Basic Information:

  VIRBase ID:  

HHID00047991

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          SH3GL1:  NM_001199944     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	SH3GL1
miRBase Accession/Entrez ID	MIMAT0000245	6455
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CNSA1//EEN//SH3D2B//SH3P8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SH3GL1	chr19:4377391(-) A-I      intronic chr19:4377414(-) A-I      intronic chr19:4377461(-) A-I      intronic chr19:4377447(-) A-I      intronic chr19:4377426(-) A-I      intronic chr19:4398012(-) A-I      intronic chr19:4398013(-) A-I      intronic chr19:4398601(-) A-I      intronic chr19:4377345(-) A-I      intronic chr19:4376336(-) A-I      intronic chr19:4396284(-) A-I      intronic chr19:4399260(-) A-I      intronic chr19:4387953(-) A-I      intronic chr19:4398564(-) A-I      intronic chr19:4398620(-) A-I      intronic chr19:4398573(-) A-I      intronic chr19:4398566(-) A-I      intronic chr19:4384880(-) A-I      intronic chr19:4384842(-) A-I      intronic chr19:4381822(-) A-I      intronic chr19:4384969(-) A-I      intronic chr19:4381766(-) A-I      intronic chr19:4398563(-) A-I      intronic chr19:4398517(-) A-I      intronic chr19:4398508(-) A-I      intronic chr19:4398465(-) A-I      intronic chr19:4398063(-) A-I      intronic chr19:4397982(-) A-I      intronic chr19:4397955(-) A-I      intronic chr19:4397882(-) A-I      intronic chr19:4399151(-) A-I      intronic chr19:4379301(-) A-I      intronic chr19:4396168(-) A-I      intronic chr19:4387978(-) A-I      intronic chr19:4396268(-) A-I      intronic chr19:4396149(-) A-I      intronic chr19:4395746(-) A-I      intronic chr19:4392900(-) A-I      intronic chr19:4392770(-) A-I      intronic chr19:4388052(-) A-I      intronic chr19:4387995(-) A-I      intronic chr19:4387972(-) A-I      intronic chr19:4387114(-) A-I      intronic chr19:4386581(-) A-I      intronic chr19:4384989(-) A-I      intronic chr19:4384929(-) A-I      intronic chr19:4388051(-) A-I      intronic chr19:4379311(-) A-I      intronic chr19:4398137(-) A-I      intronic chr19:4399270(-) A-I      intronic chr19:4398043(-) A-I      intronic chr19:4379315(-) A-I      intronic chr19:4384979(-) A-I      intronic chr19:4388128(-) A-I      intronic chr19:4381818(-) A-I      intronic chr19:4392511(-) A-I      intronic chr19:4387031(-) A-I      intronic chr19:4372078(-) A-I      intronic chr19:4387002(-) A-I      intronic chr19:4387072(-) A-I      intronic chr19:4385019(-) A-I      intronic chr19:4399154(-) A-I      intronic chr19:4399096(-) A-I      intronic chr19:4386608(-) A-I      intronic chr19:4381828(-) A-I      intronic chr19:4388040(-) A-I      intronic chr19:4392358(-) A-I      intronic chr19:4387835(-) A-I      intronic chr19:4385062(-) A-I      intronic chr19:4385001(-) A-I      intronic chr19:4388022(-) A-I      intronic chr19:4398504(-) A-I      intronic chr19:4399230(-) A-I      intronic chr19:4387001(-) A-I      intronic chr19:4384938(-) A-I      intronic chr19:4383001(-) A-I      intronic chr19:4383088(-) A-I      intronic chr19:4387942(-) A-I      intronic chr19:4398026(-) A-I      intronic chr19:4385025(-) A-I      intronic chr19:4399217(-) A-I      intronic chr19:4387819(-) A-I      intronic chr19:4396360(-) A-I      intronic chr19:4386943(-) A-I      intronic chr19:4396274(-) A-I      intronic chr19:4397878(-) A-I      intronic chr19:4384977(-) A-I      intronic chr19:4397972(-) A-I      intronic chr19:4397946(-) A-I      intronic chr19:4384844(-) A-I      intronic chr19:4384928(-) A-I      intronic chr19:4398505(-) A-I      intronic chr19:4387981(-) A-I      intronic chr19:4387098(-) A-I      intronic chr19:4385015(-) A-I      intronic chr19:4392894(-) A-I      intronic chr19:4383447(-) A-I      intronic chr19:4385018(-) A-I      intronic chr19:4392469(-) A-I      intronic chr19:4387832(-) A-I      intronic chr19:4364382(-) A-I      intronic chr19:4383350(-) A-I      intronic chr19:4399231(-) A-I      intronic chr19:4392349(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SH3GL1	chr19:4362691(-) C-G exon CDS    21725310 chr19:4396781(-) A-G intron -    22484847 chr19:4396785(-) A-G intron -    22484847 chr19:4384918(-) A-G intron -    22484847 chr19:4385001(-) A-G intron -    22484847 chr19:4393366(-) G-A intron -    22484847 chr19:4398137(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SH3GL1	chr19:4360393-4360394(-) m6A 3'UTR       27773535 chr19:4360420-4360421(-) m6A 3'UTR       27773535 chr19:4360518-4360519(-) m6A 3'UTR       27773535 chr19:4360643-4360644(-) m6A 3'UTR       24284625//27773535 chr19:4360777-4360778(-) m6A 3'UTR       24284625//27773535//22575960 chr19:4360942-4360943(-) m6A 3'UTR       24284625//27773535 chr19:4360949-4360950(-) m6A 3'UTR       24284625//27773535 chr19:4360977-4360978(-) m6A 3'UTR       24284625//27773535 chr19:4361136-4361137(-) m6A 3'UTR       27773535 chr19:4361444-4361445(-) m6A 3'UTR       24284625 chr19:4361678-4361679(-) m6A CDS       24284625//27371828//27773536//22575960 chr19:4361745-4361746(-) Gm CDS       - chr19:4361783-4361784(-) m6A CDS       24284625//27773535//27371828//27773536//22575960 chr19:4362343-4362344(-) m6A CDS       24284625//27773535//27371828//27773536//22575960 chr19:4362361-4362362(-) Tm CDS       - chr19:4363423-4363424(-) m6A CDS       24284625//24981863//27773535//27371828//27773536//22575960 chr19:4363721-4363722(-) m6A CDS       24284625//24981863//27371828//27773536//22575960 chr19:4363745-4363746(-) m6A CDS       24284625//24981863//27371828//27773536//22575960 chr19:4363840-4363841(-) m6A CDS       24284625//24981863//27773535//27371828//27773536//22575960 chr19:4363860-4363861(-) m6A CDS       24284625//27773535//27371828//27773536//22575960 chr19:4364100-4364101(-) m6A CDS       24284625//27773535//27371828//27773536//22575960 chr19:4364115-4364116(-) m6A CDS       24284625//27773535//27371828//27773536//22575960 chr19:4364136-4364137(-) m6A CDS//intron       24284625//27773535//27371828//27773536//22575960 chr19:4364154-4364155(-) m6A CDS//intron       24284625//27773535//27371828//27773536//22575960 chr19:4364163-4364164(-) m6A CDS//intron       24284625//24209618//27773535//27371828//27773536//22575960 chr19:4365561-4365562(-) m6A CDS//intron       24284625//24209618//27773535//27371828//27773536//22575960 chr19:4366524-4366525(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536 chr19:4366957-4366958(-) m6A 5'UTR//CDS       24209618//24981863//27773535//27371828//22575960 chr19:4380184-4380185(-) m1A 5'UTR//intron       26863196//26863410 chr19:4380225-4380226(-) m6A 5'UTR//intron       24209618//27773535//27371828//22575960 chr19:4380244-4380245(-) m6A 5'UTR//intron       24209618 chr19:4395978-4395979(-) m6A 5'UTR//intron       24209618 chr19:4400343-4400344(-) m1A CDS       26863196//26863410 chr19:4400450-4400451(-) m6A 5'UTR       24209618//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	SH3GL1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: SH3GL1

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).