Basic Information:

  VIRBase ID:  

HHID00044876

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:  MIMAT0000088          NPAT:  NM_001321307     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30a-3p	NPAT
miRBase Accession/Entrez ID	MIMAT0000088	4863
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	E14//E14/NPAT//p220

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30a-3p	rs149150037 chr6:71403567    G/A rs149150037 chr6:71403567    G/C rs370184894 chr6:71403566    C/A rs370184894 chr6:71403566    C/T rs552541514 chr6:71403558    C/G rs745605208 chr6:71403563    ATCCG/A rs746505574 chr6:71403557    G/A rs746505574 chr6:71403557    G/T rs746965145 chr6:71403554    GCT/G rs750918072 chr6:71403564    T/C rs765735953 chr6:71403560    A/T rs770865356 chr6:71403559    A/AC rs776574456 chr6:71403560    A/AAGCTGGAGT rs368070339 chr6:71403571    G/A rs769702885 chr6:71403570    TG/T rs775921090 chr6:71403574    AGCC/A rs781617967 chr6:71403573    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NPAT	chr11:108052068(-) A-I      intronic chr11:108049578(-) A-I      intronic chr11:108048626(-) A-I      intronic chr11:108036947(-) A-I      intronic chr11:108031424(-) A-I      intronic chr11:108058126(-) A-I      intronic chr11:108058129(-) A-I      intronic chr11:108031449(-) A-I      intronic chr11:108031457(-) A-I      intronic chr11:108058132(-) A-I      intronic chr11:108058133(-) A-I      intronic chr11:108058135(-) A-I      intronic chr11:108058141(-) A-I      intronic chr11:108058143(-) A-I      intronic chr11:108082213(-) A-I      intronic chr11:108082012(-) A-I      intronic chr11:108081802(-) A-I      intronic chr11:108058127(-) A-I      intronic chr11:108056904(-) A-I      intronic chr11:108052071(-) A-I      intronic chr11:108048667(-) A-I      intronic chr11:108048651(-) A-I      intronic chr11:108048625(-) A-I      intronic chr11:108048623(-) A-I      intronic chr11:108079301(-) A-I      intronic chr11:108048090(-) A-I      intronic chr11:108048006(-) A-I      intronic chr11:108058079(-) A-I      intronic chr11:108053912(-) A-I      intronic chr11:108053839(-) A-I      intronic chr11:108053822(-) A-I      intronic chr11:108079171(-) A-I      intronic chr11:108088711(-) A-I      intronic chr11:108088598(-) A-I      intronic chr11:108088535(-) A-I      intronic chr11:108048005(-) A-I      intronic chr11:108036971(-) A-I      intronic chr11:108084911(-) A-I      intronic chr11:108084889(-) A-I      intronic chr11:108084887(-) A-I      intronic chr11:108036110(-) A-I      intronic chr11:108084712(-) A-I      intronic chr11:108084707(-) A-I      intronic chr11:108055009(-) A-I      intronic chr11:108084676(-) A-I      intronic chr11:108076116(-) A-I      intronic chr11:108035747(-) A-I      intronic chr11:108053738(-) A-I      intronic chr11:108053463(-) A-I      intronic chr11:108035656(-) A-I      intronic chr11:108088528(-) A-I      intronic chr11:108036455(-) A-I      intronic chr11:108036425(-) A-I      intronic chr11:108053369(-) A-I      intronic chr11:108035655(-) A-I      intronic chr11:108053365(-) A-I      intronic chr11:108035651(-) A-I      intronic chr11:108055554(-) A-I      intronic chr11:108055288(-) A-I      intronic chr11:108082537(-) A-I      intronic chr11:108053362(-) A-I      intronic chr11:108053267(-) A-I      intronic chr11:108082527(-) A-I      intronic chr11:108053330(-) A-I      intronic chr11:108082511(-) A-I      intronic chr11:108055017(-) A-I      intronic chr11:108079289(-) A-I      intronic chr11:108082663(-) A-I      intronic chr11:108037036(-) A-I      intronic chr11:108079220(-) A-I      intronic chr11:108079214(-) A-I      intronic chr11:108035638(-) A-I      intronic chr11:108035494(-) A-I      intronic chr11:108048113(-) A-I      intronic chr11:108079203(-) A-I      intronic chr11:108079197(-) A-I      intronic chr11:108079193(-) A-I      intronic chr11:108079112(-) A-I      intronic chr11:108079101(-) A-I      intronic chr11:108076672(-) A-I      intronic chr11:108076066(-) A-I      intronic chr11:108048132(-) A-I      intronic chr11:108050239(-) A-I      intronic chr11:108051008(-) A-I      intronic chr11:108076578(-) A-I      intronic chr11:108076152(-) A-I      intronic chr11:108054446(-) A-I      intronic chr11:108084793(-) A-I      intronic chr11:108076148(-) A-I      intronic chr11:108065509(-) A-I      intronic chr11:108054311(-) A-I      intronic chr11:108049359(-) A-I      intronic chr11:108057023(-) A-I      intronic chr11:108076203(-) A-I      intronic chr11:108048531(-) A-I      intronic chr11:108048572(-) A-I      intronic chr11:108056882(-) A-I      intronic chr11:108056828(-) A-I      intronic chr11:108052116(-) A-I      intronic chr11:108049502(-) A-I      intronic chr11:108056812(-) A-I      intronic chr11:108056806(-) A-I      intronic chr11:108076770(-) A-I      intronic chr11:108079253(-) A-I      intronic chr11:108052025(-) A-I      intronic chr11:108048707(-) A-I      intronic chr11:108055075(-) A-I      intronic chr11:108055197(-) A-I      intronic chr11:108085632(-) A-I      intronic chr11:108054617(-) A-I      intronic chr11:108055155(-) A-I      intronic chr11:108079191(-) A-I      intronic chr11:108055090(-) A-I      intronic chr11:108052073(-) A-I      intronic chr11:108052028(-) A-I      intronic chr11:108055099(-) A-I      intronic chr11:108084854(-) A-I      intronic chr11:108082555(-) A-I      intronic chr11:108055077(-) A-I      intronic chr11:108082208(-) A-I      intronic chr11:108050852(-) A-I      intronic chr11:108054977(-) A-I      intronic chr11:108054576(-) A-I      intronic chr11:108054445(-) A-I      intronic chr11:108049340(-) A-I      intronic chr11:108079314(-) A-I      intronic chr11:108036499(-) A-I      intronic chr11:108053335(-) A-I      intronic chr11:108054366(-) A-I      intronic chr11:108049326(-) A-I      intronic chr11:108036979(-) A-I      intronic chr11:108054337(-) A-I      intronic chr11:108054284(-) A-I      intronic chr11:108048733(-) A-I      intronic chr11:108053995(-) A-I      intronic chr11:108048712(-) A-I      intronic chr11:108053965(-) A-I      intronic chr11:108054572(-) A-I      intronic chr11:108034034(-) A-I      intronic chr11:108079309(-) A-I      intronic chr11:108055087(-) A-I      intronic chr11:108036246(-) A-I      intronic chr11:108079134(-) A-I      intronic chr11:108082596(-) A-I      intronic chr11:108054578(-) A-I      intronic chr11:108049341(-) A-I      intronic chr11:108054600(-) A-I      intronic chr11:108076214(-) A-I      intronic chr11:108056976(-) A-I      intronic chr11:108079100(-) A-I      intronic chr11:108082146(-) A-I      intronic chr11:108036783(-) A-I      intronic chr11:108084809(-) A-I      intronic chr11:108082564(-) A-I      intronic chr11:108055550(-) A-I      intronic chr11:108052186(-) A-I      intronic chr11:108051946(-) A-I      intronic chr11:108050862(-) A-I      intronic chr11:108082264(-) A-I      intronic chr11:108076238(-) A-I      intronic chr11:108045444(-) A-I      intronic chr11:108075998(-) A-I      intronic chr11:108076663(-) A-I      intronic chr11:108076054(-) A-I      intronic chr11:108058097(-) A-I      intronic chr11:108054520(-) A-I      intronic chr11:108081824(-) A-I      intronic chr11:108055395(-) A-I      intronic chr11:108031446(-) A-I      intronic chr11:108052170(-) A-I      intronic chr11:108088644(-) A-I      intronic chr11:108054954(-) A-I      intronic chr11:108054009(-) A-I      intronic chr11:108036476(-) A-I      intronic chr11:108048178(-) A-I      intronic chr11:108053490(-) A-I      intronic chr11:108082528(-) A-I      intronic chr11:108066493(-) A-I      intronic chr11:108054272(-) A-I      intronic chr11:108065844(-) A-I      intronic chr11:108065514(-) A-I      intronic chr11:108076650(-) A-I      intronic chr11:108045525(-) A-I      intronic chr11:108080602(-) A-I      intronic chr11:108053972(-) A-I      intronic chr11:108050248(-) A-I      intronic chr11:108084693(-) A-I      intronic chr11:108049342(-) A-I      intronic chr11:108050083(-) A-I      intronic chr11:108084896(-) A-I      intronic chr11:108050882(-) A-I      intronic chr11:108050803(-) A-I      intronic chr11:108082565(-) A-I      intronic chr11:108030245(-) A-I      intronic chr11:108048532(-) A-I      intronic chr11:108050939(-) A-I      intronic chr11:108053913(-) A-I      intronic chr11:108084743(-) A-I      intronic chr11:108035594(-) A-I      intronic chr11:108048166(-) A-I      intronic chr11:108054356(-) A-I      intronic chr11:108036477(-) A-I      intronic chr11:108052109(-) A-I      intronic chr11:108055530(-) A-I      intronic chr11:108033250(-) A-I      intronic chr11:108063543(-) A-I      intronic chr11:108031445(-) A-I      intronic chr11:108079113(-) A-I      intronic chr11:108054588(-) A-I      intronic chr11:108036426(-) A-I      intronic chr11:108084869(-) A-I      intronic chr11:108056999(-) A-I      intronic chr11:108055372(-) A-I      intronic chr11:108053385(-) A-I      intronic chr11:108055185(-) A-I      intronic chr11:108049477(-) A-I      intronic chr11:108053836(-) A-I      intronic chr11:108076142(-) A-I      intronic chr11:108052019(-) A-I      intronic chr11:108035751(-) A-I      intronic chr11:108049517(-) A-I      intronic chr11:108082148(-) A-I      intronic chr11:108081780(-) A-I      intronic chr11:108084729(-) A-I      intronic chr11:108076567(-) A-I      intronic chr11:108050824(-) A-I      intronic chr11:108053933(-) A-I      intronic chr11:108037085(-) A-I      intronic chr11:108035686(-) A-I      intronic chr11:108049328(-) A-I      intronic chr11:108055034(-) A-I      intronic chr11:108031467(-) A-I      intronic chr11:108055331(-) A-I      intronic chr11:108035547(-) A-I      intronic chr11:108088714(-) A-I      intronic chr11:108036018(-) A-I      intronic chr11:108036997(-) A-I      intronic chr11:108051934(-) A-I      intronic chr11:108054943(-) A-I      intronic chr11:108036989(-) A-I      intronic chr11:108035755(-) A-I      intronic chr11:108055531(-) A-I      intronic chr11:108050809(-) A-I      intronic chr11:108046733(-) A-I      intronic chr11:108037019(-) A-I      intronic chr11:108050932(-) A-I      intronic chr11:108085633(-) A-I      intronic chr11:108055136(-) A-I      intronic chr11:108036785(-) A-I      intronic chr11:108065488(-) A-I      intronic chr11:108048734(-) A-I      intronic chr11:108082126(-) A-I      intronic chr11:108082674(-) A-I      intronic chr11:108036589(-) A-I      intronic chr11:108053993(-) A-I      intronic chr11:108054429(-) A-I      intronic chr11:108050836(-) A-I      intronic chr11:108082673(-) A-I      intronic chr11:108076070(-) A-I      intronic chr11:108082057(-) A-I      intronic chr11:108088637(-) A-I      intronic chr11:108036475(-) A-I      intronic chr11:108031507(-) A-I      intronic chr11:108050959(-) A-I      intronic chr11:108084683(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NPAT	chr11:108031446(-) A-I intron -    22327324 chr11:108079083(-) A-I intron -    21960545 chr11:108079265(-) A-I intron -    21960545 chr11:108029109(-) A-T exon 3'UTR    21725310 chr11:108031445(-) A-G intron -    22484847 chr11:108031446(-) A-G intron -    22484847 chr11:108083345(-) C-T intron -    22484847 chr11:108048113(-) A-G intron -    22484847 chr11:108048707(-) A-G intron -    22484847 chr11:108048734(-) A-G intron -    22484847 chr11:108049477(-) A-G intron -    22484847 chr11:108050803(-) A-G intron -    22484847 chr11:108050809(-) A-G intron -    22484847 chr11:108052116(-) A-G intron -    22484847 chr11:108055372(-) A-G intron -    22484847 chr11:108082596(-) A-G intron -    22484847 chr11:108082674(-) A-G intron -    22484847 chr11:108084854(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NPAT	chr11:108029426-108029427(-) m6A 3'UTR//exon       27773535 chr11:108029493-108029494(-) m6A 3'UTR//exon       27773535//22608085 chr11:108029516-108029517(-) m6A 3'UTR//exon       27773535//22608085 chr11:108029551-108029552(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr11:108029617-108029618(-) m6A 3'UTR//exon       24209618//24981863//26404942//27773535//22608085 chr11:108029632-108029633(-) m6A 3'UTR//exon       24209618//24981863//26404942//27773535//22608085 chr11:108029648-108029649(-) m6A 3'UTR//exon       24209618//24981863//26404942//27773535//22608085 chr11:108029658-108029659(-) m6A 3'UTR//exon       24209618//24981863//26404942//27773535//22608085 chr11:108029667-108029668(-) m6A 3'UTR//exon       24209618//24981863//26404942//27773535//22608085 chr11:108029702-108029703(-) m6A CDS//exon       24981863//27773535//22608085 chr11:108031670-108031671(-) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr11:108031776-108031777(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr11:108031835-108031836(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr11:108031848-108031849(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr11:108031877-108031878(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr11:108031919-108031920(-) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr11:108031966-108031967(-) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr11:108031978-108031979(-) m6A CDS//exon//intron       24284625//24981863//27773535//22608085 chr11:108032004-108032005(-) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22608085 chr11:108032113-108032114(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr11:108032119-108032120(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr11:108032165-108032166(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr11:108032182-108032183(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr11:108032257-108032258(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108032281-108032282(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108032382-108032383(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108032488-108032489(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108032552-108032553(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108032573-108032574(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108032641-108032642(-) m6A CDS//exon       22608085 chr11:108042936-108042937(-) m6A CDS//exon       27773535 chr11:108042972-108042973(-) m6A CDS//exon       24284625//27773535//22608085 chr11:108042988-108042989(-) m6A CDS//exon       24284625//27773535//22608085 chr11:108043072-108043073(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr11:108043236-108043237(-) m6A CDS//exon       24284625//22608085 chr11:108043248-108043249(-) m6A CDS//exon       24284625//24981863//26404942//22608085 chr11:108043277-108043278(-) m6A CDS//exon       24284625//24981863//26404942//22608085 chr11:108043327-108043328(-) m6A CDS//exon       24284625//24981863//26404942//22608085 chr11:108043355-108043356(-) m6A CDS//exon       24284625//24981863//26404942//22608085 chr11:108043410-108043411(-) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr11:108043445-108043446(-) m6A CDS//exon       24284625//24981863//26404942//22608085 chr11:108043541-108043542(-) m6A CDS//exon       24284625//24981863//22608085 chr11:108043620-108043621(-) m6A CDS//exon       24284625//22608085 chr11:108044033-108044034(-) m6A CDS//exon       24981863//27773535//22608085 chr11:108044142-108044143(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr11:108044247-108044248(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:108044275-108044276(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr11:108044405-108044406(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:108044422-108044423(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:108044475-108044476(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108044483-108044484(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108046984-108046985(-) m6A CDS//exon       27773535 chr11:108047014-108047015(-) m6A CDS//exon       27773535 chr11:108047095-108047096(-) m6A CDS//exon       27773535 chr11:108047758-108047759(-) m6A CDS//exon       27773535 chr11:108047768-108047769(-) m6A CDS//exon       27773535 chr11:108047772-108047773(-) m6A CDS//exon       27773535 chr11:108047782-108047783(-) m6A CDS//exon       27773535 chr11:108055964-108055965(-) m6A CDS//exon       27773535 chr11:108055987-108055988(-) m6A CDS//exon       27773535 chr11:108093349-108093350(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30a-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	NPAT	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30a-3p	Sorafenib 216239 Drug interaction    RC00000903

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30a-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30a-3p
Interactor2: NPAT

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.