Detail Information

Basic Information:


  VIRBase ID:  

HHID00060899

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           OSBP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p OSBP
miRBase
Accession/Entrez ID		 MIMAT0003247 5007
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - OSBP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR OSBP
chr11:59351503(-) A-I      intronic
chr11:59351490(-) A-I      intronic
chr11:59351289(-) A-I      intronic
chr11:59354906(-) A-I      intronic
chr11:59356852(-) A-I      intronic
chr11:59357276(-) A-I      intronic
chr11:59350666(-) A-I      intronic
chr11:59356911(-) A-I      intronic
chr11:59351283(-) A-I      intronic
chr11:59356660(-) A-I      intronic
chr11:59350641(-) A-I      intronic
chr11:59350723(-) A-I      intronic
chr11:59351214(-) A-I      intronic
chr11:59356930(-) A-I      intronic
chr11:59360543(-) A-I      intronic
chr11:59371265(-) A-I      intronic
chr11:59356919(-) A-I      intronic
chr11:59351225(-) A-I      intronic
chr11:59351242(-) A-I      intronic
chr11:59360377(-) A-I      intronic
chr11:59357253(-) A-I      intronic
chr11:59360329(-) A-I      intronic
chr11:59347322(-) A-I      intronic
chr11:59351246(-) A-I      intronic
chr11:59351286(-) A-I      intronic
chr11:59356220(-) A-I      intronic
chr11:59351306(-) A-I      intronic
chr11:59370272(-) A-I      intronic
chr11:59360397(-) A-I      intronic
chr11:59351326(-) A-I      intronic
chr11:59351516(-) A-I      intronic
chr11:59370335(-) A-I      intronic
chr11:59370330(-) A-I      intronic
chr11:59351521(-) A-I      intronic
chr11:59365387(-) A-I      intronic
chr11:59364750(-) A-I      intronic
chr11:59351534(-) A-I      intronic
chr11:59364702(-) A-I      intronic
chr11:59351557(-) A-I      intronic
chr11:59363247(-) A-I      intronic
chr11:59355952(-) A-I      intronic
chr11:59364700(-) A-I      intronic
chr11:59360366(-) A-I      intronic
chr11:59360273(-) A-I      intronic
chr11:59356711(-) A-I      intronic
chr11:59351597(-) A-I      intronic
chr11:59371174(-) A-I      intronic
chr11:59363334(-) A-I      intronic
chr11:59356253(-) A-I      intronic
chr11:59350722(-) A-I      intronic
chr11:59360270(-) A-I      intronic
chr11:59359361(-) A-I      intronic
chr11:59355887(-) A-I      intronic
chr11:59356359(-) A-I      intronic
chr11:59351565(-) A-I      intronic
chr11:59363287(-) A-I      intronic
chr11:59363210(-) A-I      intronic
chr11:59355841(-) A-I      intronic
chr11:59359205(-) A-I      intronic
chr11:59363153(-) A-I      intronic
chr11:59356891(-) A-I      intronic
chr11:59363140(-) A-I      intronic
chr11:59363138(-) A-I      intronic
chr11:59359167(-) A-I      intronic
chr11:59360522(-) A-I      intronic
chr11:59359166(-) A-I      intronic
chr11:59356490(-) A-I      intronic
chr11:59355844(-) A-I      intronic
chr11:59356707(-) A-I      intronic
chr11:59360513(-) A-I      intronic
chr11:59350566(-) A-I      intronic
chr11:59360489(-) A-I      intronic
chr11:59360560(-) A-I      intronic
chr11:59360487(-) A-I      intronic
chr11:59351132(-) A-I      intronic
chr11:59356829(-) A-I      intronic
chr11:59359156(-) A-I      intronic
chr11:59351693(-) A-I      intronic
chr11:59351619(-) A-I      intronic
chr11:59355965(-) A-I      intronic
chr11:59357410(-) A-I      intronic
chr11:59355885(-) A-I      intronic
chr11:59356952(-) A-I      intronic
chr11:59360474(-) A-I      intronic
chr11:59360447(-) A-I      intronic
chr11:59360437(-) A-I      intronic
chr11:59360415(-) A-I      intronic
chr11:59363309(-) A-I      intronic
chr11:59351281(-) A-I      intronic
chr11:59351639(-) A-I      intronic
chr11:59356908(-) A-I      intronic
chr11:59356366(-) A-I      intronic
chr11:59356882(-) A-I      intronic
chr11:59364669(-) A-I      intronic
chr11:59360490(-) A-I      intronic
chr11:59360450(-) A-I      intronic
chr11:59364755(-) A-I      intronic
chr11:59364670(-) A-I      intronic
chr11:59356378(-) A-I      intronic
chr11:59351202(-) A-I      intronic
chr11:59350690(-) A-I      intronic
chr11:59371192(-) A-I      intronic
chr11:59357228(-) A-I      intronic
chr11:59351273(-) A-I      intronic
chr11:59351277(-) A-I      intronic
chr11:59363245(-) A-I      intronic
chr11:59360297(-) A-I      intronic
chr11:59355881(-) A-I      intronic
chr11:59356727(-) A-I      intronic
chr11:59351316(-) A-I      intronic
chr11:59356222(-) A-I      intronic
chr11:59355824(-) A-I      intronic
chr11:59360449(-) A-I      intronic
chr11:59356356(-) A-I      intronic
chr11:59357213(-) A-I      intronic
chr11:59365233(-) A-I      intronic
chr11:59357393(-) A-I      intronic
chr11:59356734(-) A-I      intronic
chr11:59357284(-) A-I      intronic
chr11:59350618(-) A-I      intronic
chr11:59351288(-) A-I      intronic
chr11:59351628(-) A-I      intronic
chr11:59351598(-) A-I      intronic
chr11:59356313(-) A-I      intronic
chr11:59360341(-) A-I      intronic
chr11:59351383(-) A-I      intronic
chr11:59351419(-) A-I      intronic
chr11:59356656(-) A-I      intronic
chr11:59350703(-) A-I      intronic
chr11:59363295(-) A-I      intronic
chr11:59357425(-) A-I      intronic
chr11:59350702(-) A-I      intronic
chr11:59357409(-) A-I      intronic
chr11:59356669(-) A-I      intronic
chr11:59356687(-) A-I      intronic
chr11:59373132(-) A-I      intronic
chr11:59356236(-) A-I      intronic
chr11:59357067(-) A-I      intronic
chr11:59360503(-) A-I      intronic
chr11:59356257(-) A-I      intronic
chr11:59356725(-) A-I      intronic
chr11:59363335(-) A-I      intronic
chr11:59363360(-) A-I      intronic
chr11:59363304(-) A-I      intronic
chr11:59351307(-) A-I      intronic
chr11:59363191(-) A-I      intronic
chr11:59351337(-) A-I      intronic
chr11:59356906(-) A-I      intronic
chr11:59351559(-) A-I      intronic
chr11:59360475(-) A-I      intronic
chr11:59359190(-) A-I      intronic
chr11:59360544(-) A-I      intronic
chr11:59360433(-) A-I      intronic
chr11:59351213(-) A-I      intronic
chr11:59355933(-) A-I      intronic
chr11:59351340(-) A-I      intronic
chr11:59357201(-) A-I      intronic
chr11:59356261(-) A-I      intronic
chr11:59351257(-) A-I      intronic
chr11:59351252(-) A-I      intronic
chr11:59350779(-) A-I      intronic
chr11:59357399(-) A-I      intronic
chr11:59357027(-) A-I      intronic
chr11:59345981(-) A-I      intronic
chr11:59351353(-) A-I      intronic
chr11:59350621(-) A-I      intronic
chr11:59357334(-) A-I      intronic
chr11:59365460(-) A-I      intronic
chr11:59363300(-) A-I      intronic
chr11:59364696(-) A-I      intronic
chr11:59354929(-) A-I      intronic
chr11:59360407(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED OSBP
chr11:59351692(-) A-I intron -    21960545
chr11:59350566(-) A-G intron -    22484847
chr11:59351213(-) A-G intron -    22484847
chr11:59351597(-) A-G intron -    22484847
chr11:59351619(-) A-G intron -    22484847
chr11:59356222(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase OSBP
chr11:59343046-59343047(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:59343079-59343080(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:59343136-59343137(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343251-59343252(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343272-59343273(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343299-59343300(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343353-59343354(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343396-59343397(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343477-59343478(-) m6A 3'UTR       24284625//24209618//27773535//22608085
chr11:59343597-59343598(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343606-59343607(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343730-59343731(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343856-59343857(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59343898-59343899(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344006-59344007(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344059-59344060(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344077-59344078(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344082-59344083(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344143-59344144(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344326-59344327(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:59344332-59344333(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:59344392-59344393(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr11:59344417-59344418(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr11:59344483-59344484(-) m6A 3'UTR//CDS       24209618//24981863//27371828//22608085
chr11:59347704-59347705(-) m6A 3'UTR//CDS       -
chr11:59347711-59347712(-) m6A 3'UTR//CDS       -
chr11:59361212-59361213(-) m6A exon//intron       -
chr11:59368005-59368006(-) m6A CDS//exon       27773535
chr11:59368038-59368039(-) m6A CDS//exon       27773535
chr11:59368060-59368061(-) m6A CDS//exon       27773535
chr11:59368078-59368079(-) m6A CDS       27773535
chr11:59368294-59368295(-) m6A CDS       27773535
chr11:59368833-59368834(-) m6A CDS       27773535
chr11:59369141-59369142(-) m6A CDS       27773535
chr11:59376010-59376011(-) m6A CDS       27371828
chr11:59376119-59376120(-) m6A CDS       27371828
chr11:59376141-59376142(-) m6A CDS       27371828
chr11:59376165-59376166(-) m6A CDS       27371828
chr11:59376174-59376175(-) m6A CDS       27371828
chr11:59377893-59377894(-) m6A CDS       22575960
chr11:59377952-59377953(-) m6A CDS       24209618//27773535//22575960
chr11:59377990-59377991(-) m6A CDS       24209618//27773535
chr11:59378043-59378044(-) m6A CDS       24209618//27773535
chr11:59382777-59382778(-) Cm CDS       -
chr11:59382842-59382843(-) m6A CDS       24209618//27773535
chr11:59383430-59383431(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
OSBP
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: OSBP

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...