Detail Information

Basic Information:


  VIRBase ID:  

HHID00060960

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           DSCC1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p DSCC1
miRBase
Accession/Entrez ID		 MIMAT0003247 79075
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DCC1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DSCC1
chr8:120857441(-) A-I      intronic
chr8:120856832(-) A-I      intronic
chr8:120861600(-) A-I      intronic
chr8:120858514(-) A-I      intronic
chr8:120861608(-) A-I      intronic
chr8:120856663(-) A-I      intronic
chr8:120856173(-) A-I      intronic
chr8:120856632(-) A-I      intronic
chr8:120856486(-) A-I      intronic
chr8:120853482(-) A-I      intronic
chr8:120853459(-) A-I      intronic
chr8:120858486(-) A-I      intronic
chr8:120853451(-) A-I      intronic
chr8:120853070(-) A-I      intronic
chr8:120853024(-) A-I      intronic
chr8:120858088(-) A-I      intronic
chr8:120852907(-) A-I      intronic
chr8:120861584(-) A-I      intronic
chr8:120861524(-) A-I      intronic
chr8:120856210(-) A-I      intronic
chr8:120858482(-) A-I      intronic
chr8:120858465(-) A-I      intronic
chr8:120856220(-) A-I      intronic
chr8:120858006(-) A-I      intronic
chr8:120857997(-) A-I      intronic
chr8:120858492(-) A-I      intronic
chr8:120858067(-) A-I      intronic
chr8:120858106(-) A-I      intronic
chr8:120858533(-) A-I      intronic
chr8:120856230(-) A-I      intronic
chr8:120858547(-) A-I      intronic
chr8:120858837(-) A-I      intronic
chr8:120861174(-) A-I      intronic
chr8:120861180(-) A-I      intronic
chr8:120861534(-) A-I      intronic
chr8:120856221(-) A-I      intronic
chr8:120852986(-) A-I      intronic
chr8:120858931(-) A-I      intronic
chr8:120861467(-) A-I      intronic
chr8:120856155(-) A-I      intronic
chr8:120856196(-) A-I      intronic
chr8:120853518(-) A-I      intronic
chr8:120857454(-) A-I      intronic
chr8:120860044(-) A-I      intronic
chr8:120860030(-) A-I      intronic
chr8:120859071(-) A-I      intronic
chr8:120857464(-) A-I      intronic
chr8:120856633(-) A-I      intronic
chr8:120858478(-) A-I      intronic
chr8:120858389(-) A-I      intronic
chr8:120857466(-) A-I      intronic
chr8:120853399(-) A-I      intronic
chr8:120856168(-) A-I      intronic
chr8:120858163(-) A-I      intronic
chr8:120856433(-) A-I      intronic
chr8:120860014(-) A-I      intronic
chr8:120856113(-) A-I      intronic
chr8:120851181(-) A-I      intronic
chr8:120851192(-) A-I      intronic
chr8:120856079(-) A-I      intronic
chr8:120859054(-) A-I      intronic
chr8:120853337(-) A-I      intronic
chr8:120856917(-) A-I      intronic
chr8:120857598(-) A-I      intronic
chr8:120858993(-) A-I      intronic
chr8:120860082(-) A-I      intronic
chr8:120860449(-) A-I      intronic
chr8:120858967(-) A-I      intronic
chr8:120856289(-) A-I      intronic
chr8:120853030(-) A-I      intronic
chr8:120856547(-) A-I      intronic
chr8:120856290(-) A-I      intronic
chr8:120860382(-) A-I      intronic
chr8:120856596(-) A-I      intronic
chr8:120861481(-) A-I      intronic
chr8:120851193(-) A-I      intronic
chr8:120851138(-) A-I      intronic
chr8:120853328(-) A-I      intronic
chr8:120856555(-) A-I      intronic
chr8:120851229(-) A-I      intronic
chr8:120853138(-) A-I      intronic
chr8:120860066(-) A-I      intronic
chr8:120856456(-) A-I      intronic
chr8:120858041(-) A-I      intronic
chr8:120857944(-) A-I      intronic
chr8:120852948(-) A-I      intronic
chr8:120856181(-) A-I      intronic
chr8:120856236(-) A-I      intronic
chr8:120853425(-) A-I      intronic
chr8:120852922(-) A-I      intronic
chr8:120856592(-) A-I      intronic
chr8:120852935(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DSCC1
chr8:120851098(-) A-I intron -    15342557
chr8:120851138(-) A-I intron -    15342557
chr8:120851141(-) A-I intron -    15342557
chr8:120851181(-) A-I intron -    15342557
chr8:120851192(-) A-I intron -    15342557
chr8:120851193(-) A-I intron -    15342557
chr8:120851201(-) A-I intron -    15342557
chr8:120852922(-) A-G intron -    22484847
chr8:120852935(-) A-G intron -    22484847
chr8:120852947(-) A-G intron -    22484847
chr8:120852948(-) A-G intron -    22484847
chr8:120853004(-) A-G intron -    22484847
chr8:120853030(-) A-G intron -    22484847
chr8:120853040(-) A-G intron -    22484847
chr8:120853138(-) A-G intron -    22484847
chr8:120853518(-) A-G intron -    22484847
chr8:120856168(-) A-G intron -    22484847
chr8:120856181(-) A-G intron -    22484847
chr8:120856547(-) A-G intron -    22484847
chr8:120856555(-) A-G intron -    22484847
chr8:120856596(-) A-G intron -    22484847
chr8:120856597(-) A-G intron -    22484847
chr8:120856619(-) A-G intron -    22484847
chr8:120857464(-) A-G intron -    22484847
chr8:120857598(-) A-G intron -    22484847
chr8:120857945(-) A-G intron -    22484847
chr8:120861481(-) A-G intron -    22484847
chr8:120861511(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DSCC1
chr8:120847107-120847108(-) m6A 3'UTR       24981863
chr8:120865324-120865325(-) Am CDS//exon       -
chr8:120867858-120867859(-) m6A CDS//exon       27773536
chr8:120868025-120868026(-) m6A CDS//exon       27773536
chr8:120868047-120868048(-) m6A 5'UTR//exon       24981863//27773536
chr8:120868055-120868056(-) m6A 5'UTR//exon       24981863//27773536
chr8:120868101-120868102(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
DSCC1
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: DSCC1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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