Basic Information:

  VIRBase ID:  

HHID00060966

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:  MIMAT0003247          MACROD2:  NM_001351664     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-582-5p	MACROD2
miRBase Accession/Entrez ID	MIMAT0003247	140733
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf133//C2orf133

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-582-5p	rs1190339760 chr5:59703674    G/A rs1291143355 chr5:59703672    T/A rs1455812678 chr5:59703667    G/GT rs753758364 chr5:59703675    T/C rs779684016 chr5:59703670    A/C rs779684016 chr5:59703670    A/G rs1245677877 chr5:59703684    T/A rs373502275 chr5:59703686    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MACROD2	chr20:14121989(+) A-I      intronic chr20:15739670(+) A-I      intronic chr20:15739615(+) A-I      intronic chr20:14121965(+) A-I      intronic chr20:15536339(+) A-I      intronic chr20:15536359(+) A-I      intronic chr20:15536401(+) A-I      intronic chr20:15739686(+) A-I      intronic chr20:15739633(+) A-I      intronic chr20:15739578(+) A-I      intronic chr20:14121964(+) A-I      intronic chr20:15536370(+) A-I      intronic chr20:15739637(+) A-I      intronic chr20:14121933(+) A-I      intronic chr20:15739592(+) A-I      intronic chr20:15739628(+) A-I      intronic chr20:15739614(+) A-I      intronic chr20:14121987(+) A-I      intronic chr20:14121986(+) A-I      intronic chr20:15739672(+) A-I      intronic chr20:14307153(+) A-I      intronic chr20:15739662(+) A-I      intronic chr20:14429122(+) A-I      intronic chr20:14429139(+) A-I      intronic chr20:14429141(+) A-I      intronic chr20:14429152(+) A-I      intronic chr20:14429167(+) A-I      intronic chr20:14855896(+) A-I      intronic chr20:14855906(+) A-I      intronic chr20:14855913(+) A-I      intronic chr20:14855959(+) A-I      intronic chr20:16002853(+) A-I      intronic chr20:16002898(+) A-I      intronic chr20:16002903(+) A-I      intronic chr20:16002943(+) A-I      intronic chr20:15953232(+) A-I      intronic chr20:15953215(+) A-I      intronic chr20:15751959(+) A-I      intronic chr20:15751949(+) A-I      intronic chr20:15751919(+) A-I      intronic chr20:15751844(+) A-I      intronic chr20:15735694(+) A-I      intronic chr20:15735026(+) A-I      intronic chr20:15705580(+) A-I      intronic chr20:15705550(+) A-I      intronic chr20:15688253(+) A-I      intronic chr20:15688252(+) A-I      intronic chr20:15588291(+) A-I      intronic chr20:15588240(+) A-I      intronic chr20:15566017(+) A-I      intronic chr20:15566003(+) A-I      intronic chr20:15562509(+) A-I      intronic chr20:15562505(+) A-I      intronic chr20:15547114(+) A-I      intronic chr20:15547103(+) A-I      intronic chr20:15547064(+) A-I      intronic chr20:15541297(+) A-I      intronic chr20:15539761(+) A-I      intronic chr20:15536395(+) A-I      intronic chr20:15536329(+) A-I      intronic chr20:15163955(+) A-I      intronic chr20:14942976(+) A-I      intronic chr20:14942237(+) A-I      intronic chr20:14912527(+) A-I      intronic chr20:14911561(+) A-I      intronic chr20:14910687(+) A-I      intronic chr20:14910620(+) A-I      intronic chr20:14910619(+) A-I      intronic chr20:14910596(+) A-I      intronic chr20:14910552(+) A-I      intronic chr20:14876889(+) A-I      intronic chr20:14876886(+) A-I      intronic chr20:14876873(+) A-I      intronic chr20:14871301(+) A-I      intronic chr20:14871297(+) A-I      intronic chr20:14769157(+) A-I      intronic chr20:14761087(+) A-I      intronic chr20:14016694(+) A-I      intronic chr20:14761023(+) A-I      intronic chr20:14760947(+) A-I      intronic chr20:14699842(+) A-I      intronic chr20:14699763(+) A-I      intronic chr20:14699757(+) A-I      intronic chr20:14698835(+) A-I      intronic chr20:14686707(+) A-I      intronic chr20:14686706(+) A-I      intronic chr20:14016667(+) A-I      intronic chr20:16002835(+) A-I      intronic chr20:14466093(+) A-I      intronic chr20:14423481(+) A-I      intronic chr20:14377913(+) A-I      intronic chr20:14377901(+) A-I      intronic chr20:14377843(+) A-I      intronic chr20:14377841(+) A-I      intronic chr20:14339591(+) A-I      intronic chr20:14339586(+) A-I      intronic chr20:14328712(+) A-I      intronic chr20:16002837(+) A-I      intronic chr20:15953284(+) A-I      intronic chr20:14326513(+) A-I      intronic chr20:14322192(+) A-I      intronic chr20:14246552(+) A-I      intronic chr20:14209611(+) A-I      intronic chr20:14209605(+) A-I      intronic chr20:14209601(+) A-I      intronic chr20:14183499(+) A-I      intronic chr20:14161731(+) A-I      intronic chr20:14139899(+) A-I      intronic chr20:14139628(+) A-I      intronic chr20:14111150(+) A-I      intronic chr20:14079879(+) A-I      intronic chr20:14079873(+) A-I      intronic chr20:14946964(+) A-I      intronic chr20:15659866(+) A-I      intronic chr20:14059219(+) A-I      intronic chr20:14922569(+) A-I      intronic chr20:14241241(+) A-I      intronic chr20:14183684(+) A-I      intronic chr20:14701333(+) A-I      intronic chr20:14113450(+) A-I      intronic chr20:14116108(+) A-I      intronic chr20:13995503(+) A-I      intronic chr20:15579948(+) A-I      intronic chr20:15536353(+) A-I      intronic chr20:15751906(+) A-I      intronic chr20:14100653(+) A-I      intronic chr20:14377355(+) A-I      intronic chr20:14241211(+) A-I      intronic chr20:15518150(+) A-I      intronic chr20:14111700(+) A-I      intronic chr20:14183683(+) A-I      intronic chr20:16004040(+) A-I      intronic chr20:14701790(+) A-I      intronic chr20:14920900(+) A-I      intronic chr20:14913235(+) A-I      intronic chr20:14699625(+) A-I      intronic chr20:14968942(+) A-I      intronic chr20:14318893(+) A-I      intronic chr20:14769532(+) A-I      intronic chr20:14698899(+) A-I      intronic chr20:14920881(+) A-I      intronic chr20:15758473(+) A-I      intronic chr20:15688281(+) A-I      intronic chr20:14112486(+) A-I      intronic chr20:14699731(+) A-I      intronic chr20:15526779(+) A-I      intronic chr20:15751965(+) A-I      intronic chr20:14100108(+) A-I      intronic chr20:14030131(+) A-I      intronic chr20:14363235(+) A-I      intronic chr20:14770343(+) A-I      intronic chr20:14132674(+) A-I      intronic chr20:14363259(+) A-I      intronic chr20:14838520(+) A-I      intronic chr20:14112929(+) A-I      intronic chr20:15689556(+) A-I      intronic chr20:15534245(+) A-I      intronic chr20:14761088(+) A-I      intronic chr20:14133214(+) A-I      intronic chr20:15739471(+) A-I      intronic chr20:14257822(+) A-I      intronic chr20:14699798(+) A-I      intronic chr20:14968931(+) A-I      intronic chr20:14914088(+) A-I      intronic chr20:14708101(+) A-I      intronic chr20:14328752(+) A-I      intronic chr20:14686881(+) A-I      intronic chr20:13995511(+) A-I      intronic chr20:15541150(+) A-I      intronic chr20:14635036(+) A-I      intronic chr20:14698824(+) A-I      intronic chr20:14295385(+) A-I      intronic chr20:14770327(+) A-I      intronic chr20:15588362(+) A-I      intronic chr20:14099548(+) A-I      intronic chr20:15547057(+) A-I      intronic chr20:15765779(+) A-I      intronic chr20:15536363(+) A-I      intronic chr20:15022145(+) A-I      intronic chr20:15571381(+) A-I      intronic chr20:14369902(+) A-I      intronic chr20:15534181(+) A-I      intronic chr20:15532311(+) A-I      intronic chr20:14122227(+) A-I      intronic chr20:14100712(+) A-I      intronic chr20:15536310(+) A-I      intronic chr20:15690264(+) A-I      intronic chr20:15048176(+) A-I      intronic chr20:14912389(+) A-I      intronic chr20:14914196(+) A-I      intronic chr20:14449297(+) A-I      intronic chr20:15047381(+) A-I      intronic chr20:14698685(+) A-I      intronic chr20:13996046(+) A-I      intronic chr20:15520583(+) A-I      intronic chr20:14244562(+) A-I      intronic chr20:15444133(+) A-I      intronic chr20:15534118(+) A-I      intronic chr20:15571387(+) A-I      intronic chr20:14112698(+) A-I      intronic chr20:15758464(+) A-I      intronic chr20:15739741(+) A-I      intronic chr20:14701740(+) A-I      intronic chr20:15534274(+) A-I      intronic chr20:15098938(+) A-I      intronic chr20:14826970(+) A-I      intronic chr20:14369877(+) A-I      intronic chr20:15616566(+) A-I      intronic chr20:14053772(+) A-I      intronic chr20:14770305(+) A-I      intronic chr20:14812371(+) A-I      intronic chr20:14111074(+) A-I      intronic chr20:15536325(+) A-I      intronic chr20:15541261(+) A-I      intronic chr20:14326278(+) A-I      intronic chr20:15686292(+) A-I      intronic chr20:13995559(+) A-I      intronic chr20:15587500(+) A-I      intronic chr20:15564423(+) A-I      intronic chr20:14912495(+) A-I      intronic chr20:15564428(+) A-I      intronic chr20:15048196(+) A-I      intronic chr20:14077225(+) A-I      intronic chr20:14701420(+) A-I      intronic chr20:15564328(+) A-I      intronic chr20:14030673(+) A-I      intronic chr20:14684584(+) A-I      intronic chr20:15752543(+) A-I      intronic chr20:14699725(+) A-I      intronic chr20:15698914(+) A-I      intronic chr20:15194611(+) A-I      intronic chr20:14769548(+) A-I      intronic chr20:14911569(+) A-I      intronic chr20:15534248(+) A-I      intronic chr20:14769160(+) A-I      intronic chr20:14142456(+) A-I      intronic chr20:14914071(+) A-I      intronic chr20:14122332(+) A-I      intronic chr20:15536380(+) A-I      intronic chr20:14635032(+) A-I      intronic chr20:15534176(+) A-I      intronic chr20:15347213(+) A-I      intronic chr20:14968958(+) A-I      intronic chr20:14698708(+) A-I      intronic chr20:15174207(+) A-I      intronic chr20:14945164(+) A-I      intronic chr20:15534145(+) A-I      intronic chr20:14187771(+) A-I      intronic chr20:14975201(+) A-I      intronic chr20:14769133(+) A-I      intronic chr20:15739462(+) A-I      intronic chr20:15751839(+) A-I      intronic chr20:14914217(+) A-I      intronic chr20:14112955(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MACROD2	chr20:15879542(+) A-I intron -    22327324 chr20:15879581(+) A-I intron -    22327324 chr20:15879583(+) A-I intron -    22327324 chr20:15879648(+) A-I intron -    22327324 chr20:15879676(+) A-I intron -    22327324 chr20:15879962(+) A-I intron -    22327324 chr20:15879970(+) A-I intron -    22327324 chr20:15916724(+) A-I intron -    22327324 chr20:15916751(+) A-I intron -    22327324 chr20:15916784(+) A-I intron -    22327324 chr20:15916823(+) A-I intron -    22327324 chr20:15536310(+) A-G intron -    22484847 chr20:15536343(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MACROD2	chr20:13982984-13982985(+) m6A CDS//exon       24209618 chr20:13982999-13983000(+) m6A CDS//exon       24209618 chr20:14738398-14738399(+) m6A intron       - chr20:15967412-15967413(+) m6A 5'UTR//CDS//exon       - chr20:15967439-15967440(+) m6A CDS//exon       - chr20:15967722-15967723(+) m6A CDS//exon       - chr20:15967776-15967777(+) m6A CDS//exon       - chr20:16021857-16021858(+) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-582-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Plasma     23663360 Exosome Serum     25349172 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	MACROD2	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-582-5p	Iodine Green 9956454 Drug sensitive Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive Secalonic acid D 73431 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive 6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Staurosporine, 98% 49831000 Drug resistant Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive o6-Benzylguanine 4578 Drug resistant Triciribine phosphate 43860 Drug resistant Aminopyrimidine-CH3 406278 Drug sensitive Aminopyrimidine-F 406276 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive Hookerianamide J 25016666 Drug sensitive Antimycin A3 245869 Drug sensitive Kinetin riboside 20345 Drug resistant 4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant Astrazon Orange R 135747272 Drug sensitive 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tunicamycin - Drug resistant (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 2k2S,S? - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-582-5p	Formaldehyde 712 Drug interaction    RC00006017 Alocrest 60780 Drug interaction    RC00006022 Vincristine 5978 Drug interaction    RC00006020 Sunitinib 5329102 Drug interaction    RC00006023 Doxorubicin 31703 Drug interaction    RC00006021 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019 Verapamil 2520 Drug interaction    RC00006018 Navitoclax 24978538 Drug interaction    RC00006024

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-582-5p	Cisplatin 5702198       21575166 Sirolimus 5284616       30666128 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-582-5p	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528 l-685,458       5479543 Selumetinib       10127622

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-582-5p
Interactor2: MACROD2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.