Detail Information

Basic Information:


  VIRBase ID:  

HHID00060874

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-582-5p:           ADPRH:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-582-5p ADPRH
miRBase
Accession/Entrez ID		 MIMAT0003247 141
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ARH1//hARH1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-582-5p
rs1190339760 chr5:59703674    G/A
rs1291143355 chr5:59703672    T/A
rs1455812678 chr5:59703667    G/GT
rs753758364 chr5:59703675    T/C
rs779684016 chr5:59703670    A/C
rs779684016 chr5:59703670    A/G
rs1245677877 chr5:59703684    T/A
rs373502275 chr5:59703686    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ADPRH
chr3:119303362(+) A-I      intronic
chr3:119303299(+) A-I      intronic
chr3:119303290(+) A-I      intronic
chr3:119303274(+) A-I      intronic
chr3:119303258(+) A-I      intronic
chr3:119302774(+) A-I      intronic
chr3:119302764(+) A-I      intronic
chr3:119302724(+) A-I      intronic
chr3:119302718(+) A-I      intronic
chr3:119302705(+) A-I      intronic
chr3:119301526(+) A-I      intronic
chr3:119300070(+) A-I      intronic
chr3:119301466(+) A-I      intronic
chr3:119303263(+) A-I      intronic
chr3:119303400(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ADPRH
chr3:119302024(+) T-C intron -    22484847
chr3:119302042(+) T-C intron -    22484847
chr3:119303263(+) A-G intron -    22484847
chr3:119303288(+) T-C intron -    22484847
chr3:119303328(+) T-C intron -    22484847
chr3:119304535(+) T-C intron -    22484847
chr3:119304561(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADPRH
chr3:119298573-119298574(+) m6A 5'UTR//exon       24981863
chr3:119299165-119299166(+) m6A 5'UTR//intron       -
chr3:119299218-119299219(+) m6A 5'UTR//intron       -
chr3:119299471-119299472(+) m6A 5'UTR//intron       -
chr3:119299476-119299477(+) m6A 5'UTR//intron       -
chr3:119300980-119300981(+) m6A 5'UTR//intron       -
chr3:119301012-119301013(+) m6A 5'UTR//intron       -
chr3:119301281-119301282(+) m6A CDS//intron       -
chr3:119301293-119301294(+) m6A CDS//intron       -
chr3:119305278-119305279(+) m6A CDS//exon       -
chr3:119305390-119305391(+) m6A CDS//exon       -
chr3:119305414-119305415(+) m6A CDS//exon       -
chr3:119306323-119306324(+) m6A CDS//exon       -
chr3:119306346-119306347(+) m6A CDS//exon       -
chr3:119306510-119306511(+) m6A CDS//exon       -
chr3:119306555-119306556(+) m6A CDS//exon       -
chr3:119306640-119306641(+) m6A CDS//exon       -
chr3:119306654-119306655(+) m6A CDS//exon       -
chr3:119308496-119308497(+) m6A 3'UTR       -
chr3:119308585-119308586(+) m6A 3'UTR       -
chr3:119308593-119308594(+) m6A 3'UTR       -
chr3:119308609-119308610(+) m6A 3'UTR       -
chr3:119308740-119308741(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-582-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ADPRH
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-582-5p
Iodine Green 9956454 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
o6-Benzylguanine 4578 Drug resistant
Triciribine phosphate 43860 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Antimycin A3 245869 Drug sensitive
Kinetin riboside 20345 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tunicamycin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
2k2S,S? - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-582-5p
Formaldehyde 712 Drug interaction    RC00006017
Alocrest 60780 Drug interaction    RC00006022
Vincristine 5978 Drug interaction    RC00006020
Sunitinib 5329102 Drug interaction    RC00006023
Doxorubicin 31703 Drug interaction    RC00006021
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006019
Verapamil 2520 Drug interaction    RC00006018
Navitoclax 24978538 Drug interaction    RC00006024
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-582-5p
Cisplatin 5702198       21575166
Sirolimus 5284616       30666128
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-582-5p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
l-685,458       5479543
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-582-5p
Interactor2: ADPRH

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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