G intron -    22484847 chr3:142262676(-) A-G intron -    22484847 chr3:142262716(-) A-G intron -    22484847 chr3:142262717(-) A-G intron -    22484847 chr3:142262740(-) A-G intron -    22484847 chr3:142263097(-) A-G intron -    22484847 chr3:142263112(-) A-G intron -    22484847 chr3:142263182(-) A-G intron -    22484847 chr3:142269681(-) T-C intron -    22484847 chr3:142269741(-) A-G intron -    22484847 chr3:142269793(-) A-G intron -    22484847 chr3:142270174(-) A-G intron -    22484847 chr3:142270215(-) A-G intron -    22484847 chr3:142270216(-) A-G intron -    22484847 chr3:142271366(-) C-T intron -    22484847 chr3:142276613(-) A-G intron -    22484847 chr3:142277114(-) A-G intron -    22484847 chr3:142277177(-) A-G intron -    22484847 chr3:142283804(-) T-C intron -    22484847 chr3:142285406(-) A-G intron -    22484847 chr3:142285425(-) A-G intron -    22484847 chr3:142285427(-) A-G intron -    22484847 chr3:142285654(-) A-G intron -    22484847 chr3:142285707(-) A-G intron -    22484847 chr3:142289423(-) A-G intron -    22484847 chr3:142290120(-) A-G intron -    22484847 chr3:142290142(-) A-G intron -    22484847 chr3:142292173(-) A-G intron -    22484847 chr3:142292181(-) A-G intron -    22484847 chr3:142292227(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATR	chr3:142168092-142168093(-) m6A 3'UTR       27773535 chr3:142168284-142168285(-) m6A 3'UTR//CDS       24981863//27773535 chr3:142168313-142168314(-) m6A 3'UTR//CDS       24981863//27773535 chr3:142168351-142168352(-) m6A 3'UTR//CDS       24981863 chr3:142168372-142168373(-) m6A 3'UTR//CDS       24981863 chr3:142210095-142210096(-) Cm intron       - chr3:142279244-142279245(-) m6A 3'UTR//CDS//intron       24981863 chr3:142279275-142279276(-) m6A 3'UTR//CDS//intron       24981863 chr3:142279281-142279282(-) m6A 3'UTR//CDS//intron       24981863 chr3:142279289-142279290(-) m6A 3'UTR//CDS//intron       24981863 chr3:142280095-142280096(-) m6A 3'UTR//CDS       24981863 chr3:142280117-142280118(-) m6A 3'UTR//CDS       24981863 chr3:142280177-142280178(-) m6A 3'UTR//CDS       24981863 chr3:142280190-142280191(-) m6A 3'UTR//CDS       24981863 chr3:142281271-142281272(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr3:142281301-142281302(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr3:142281342-142281343(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr3:142281376-142281377(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:142281409-142281410(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:142281463-142281464(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:142281481-142281482(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:142281565-142281566(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:142281691-142281692(-) m6A CDS//intron       24284625//24981863//22608085 chr3:142281779-142281780(-) m6A CDS//intron       24284625//24981863//22608085 chr3:142297537-142297538(-) m6A CDS       24981863 chr3:142297586-142297587(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ATR	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: ATR

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.