Basic Information:

  VIRBase ID:  

HHID00056471

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-361-5p:  MIMAT0000703          LNPEP:  NM_005575     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-361-5p	LNPEP
miRBase Accession/Entrez ID	MIMAT0000703	4012
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAP//IRAP//P-LAP//PLAP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-361-5p	rs1201941835 chrX:85903694    T/C rs1341659793 chrX:85903684    C/A rs1430235395 chrX:85903683    A/AC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LNPEP	chr5:96291326(+) A-I      intronic chr5:96291324(+) A-I      intronic chr5:96291244(+) A-I      intronic chr5:96291055(+) A-I      intronic chr5:96290762(+) A-I      intronic chr5:96290760(+) A-I      intronic chr5:96290748(+) A-I      intronic chr5:96290747(+) A-I      intronic chr5:96290693(+) A-I      intronic chr5:96290685(+) A-I      intronic chr5:96290626(+) A-I      intronic chr5:96280312(+) A-I      intronic chr5:96279025(+) A-I      intronic chr5:96278148(+) A-I      intronic chr5:96290671(+) A-I      intronic chr5:96281029(+) A-I      intronic chr5:96281089(+) A-I      intronic chr5:96281090(+) A-I      intronic chr5:96359087(+) A-I      intronic chr5:96331488(+) A-I      intronic chr5:96331372(+) A-I      intronic chr5:96331264(+) A-I      intronic chr5:96330744(+) A-I      intronic chr5:96330732(+) A-I      intronic chr5:96330697(+) A-I      intronic chr5:96294296(+) A-I      5'UTR chr5:96294312(+) A-I      5'UTR chr5:96294314(+) A-I      5'UTR chr5:96294343(+) A-I      5'UTR chr5:96330683(+) A-I      intronic chr5:96291064(+) A-I      intronic chr5:96331326(+) A-I      intronic chr5:96331491(+) A-I      intronic chr5:96330626(+) A-I      intronic chr5:96324588(+) A-I      intronic chr5:96279065(+) A-I      intronic chr5:96280377(+) A-I      intronic chr5:96280373(+) A-I      intronic chr5:96331362(+) A-I      intronic chr5:96279174(+) A-I      intronic chr5:96330559(+) A-I      intronic chr5:96280837(+) A-I      intronic chr5:96330737(+) A-I      intronic chr5:96281055(+) A-I      intronic chr5:96280366(+) A-I      intronic chr5:96281016(+) A-I      intronic chr5:96331284(+) A-I      intronic chr5:96280839(+) A-I      intronic chr5:96331427(+) A-I      intronic chr5:96291143(+) A-I      intronic chr5:96279253(+) A-I      intronic chr5:96278100(+) A-I      intronic chr5:96278273(+) A-I      intronic chr5:96330757(+) A-I      intronic chr5:96331307(+) A-I      intronic chr5:96279191(+) A-I      intronic chr5:96330558(+) A-I      intronic chr5:96278247(+) A-I      intronic chr5:96362964(+) A-I      intronic chr5:96330550(+) A-I      intronic chr5:96291154(+) A-I      intronic chr5:96331380(+) A-I      intronic chr5:96331416(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LNPEP	chr5:96278247(+) A-G intron -    22484847 chr5:96278273(+) A-G intron -    22484847 chr5:96279065(+) A-G intron -    22484847 chr5:96279091(+) A-G intron -    22484847 chr5:96279174(+) A-G intron -    22484847 chr5:96279191(+) A-G intron -    22484847 chr5:96279200(+) A-G intron -    22484847 chr5:96280342(+) A-G intron -    22484847 chr5:96280366(+) A-G intron -    22484847 chr5:96280373(+) A-G intron -    22484847 chr5:96280376(+) A-G intron -    22484847 chr5:96280377(+) A-G intron -    22484847 chr5:96280478(+) A-G intron -    22484847 chr5:96280839(+) A-G intron -    22484847 chr5:96284089(+) T-C intron -    22484847 chr5:96291063(+) A-G intron -    22484847 chr5:96291064(+) A-G intron -    22484847 chr5:96291154(+) A-G intron -    22484847 chr5:96330558(+) A-G intron -    22484847 chr5:96330559(+) A-G intron -    22484847 chr5:96330626(+) A-G intron -    22484847 chr5:96330628(+) A-G intron -    22484847 chr5:96330683(+) A-G intron -    22484847 chr5:96330691(+) A-G intron -    22484847 chr5:96330692(+) A-G intron -    22484847 chr5:96330733(+) A-G intron -    22484847 chr5:96330737(+) A-G intron -    22484847 chr5:96330757(+) A-G intron -    22484847 chr5:96331284(+) A-G intron -    22484847 chr5:96331307(+) A-G intron -    22484847 chr5:96331326(+) A-G intron -    22484847 chr5:96331362(+) A-G intron -    22484847 chr5:96331416(+) A-G intron -    22484847 chr5:96337659(+) C-T intron -    22484847 chr5:96337700(+) T-C intron -    22484847 chr5:96357654(+) G-T intron -    22484847 chr5:96357728(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LNPEP	chr5:96271123-96271124(+) m6A exon       24284625 chr5:96271191-96271192(+) m6A 5'UTR//exon       24284625//24981863 chr5:96271250-96271251(+) m6A 5'UTR//exon       24284625//24981863 chr5:96271427-96271428(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr5:96271433-96271434(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr5:96271519-96271520(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr5:96271614-96271615(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr5:96271708-96271709(+) m6A 5'UTR//exon       24284625 chr5:96271903-96271904(+) m6A exon//intron       24981863 chr5:96314874-96314875(+) m6A CDS       - chr5:96314893-96314894(+) m6A CDS       - chr5:96315090-96315091(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr5:96315149-96315150(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr5:96315255-96315256(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr5:96315268-96315269(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr5:96315355-96315356(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr5:96315372-96315373(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr5:96315511-96315512(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr5:96315544-96315545(+) m6A CDS       24284625//24981863//26404942//22608085 chr5:96320807-96320808(+) m6A CDS       24284625 chr5:96364476-96364477(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:96364517-96364518(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr5:96364523-96364524(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr5:96364582-96364583(+) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr5:96364712-96364713(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr5:96364735-96364736(+) m6A 3'UTR       24284625//24981863//22608085 chr5:96365461-96365462(+) m6A 3'UTR       24981863 chr5:96365520-96365521(+) m6A 3'UTR       24981863 chr5:96372712-96372713(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-361-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Neural progenitor cells     21363885 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25349172 Exosome Blood|Kidney tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	LNPEP	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-361-5p	7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive Pharmakon1600-01503602 60148415 Drug sensitive Ayanin 5280682 Drug resistant Rogiolol 402519 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Jasplakinolide epoxide C 372550 Drug sensitive Antineoplastic-642316 369949 Drug sensitive Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive Dibutyltin dichloride 12688 Drug sensitive Capri Blue 102162 Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug resistant antineoplastic-d655481 - Drug resistant 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-361-5p	Formaldehyde 712 Drug interaction    RC00004017 Gemcitabine 60750 Drug interaction    RC00004022 Eloxatine 5310940 Drug interaction    RC00004027 Diethylstilbestrol 448537 Drug interaction    RC00004025 Paclitaxel 36314 Drug interaction    RC00004021 5-Fluorouracil 3385 Drug interaction    RC00004019 Doxorubicin 31703 Drug interaction    RC00004020 Tamoxifen 2733526 Drug interaction    RC00004026 Verapamil 2520 Drug interaction    RC00004018 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028 Docetaxel 148124 Drug interaction    RC00004024 Methotrexate 126941 Drug interaction    RC00004023 Glucocorticoid - Drug interaction    RC00004031 platinum-based doublet chemotherapy - Drug interaction    RC00004029 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-361-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-361-5p	Topotecan       60700 Palbociclib       5330286

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-361-5p
Interactor2: LNPEP

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.