Basic Information:

  VIRBase ID:  

HHID00044867

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:  MIMAT0000088          CDC6:  NM_001254     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30a-3p	CDC6
miRBase Accession/Entrez ID	MIMAT0000088	990
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDC18L//HsCDC18//HsCDC6//MGORS5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30a-3p	rs149150037 chr6:71403567    G/A rs149150037 chr6:71403567    G/C rs370184894 chr6:71403566    C/A rs370184894 chr6:71403566    C/T rs552541514 chr6:71403558    C/G rs745605208 chr6:71403563    ATCCG/A rs746505574 chr6:71403557    G/A rs746505574 chr6:71403557    G/T rs746965145 chr6:71403554    GCT/G rs750918072 chr6:71403564    T/C rs765735953 chr6:71403560    A/T rs770865356 chr6:71403559    A/AC rs776574456 chr6:71403560    A/AAGCTGGAGT rs368070339 chr6:71403571    G/A rs769702885 chr6:71403570    TG/T rs775921090 chr6:71403574    AGCC/A rs781617967 chr6:71403573    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC6	chr17:38458790(+) A-I      3'UTR chr17:38456670(+) A-I      intronic chr17:38454762(+) A-I      intronic chr17:38456669(+) A-I      intronic chr17:38455895(+) A-I      intronic chr17:38448764(+) A-I      intronic chr17:38448767(+) A-I      intronic chr17:38453439(+) A-I      intronic chr17:38455894(+) A-I      intronic chr17:38456629(+) A-I      intronic chr17:38456674(+) A-I      intronic chr17:38456698(+) A-I      intronic chr17:38448115(+) A-I      intronic chr17:38448124(+) A-I      intronic chr17:38448127(+) A-I      intronic chr17:38448516(+) A-I      intronic chr17:38448019(+) A-I      intronic chr17:38448017(+) A-I      intronic chr17:38456450(+) A-I      intronic chr17:38455539(+) A-I      intronic chr17:38455892(+) A-I      intronic chr17:38454678(+) A-I      intronic chr17:38449370(+) A-I      intronic chr17:38456651(+) A-I      intronic chr17:38455940(+) A-I      intronic chr17:38454890(+) A-I      intronic chr17:38458684(+) A-I      3'UTR chr17:38454875(+) A-I      intronic chr17:38455900(+) A-I      intronic chr17:38458843(+) A-I      3'UTR chr17:38453455(+) A-I      intronic chr17:38458736(+) A-I      3'UTR chr17:38455493(+) A-I      intronic chr17:38454907(+) A-I      intronic chr17:38456602(+) A-I      intronic chr17:38455582(+) A-I      intronic chr17:38455936(+) A-I      intronic chr17:38456703(+) A-I      intronic chr17:38456333(+) A-I      intronic chr17:38456628(+) A-I      intronic chr17:38456234(+) A-I      intronic chr17:38455941(+) A-I      intronic chr17:38453940(+) A-I      intronic chr17:38458746(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC6	chr17:38455940(+) A-G intron -    22484847 chr17:38455941(+) A-G intron -    22484847 chr17:38456703(+) A-G intron -    22484847 chr17:38458843(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC6	chr17:38445742-38445743(+) m6A CDS       24981863 chr17:38445754-38445755(+) m6A CDS       24981863//27773535//22575960 chr17:38445770-38445771(+) m6A CDS       24981863//27773535//22575960 chr17:38445776-38445777(+) m6A CDS       24981863//27773535//22575960 chr17:38445792-38445793(+) m6A CDS       24981863//27773535//22575960 chr17:38449831-38449832(+) m6A CDS//intron       24981863//27773535 chr17:38449853-38449854(+) m6A CDS//intron       24981863//27773535 chr17:38451642-38451643(+) Y CDS//exon       26075521 chr17:38457751-38457752(+) m6A CDS       27773535 chr17:38457771-38457772(+) m6A CDS       27773535//22575960 chr17:38457837-38457838(+) m6A CDS       27773535//22575960 chr17:38457845-38457846(+) m6A CDS       27773535//22575960 chr17:38458793-38458794(+) m6A 3'UTR       24209618 chr17:38458828-38458829(+) m6A 3'UTR       24209618 chr17:38458927-38458928(+) m6A 3'UTR       27773535 chr17:38459000-38459001(+) m6A 3'UTR       27773535//22575960//22608085 chr17:38459078-38459079(+) m6A 3'UTR       27773535//22608085 chr17:38459127-38459128(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30a-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CDC6	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30a-3p	Sorafenib 216239 Drug interaction    RC00000903

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30a-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30a-3p
Interactor2: CDC6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.