Detail Information

Basic Information:


  VIRBase ID:  

HHID00060940

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           RRM2B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p RRM2B
miRBase
Accession/Entrez ID		 MIMAT0003247 50484
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MTDPS8A//MTDPS8B//P53R2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RRM2B
chr8:103221315(-) A-I      intronic
chr8:103221190(-) A-I      intronic
chr8:103221186(-) A-I      intronic
chr8:103246146(-) A-I      intronic
chr8:103246069(-) A-I      intronic
chr8:103242086(-) A-I      intronic
chr8:103221212(-) A-I      intronic
chr8:103221206(-) A-I      intronic
chr8:103234473(-) A-I      intronic
chr8:103221175(-) A-I      intronic
chr8:103221173(-) A-I      intronic
chr8:103221174(-) A-I      intronic
chr8:103242062(-) A-I      intronic
chr8:103242055(-) A-I      intronic
chr8:103242007(-) A-I      intronic
chr8:103241984(-) A-I      intronic
chr8:103238994(-) A-I      intronic
chr8:103238999(-) A-I      intronic
chr8:103234504(-) A-I      intronic
chr8:103241419(-) A-I      intronic
chr8:103221256(-) A-I      intronic
chr8:103232840(-) A-I      intronic
chr8:103232909(-) A-I      intronic
chr8:103234417(-) A-I      intronic
chr8:103246177(-) A-I      intronic
chr8:103246189(-) A-I      intronic
chr8:103246237(-) A-I      intronic
chr8:103247887(-) A-I      intronic
chr8:103247929(-) A-I      intronic
chr8:103239004(-) A-I      intronic
chr8:103239009(-) A-I      intronic
chr8:103234500(-) A-I      intronic
chr8:103239070(-) A-I      intronic
chr8:103239080(-) A-I      intronic
chr8:103241333(-) A-I      intronic
chr8:103232823(-) A-I      intronic
chr8:103232367(-) A-I      intronic
chr8:103241373(-) A-I      intronic
chr8:103236603(-) A-I      intronic
chr8:103232345(-) A-I      intronic
chr8:103221339(-) A-I      intronic
chr8:103221292(-) A-I      intronic
chr8:103232262(-) A-I      intronic
chr8:103246070(-) A-I      intronic
chr8:103232222(-) A-I      intronic
chr8:103232875(-) A-I      intronic
chr8:103223378(-) A-I      intronic
chr8:103241227(-) A-I      intronic
chr8:103232384(-) A-I      intronic
chr8:103232332(-) A-I      intronic
chr8:103232783(-) A-I      intronic
chr8:103242009(-) A-I      intronic
chr8:103246209(-) A-I      intronic
chr8:103232319(-) A-I      intronic
chr8:103241381(-) A-I      intronic
chr8:103232452(-) A-I      intronic
chr8:103242085(-) A-I      intronic
chr8:103223342(-) A-I      intronic
chr8:103234468(-) A-I      intronic
chr8:103232301(-) A-I      intronic
chr8:103241875(-) A-I      intronic
chr8:103244066(-) A-I      intronic
chr8:103234508(-) A-I      intronic
chr8:103234537(-) A-I      intronic
chr8:103241442(-) A-I      intronic
chr8:103232284(-) A-I      intronic
chr8:103235724(-) A-I      intronic
chr8:103234464(-) A-I      intronic
chr8:103232831(-) A-I      intronic
chr8:103246218(-) A-I      intronic
chr8:103248056(-) A-I      intronic
chr8:103241302(-) A-I      intronic
chr8:103232323(-) A-I      intronic
chr8:103246226(-) A-I      intronic
chr8:103241995(-) A-I      intronic
chr8:103232318(-) A-I      intronic
chr8:103235823(-) A-I      intronic
chr8:103242092(-) A-I      intronic
chr8:103232883(-) A-I      intronic
chr8:103234402(-) A-I      intronic
chr8:103234475(-) A-I      intronic
chr8:103246224(-) A-I      intronic
chr8:103232827(-) A-I      intronic
chr8:103234401(-) A-I      intronic
chr8:103241325(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RRM2B
chr8:103232301(-) A-G intron -    22484847
chr8:103232323(-) A-G intron -    22484847
chr8:103232332(-) A-G intron -    22484847
chr8:103232783(-) A-G intron -    22484847
chr8:103232827(-) A-G intron -    22484847
chr8:103232936(-) A-G intron -    22484847
chr8:103235724(-) A-G intron -    22484847
chr8:103235823(-) A-G intron -    22484847
chr8:103239303(-) A-G intron -    22484847
chr8:103241258(-) A-G intron -    22484847
chr8:103241302(-) A-G intron -    22484847
chr8:103241325(-) A-G intron -    22484847
chr8:103241337(-) A-G intron -    22484847
chr8:103241381(-) A-G intron -    22484847
chr8:103241442(-) A-G intron -    22484847
chr8:103241875(-) A-G intron -    22484847
chr8:103241995(-) A-G intron -    22484847
chr8:103242009(-) A-G intron -    22484847
chr8:103242085(-) A-G intron -    22484847
chr8:103242092(-) A-G intron -    22484847
chr8:103244008(-) T-C intron -    22484847
chr8:103244066(-) A-G intron -    22484847
chr8:103246070(-) A-G intron -    22484847
chr8:103246209(-) A-G intron -    22484847
chr8:103246218(-) A-G intron -    22484847
chr8:103246224(-) A-G intron -    22484847
chr8:103246225(-) A-G intron -    22484847
chr8:103246226(-) A-G intron -    22484847
chr8:103246270(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RRM2B
chr8:103217553-103217554(-) Y 3'UTR       25219674
chr8:103220263-103220264(-) m6A 3'UTR//exon       24981863//22608085
chr8:103220332-103220333(-) m6A 3'UTR//exon       24981863//26404942//22608085
chr8:103220341-103220342(-) m6A 3'UTR//exon       24981863//26404942//22608085
chr8:103220356-103220357(-) m6A 3'UTR//exon       24981863//22608085
chr8:103250951-103250952(-) m6A 5'UTR//CDS//exon//intron       24981863
chr8:103250985-103250986(-) m6A 5'UTR//CDS//exon//intron       24981863
chr8:103251183-103251184(-) m6A 5'UTR       25456834//24981863//27371828
chr8:103251191-103251192(-) m6A 5'UTR       25456834//24981863//27371828
chr8:103251200-103251201(-) m6A 5'UTR       25456834//24981863//27371828
chr8:103251253-103251254(-) m6A 5'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
RRM2B
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: RRM2B

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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