Detail Information

Basic Information:


  VIRBase ID:  

HHID00060916

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           STK17B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p STK17B
miRBase
Accession/Entrez ID		 MIMAT0003247 9262
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DRAK2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STK17B
chr2:197017773(-) A-I      intronic
chr2:197006911(-) A-I      intronic
chr2:197012678(-) A-I      intronic
chr2:197012672(-) A-I      intronic
chr2:197011181(-) A-I      intronic
chr2:197023546(-) A-I      intronic
chr2:197021767(-) A-I      intronic
chr2:197021706(-) A-I      intronic
chr2:197006167(-) A-I      intronic
chr2:197028655(-) A-I      intronic
chr2:197028527(-) A-I      intronic
chr2:197027514(-) A-I      intronic
chr2:197011084(-) A-I      intronic
chr2:197006894(-) A-I      intronic
chr2:197007013(-) A-I      intronic
chr2:197006952(-) A-I      intronic
chr2:197027505(-) A-I      intronic
chr2:197027492(-) A-I      intronic
chr2:197011111(-) A-I      intronic
chr2:197026445(-) A-I      intronic
chr2:197026443(-) A-I      intronic
chr2:197011171(-) A-I      intronic
chr2:197006880(-) A-I      intronic
chr2:197027482(-) A-I      intronic
chr2:197012552(-) A-I      intronic
chr2:197012561(-) A-I      intronic
chr2:197026415(-) A-I      intronic
chr2:197011165(-) A-I      intronic
chr2:197024149(-) A-I      intronic
chr2:197012548(-) A-I      intronic
chr2:197023658(-) A-I      intronic
chr2:197026424(-) A-I      intronic
chr2:197026418(-) A-I      intronic
chr2:197012623(-) A-I      intronic
chr2:197012636(-) A-I      intronic
chr2:197023587(-) A-I      intronic
chr2:197006220(-) A-I      intronic
chr2:197016832(-) A-I      intronic
chr2:197016833(-) A-I      intronic
chr2:197016999(-) A-I      intronic
chr2:197021751(-) A-I      intronic
chr2:197012657(-) A-I      intronic
chr2:197017759(-) A-I      intronic
chr2:197017781(-) A-I      intronic
chr2:197017798(-) A-I      intronic
chr2:197018779(-) A-I      intronic
chr2:197018796(-) A-I      intronic
chr2:197017752(-) A-I      intronic
chr2:197016916(-) A-I      intronic
chr2:197011100(-) A-I      intronic
chr2:197012600(-) A-I      intronic
chr2:197018906(-) A-I      intronic
chr2:197014026(-) A-I      intronic
chr2:197007055(-) A-I      intronic
chr2:197017002(-) A-I      intronic
chr2:197024282(-) A-I      intronic
chr2:197011051(-) A-I      intronic
chr2:197024235(-) A-I      intronic
chr2:197017680(-) A-I      intronic
chr2:197017000(-) A-I      intronic
chr2:197018846(-) A-I      intronic
chr2:197018911(-) A-I      intronic
chr2:197016955(-) A-I      intronic
chr2:197006373(-) A-I      intronic
chr2:197016891(-) A-I      intronic
chr2:197016959(-) A-I      intronic
chr2:197018875(-) A-I      intronic
chr2:197017060(-) A-I      intronic
chr2:197016969(-) A-I      intronic
chr2:197012604(-) A-I      intronic
chr2:197006367(-) A-I      intronic
chr2:197016995(-) A-I      intronic
chr2:197017082(-) A-I      intronic
chr2:197017077(-) A-I      intronic
chr2:197010952(-) A-I      intronic
chr2:197017795(-) A-I      intronic
chr2:197011088(-) A-I      intronic
chr2:197016977(-) A-I      intronic
chr2:197016885(-) A-I      intronic
chr2:197026381(-) A-I      intronic
chr2:197017005(-) A-I      intronic
chr2:197018736(-) A-I      intronic
chr2:197018718(-) A-I      intronic
chr2:197006921(-) A-I      intronic
chr2:197011020(-) A-I      intronic
chr2:197013945(-) A-I      intronic
chr2:197010986(-) A-I      intronic
chr2:197016942(-) A-I      intronic
chr2:197027551(-) A-I      intronic
chr2:197014057(-) A-I      intronic
chr2:197018830(-) A-I      intronic
chr2:197018748(-) A-I      intronic
chr2:197006149(-) A-I      intronic
chr2:197011038(-) A-I      intronic
chr2:197012681(-) A-I      intronic
chr2:197005303(-) A-I      intronic
chr2:197012584(-) A-I      intronic
chr2:197027439(-) A-I      intronic
chr2:197018834(-) A-I      intronic
chr2:197006271(-) A-I      intronic
chr2:197006195(-) A-I      intronic
chr2:197006211(-) A-I      intronic
chr2:197024199(-) A-I      intronic
chr2:197018732(-) A-I      intronic
chr2:197018814(-) A-I      intronic
chr2:197023652(-) A-I      intronic
chr2:197014056(-) A-I      intronic
chr2:197011145(-) A-I      intronic
chr2:197024163(-) A-I      intronic
chr2:197017003(-) A-I      intronic
chr2:197018705(-) A-I      intronic
chr2:197006874(-) A-I      intronic
chr2:197007061(-) A-I      intronic
chr2:197018766(-) A-I      intronic
chr2:197012620(-) A-I      intronic
chr2:197024132(-) A-I      intronic
chr2:197010996(-) A-I      intronic
chr2:197016106(-) A-I      intronic
chr2:197026367(-) A-I      intronic
chr2:197024195(-) A-I      intronic
chr2:197011194(-) A-I      intronic
chr2:197026441(-) A-I      intronic
chr2:197024145(-) A-I      intronic
chr2:197011152(-) A-I      intronic
chr2:197027506(-) A-I      intronic
chr2:197006352(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STK17B
chr2:197017795(-) A-I intron -    15342557
chr2:197018402(-) A-I intron -    15342557
chr2:197018717(-) A-I intron -    15342557   //15258596
chr2:197018766(-) A-I intron -    15342557   //15258596
chr2:197018767(-) A-I intron -    15342557   //15258596
chr2:197018801(-) A-I intron -    15342557   //15258596
chr2:197018830(-) A-I intron -    15342557   //15258596
chr2:197018846(-) A-I intron -    15342557   //15258596
chr2:197018875(-) A-I intron -    15342557
chr2:197000389(-) G-C exon 3'UTR    22484847
chr2:197006121(-) A-G intron -    22484847
chr2:197006195(-) A-G intron -    22484847
chr2:197006211(-) A-G intron -    22484847
chr2:197006261(-) A-G intron -    22484847
chr2:197006271(-) A-G intron -    22484847
chr2:197006352(-) A-G intron -    22484847
chr2:197006367(-) A-G intron -    22484847
chr2:197006373(-) A-G intron -    22484847
chr2:197006375(-) A-G intron -    22484847
chr2:197006874(-) A-G intron -    22484847
chr2:197006875(-) A-G intron -    22484847
chr2:197006921(-) A-G intron -    22484847
chr2:197007061(-) A-G intron -    22484847
chr2:197011100(-) A-G intron -    22484847
chr2:197011145(-) A-G intron -    22484847
chr2:197011194(-) A-G intron -    22484847
chr2:197012725(-) A-G intron -    22484847
chr2:197014057(-) A-G intron -    22484847
chr2:197017795(-) A-G intron -    22484847
chr2:197018732(-) A-G intron -    22484847
chr2:197018793(-) A-G intron -    22484847
chr2:197018801(-) A-G intron -    22484847
chr2:197018814(-) A-G intron -    22484847
chr2:197018830(-) A-G intron -    22484847
chr2:197018836(-) A-G intron -    22484847
chr2:197018846(-) A-G intron -    22484847
chr2:197018858(-) A-G intron -    22484847
chr2:197023652(-) A-G intron -    22484847
chr2:197024132(-) A-G intron -    22484847
chr2:197024282(-) A-G intron -    22484847
chr2:197026441(-) A-G intron -    22484847
chr2:197027439(-) A-G intron -    22484847
chr2:197027502(-) A-G intron -    22484847
chr2:197027506(-) A-G intron -    22484847
chr2:197027551(-) A-G intron -    22484847
chr2:197027557(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STK17B
chr2:196999511-196999512(-) m6A 3'UTR       26404942
chr2:196999647-196999648(-) m6A 3'UTR       26404942
chr2:197001026-197001027(-) m6A 3'UTR       26404942
chr2:197001039-197001040(-) m6A 3'UTR       26404942
chr2:197001889-197001890(-) m6A 3'UTR       27773535
chr2:197002145-197002146(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr2:197002194-197002195(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002273-197002274(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002292-197002293(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002316-197002317(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002321-197002322(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002352-197002353(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002370-197002371(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr2:197002390-197002391(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr2:197002399-197002400(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr2:197002446-197002447(-) m6A CDS       24981863//26404942//22608085
chr2:197004376-197004377(-) m6A CDS       24981863//27773535//22608085
chr2:197004407-197004408(-) m6A CDS       27773535
chr2:197004452-197004453(-) m6A CDS       27773535
chr2:197021353-197021354(-) m6A CDS       24981863//26404942//27773535
chr2:197028027-197028028(-) m6A CDS       26404942//27773535
chr2:197028124-197028125(-) m6A 5'UTR       27773535
chr2:197036074-197036075(-) m6A 5'UTR//intron       27371828
chr2:197036108-197036109(-) m6A 5'UTR//intron       27371828
chr2:197036142-197036143(-) m6A 5'UTR//intron       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
STK17B
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: STK17B

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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