Basic Information:

  VIRBase ID:  

HHID00065504

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-5p:  MIMAT0004570          APC:  NM_000038     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-5p	APC
miRBase Accession/Entrez ID	MIMAT0004570	324
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BTPS2//DESMD//DP2//DP2.5//DP3//GS//PPP1R46

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-5p	rs1240009384 chrX:66018913    A/T rs1397275461 chrX:66018904    G/T rs1464475149 chrX:66018916    T/C rs761701581 chrX:66018906    C/G rs772305537 chrX:66018909    G/A rs774279244 chrX:66018895    C/T rs890919635 chrX:66018896    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APC	chr5:112144294(+) A-I      intronic chr5:112140611(+) A-I      intronic chr5:112140194(+) A-I      intronic chr5:112140183(+) A-I      intronic chr5:112072496(+) A-I      intronic chr5:112072552(+) A-I      intronic chr5:112075301(+) A-I      intronic chr5:112171975(+) A-I      intronic chr5:112156766(+) A-I      intronic chr5:112156658(+) A-I      intronic chr5:112152702(+) A-I      intronic chr5:112151399(+) A-I      intronic chr5:112152695(+) A-I      intronic chr5:112122785(+) A-I      intronic chr5:112122765(+) A-I      intronic chr5:112122686(+) A-I      intronic chr5:112122678(+) A-I      intronic chr5:112060892(+) A-I      intronic chr5:112152666(+) A-I      intronic chr5:112152665(+) A-I      intronic chr5:112152329(+) A-I      intronic chr5:112151431(+) A-I      intronic chr5:112151400(+) A-I      intronic chr5:112099863(+) A-I      intronic chr5:112075328(+) A-I      intronic chr5:112075333(+) A-I      intronic chr5:112075337(+) A-I      intronic chr5:112099822(+) A-I      intronic chr5:112119311(+) A-I      intronic chr5:112099832(+) A-I      intronic chr5:112071097(+) A-I      intronic chr5:112072451(+) A-I      intronic chr5:112117640(+) A-I      intronic chr5:112072490(+) A-I      intronic chr5:112100852(+) A-I      intronic chr5:112045413(+) A-I      intronic chr5:112045420(+) A-I      intronic chr5:112045552(+) A-I      intronic chr5:112045487(+) A-I      intronic chr5:112048115(+) A-I      intronic chr5:112048220(+) A-I      intronic chr5:112151355(+) A-I      intronic chr5:112048300(+) A-I      intronic chr5:112120732(+) A-I      intronic chr5:112048349(+) A-I      intronic chr5:112048669(+) A-I      intronic chr5:112048686(+) A-I      intronic chr5:112048710(+) A-I      intronic chr5:112048717(+) A-I      intronic chr5:112056839(+) A-I      intronic chr5:112056968(+) A-I      intronic chr5:112056990(+) A-I      intronic chr5:112058944(+) A-I      intronic chr5:112060684(+) A-I      intronic chr5:112120716(+) A-I      intronic chr5:112120569(+) A-I      intronic chr5:112060704(+) A-I      intronic chr5:112119308(+) A-I      intronic chr5:112112417(+) A-I      intronic chr5:112112385(+) A-I      intronic chr5:112112418(+) A-I      intronic chr5:112100931(+) A-I      intronic chr5:112119304(+) A-I      intronic chr5:112119270(+) A-I      intronic chr5:112060829(+) A-I      intronic chr5:112099849(+) A-I      intronic chr5:112060859(+) A-I      intronic chr5:112070541(+) A-I      intronic chr5:112070567(+) A-I      intronic chr5:112070581(+) A-I      intronic chr5:112070972(+) A-I      intronic chr5:112079661(+) A-I      intronic chr5:112122685(+) A-I      intronic chr5:112142709(+) A-I      intronic chr5:112093288(+) A-I      intronic chr5:112094141(+) A-I      intronic chr5:112127725(+) A-I      intronic chr5:112093273(+) A-I      intronic chr5:112048311(+) A-I      intronic chr5:112121869(+) A-I      intronic chr5:112103954(+) A-I      intronic chr5:112142477(+) A-I      intronic chr5:112157083(+) A-I      intronic chr5:112103730(+) A-I      intronic chr5:112048164(+) A-I      intronic chr5:112119371(+) A-I      intronic chr5:112156926(+) A-I      intronic chr5:112081516(+) A-I      intronic chr5:112157061(+) A-I      intronic chr5:112152291(+) A-I      intronic chr5:112144199(+) A-I      intronic chr5:112156671(+) A-I      intronic chr5:112082761(+) A-I      intronic chr5:112142513(+) A-I      intronic chr5:112119257(+) A-I      intronic chr5:112119228(+) A-I      intronic chr5:112104073(+) A-I      intronic chr5:112100902(+) A-I      intronic chr5:112120657(+) A-I      intronic chr5:112099679(+) A-I      intronic chr5:112152806(+) A-I      intronic chr5:112057074(+) A-I      intronic chr5:112084449(+) A-I      intronic chr5:112100833(+) A-I      intronic chr5:112099756(+) A-I      intronic chr5:112156703(+) A-I      intronic chr5:112091552(+) A-I      intronic chr5:112120749(+) A-I      intronic chr5:112084396(+) A-I      intronic chr5:112048748(+) A-I      intronic chr5:112164275(+) A-I      intronic chr5:112152741(+) A-I      intronic chr5:112151480(+) A-I      intronic chr5:112104841(+) A-I      intronic chr5:112161271(+) A-I      intronic chr5:112048158(+) A-I      intronic chr5:112048168(+) A-I      intronic chr5:112127707(+) A-I      intronic chr5:112060932(+) A-I      intronic chr5:112117551(+) A-I      intronic chr5:112144924(+) A-I      intronic chr5:112142415(+) A-I      intronic chr5:112140593(+) A-I      intronic chr5:112119435(+) A-I      intronic chr5:112069829(+) A-I      intronic chr5:112101000(+) A-I      intronic chr5:112156659(+) A-I      intronic chr5:112048590(+) A-I      intronic chr5:112048230(+) A-I      intronic chr5:112122638(+) A-I      intronic chr5:112082746(+) A-I      intronic chr5:112157155(+) A-I      intronic chr5:112156929(+) A-I      intronic chr5:112120612(+) A-I      intronic chr5:112120686(+) A-I      intronic chr5:112070973(+) A-I      intronic chr5:112099746(+) A-I      intronic chr5:112048718(+) A-I      intronic chr5:112094124(+) A-I      intronic chr5:112120663(+) A-I      intronic chr5:112122711(+) A-I      intronic chr5:112056950(+) A-I      intronic chr5:112144345(+) A-I      intronic chr5:112119300(+) A-I      intronic chr5:112120670(+) A-I      intronic chr5:112093173(+) A-I      intronic chr5:112061177(+) A-I      intronic chr5:112093275(+) A-I      intronic chr5:112093224(+) A-I      intronic chr5:112152705(+) A-I      intronic chr5:112171989(+) A-I      intronic chr5:112082800(+) A-I      intronic chr5:112140627(+) A-I      intronic chr5:112119845(+) A-I      intronic chr5:112122665(+) A-I      intronic chr5:112093169(+) A-I      intronic chr5:112060938(+) A-I      intronic chr5:112093278(+) A-I      intronic chr5:112061212(+) A-I      intronic chr5:112144184(+) A-I      intronic chr5:112156652(+) A-I      intronic chr5:112157021(+) A-I      intronic chr5:112096525(+) A-I      intronic chr5:112119264(+) A-I      intronic chr5:112122724(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	APC	chr5:112178854(+) A-I exon CDS    19478186 chr5:112048158(+) A-G intron -    22484847 chr5:112048168(+) A-G intron -    22484847 chr5:112048311(+) A-G intron -    22484847 chr5:112048590(+) A-G intron -    22484847 chr5:112048718(+) A-G intron -    22484847 chr5:112048748(+) A-G intron -    22484847 chr5:112060781(+) A-G intron -    22484847 chr5:112060890(+) A-G intron -    22484847 chr5:112060938(+) A-G intron -    22484847 chr5:112061177(+) A-G intron -    22484847 chr5:112093278(+) A-G intron -    22484847 chr5:112095053(+) C-T intron -    22484847 chr5:112100833(+) A-G intron -    22484847 chr5:112100902(+) A-G intron -    22484847 chr5:112101063(+) A-G intron -    22484847 chr5:112117590(+) A-G intron -    22484847 chr5:112119228(+) A-G intron -    22484847 chr5:112121830(+) T-G intron -    22484847 chr5:112126081(+) A-G intron -    22484847 chr5:112130916(+) G-A intron -    22484847 chr5:112142415(+) A-G intron -    22484847 chr5:112142477(+) A-G intron -    22484847 chr5:112142709(+) A-G intron -    22484847 chr5:112151480(+) A-G intron -    22484847 chr5:112152291(+) A-G intron -    22484847 chr5:112152370(+) A-G intron -    22484847 chr5:112152741(+) A-G intron -    22484847 chr5:112152806(+) A-G intron -    22484847 chr5:112156659(+) A-G intron -    22484847 chr5:112156703(+) A-G intron -    22484847 chr5:112157021(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APC	chr5:112043289-112043290(+) m6A 5'UTR       24981863 chr5:112043318-112043319(+) m6A 5'UTR       24981863 chr5:112074087-112074088(+) m6A 5'UTR//intron       - chr5:112151284-112151285(+) m6A 3'UTR//CDS       24981863 chr5:112154725-112154726(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112154753-112154754(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112154825-112154826(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112170855-112170856(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr5:112173266-112173267(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr5:112173280-112173281(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr5:112173337-112173338(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:112173371-112173372(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:112173389-112173390(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:112173416-112173417(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:112173558-112173559(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr5:112173604-112173605(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112173620-112173621(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112173660-112173661(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22575960//22608085 chr5:112173725-112173726(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22575960//22608085 chr5:112173904-112173905(+) m6A 3'UTR//CDS       24284625//22608085 chr5:112173998-112173999(+) m6A 3'UTR//CDS       24284625//22608085 chr5:112174088-112174089(+) m6A 3'UTR//CDS       22608085 chr5:112174126-112174127(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112174230-112174231(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112174350-112174351(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112174400-112174401(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112174443-112174444(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr5:112174449-112174450(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr5:112174473-112174474(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr5:112174488-112174489(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr5:112174545-112174546(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112174572-112174573(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr5:112174624-112174625(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr5:112174743-112174744(+) m6A 3'UTR//CDS       24981863 chr5:112174764-112174765(+) m6A 3'UTR//CDS       24981863 chr5:112174866-112174867(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112174899-112174900(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112174912-112174913(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112174917-112174918(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112175062-112175063(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112175071-112175072(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112175227-112175228(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112175284-112175285(+) m6A 3'UTR//CDS       24981863 chr5:112175298-112175299(+) m6A 3'UTR//CDS       24981863 chr5:112175574-112175575(+) m6A 3'UTR//CDS       24981863 chr5:112175602-112175603(+) m6A 3'UTR//CDS       24981863 chr5:112175623-112175624(+) m6A 3'UTR//CDS       24981863 chr5:112175632-112175633(+) m6A 3'UTR//CDS       24981863 chr5:112175899-112175900(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112175933-112175934(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112175956-112175957(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112175975-112175976(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112176079-112176080(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112176114-112176115(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112176138-112176139(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112176155-112176156(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112176229-112176230(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112176239-112176240(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112176403-112176404(+) m6A 3'UTR//CDS       22608085 chr5:112176533-112176534(+) m6A 3'UTR//CDS       22608085 chr5:112176603-112176604(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112176621-112176622(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112176649-112176650(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112176671-112176672(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112176710-112176711(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112176729-112176730(+) m6A 3'UTR//CDS       24981863//22608085 chr5:112176844-112176845(+) m6A 3'UTR//CDS       22608085 chr5:112176987-112176988(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112177018-112177019(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112177062-112177063(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112177077-112177078(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr5:112177106-112177107(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr5:112177115-112177116(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr5:112177226-112177227(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr5:112177245-112177246(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr5:112177258-112177259(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr5:112177284-112177285(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr5:112177293-112177294(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr5:112177361-112177362(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112177455-112177456(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr5:112177476-112177477(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr5:112177545-112177546(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112177557-112177558(+) m6A 3'UTR//CDS       22608085 chr5:112177932-112177933(+) m6A 3'UTR//CDS       24284625//22608085 chr5:112177949-112177950(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112177975-112177976(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112178053-112178054(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112178086-112178087(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112178155-112178156(+) m6A 3'UTR//CDS       24284625//22608085 chr5:112178223-112178224(+) m6A 3'UTR//CDS       24284625//22608085 chr5:112178247-112178248(+) m6A 3'UTR//CDS       24284625//22608085 chr5:112178270-112178271(+) m6A 3'UTR//CDS       24284625//22608085 chr5:112178332-112178333(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr5:112178403-112178404(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112178420-112178421(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112178430-112178431(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr5:112178490-112178491(+) m6A CDS       24284625//24981863//26404942//22608085 chr5:112178535-112178536(+) m6A CDS       24284625//24981863//26404942//22608085 chr5:112178592-112178593(+) m6A CDS       24284625//24981863//22608085 chr5:112178700-112178701(+) m6A CDS       24284625 chr5:112178808-112178809(+) m6A CDS       24284625 chr5:112178853-112178854(+) m6A CDS       24284625 chr5:112178904-112178905(+) m6A CDS       24284625//22608085 chr5:112178926-112178927(+) m6A CDS       24284625//22608085 chr5:112178949-112178950(+) m6A CDS       24284625//24981863//22608085 chr5:112178989-112178990(+) m6A CDS       24284625//24981863//27773535//22608085 chr5:112179060-112179061(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr5:112179068-112179069(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr5:112179082-112179083(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr5:112179087-112179088(+) m6A CDS       24284625//24981863//27773535//22608085 chr5:112179101-112179102(+) m6A CDS       24284625//24981863//27773535//22608085 chr5:112179121-112179122(+) m6A CDS       24284625//24981863//27773535//22608085 chr5:112179175-112179176(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr5:112179214-112179215(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:112179250-112179251(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:112179278-112179279(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:112179368-112179369(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr5:112179399-112179400(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr5:112179458-112179459(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr5:112179496-112179497(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112179507-112179508(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112179513-112179514(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112179541-112179542(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112179597-112179598(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112179616-112179617(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:112179748-112179749(+) m6A CDS       24284625//24209618//24981863//22608085 chr5:112179772-112179773(+) m6A CDS       24284625//24209618//24981863//22608085 chr5:112179840-112179841(+) m6A 3'UTR       24981863//26404942//22608085 chr5:112179878-112179879(+) m6A 3'UTR       24981863//26404942//22608085 chr5:112179897-112179898(+) m6A 3'UTR       24981863//22608085 chr5:112179907-112179908(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-5p	Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	APC	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-5p
Interactor2: APC

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.