Basic Information:

  VIRBase ID:  

HHID00056484

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-361-5p:  MIMAT0000703          PIP4K2C:  NM_024779     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-361-5p	PIP4K2C
miRBase Accession/Entrez ID	MIMAT0000703	79837
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PIP5K2C

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-361-5p	rs1201941835 chrX:85903694    T/C rs1341659793 chrX:85903684    C/A rs1430235395 chrX:85903683    A/AC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIP4K2C	chr12:57992210(+) A-I      intronic chr12:57989497(+) A-I      intronic chr12:57991891(+) A-I      intronic chr12:57992108(+) A-I      intronic chr12:57991929(+) A-I      intronic chr12:57991946(+) A-I      intronic chr12:57992048(+) A-I      intronic chr12:57993846(+) A-I      intronic chr12:57991947(+) A-I      intronic chr12:57991914(+) A-I      intronic chr12:57988530(+) A-I      intronic chr12:57991883(+) A-I      intronic chr12:57990276(+) A-I      intronic chr12:57991877(+) A-I      intronic chr12:57992206(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIP4K2C	chr12:57991883(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIP4K2C	chr12:57985069-57985070(+) m6A 5'UTR       24981863 chr12:57985153-57985154(+) m6A CDS       24284625 chr12:57985162-57985163(+) m1A CDS       26863196//26863410 chr12:57988964-57988965(+) m6A 3'UTR//CDS       - chr12:57989686-57989687(+) m6A 3'UTR//CDS//intron       - chr12:57995392-57995393(+) m6A 3'UTR       24284625//24981863 chr12:57995435-57995436(+) m6A 3'UTR//intron       24284625//24981863 chr12:57995743-57995744(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr12:57995753-57995754(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr12:57995761-57995762(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:57995808-57995809(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:57995845-57995846(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:57996006-57996007(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr12:57996016-57996017(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr12:57996188-57996189(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:57996207-57996208(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:57996213-57996214(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:57996641-57996642(+) m6A 3'UTR       24209618 chr12:57996820-57996821(+) m6A 3'UTR       24284625//24981863//26404942 chr12:57996957-57996958(+) m6A 3'UTR       24981863//27773535//22608085 chr12:57997013-57997014(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-361-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Neural progenitor cells     21363885 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25349172 Exosome Blood|Kidney tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	PIP4K2C	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-361-5p	7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive Pharmakon1600-01503602 60148415 Drug sensitive Ayanin 5280682 Drug resistant Rogiolol 402519 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Jasplakinolide epoxide C 372550 Drug sensitive Antineoplastic-642316 369949 Drug sensitive Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive Dibutyltin dichloride 12688 Drug sensitive Capri Blue 102162 Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug resistant antineoplastic-d655481 - Drug resistant 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-361-5p	Formaldehyde 712 Drug interaction    RC00004017 Gemcitabine 60750 Drug interaction    RC00004022 Eloxatine 5310940 Drug interaction    RC00004027 Diethylstilbestrol 448537 Drug interaction    RC00004025 Paclitaxel 36314 Drug interaction    RC00004021 5-Fluorouracil 3385 Drug interaction    RC00004019 Doxorubicin 31703 Drug interaction    RC00004020 Tamoxifen 2733526 Drug interaction    RC00004026 Verapamil 2520 Drug interaction    RC00004018 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028 Docetaxel 148124 Drug interaction    RC00004024 Methotrexate 126941 Drug interaction    RC00004023 Glucocorticoid - Drug interaction    RC00004031 platinum-based doublet chemotherapy - Drug interaction    RC00004029 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-361-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-361-5p	Topotecan       60700 Palbociclib       5330286

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-361-5p
Interactor2: PIP4K2C

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.