Basic Information:

  VIRBase ID:  

HHID00060946

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:  MIMAT0003247          PTCD3:  NM_017952     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-582-5p	PTCD3
miRBase Accession/Entrez ID	MIMAT0003247	55037
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COXPD51//MRP-S39

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-582-5p	rs1190339760 chr5:59703674    G/A rs1291143355 chr5:59703672    T/A rs1455812678 chr5:59703667    G/GT rs753758364 chr5:59703675    T/C rs779684016 chr5:59703670    A/C rs779684016 chr5:59703670    A/G rs1245677877 chr5:59703684    T/A rs373502275 chr5:59703686    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PTCD3	chr2:86355298(+) A-I      intronic chr2:86339737(+) A-I      intronic chr2:86338524(+) A-I      intronic chr2:86338495(+) A-I      intronic chr2:86338590(+) A-I      intronic chr2:86338561(+) A-I      intronic chr2:86338545(+) A-I      intronic chr2:86338551(+) A-I      intronic chr2:86338591(+) A-I      intronic chr2:86338596(+) A-I      intronic chr2:86338783(+) A-I      intronic chr2:86339067(+) A-I      intronic chr2:86339101(+) A-I      intronic chr2:86343517(+) A-I      intronic chr2:86339127(+) A-I      intronic chr2:86339128(+) A-I      intronic chr2:86339129(+) A-I      intronic chr2:86339273(+) A-I      intronic chr2:86339368(+) A-I      intronic chr2:86339410(+) A-I      intronic chr2:86339628(+) A-I      intronic chr2:86338528(+) A-I      intronic chr2:86338494(+) A-I      intronic chr2:86366368(+) A-I      3'UTR chr2:86339698(+) A-I      intronic chr2:86340780(+) A-I      intronic chr2:86349677(+) A-I      intronic chr2:86357329(+) A-I      intronic chr2:86356644(+) A-I      intronic chr2:86347740(+) A-I      intronic chr2:86350305(+) A-I      intronic chr2:86355305(+) A-I      intronic chr2:86356535(+) A-I      intronic chr2:86357262(+) A-I      intronic chr2:86355322(+) A-I      intronic chr2:86356540(+) A-I      intronic chr2:86338968(+) A-I      intronic chr2:86366514(+) A-I      3'UTR chr2:86366789(+) A-I      3'UTR chr2:86366543(+) A-I      3'UTR chr2:86366654(+) A-I      3'UTR chr2:86366362(+) A-I      3'UTR chr2:86366442(+) A-I      3'UTR chr2:86339361(+) A-I      intronic chr2:86353075(+) A-I      intronic chr2:86338924(+) A-I      intronic chr2:86347853(+) A-I      intronic chr2:86358601(+) A-I      intronic chr2:86353206(+) A-I      intronic chr2:86357308(+) A-I      intronic chr2:86340883(+) A-I      intronic chr2:86349629(+) A-I      intronic chr2:86355336(+) A-I      intronic chr2:86349674(+) A-I      intronic chr2:86338652(+) A-I      intronic chr2:86353905(+) A-I      intronic chr2:86349574(+) A-I      intronic chr2:86357302(+) A-I      intronic chr2:86355416(+) A-I      intronic chr2:86355352(+) A-I      intronic chr2:86339712(+) A-I      intronic chr2:86341593(+) A-I      intronic chr2:86340764(+) A-I      intronic chr2:86339684(+) A-I      intronic chr2:86339575(+) A-I      intronic chr2:86353090(+) A-I      intronic chr2:86339754(+) A-I      intronic chr2:86356730(+) A-I      intronic chr2:86356539(+) A-I      intronic chr2:86357344(+) A-I      intronic chr2:86350306(+) A-I      intronic chr2:86346679(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PTCD3	chr2:86336529(+) C-A intron -    22484847 chr2:86338652(+) A-G intron -    22484847 chr2:86338968(+) A-G intron -    22484847 chr2:86339361(+) A-G intron -    22484847 chr2:86339618(+) A-G intron -    22484847 chr2:86339684(+) A-G intron -    22484847 chr2:86339698(+) A-G intron -    22484847 chr2:86339712(+) A-G intron -    22484847 chr2:86347740(+) A-G intron -    22484847 chr2:86349566(+) A-G intron -    22484847 chr2:86349604(+) A-G intron -    22484847 chr2:86349674(+) A-G intron -    22484847 chr2:86349677(+) A-G intron -    22484847 chr2:86349709(+) T-G intron -    22484847 chr2:86350264(+) A-G intron -    22484847 chr2:86353278(+) G-A intron -    22484847 chr2:86355319(+) A-G intron -    22484847 chr2:86355320(+) A-G intron -    22484847 chr2:86355322(+) A-G intron -    22484847 chr2:86355336(+) A-G intron -    22484847 chr2:86356535(+) A-G intron -    22484847 chr2:86356539(+) A-G intron -    22484847 chr2:86366362(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTCD3	chr2:86333456-86333457(+) m6A CDS//exon       24981863//22608085 chr2:86334259-86334260(+) m6A CDS//intron       24981863 chr2:86334283-86334284(+) m6A CDS//intron       24981863 chr2:86335512-86335513(+) m6A CDS//exon       24981863 chr2:86335631-86335632(+) m1A 3'UTR//CDS//exon       26863196 chr2:86335654-86335655(+) m6A 3'UTR//CDS//exon       - chr2:86364130-86364131(+) m6A CDS       - chr2:86364257-86364258(+) m6A CDS       - chr2:86364741-86364742(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr2:86365192-86365193(+) m6A 3'UTR       27773535 chr2:86367954-86367955(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr2:86367994-86367995(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:86368018-86368019(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:86368044-86368045(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:86368053-86368054(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:86368068-86368069(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:86368084-86368085(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr2:86368190-86368191(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr2:86368292-86368293(+) m6A 3'UTR       24284625//24981863//22608085 chr2:86368303-86368304(+) m6A 3'UTR       24284625//24981863//22608085 chr2:86368312-86368313(+) m6A 3'UTR       24284625//24981863//22608085 chr2:86368425-86368426(+) m6A 3'UTR       24284625//24981863//22608085 chr2:86368440-86368441(+) m6A 3'UTR       24284625//24981863//22608085 chr2:86368474-86368475(+) m6A 3'UTR       24284625//24981863//22608085 chr2:86368579-86368580(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr2:86368602-86368603(+) m6A 3'UTR       24981863//27773535//22608085 chr2:86368610-86368611(+) m6A 3'UTR       24981863//27773535//22608085 chr2:86368626-86368627(+) m6A 3'UTR       24981863//27773535//22608085 chr2:86368639-86368640(+) m6A 3'UTR       24981863//27773535//22608085 chr2:86368686-86368687(+) m6A 3'UTR       24981863//27773535//22608085 chr2:86368734-86368735(+) m6A 3'UTR       27773535//22608085 chr2:86368778-86368779(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-582-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Plasma     23663360 Exosome Serum     25349172 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	PTCD3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-582-5p	Iodine Green 9956454 Drug sensitive Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive Secalonic acid D 73431 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive 6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Staurosporine, 98% 49831000 Drug resistant Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive o6-Benzylguanine 4578 Drug resistant Triciribine phosphate 43860 Drug resistant Aminopyrimidine-CH3 406278 Drug sensitive Aminopyrimidine-F 406276 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive Hookerianamide J 25016666 Drug sensitive Antimycin A3 245869 Drug sensitive Kinetin riboside 20345 Drug resistant 4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant Astrazon Orange R 135747272 Drug sensitive 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tunicamycin - Drug resistant (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 2k2S,S? - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-582-5p	Formaldehyde 712 Drug interaction    RC00006017 Alocrest 60780 Drug interaction    RC00006022 Vincristine 5978 Drug interaction    RC00006020 Sunitinib 5329102 Drug interaction    RC00006023 Doxorubicin 31703 Drug interaction    RC00006021 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019 Verapamil 2520 Drug interaction    RC00006018 Navitoclax 24978538 Drug interaction    RC00006024

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-582-5p	Cisplatin 5702198       21575166 Sirolimus 5284616       30666128 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-582-5p	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528 l-685,458       5479543 Selumetinib       10127622

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-582-5p
Interactor2: PTCD3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.