Detail Information

Basic Information:


  VIRBase ID:  

HHID00060935

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           DSTYK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p DSTYK
miRBase
Accession/Entrez ID		 MIMAT0003247 25778
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAKUT1//DustyPK//HDCMD38P//RIP5//RIPK5//SPG23

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DSTYK
chr1:205142952(-) A-I      intronic
chr1:205142949(-) A-I      intronic
chr1:205142975(-) A-I      intronic
chr1:205142985(-) A-I      intronic
chr1:205142958(-) A-I      intronic
chr1:205142967(-) A-I      intronic
chr1:205172962(-) A-I      intronic
chr1:205172961(-) A-I      intronic
chr1:205171008(-) A-I      intronic
chr1:205170240(-) A-I      intronic
chr1:205170227(-) A-I      intronic
chr1:205170226(-) A-I      intronic
chr1:205170221(-) A-I      intronic
chr1:205169591(-) A-I      intronic
chr1:205169551(-) A-I      intronic
chr1:205169313(-) A-I      intronic
chr1:205166043(-) A-I      intronic
chr1:205166025(-) A-I      intronic
chr1:205166024(-) A-I      intronic
chr1:205165563(-) A-I      intronic
chr1:205165519(-) A-I      intronic
chr1:205165511(-) A-I      intronic
chr1:205154614(-) A-I      intronic
chr1:205154325(-) A-I      intronic
chr1:205154220(-) A-I      intronic
chr1:205154217(-) A-I      intronic
chr1:205154091(-) A-I      intronic
chr1:205153780(-) A-I      intronic
chr1:205150974(-) A-I      intronic
chr1:205149665(-) A-I      intronic
chr1:205143012(-) A-I      intronic
chr1:205142971(-) A-I      intronic
chr1:205142436(-) A-I      intronic
chr1:205142435(-) A-I      intronic
chr1:205133504(-) A-I      intronic
chr1:205128292(-) A-I      intronic
chr1:205145860(-) A-I      intronic
chr1:205177745(-) A-I      intronic
chr1:205177143(-) A-I      intronic
chr1:205177006(-) A-I      intronic
chr1:205177071(-) A-I      intronic
chr1:205134264(-) A-I      intronic
chr1:205143759(-) A-I      intronic
chr1:205150659(-) A-I      intronic
chr1:205150661(-) A-I      intronic
chr1:205146168(-) A-I      intronic
chr1:205126720(-) A-I      intronic
chr1:205148003(-) A-I      intronic
chr1:205172502(-) A-I      intronic
chr1:205141357(-) A-I      intronic
chr1:205146104(-) A-I      intronic
chr1:205148188(-) A-I      intronic
chr1:205154567(-) A-I      intronic
chr1:205165635(-) A-I      intronic
chr1:205172515(-) A-I      intronic
chr1:205171065(-) A-I      intronic
chr1:205144416(-) A-I      intronic
chr1:205150942(-) A-I      intronic
chr1:205149820(-) A-I      intronic
chr1:205114651(-) A-I      3'UTR
chr1:205171105(-) A-I      intronic
chr1:205148181(-) A-I      intronic
chr1:205168045(-) A-I      intronic
chr1:205165983(-) A-I      intronic
chr1:205146142(-) A-I      intronic
chr1:205164099(-) A-I      intronic
chr1:205124283(-) A-I      intronic
chr1:205135064(-) A-I      intronic
chr1:205169452(-) A-I      intronic
chr1:205143289(-) A-I      intronic
chr1:205146332(-) A-I      intronic
chr1:205143123(-) A-I      intronic
chr1:205171016(-) A-I      intronic
chr1:205153617(-) A-I      intronic
chr1:205132636(-) A-I      intronic
chr1:205124259(-) A-I      intronic
chr1:205150934(-) A-I      intronic
chr1:205171075(-) A-I      intronic
chr1:205135546(-) A-I      intronic
chr1:205128285(-) A-I      intronic
chr1:205141685(-) A-I      intronic
chr1:205169303(-) A-I      intronic
chr1:205177767(-) A-I      intronic
chr1:205169521(-) A-I      intronic
chr1:205134961(-) A-I      intronic
chr1:205150665(-) A-I      intronic
chr1:205143962(-) A-I      intronic
chr1:205177835(-) A-I      intronic
chr1:205164029(-) A-I      intronic
chr1:205166002(-) A-I      intronic
chr1:205171111(-) A-I      intronic
chr1:205161968(-) A-I      intronic
chr1:205161943(-) A-I      intronic
chr1:205134289(-) A-I      intronic
chr1:205141136(-) A-I      intronic
chr1:205148006(-) A-I      intronic
chr1:205150679(-) A-I      intronic
chr1:205142439(-) A-I      intronic
chr1:205134324(-) A-I      intronic
chr1:205146213(-) A-I      intronic
chr1:205170976(-) A-I      intronic
chr1:205148555(-) A-I      intronic
chr1:205169574(-) A-I      intronic
chr1:205161951(-) A-I      intronic
chr1:205153588(-) A-I      intronic
chr1:205112269(-) A-I      3'UTR
chr1:205133487(-) A-I      intronic
chr1:205143067(-) A-I      intronic
chr1:205177847(-) A-I      intronic
chr1:205169302(-) A-I      intronic
chr1:205144138(-) A-I      intronic
chr1:205148559(-) A-I      intronic
chr1:205177070(-) A-I      intronic
chr1:205135529(-) A-I      intronic
chr1:205148189(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DSTYK
chr1:205148555(-) A-I intron -    15545495
chr1:205148559(-) A-I intron -    15545495
chr1:205177799(-) A-I intron -    21960545
chr1:205124232(-) G-C intron -    22484847
chr1:205124259(-) A-G intron -    22484847
chr1:205124274(-) T-C intron -    22484847
chr1:205124283(-) A-G intron -    22484847
chr1:205134264(-) A-G intron -    22484847
chr1:205143067(-) A-G intron -    22484847
chr1:205143123(-) A-G intron -    22484847
chr1:205143289(-) A-G intron -    22484847
chr1:205143759(-) A-G intron -    22484847
chr1:205143867(-) T-A intron -    22484847
chr1:205150659(-) A-G intron -    22484847
chr1:205150661(-) A-G intron -    22484847
chr1:205150665(-) A-G intron -    22484847
chr1:205150679(-) A-G intron -    22484847
chr1:205153617(-) A-G intron -    22484847
chr1:205171016(-) A-G intron -    22484847
chr1:205171065(-) A-G intron -    22484847
chr1:205171075(-) A-G intron -    22484847
chr1:205171105(-) A-G intron -    22484847
chr1:205171111(-) A-G intron -    22484847
chr1:205172914(-) A-C intron -    22484847
chr1:205177835(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DSTYK
chr1:205116080-205116081(-) m6A 3'UTR       27773535
chr1:205116127-205116128(-) m6A 3'UTR       27773535
chr1:205116215-205116216(-) m6A 3'UTR       27773535
chr1:205116221-205116222(-) m6A 3'UTR       27773535
chr1:205116229-205116230(-) m6A 3'UTR       27773535
chr1:205116266-205116267(-) m6A 3'UTR       27773535
chr1:205116341-205116342(-) m6A 3'UTR       27773535
chr1:205116353-205116354(-) m6A 3'UTR       27773535
chr1:205116526-205116527(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116553-205116554(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116560-205116561(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116578-205116579(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116594-205116595(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116676-205116677(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr1:205116703-205116704(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr1:205116710-205116711(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr1:205132927-205132928(-) m6A CDS//intron       24284625
chr1:205138324-205138325(-) m6A CDS//intron       27773535//22608085
chr1:205138347-205138348(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085
chr1:205138466-205138467(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:205138526-205138527(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138557-205138558(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138591-205138592(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138609-205138610(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138658-205138659(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138745-205138746(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138765-205138766(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138846-205138847(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:205156578-205156579(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr1:205156609-205156610(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:205156643-205156644(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156683-205156684(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156692-205156693(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156718-205156719(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156724-205156725(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156873-205156874(-) m6A CDS       24284625//24209618//24981863
chr1:205180413-205180414(-) m6A CDS       24284625//24981863//27773536
chr1:205180521-205180522(-) m6A CDS       24981863//27371828//27773536
chr1:205180532-205180533(-) m6A CDS       24981863//27371828//27773536
chr1:205180680-205180681(-) m6A 5'UTR       25456834//24981863//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
DSTYK
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: DSTYK

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...