Detail Information

Basic Information:


  VIRBase ID:  

HHID00056468

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-361-5p:           IMPA1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-361-5p IMPA1
miRBase
Accession/Entrez ID		 MIMAT0000703 3612
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IMP//IMPA//MRT59

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-361-5p
rs1201941835 chrX:85903694    T/C
rs1341659793 chrX:85903684    C/A
rs1430235395 chrX:85903683    A/AC

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IMPA1
chr8:82580219(-) A-I      intronic
chr8:82580187(-) A-I      intronic
chr8:82580264(-) A-I      intronic
chr8:82580728(-) A-I      intronic
chr8:82589160(-) A-I      intronic
chr8:82589096(-) A-I      intronic
chr8:82589368(-) A-I      intronic
chr8:82589433(-) A-I      intronic
chr8:82590722(-) A-I      intronic
chr8:82580197(-) A-I      intronic
chr8:82590759(-) A-I      intronic
chr8:82589508(-) A-I      intronic
chr8:82589505(-) A-I      intronic
chr8:82590844(-) A-I      intronic
chr8:82590926(-) A-I      intronic
chr8:82580088(-) A-I      intronic
chr8:82589567(-) A-I      intronic
chr8:82569605(-) A-I      3'UTR
chr8:82569966(-) A-I      3'UTR
chr8:82569649(-) A-I      3'UTR
chr8:82569547(-) A-I      3'UTR
chr8:82569577(-) A-I      3'UTR
chr8:82569578(-) A-I      3'UTR
chr8:82569587(-) A-I      3'UTR
chr8:82590805(-) A-I      intronic
chr8:82589146(-) A-I      intronic
chr8:82589055(-) A-I      intronic
chr8:82590888(-) A-I      intronic
chr8:82580574(-) A-I      intronic
chr8:82589428(-) A-I      intronic
chr8:82590827(-) A-I      intronic
chr8:82590803(-) A-I      intronic
chr8:82580745(-) A-I      intronic
chr8:82589028(-) A-I      intronic
chr8:82570013(-) A-I      3'UTR
chr8:82569692(-) A-I      3'UTR
chr8:82570086(-) A-I      3'UTR
chr8:82569604(-) A-I      3'UTR
chr8:82569733(-) A-I      3'UTR
chr8:82569645(-) A-I      3'UTR
chr8:82580814(-) A-I      intronic
chr8:82590927(-) A-I      intronic
chr8:82580733(-) A-I      intronic
chr8:82589147(-) A-I      intronic
chr8:82589487(-) A-I      intronic
chr8:82589512(-) A-I      intronic
chr8:82588963(-) A-I      intronic
chr8:82589052(-) A-I      intronic
chr8:82589427(-) A-I      intronic
chr8:82589106(-) A-I      intronic
chr8:82589469(-) A-I      intronic
chr8:82589625(-) A-I      intronic
chr8:82589479(-) A-I      intronic
chr8:82590864(-) A-I      intronic
chr8:82590670(-) A-I      intronic
chr8:82589507(-) A-I      intronic
chr8:82589104(-) A-I      intronic
chr8:82589602(-) A-I      intronic
chr8:82589537(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IMPA1
chr8:82589002(-) A-I intron -    22327324
chr8:82570086(-) A-G exon 3'UTR    22484847
chr8:82580733(-) A-G intron -    22484847
chr8:82580745(-) A-G intron -    22484847
chr8:82580814(-) A-G intron -    22484847
chr8:82589002(-) A-G intron -    22484847
chr8:82589052(-) A-G intron -    22484847
chr8:82589055(-) A-G intron -    22484847
chr8:82589468(-) A-G intron -    22484847
chr8:82589479(-) A-G intron -    22484847
chr8:82589487(-) A-G intron -    22484847
chr8:82589512(-) A-G intron -    22484847
chr8:82589625(-) A-G intron -    22484847
chr8:82590805(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IMPA1
chr8:82586390-82586391(-) m6A exon//intron       27773535
chr8:82586539-82586540(-) m6A exon//intron       27773535
chr8:82586575-82586576(-) m6A exon//intron       27773535
chr8:82586993-82586994(-) m6A 3'UTR//intron       27773535
chr8:82587003-82587004(-) m6A 3'UTR//intron       27773535
chr8:82587058-82587059(-) m6A CDS//intron       27773535
chr8:82598031-82598032(-) m6A CDS//intron       24981863
chr8:82598041-82598042(-) m6A CDS//intron       24981863
chr8:82598047-82598048(-) m6A CDS//intron       24981863
chr8:82598102-82598103(-) m6A CDS//intron       24981863
chr8:82598575-82598576(-) m6A 5'UTR       24981863
chr8:82598672-82598673(-) m6A 5'UTR       27773535//22608085
chr8:82598723-82598724(-) m6A 5'UTR       27773535//22608085
chr8:82598740-82598741(-) m6A 5'UTR       27773535//22608085
chr8:82598756-82598757(-) m6A 5'UTR       27773535//22608085
chr8:82598820-82598821(-) m6A 5'UTR       27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-361-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25349172
Exosome Blood|Kidney tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
IMPA1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-361-5p
7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive
Pharmakon1600-01503602 60148415 Drug sensitive
Ayanin 5280682 Drug resistant
Rogiolol 402519 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Jasplakinolide epoxide C 372550 Drug sensitive
Antineoplastic-642316 369949 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
Dibutyltin dichloride 12688 Drug sensitive
Capri Blue 102162 Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug resistant
antineoplastic-d655481 - Drug resistant
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-361-5p
Formaldehyde 712 Drug interaction    RC00004017
Gemcitabine 60750 Drug interaction    RC00004022
Eloxatine 5310940 Drug interaction    RC00004027
Diethylstilbestrol 448537 Drug interaction    RC00004025
Paclitaxel 36314 Drug interaction    RC00004021
5-Fluorouracil 3385 Drug interaction    RC00004019
Doxorubicin 31703 Drug interaction    RC00004020
Tamoxifen 2733526 Drug interaction    RC00004026
Verapamil 2520 Drug interaction    RC00004018
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028
Docetaxel 148124 Drug interaction    RC00004024
Methotrexate 126941 Drug interaction    RC00004023
Glucocorticoid - Drug interaction    RC00004031
platinum-based doublet chemotherapy - Drug interaction    RC00004029
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-361-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-361-5p
Topotecan       60700
Palbociclib       5330286

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-361-5p
Interactor2: IMPA1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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