Basic Information:

  VIRBase ID:  

HHID00062072

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:  MIMAT0004481          TNF:  NM_000594     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-3p	TNF
miRBase Accession/Entrez ID	MIMAT0004481	7124
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DIF//TNF-alpha//TNFA//TNFSF2//TNLG1F

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-3p	rs1219969167 chr9:94176028    T/G rs1399588338 chr9:94176027    G/A rs1453867589 chr9:94176023    T/A rs770208205 chr9:94176022    C/T rs1265084977 chr22:46112817    T/C rs372596018 chr22:46112808    T/C rs1198423693 chr9:94176020    A/G rs748585376 chr9:94176015    A/G rs781681931 chr9:94176014    T/G rs972845958 chr9:94176013    CTA/C rs779353569 chr22:46112805    C/T rs970921980 chr22:46112807    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TNF	chr6:31543363-31543364(+) m6A 5'UTR       - chr6:31543373-31543374(+) m6A 5'UTR       - chr6:31543403-31543404(+) m6A 5'UTR       - chr6:31543416-31543417(+) m6A 5'UTR       - chr6:31543513-31543514(+) m6A 5'UTR       - chr6:31545104-31545105(+) m6A CDS       26404942 chr6:31545152-31545153(+) m6A CDS       26404942 chr6:31545323-31545324(+) m6A 3'UTR       26404942 chr6:31545382-31545383(+) m6A 3'UTR       26404942 chr6:31545434-31545435(+) m6A 3'UTR       26404942 chr6:31545447-31545448(+) m6A 3'UTR       26404942 chr6:31545462-31545463(+) m6A 3'UTR       26404942 chr6:31545476-31545477(+) m6A 3'UTR       26404942 chr6:31545537-31545538(+) m6A 3'UTR       26404942 chr6:31545552-31545553(+) m6A 3'UTR       26404942 chr6:31545599-31545600(+) m6A 3'UTR       26404942 chr6:31545636-31545637(+) m6A 3'UTR       26404942 chr6:31545646-31545647(+) m6A 3'UTR       26404942 chr6:31545673-31545674(+) m6A 3'UTR       26404942 chr6:31545706-31545707(+) m6A 3'UTR       26404942 chr6:31545717-31545718(+) m6A 3'UTR       26404942 chr6:31545833-31545834(+) m6A 3'UTR       26404942 chr6:31545851-31545852(+) m6A 3'UTR       26404942 chr6:31545879-31545880(+) m6A 3'UTR       26404942 chr6:31545906-31545907(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	TNF	Exosome Blood     - Polysome HeLa cells     26000482

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-3p
Interactor2: TNF

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.