Detail Information

Basic Information:


  VIRBase ID:  

HHID00060932

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           PIP5K1C:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p PIP5K1C
miRBase
Accession/Entrez ID		 MIMAT0003247 23396
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LCCS3//PIP5K-GAMMA//PIP5K1-gamma//PIP5Kgamma

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PIP5K1C
chr19:3682209(-) A-I      intronic
chr19:3682206(-) A-I      intronic
chr19:3648217(-) A-I      intronic
chr19:3648190(-) A-I      intronic
chr19:3682192(-) A-I      intronic
chr19:3682180(-) A-I      intronic
chr19:3648224(-) A-I      intronic
chr19:3648185(-) A-I      intronic
chr19:3648198(-) A-I      intronic
chr19:3648216(-) A-I      intronic
chr19:3686633(-) A-I      intronic
chr19:3677363(-) A-I      intronic
chr19:3685984(-) A-I      intronic
chr19:3686026(-) A-I      intronic
chr19:3686088(-) A-I      intronic
chr19:3686616(-) A-I      intronic
chr19:3689386(-) A-I      intronic
chr19:3689406(-) A-I      intronic
chr19:3640342(-) A-I      intronic
chr19:3640431(-) A-I      intronic
chr19:3640770(-) A-I      intronic
chr19:3640781(-) A-I      intronic
chr19:3640891(-) A-I      intronic
chr19:3641018(-) A-I      intronic
chr19:3641137(-) A-I      intronic
chr19:3641156(-) A-I      intronic
chr19:3647728(-) A-I      intronic
chr19:3647753(-) A-I      intronic
chr19:3647912(-) A-I      intronic
chr19:3648134(-) A-I      intronic
chr19:3648309(-) A-I      intronic
chr19:3651129(-) A-I      intronic
chr19:3682320(-) A-I      intronic
chr19:3682338(-) A-I      intronic
chr19:3674694(-) A-I      intronic
chr19:3689525(-) A-I      intronic
chr19:3695850(-) A-I      intronic
chr19:3695854(-) A-I      intronic
chr19:3695875(-) A-I      intronic
chr19:3695758(-) A-I      intronic
chr19:3674790(-) A-I      intronic
chr19:3647762(-) A-I      intronic
chr19:3647833(-) A-I      intronic
chr19:3682137(-) A-I      intronic
chr19:3681399(-) A-I      intronic
chr19:3689455(-) A-I      intronic
chr19:3677534(-) A-I      intronic
chr19:3677518(-) A-I      intronic
chr19:3677498(-) A-I      intronic
chr19:3677469(-) A-I      intronic
chr19:3680418(-) A-I      intronic
chr19:3681398(-) A-I      intronic
chr19:3689093(-) A-I      intronic
chr19:3677069(-) A-I      intronic
chr19:3680496(-) A-I      intronic
chr19:3648036(-) A-I      intronic
chr19:3640829(-) A-I      intronic
chr19:3648293(-) A-I      intronic
chr19:3640790(-) A-I      intronic
chr19:3648299(-) A-I      intronic
chr19:3662684(-) A-I      intronic
chr19:3640508(-) A-I      intronic
chr19:3677433(-) A-I      intronic
chr19:3640852(-) A-I      intronic
chr19:3663647(-) A-I      intronic
chr19:3647688(-) A-I      intronic
chr19:3648248(-) A-I      intronic
chr19:3676880(-) A-I      intronic
chr19:3647823(-) A-I      intronic
chr19:3648220(-) A-I      intronic
chr19:3641131(-) A-I      intronic
chr19:3693826(-) A-I      intronic
chr19:3681357(-) A-I      intronic
chr19:3677048(-) A-I      intronic
chr19:3654097(-) A-I      intronic
chr19:3693954(-) A-I      intronic
chr19:3689077(-) A-I      intronic
chr19:3681403(-) A-I      intronic
chr19:3677017(-) A-I      intronic
chr19:3690429(-) A-I      intronic
chr19:3695931(-) A-I      intronic
chr19:3674696(-) A-I      intronic
chr19:3686220(-) A-I      intronic
chr19:3680440(-) A-I      intronic
chr19:3663601(-) A-I      intronic
chr19:3686020(-) A-I      intronic
chr19:3695975(-) A-I      intronic
chr19:3647845(-) A-I      intronic
chr19:3687028(-) A-I      intronic
chr19:3640796(-) A-I      intronic
chr19:3690437(-) A-I      intronic
chr19:3680467(-) A-I      intronic
chr19:3677577(-) A-I      intronic
chr19:3641101(-) A-I      intronic
chr19:3695942(-) A-I      intronic
chr19:3687277(-) A-I      intronic
chr19:3663131(-) A-I      intronic
chr19:3640849(-) A-I      intronic
chr19:3674727(-) A-I      intronic
chr19:3640853(-) A-I      intronic
chr19:3648292(-) A-I      intronic
chr19:3687079(-) A-I      intronic
chr19:3641085(-) A-I      intronic
chr19:3676863(-) A-I      intronic
chr19:3663091(-) A-I      intronic
chr19:3682460(-) A-I      intronic
chr19:3696020(-) A-I      intronic
chr19:3687128(-) A-I      intronic
chr19:3693966(-) A-I      intronic
chr19:3687011(-) A-I      intronic
chr19:3677336(-) A-I      intronic
chr19:3676952(-) A-I      intronic
chr19:3682625(-) A-I      intronic
chr19:3695860(-) A-I      intronic
chr19:3639527(-) A-I      intronic
chr19:3685998(-) A-I      intronic
chr19:3681457(-) A-I      intronic
chr19:3648155(-) A-I      intronic
chr19:3685952(-) A-I      intronic
chr19:3640813(-) A-I      intronic
chr19:3641091(-) A-I      intronic
chr19:3648151(-) A-I      intronic
chr19:3686124(-) A-I      intronic
chr19:3681367(-) A-I      intronic
chr19:3641046(-) A-I      intronic
chr19:3677000(-) A-I      intronic
chr19:3682435(-) A-I      intronic
chr19:3680490(-) A-I      intronic
chr19:3695882(-) A-I      intronic
chr19:3681462(-) A-I      intronic
chr19:3694021(-) A-I      intronic
chr19:3687274(-) A-I      intronic
chr19:3680457(-) A-I      intronic
chr19:3687265(-) A-I      intronic
chr19:3647937(-) A-I      intronic
chr19:3674659(-) A-I      intronic
chr19:3681261(-) A-I      intronic
chr19:3677032(-) A-I      intronic
chr19:3682224(-) A-I      intronic
chr19:3689404(-) A-I      intronic
chr19:3680371(-) A-I      intronic
chr19:3689161(-) A-I      intronic
chr19:3686016(-) A-I      intronic
chr19:3681361(-) A-I      intronic
chr19:3647882(-) A-I      intronic
chr19:3648161(-) A-I      intronic
chr19:3682260(-) A-I      intronic
chr19:3681366(-) A-I      intronic
chr19:3686500(-) A-I      intronic
chr19:3641042(-) A-I      intronic
chr19:3674689(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PIP5K1C
chr19:3648325(-) A-I intron -    22327324
chr19:3648293(-) A-G intron -    22484847
chr19:3648299(-) A-G intron -    22484847
chr19:3674727(-) A-G intron -    22484847
chr19:3676880(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PIP5K1C
chr19:3630269-3630270(-) m6A 3'UTR       24284625//27773535
chr19:3630294-3630295(-) m6A 3'UTR       24284625//27773535
chr19:3630319-3630320(-) m6A 3'UTR       24284625//27773535
chr19:3630425-3630426(-) m6A 3'UTR       24284625//27773535
chr19:3630432-3630433(-) m6A 3'UTR       24284625//27773535
chr19:3630442-3630443(-) m6A 3'UTR       24284625//27773535
chr19:3630454-3630455(-) m6A 3'UTR       24284625//27773535
chr19:3630618-3630619(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535
chr19:3630685-3630686(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3630700-3630701(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3630722-3630723(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3630857-3630858(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr19:3630897-3630898(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr19:3630919-3630920(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3630977-3630978(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3630984-3630985(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3631085-3631086(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr19:3631129-3631130(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr19:3631323-3631324(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3631342-3631343(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3631399-3631400(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3631541-3631542(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr19:3631576-3631577(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr19:3631639-3631640(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27371828//27773536//22575960
chr19:3631665-3631666(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27371828//27773536//22575960
chr19:3631800-3631801(-) m6A 3'UTR       24284625//24981863//22575960
chr19:3631840-3631841(-) m6A 3'UTR       24284625//24981863//27371828//22575960
chr19:3631954-3631955(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632049-3632050(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:3632060-3632061(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:3632112-3632113(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:3632180-3632181(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:3632227-3632228(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632274-3632275(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632308-3632309(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632390-3632391(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632464-3632465(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632486-3632487(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632584-3632585(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632599-3632600(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632612-3632613(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632654-3632655(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632738-3632739(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:3632848-3632849(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3632854-3632855(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3632863-3632864(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:3632947-3632948(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr19:3633044-3633045(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773536
chr19:3636676-3636677(-) m6A 3'UTR//intron       24284625
chr19:3636732-3636733(-) m6A 3'UTR//intron       24284625
chr19:3636777-3636778(-) m6A 3'UTR//intron       24284625//25456834
chr19:3636803-3636804(-) m6A 3'UTR//intron       24284625//25456834
chr19:3636839-3636840(-) m6A 3'UTR//intron       24284625//25456834
chr19:3642915-3642916(-) m6A CDS       24284625//27371828//27773536
chr19:3644193-3644194(-) m6A CDS//exon       24284625
chr19:3652003-3652004(-) m6A CDS//exon       25456834//24981863//27371828//27773536//22575960
chr19:3653294-3653295(-) m6A CDS//exon       25456834//24981863//27371828//27773536//22575960
chr19:3653360-3653361(-) m6A CDS//exon       24284625//22575960
chr19:3653372-3653373(-) m6A CDS//exon       24284625//22575960
chr19:3653378-3653379(-) m6A CDS//exon       24284625//22575960
chr19:3653492-3653493(-) m6A CDS//exon       24284625
chr19:3653513-3653514(-) m6A CDS//exon       24284625
chr19:3656458-3656459(-) m6A CDS//exon       24284625
chr19:3661028-3661029(-) m6A CDS//exon       24284625//27371828
chr19:3661042-3661043(-) m6A CDS//exon       24284625//27371828
chr19:3661901-3661902(-) m6A CDS//exon       24284625//27371828//27773536
chr19:3664833-3664834(-) m6A CDS//exon       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
PIP5K1C
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: PIP5K1C

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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