Basic Information:

  VIRBase ID:  

HHID00049380

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-223-3p:  MIMAT0000280          HSP90B1:  NM_003299     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-223-3p	HSP90B1
miRBase Accession/Entrez ID	MIMAT0000280	7184
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ECGP//GP96//GRP94//HEL-S-125m//HEL35//TRA1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-223-3p	rs1182356657 chrX:66018952    T/C rs1244940152 chrX:66018956    C/T rs1437865022 chrX:66018957    C/T rs1482840597 chrX:66018949    A/G rs375191439 chrX:66018939    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HSP90B1	chr12:104331716(+) A-I      intronic chr12:104328741(+) A-I      intronic chr12:104330314(+) A-I      intronic chr12:104330165(+) A-I      intronic chr12:104328605(+) A-I      intronic chr12:104338434(+) A-I      intronic chr12:104331735(+) A-I      intronic chr12:104339660(+) A-I      intronic chr12:104328584(+) A-I      intronic chr12:104328579(+) A-I      intronic chr12:104328560(+) A-I      intronic chr12:104328557(+) A-I      intronic chr12:104330304(+) A-I      intronic chr12:104328484(+) A-I      intronic chr12:104330236(+) A-I      intronic chr12:104330345(+) A-I      intronic chr12:104331789(+) A-I      intronic chr12:104331869(+) A-I      intronic chr12:104331898(+) A-I      intronic chr12:104330288(+) A-I      intronic chr12:104330170(+) A-I      intronic chr12:104328641(+) A-I      intronic chr12:104328606(+) A-I      intronic chr12:104331815(+) A-I      intronic chr12:104339008(+) A-I      intronic chr12:104330162(+) A-I      intronic chr12:104331838(+) A-I      intronic chr12:104339680(+) A-I      intronic chr12:104331828(+) A-I      intronic chr12:104330366(+) A-I      intronic chr12:104339653(+) A-I      intronic chr12:104330278(+) A-I      intronic chr12:104332947(+) A-I      intronic chr12:104331890(+) A-I      intronic chr12:104328480(+) A-I      intronic chr12:104339044(+) A-I      intronic chr12:104330142(+) A-I      intronic chr12:104331845(+) A-I      intronic chr12:104331769(+) A-I      intronic chr12:104328753(+) A-I      intronic chr12:104331690(+) A-I      intronic chr12:104338358(+) A-I      intronic chr12:104330270(+) A-I      intronic chr12:104328756(+) A-I      intronic chr12:104339100(+) A-I      intronic chr12:104330210(+) A-I      intronic chr12:104328580(+) A-I      intronic chr12:104338997(+) A-I      intronic chr12:104339607(+) A-I      intronic chr12:104330200(+) A-I      intronic chr12:104330238(+) A-I      intronic chr12:104330830(+) A-I      intronic chr12:104328662(+) A-I      intronic chr12:104339064(+) A-I      intronic chr12:104338438(+) A-I      intronic chr12:104330318(+) A-I      intronic chr12:104331933(+) A-I      intronic chr12:104330187(+) A-I      intronic chr12:104331681(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HSP90B1	chr12:104330210(+) A-I intron -    22327324 chr12:104330304(+) A-I intron -    22327324 chr12:104330318(+) A-I intron -    22327324 chr12:104330162(+) A-I intron -    21960545 chr12:104330996(+) A-I intron -    21960545 chr12:104330162(+) A-G intron -    22484847 chr12:104330200(+) A-G intron -    22484847 chr12:104330210(+) A-G intron -    22484847 chr12:104330278(+) A-G intron -    22484847 chr12:104330304(+) A-G intron -    22484847 chr12:104338358(+) A-G intron -    22484847 chr12:104339008(+) A-G intron -    22484847 chr12:104339695(+) C-A intron -    22484847 chr12:104339698(+) T-A intron -    22484847 chr12:104328580(+) A-G intron -    22484847 chr12:104328662(+) A-G intron -    22484847 chr12:104331735(+) A-G intron -    22484847 chr12:104332890(+) C-T intron -    22484847 chr12:104338523(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSP90B1	chr12:104324196-104324197(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:104324225-104324226(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:104324268-104324269(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:104324275-104324276(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:104325398-104325399(+) Gm 5'UTR//CDS//exon       - chr12:104325417-104325418(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr12:104325444-104325445(+) m6A exon//intron       24284625//24209618//24981863//27773535//22575960 chr12:104326062-104326063(+) m1A 3'UTR//5'UTR//CDS//exon       26863196 chr12:104326105-104326106(+) m6A 3'UTR//5'UTR//CDS//exon       24981863//27773535//22575960 chr12:104326162-104326163(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr12:104326617-104326618(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104326701-104326702(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104327749-104327750(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104327767-104327768(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104327806-104327807(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104327832-104327833(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104327848-104327849(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104327963-104327964(+) m6A CDS//exon       27773535 chr12:104328037-104328038(+) m6A CDS//exon       26404942//27773535 chr12:104331555-104331556(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104332021-104332022(+) m6A exon//intron       24981863//27773535//22608085 chr12:104332061-104332062(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr12:104332080-104332081(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr12:104332117-104332118(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chr12:104332123-104332124(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chr12:104332221-104332222(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104332228-104332229(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333295-104333296(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333305-104333306(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333312-104333313(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333330-104333331(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333345-104333346(+) m6A CDS//exon//intron       24981863//27773535//22608085 chr12:104335297-104335298(+) Tm CDS//exon//intron       - chr12:104335613-104335614(+) m6A CDS//exon//intron       27773535 chr12:104335648-104335649(+) m6A CDS//exon//intron       27773535//22575960 chr12:104335665-104335666(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336338-104336339(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336425-104336426(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336439-104336440(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336453-104336454(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336503-104336504(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336531-104336532(+) m6A CDS//exon//intron       27773535 chr12:104336536-104336537(+) m6A CDS//exon//intron       27773535 chr12:104336583-104336584(+) m6A exon//intron       27773535 chr12:104336658-104336659(+) m6A exon//intron       27773535 chr12:104336916-104336917(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr12:104337016-104337017(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr12:104337092-104337093(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr12:104337162-104337163(+) m6A exon//intron       27773535//22575960 chr12:104337639-104337640(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340417-104340418(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340437-104340438(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340454-104340455(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340581-104340582(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340614-104340615(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340648-104340649(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340699-104340700(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341095-104341096(+) m1A CDS//exon//intron       26863196 chr12:104341107-104341108(+) m1A CDS//exon//intron       26863196 chr12:104341111-104341112(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341118-104341119(+) Gm CDS//exon//intron       - chr12:104341121-104341122(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341131-104341132(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341143-104341144(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341181-104341182(+) m6A 3'UTR//CDS//exon       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341191-104341192(+) m1A 3'UTR//CDS//exon       26863196 chr12:104341199-104341200(+) m6A 3'UTR//CDS//exon       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341511-104341512(+) m6A 3'UTR//exon//intron       24981863//26404942//27773535//22575960 chr12:104347177-104347178(+) m6A 3'UTR       27773535 chr12:104347270-104347271(+) m6A 3'UTR       27773535//27773536 chr12:104347294-104347295(+) m6A 3'UTR       27773535//27773536 chr12:104347321-104347322(+) m6A 3'UTR       27773535//27773536 chr12:104347362-104347363(+) m6A 3'UTR       27773535 chr12:104347370-104347371(+) m6A 3'UTR       27773535 chr12:104347383-104347384(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-223-3p	Endoplasmic reticulum membrane Cortical tissue     32451872 Exosome Dendritic cells (in vitro differentiated Langerhans cells)|Healthy plasma|Mast cells (HMC-1 cell line)|PCa patient plasma     25267620 Exosome Macrophages     27396686 Exosome B cell line (Raji)|Primary dendritic cells     21505438 Exosome Breast cancer cell lines (HEK-293T|MDA-MB-231|SKBR3)|Macrophages     21939504 Exosome Ovarian follicular fluid     22116803 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma     24130905 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Saliva     25376581 Exosome Blood|Breast milk|Mast cells     - Microvesicle Liver resident stem cells|Mesenchymal stem cells     20668554 Microvesicle Plasma     23077538 Microvesicle Follicular fluid     23666971 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	HSP90B1	Chromatin K562 cells     - Cytosol K562 cells     - Cytosolic polysome Human T lymphocytes (Jurkat E6-1)     12923260 Endoplasmic reticulum HEK-293T cells     21431749 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 ER-bound polysome Human T lymphocytes (Jurkat E6-1)     12923260 Exosome Blood     - Membrane-bound ribosome Cell line (HeLa)     18192611 Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Perinuclear Human embryonic kidney cell line (HEK-293)     12923260 Ribosome HEK-293 cells     22199352 Ribosome HeLa cells     25063809

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-223-3p	Gemcitabine 60750 Drug interaction    RC00002247 Clopidogrel 60606 Drug interaction    RC00002246 Testosterone 6013 Drug interaction    RC00002242 Cholesterol 5997 Drug interaction    RC00002241 Mitomycin 5746 Drug interaction    RC00002240 RETINOIC ACID, 13-cis- 5538 Drug interaction    RC00002239 Vorinostat 5311 Drug interaction    RC00002252 Genistein 5280961 Drug interaction    RC00002251 Praziquantel 4891 Drug interaction    RC00002238 Tretinoin 444795 Drug interaction    RC00002250 Paclitaxel 36314 Drug interaction    RC00002245 5-Fluorouracil 3385 Drug interaction    RC00002237 Doxorubicin 31703 Drug interaction    RC00002244 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002236 Chlorzoxazone 2733 Drug interaction    RC00002235 Benzene 241 Drug interaction    RC00002234 Erlotinib 176870 Drug interaction    RC00002249 Methamphetamine 10836 Drug interaction    RC00002243 modified ALLIC BFM 2002 protocol - Drug interaction    RC00002253 Nesiritide - Drug interaction    RC00002254 Trastuzumab - Drug interaction    RC00002255 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002256 Interleukin 13 (IL-13) - Drug interaction    RC00002258 Glucocorticoid - Drug interaction    RC00002257

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-223-3p	Docetaxel 148124       29518547

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-223-3p
Interactor2: HSP90B1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.