Detail Information

Basic Information:


  VIRBase ID:  

HHID00056459

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-361-5p:           BLMH:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-361-5p BLMH
miRBase
Accession/Entrez ID		 MIMAT0000703 642
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BH//BMH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-361-5p
rs1201941835 chrX:85903694    T/C
rs1341659793 chrX:85903684    C/A
rs1430235395 chrX:85903683    A/AC

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BLMH
chr17:28582868(-) A-I      intronic
chr17:28597435(-) A-I      intronic
chr17:28601743(-) A-I      intronic
chr17:28601752(-) A-I      intronic
chr17:28601756(-) A-I      intronic
chr17:28601765(-) A-I      intronic
chr17:28608754(-) A-I      intronic
chr17:28606782(-) A-I      intronic
chr17:28607602(-) A-I      intronic
chr17:28608745(-) A-I      intronic
chr17:28582832(-) A-I      intronic
chr17:28595792(-) A-I      intronic
chr17:28595833(-) A-I      intronic
chr17:28595872(-) A-I      intronic
chr17:28595892(-) A-I      intronic
chr17:28596363(-) A-I      intronic
chr17:28596406(-) A-I      intronic
chr17:28596412(-) A-I      intronic
chr17:28596426(-) A-I      intronic
chr17:28605852(-) A-I      intronic
chr17:28605856(-) A-I      intronic
chr17:28606744(-) A-I      intronic
chr17:28610096(-) A-I      intronic
chr17:28610172(-) A-I      intronic
chr17:28615738(-) A-I      intronic
chr17:28615739(-) A-I      intronic
chr17:28615963(-) A-I      intronic
chr17:28583021(-) A-I      intronic
chr17:28583552(-) A-I      intronic
chr17:28609165(-) A-I      intronic
chr17:28583101(-) A-I      intronic
chr17:28615482(-) A-I      intronic
chr17:28585124(-) A-I      intronic
chr17:28583178(-) A-I      intronic
chr17:28606768(-) A-I      intronic
chr17:28583526(-) A-I      intronic
chr17:28583194(-) A-I      intronic
chr17:28582815(-) A-I      intronic
chr17:28607633(-) A-I      intronic
chr17:28596301(-) A-I      intronic
chr17:28596014(-) A-I      intronic
chr17:28615536(-) A-I      intronic
chr17:28583069(-) A-I      intronic
chr17:28615413(-) A-I      intronic
chr17:28583527(-) A-I      intronic
chr17:28583200(-) A-I      intronic
chr17:28583124(-) A-I      intronic
chr17:28583132(-) A-I      intronic
chr17:28582710(-) A-I      intronic
chr17:28582829(-) A-I      intronic
chr17:28607659(-) A-I      intronic
chr17:28615638(-) A-I      intronic
chr17:28595975(-) A-I      intronic
chr17:28615928(-) A-I      intronic
chr17:28596307(-) A-I      intronic
chr17:28605755(-) A-I      intronic
chr17:28596011(-) A-I      intronic
chr17:28601875(-) A-I      intronic
chr17:28615414(-) A-I      intronic
chr17:28607587(-) A-I      intronic
chr17:28596284(-) A-I      intronic
chr17:28610678(-) A-I      intronic
chr17:28607592(-) A-I      intronic
chr17:28593431(-) A-I      intronic
chr17:28583068(-) A-I      intronic
chr17:28610174(-) A-I      intronic
chr17:28607605(-) A-I      intronic
chr17:28606814(-) A-I      intronic
chr17:28606811(-) A-I      intronic
chr17:28615954(-) A-I      intronic
chr17:28606751(-) A-I      intronic
chr17:28583043(-) A-I      intronic
chr17:28610128(-) A-I      intronic
chr17:28610153(-) A-I      intronic
chr17:28582748(-) A-I      intronic
chr17:28582735(-) A-I      intronic
chr17:28596292(-) A-I      intronic
chr17:28615443(-) A-I      intronic
chr17:28601991(-) A-I      intronic
chr17:28606763(-) A-I      intronic
chr17:28595889(-) A-I      intronic
chr17:28595976(-) A-I      intronic
chr17:28601733(-) A-I      intronic
chr17:28595639(-) A-I      intronic
chr17:28595863(-) A-I      intronic
chr17:28596343(-) A-I      intronic
chr17:28609948(-) A-I      intronic
chr17:28596478(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BLMH
chr17:28615638(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BLMH
chr17:28575316-28575317(-) m6A 3'UTR//exon       27773535
chr17:28575350-28575351(-) m6A 3'UTR//exon       27773535
chr17:28575395-28575396(-) m6A 3'UTR//exon       27773535
chr17:28575409-28575410(-) m6A 3'UTR//exon       27773535
chr17:28575462-28575463(-) m6A 3'UTR//exon       27773535
chr17:28575866-28575867(-) m6A 3'UTR//exon       24284625//25456834//28052920//27773535//27371828//22575960//22608085
chr17:28575896-28575897(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575926-28575927(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575944-28575945(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575968-28575969(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575980-28575981(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28576000-28576001(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28576059-28576060(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:28576082-28576083(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:28576128-28576129(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960//22608085
chr17:28576214-28576215(-) m6A exon//intron       24209618
chr17:28614870-28614871(-) m6A 3'UTR//CDS//intron       -
chr17:28614927-28614928(-) m6A 3'UTR//CDS//intron       -
chr17:28618445-28618446(-) m6A 5'UTR//CDS//exon//intron       22575960
chr17:28618488-28618489(-) m6A 5'UTR//CDS//exon//intron       22575960
chr17:28618677-28618678(-) m6A 5'UTR//intron       -
chr17:28618878-28618879(-) m6A 5'UTR//exon//intron       27773536
chr17:28619025-28619026(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-361-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25349172
Exosome Blood|Kidney tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
BLMH
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-361-5p
7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive
Pharmakon1600-01503602 60148415 Drug sensitive
Ayanin 5280682 Drug resistant
Rogiolol 402519 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Jasplakinolide epoxide C 372550 Drug sensitive
Antineoplastic-642316 369949 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
Dibutyltin dichloride 12688 Drug sensitive
Capri Blue 102162 Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug resistant
antineoplastic-d655481 - Drug resistant
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-361-5p
Formaldehyde 712 Drug interaction    RC00004017
Gemcitabine 60750 Drug interaction    RC00004022
Eloxatine 5310940 Drug interaction    RC00004027
Diethylstilbestrol 448537 Drug interaction    RC00004025
Paclitaxel 36314 Drug interaction    RC00004021
5-Fluorouracil 3385 Drug interaction    RC00004019
Doxorubicin 31703 Drug interaction    RC00004020
Tamoxifen 2733526 Drug interaction    RC00004026
Verapamil 2520 Drug interaction    RC00004018
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028
Docetaxel 148124 Drug interaction    RC00004024
Methotrexate 126941 Drug interaction    RC00004023
Glucocorticoid - Drug interaction    RC00004031
platinum-based doublet chemotherapy - Drug interaction    RC00004029
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-361-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-361-5p
Topotecan       60700
Palbociclib       5330286

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-361-5p
Interactor2: BLMH

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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