Basic Information:

  VIRBase ID:  

HHID00049393

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-3p:  MIMAT0000280          ZNF680:  NM_001130022     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-3p	ZNF680
miRBase Accession/Entrez ID	MIMAT0000280	340252
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-3p	rs1182356657 chrX:66018952    T/C rs1244940152 chrX:66018956    C/T rs1437865022 chrX:66018957    C/T rs1482840597 chrX:66018949    A/G rs375191439 chrX:66018939    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF680	chr7:64020669(-) A-I      intronic chr7:64020670(-) A-I      intronic chr7:64020695(-) A-I      intronic chr7:64020743(-) A-I      intronic chr7:64020942(-) A-I      intronic chr7:64021090(-) A-I      intronic chr7:64021176(-) A-I      intronic chr7:64022191(-) A-I      intronic chr7:64003248(-) A-I      intronic chr7:63986852(-) A-I      Syn:Ser->Ser chr7:64021050(-) A-I      intronic chr7:64012682(-) A-I      intronic chr7:64012528(-) A-I      intronic chr7:64006940(-) A-I      intronic chr7:63984700(-) A-I      intronic chr7:64014101(-) A-I      intronic chr7:64003255(-) A-I      intronic chr7:64003250(-) A-I      intronic chr7:64020773(-) A-I      intronic chr7:64003233(-) A-I      intronic chr7:64003225(-) A-I      intronic chr7:64003199(-) A-I      intronic chr7:64003198(-) A-I      intronic chr7:63984033(-) A-I      intronic chr7:63984239(-) A-I      intronic chr7:63984598(-) A-I      intronic chr7:63987529(-) A-I      intronic chr7:63987534(-) A-I      intronic chr7:63987590(-) A-I      intronic chr7:63987597(-) A-I      intronic chr7:63987615(-) A-I      intronic chr7:63996245(-) A-I      intronic chr7:63996316(-) A-I      intronic chr7:63997281(-) A-I      intronic chr7:63999265(-) A-I      intronic chr7:63999387(-) A-I      intronic chr7:63999397(-) A-I      intronic chr7:64000101(-) A-I      intronic chr7:64000107(-) A-I      intronic chr7:64000266(-) A-I      intronic chr7:64000294(-) A-I      intronic chr7:64000324(-) A-I      intronic chr7:64000871(-) A-I      intronic chr7:64000878(-) A-I      intronic chr7:64003217(-) A-I      intronic chr7:64003252(-) A-I      intronic chr7:64003256(-) A-I      intronic chr7:64003259(-) A-I      intronic chr7:64005454(-) A-I      intronic chr7:64005566(-) A-I      intronic chr7:64005608(-) A-I      intronic chr7:64005628(-) A-I      intronic chr7:64006899(-) A-I      intronic chr7:64006908(-) A-I      intronic chr7:64006956(-) A-I      intronic chr7:64007045(-) A-I      intronic chr7:64012580(-) A-I      intronic chr7:64012596(-) A-I      intronic chr7:64012602(-) A-I      intronic chr7:64012605(-) A-I      intronic chr7:64012630(-) A-I      intronic chr7:64013341(-) A-I      intronic chr7:64018118(-) A-I      intronic chr7:64018145(-) A-I      intronic chr7:64019894(-) A-I      intronic chr7:64019944(-) A-I      intronic chr7:64020665(-) A-I      intronic chr7:64021046(-) A-I      intronic chr7:63999470(-) A-I      intronic chr7:64006869(-) A-I      intronic chr7:64021024(-) A-I      intronic chr7:63997202(-) A-I      intronic chr7:64018155(-) A-I      intronic chr7:64021107(-) A-I      intronic chr7:63997275(-) A-I      intronic chr7:64007034(-) A-I      intronic chr7:63984690(-) A-I      intronic chr7:63999252(-) A-I      intronic chr7:63987577(-) A-I      intronic chr7:64020671(-) A-I      intronic chr7:63997348(-) A-I      intronic chr7:64018061(-) A-I      intronic chr7:63984586(-) A-I      intronic chr7:64012668(-) A-I      intronic chr7:64010176(-) A-I      intronic chr7:64020124(-) A-I      intronic chr7:64012720(-) A-I      intronic chr7:64013421(-) A-I      intronic chr7:64018119(-) A-I      intronic chr7:64020010(-) A-I      intronic chr7:64020946(-) A-I      intronic chr7:64012537(-) A-I      intronic chr7:64005420(-) A-I      intronic chr7:63996259(-) A-I      intronic chr7:64021127(-) A-I      intronic chr7:64005439(-) A-I      intronic chr7:63986851(-) A-I      NonSyn:Ser->Gly chr7:63984207(-) A-I      intronic chr7:64012478(-) A-I      intronic chr7:64013321(-) A-I      intronic chr7:64000811(-) A-I      intronic chr7:64003205(-) A-I      intronic chr7:64020719(-) A-I      intronic chr7:64012473(-) A-I      intronic chr7:64013382(-) A-I      intronic chr7:63987609(-) A-I      intronic chr7:64000154(-) A-I      intronic chr7:63997223(-) A-I      intronic chr7:64013338(-) A-I      intronic chr7:64007009(-) A-I      intronic chr7:64000284(-) A-I      intronic chr7:63984611(-) A-I      intronic chr7:64019996(-) A-I      intronic chr7:64020606(-) A-I      intronic chr7:64020927(-) A-I      intronic chr7:64021184(-) A-I      intronic chr7:64010193(-) A-I      intronic chr7:64017770(-) A-I      intronic chr7:63984768(-) A-I      intronic chr7:64020933(-) A-I      intronic chr7:64020599(-) A-I      intronic chr7:64007107(-) A-I      intronic chr7:64012569(-) A-I      intronic chr7:64019997(-) A-I      intronic chr7:64012560(-) A-I      intronic chr7:64000113(-) A-I      intronic chr7:64013465(-) A-I      intronic chr7:64012663(-) A-I      intronic chr7:63984803(-) A-I      intronic chr7:64021078(-) A-I      intronic chr7:63997228(-) A-I      intronic chr7:64013497(-) A-I      intronic chr7:64003244(-) A-I      intronic chr7:64003200(-) A-I      intronic chr7:64020674(-) A-I      intronic chr7:63999336(-) A-I      intronic chr7:64005471(-) A-I      intronic chr7:64020686(-) A-I      intronic chr7:64007088(-) A-I      intronic chr7:64018158(-) A-I      intronic chr7:64019983(-) A-I      intronic chr7:63984697(-) A-I      intronic chr7:64013247(-) A-I      intronic chr7:64021042(-) A-I      intronic chr7:64000094(-) A-I      intronic chr7:63984035(-) A-I      intronic chr7:64021027(-) A-I      intronic chr7:64000282(-) A-I      intronic chr7:64000761(-) A-I      intronic chr7:64020520(-) A-I      intronic chr7:63984720(-) A-I      intronic chr7:64005611(-) A-I      intronic chr7:63987504(-) A-I      intronic chr7:64020629(-) A-I      intronic chr7:63984179(-) A-I      intronic chr7:63984143(-) A-I      intronic chr7:63999264(-) A-I      intronic chr7:64000102(-) A-I      intronic chr7:64005542(-) A-I      intronic chr7:64021066(-) A-I      intronic chr7:64018104(-) A-I      intronic chr7:64018081(-) A-I      intronic chr7:64020742(-) A-I      intronic chr7:63997380(-) A-I      intronic chr7:64003363(-) A-I      intronic chr7:63987370(-) A-I      intronic chr7:64018167(-) A-I      intronic chr7:64017470(-) A-I      intronic chr7:63992494(-) A-I      intronic chr7:63987445(-) A-I      intronic chr7:64007083(-) A-I      intronic chr7:64020781(-) A-I      intronic chr7:63984142(-) A-I      intronic chr7:64020656(-) A-I      intronic chr7:64003253(-) A-I      intronic chr7:64020987(-) A-I      intronic chr7:64005533(-) A-I      intronic chr7:63998049(-) A-I      intronic chr7:64020931(-) A-I      intronic chr7:63998186(-) A-I      intronic chr7:64000834(-) A-I      intronic chr7:64007064(-) A-I      intronic chr7:64010239(-) A-I      intronic chr7:64020588(-) A-I      intronic chr7:64000768(-) A-I      intronic chr7:64013356(-) A-I      intronic chr7:63997336(-) A-I      intronic chr7:64013477(-) A-I      intronic chr7:63987611(-) A-I      intronic chr7:64007011(-) A-I      intronic chr7:63987533(-) A-I      intronic chr7:63997259(-) A-I      intronic chr7:63987507(-) A-I      intronic chr7:64020668(-) A-I      intronic chr7:63986865(-) A-I      NonSyn:Glu->Gly chr7:64012467(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF680	chr7:63984142(-) A-G intron -    22484847 chr7:63984143(-) A-G intron -    22484847 chr7:63984169(-) A-G intron -    22484847 chr7:63984179(-) A-G intron -    22484847 chr7:63984207(-) A-G intron -    22484847 chr7:63984253(-) A-G intron -    22484847 chr7:63984586(-) A-G intron -    22484847 chr7:63984690(-) A-G intron -    22484847 chr7:63984768(-) A-G intron -    22484847 chr7:63984803(-) A-G intron -    22484847 chr7:63987504(-) A-G intron -    22484847 chr7:63987533(-) A-G intron -    22484847 chr7:63987608(-) A-G intron -    22484847 chr7:63987611(-) A-G intron -    22484847 chr7:63999326(-) A-G intron -    22484847 chr7:63999336(-) A-G intron -    22484847 chr7:63999470(-) A-G intron -    22484847 chr7:63999478(-) A-G intron -    22484847 chr7:64000094(-) A-G intron -    22484847 chr7:64000102(-) A-G intron -    22484847 chr7:64000113(-) A-G intron -    22484847 chr7:64000284(-) A-G intron -    22484847 chr7:64000811(-) A-G intron -    22484847 chr7:64000834(-) A-G intron -    22484847 chr7:64003356(-) A-G intron -    22484847 chr7:64003363(-) A-G intron -    22484847 chr7:64005611(-) A-G intron -    22484847 chr7:64006937(-) A-G intron -    22484847 chr7:64006999(-) A-G intron -    22484847 chr7:64007009(-) A-G intron -    22484847 chr7:64007011(-) A-G intron -    22484847 chr7:64007083(-) A-G intron -    22484847 chr7:64009505(-) C-T intron -    22484847 chr7:64012461(-) A-G intron -    22484847 chr7:64012473(-) A-G intron -    22484847 chr7:64012560(-) A-G intron -    22484847 chr7:64012569(-) A-G intron -    22484847 chr7:64012624(-) A-G intron -    22484847 chr7:64012658(-) A-G intron -    22484847 chr7:64012663(-) A-G intron -    22484847 chr7:64012668(-) A-G intron -    22484847 chr7:64012720(-) A-G intron -    22484847 chr7:64013247(-) A-G intron -    22484847 chr7:64013321(-) A-G intron -    22484847 chr7:64013332(-) A-G intron -    22484847 chr7:64013338(-) A-G intron -    22484847 chr7:64013356(-) A-G intron -    22484847 chr7:64013392(-) A-G intron -    22484847 chr7:64013421(-) A-G intron -    22484847 chr7:64013451(-) A-G intron -    22484847 chr7:64013465(-) A-G intron -    22484847 chr7:64013497(-) A-G intron -    22484847 chr7:64018081(-) A-G intron -    22484847 chr7:64019919(-) A-G intron -    22484847 chr7:64019996(-) A-G intron -    22484847 chr7:64019997(-) A-G intron -    22484847 chr7:64020010(-) A-G intron -    22484847 chr7:64020087(-) A-G intron -    22484847 chr7:64020124(-) A-G intron -    22484847 chr7:64020606(-) A-G intron -    22484847 chr7:64020629(-) A-G intron -    22484847 chr7:64020671(-) A-G intron -    22484847 chr7:64020686(-) A-G intron -    22484847 chr7:64020719(-) A-G intron -    22484847 chr7:64020742(-) A-G intron -    22484847 chr7:64020751(-) A-G intron -    22484847 chr7:64020781(-) A-G intron -    22484847 chr7:64020986(-) A-G intron -    22484847 chr7:64020987(-) A-G intron -    22484847 chr7:64021066(-) A-G intron -    22484847 chr7:64021107(-) A-G intron -    22484847 chr7:64021108(-) A-G intron -    22484847 chr7:64021184(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF680	chr7:63980274-63980275(-) m6A 3'UTR       27773535 chr7:63980826-63980827(-) m6A 3'UTR       27773535 chr7:63980839-63980840(-) m6A 3'UTR       27773535 chr7:63980965-63980966(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63980980-63980981(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63980996-63980997(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981061-63981062(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981081-63981082(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981172-63981173(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981212-63981213(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981388-63981389(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981416-63981417(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981499-63981500(-) m6A 3'UTR       24981863//27773535//22608085 chr7:63981517-63981518(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:63981526-63981527(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:63981536-63981537(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:63981574-63981575(-) m6A CDS       24284625//24981863//27773535//22608085 chr7:63981583-63981584(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr7:63981610-63981611(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr7:63981667-63981668(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr7:63981919-63981920(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr7:63981946-63981947(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr7:63981956-63981957(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr7:63982030-63982031(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr7:63982040-63982041(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr7:63982087-63982088(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr7:63982114-63982115(-) m6A CDS       24284625//24981863//27773535//22608085 chr7:63982124-63982125(-) m6A CDS       24284625//24981863//27773535//22608085 chr7:63982142-63982143(-) m6A CDS       24284625//24981863//27773535//22608085 chr7:63982171-63982172(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr7:63982259-63982260(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr7:63982282-63982283(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr7:63982339-63982340(-) m6A CDS//exon       24981863//27773535//22608085 chr7:63982366-63982367(-) m6A CDS//exon       24981863//27773535//22608085 chr7:63982423-63982424(-) m6A CDS//exon       24981863//27773535//22608085 chr7:63982450-63982451(-) m6A CDS//exon       24981863//27773535//22608085 chr7:63982622-63982623(-) m6A CDS//exon       24981863//27773535//22608085 chr7:63982689-63982690(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr7:63982708-63982709(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr7:63982783-63982784(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr7:63982853-63982854(-) m6A CDS//exon       24981863//27773535//22608085 chr7:64021386-64021387(-) m6A exon//intron       27773535 chr7:64021460-64021461(-) m6A exon//intron       27773535 chr7:64021500-64021501(-) m6A exon//intron       27773535 chr7:64021544-64021545(-) m6A exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-3p	Endoplasmic reticulum membrane Cortical tissue     32451872 Exosome Dendritic cells (in vitro differentiated Langerhans cells)|Healthy plasma|Mast cells (HMC-1 cell line)|PCa patient plasma     25267620 Exosome Macrophages     27396686 Exosome B cell line (Raji)|Primary dendritic cells     21505438 Exosome Breast cancer cell lines (HEK-293T|MDA-MB-231|SKBR3)|Macrophages     21939504 Exosome Ovarian follicular fluid     22116803 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma     24130905 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Saliva     25376581 Exosome Blood|Breast milk|Mast cells     - Microvesicle Liver resident stem cells|Mesenchymal stem cells     20668554 Microvesicle Plasma     23077538 Microvesicle Follicular fluid     23666971 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ZNF680	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-223-3p	Gemcitabine 60750 Drug interaction    RC00002247 Clopidogrel 60606 Drug interaction    RC00002246 Testosterone 6013 Drug interaction    RC00002242 Cholesterol 5997 Drug interaction    RC00002241 Mitomycin 5746 Drug interaction    RC00002240 RETINOIC ACID, 13-cis- 5538 Drug interaction    RC00002239 Vorinostat 5311 Drug interaction    RC00002252 Genistein 5280961 Drug interaction    RC00002251 Praziquantel 4891 Drug interaction    RC00002238 Tretinoin 444795 Drug interaction    RC00002250 Paclitaxel 36314 Drug interaction    RC00002245 5-Fluorouracil 3385 Drug interaction    RC00002237 Doxorubicin 31703 Drug interaction    RC00002244 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002236 Chlorzoxazone 2733 Drug interaction    RC00002235 Benzene 241 Drug interaction    RC00002234 Erlotinib 176870 Drug interaction    RC00002249 Methamphetamine 10836 Drug interaction    RC00002243 modified ALLIC BFM 2002 protocol - Drug interaction    RC00002253 Nesiritide - Drug interaction    RC00002254 Trastuzumab - Drug interaction    RC00002255 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002256 Interleukin 13 (IL-13) - Drug interaction    RC00002258 Glucocorticoid - Drug interaction    RC00002257

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-223-3p	Docetaxel 148124       29518547

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-3p
Interactor2: ZNF680

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.