Basic Information:

  VIRBase ID:  

HHID00056480

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-361-5p:  MIMAT0000703          AAR2:  NM_001271874     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-361-5p	AAR2
miRBase Accession/Entrez ID	MIMAT0000703	25980
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf4//CGI-23

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-361-5p	rs1201941835 chrX:85903694    T/C rs1341659793 chrX:85903684    C/A rs1430235395 chrX:85903683    A/AC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AAR2	chr20:34829459(+) A-I      intronic chr20:34835614(+) A-I      intronic chr20:34830995(+) A-I      intronic chr20:34830985(+) A-I      intronic chr20:34836375(+) A-I      intronic chr20:34838980(+) A-I      intronic chr20:34830497(+) A-I      intronic chr20:34838996(+) A-I      intronic chr20:34838998(+) A-I      intronic chr20:34830442(+) A-I      intronic chr20:34830506(+) A-I      intronic chr20:34830514(+) A-I      intronic chr20:34825774(+) A-I      intronic chr20:34830500(+) A-I      intronic chr20:34830964(+) A-I      intronic chr20:34836332(+) A-I      intronic chr20:34836311(+) A-I      intronic chr20:34830392(+) A-I      intronic chr20:34826599(+) A-I      intronic chr20:34826424(+) A-I      intronic chr20:34836440(+) A-I      intronic chr20:34830393(+) A-I      intronic chr20:34836357(+) A-I      intronic chr20:34826587(+) A-I      intronic chr20:34835748(+) A-I      intronic chr20:34830417(+) A-I      intronic chr20:34831013(+) A-I      intronic chr20:34835720(+) A-I      intronic chr20:34826520(+) A-I      intronic chr20:34836387(+) A-I      intronic chr20:34826557(+) A-I      intronic chr20:34826401(+) A-I      intronic chr20:34825945(+) A-I      intronic chr20:34831043(+) A-I      intronic chr20:34829453(+) A-I      intronic chr20:34829447(+) A-I      intronic chr20:34825967(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AAR2	chr20:34824524-34824525(+) m6A 5'UTR//intron       24284625 chr20:34824654-34824655(+) m6A 5'UTR//intron       - chr20:34827863-34827864(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34827877-34827878(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34827980-34827981(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34828085-34828086(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34828145-34828146(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34828304-34828305(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:34828399-34828400(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:34828481-34828482(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:34828501-34828502(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34832622-34832623(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:34832696-34832697(+) m6A CDS       24284625//22575960 chr20:34832807-34832808(+) m6A CDS       24284625 chr20:34832822-34832823(+) m6A CDS       24284625 chr20:34843596-34843597(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34843609-34843610(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34843617-34843618(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34843751-34843752(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr20:34843949-34843950(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr20:34843998-34843999(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844017-34844018(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844048-34844049(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844055-34844056(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844174-34844175(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844331-34844332(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844405-34844406(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844542-34844543(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr20:34844654-34844655(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844687-34844688(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr20:34844731-34844732(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr20:34844778-34844779(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr20:34844851-34844852(+) m6A 3'UTR//intron       24209618//24981863//22608085 chr20:34858456-34858457(+) m6A CDS       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-361-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Neural progenitor cells     21363885 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25349172 Exosome Blood|Kidney tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	AAR2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-361-5p	7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive Pharmakon1600-01503602 60148415 Drug sensitive Ayanin 5280682 Drug resistant Rogiolol 402519 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Jasplakinolide epoxide C 372550 Drug sensitive Antineoplastic-642316 369949 Drug sensitive Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive Dibutyltin dichloride 12688 Drug sensitive Capri Blue 102162 Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug resistant antineoplastic-d655481 - Drug resistant 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-361-5p	Formaldehyde 712 Drug interaction    RC00004017 Gemcitabine 60750 Drug interaction    RC00004022 Eloxatine 5310940 Drug interaction    RC00004027 Diethylstilbestrol 448537 Drug interaction    RC00004025 Paclitaxel 36314 Drug interaction    RC00004021 5-Fluorouracil 3385 Drug interaction    RC00004019 Doxorubicin 31703 Drug interaction    RC00004020 Tamoxifen 2733526 Drug interaction    RC00004026 Verapamil 2520 Drug interaction    RC00004018 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028 Docetaxel 148124 Drug interaction    RC00004024 Methotrexate 126941 Drug interaction    RC00004023 Glucocorticoid - Drug interaction    RC00004031 platinum-based doublet chemotherapy - Drug interaction    RC00004029 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-361-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-361-5p	Topotecan       60700 Palbociclib       5330286

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-361-5p
Interactor2: AAR2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.