Detail Information

Basic Information:


  VIRBase ID:  

HHID00056464

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-361-5p:           GATM:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-361-5p GATM
miRBase
Accession/Entrez ID		 MIMAT0000703 2628
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AGAT//AT//CCDS3//FRTS1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-361-5p
rs1201941835 chrX:85903694    T/C
rs1341659793 chrX:85903684    C/A
rs1430235395 chrX:85903683    A/AC

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GATM
chr15:45665531(-) A-I      intronic
chr15:45665506(-) A-I      intronic
chr15:45665502(-) A-I      intronic
chr15:45665499(-) A-I      intronic
chr15:45662411(-) A-I      intronic
chr15:45665451(-) A-I      intronic
chr15:45663246(-) A-I      intronic
chr15:45667472(-) A-I      intronic
chr15:45665589(-) A-I      intronic
chr15:45663177(-) A-I      intronic
chr15:45663139(-) A-I      intronic
chr15:45662536(-) A-I      intronic
chr15:45662382(-) A-I      intronic
chr15:45662462(-) A-I      intronic
chr15:45663100(-) A-I      intronic
chr15:45663096(-) A-I      intronic
chr15:45663136(-) A-I      intronic
chr15:45662527(-) A-I      intronic
chr15:45665417(-) A-I      intronic
chr15:45662452(-) A-I      intronic
chr15:45663176(-) A-I      intronic
chr15:45663110(-) A-I      intronic
chr15:45662405(-) A-I      intronic
chr15:45667354(-) A-I      intronic
chr15:45665606(-) A-I      intronic
chr15:45662339(-) A-I      intronic
chr15:45665528(-) A-I      intronic
chr15:45665579(-) A-I      intronic
chr15:45663244(-) A-I      intronic
chr15:45662446(-) A-I      intronic
chr15:45662408(-) A-I      intronic
chr15:45663109(-) A-I      intronic
chr15:45662491(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GATM
chr15:45663176(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GATM
chr15:45656967-45656968(-) m6A exon//intron       27773535
chr15:45657030-45657031(-) m6A CDS//exon       27773535
chr15:45658285-45658286(-) m6A CDS//exon       27773535
chr15:45661778-45661779(-) m6A exon//intron       27773535
chr15:45668868-45668869(-) m6A 5'UTR//CDS//exon//intron       22575960
chr15:45668898-45668899(-) m6A 5'UTR//CDS//exon//intron       22575960
chr15:45668943-45668944(-) m6A 5'UTR//CDS//exon//intron       22575960
chr15:45668983-45668984(-) m6A 5'UTR//CDS//exon//intron       22575960
chr15:45669007-45669008(-) m6A 5'UTR//CDS//exon//intron       -
chr15:45670668-45670669(-) m6A 5'UTR//exon//intron       25456834//24981863
chr15:45670683-45670684(-) m6A 5'UTR//exon//intron       25456834//24981863
chr15:45670707-45670708(-) m6A 5'UTR//exon//intron       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-361-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25349172
Exosome Blood|Kidney tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
GATM
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-361-5p
7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive
Pharmakon1600-01503602 60148415 Drug sensitive
Ayanin 5280682 Drug resistant
Rogiolol 402519 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Jasplakinolide epoxide C 372550 Drug sensitive
Antineoplastic-642316 369949 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
Dibutyltin dichloride 12688 Drug sensitive
Capri Blue 102162 Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug resistant
antineoplastic-d655481 - Drug resistant
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-361-5p
Formaldehyde 712 Drug interaction    RC00004017
Gemcitabine 60750 Drug interaction    RC00004022
Eloxatine 5310940 Drug interaction    RC00004027
Diethylstilbestrol 448537 Drug interaction    RC00004025
Paclitaxel 36314 Drug interaction    RC00004021
5-Fluorouracil 3385 Drug interaction    RC00004019
Doxorubicin 31703 Drug interaction    RC00004020
Tamoxifen 2733526 Drug interaction    RC00004026
Verapamil 2520 Drug interaction    RC00004018
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028
Docetaxel 148124 Drug interaction    RC00004024
Methotrexate 126941 Drug interaction    RC00004023
Glucocorticoid - Drug interaction    RC00004031
platinum-based doublet chemotherapy - Drug interaction    RC00004029
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-361-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-361-5p
Topotecan       60700
Palbociclib       5330286

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-361-5p
Interactor2: GATM

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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