Detail Information

Basic Information:


  VIRBase ID:  

HHID00039609

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7d-5p:           ADRB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7d-5p ADRB2
miRBase
Accession/Entrez ID		 MIMAT0000065 154
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADRB2R//ADRBR//B2AR//BAR//BETA2AR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7d-5p
rs1329655735 chr9:94178854    T/G
rs1467512593 chr9:94178853    T/C
rs1462778813 chr9:94178842    G/GAGGT

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADRB2
chr5:148206691-148206692(+) m6A CDS       24284625//24981863//22608085
chr5:148206721-148206722(+) m6A CDS       24284625//24981863//22608085
chr5:148206760-148206761(+) m6A CDS       24284625//24981863//22608085
chr5:148206958-148206959(+) m6A CDS       24284625//22608085
chr5:148206980-148206981(+) m6A CDS       24284625//22608085
chr5:148207124-148207125(+) m6A CDS       24284625//25456834//24981863//22608085
chr5:148207164-148207165(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr5:148207500-148207501(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207518-148207519(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207532-148207533(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207550-148207551(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207658-148207659(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr5:148207676-148207677(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207683-148207684(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207710-148207711(+) m6A 3'UTR       24981863//22608085
chr5:148208019-148208020(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208043-148208044(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208058-148208059(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208064-148208065(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7d-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Colon cancer cells     20864815
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical carcinoma cell line (SiHa)     25760330
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Epidermal melanocytes (HEMa-LP)     23056502
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa cells     22058130
ADRB2
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7d-5p
Hyaluronidase 91820602 Drug interaction    RC00000277
Formaldehyde 712 Drug interaction    RC00000260
Gemcitabine 60750 Drug interaction    RC00000271
Estradiol 5757 Drug interaction    RC00000265
Temozolomide 5394 Drug interaction    RC00000264
Eloxatine 5310940 Drug interaction    RC00000276
Imatinib 5291 Drug interaction    RC00000263
Cholecalciferol 5280795 Drug interaction    RC00000275
Cocaine 446220 Drug interaction    RC00000274
Tretinoin 444795 Drug interaction    RC00000273
Paroxetine 43815 Drug interaction    RC00000270
Carboplatinum 38904 Drug interaction    RC00000269
Paclitaxel 36314 Drug interaction    RC00000268
5-Fluorouracil 3385 Drug interaction    RC00000262
Doxorubicin 31703 Drug interaction    RC00000267
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000261
Benzene 241 Drug interaction    RC00000259
Arsenic trioxide 14888 Drug interaction    RC00000266
Ginsenoside Rh2 119307 Drug interaction    RC00000272
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00000278
CDF(analogues of curcumin) - Drug interaction    RC00000279
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000280
Marine fungal metabolite 1386A - Drug interaction    RC00000281
Olea europaea leaf extract - Drug interaction    RC00000282
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7d-5p
Tivantinib 11494412       31063487
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7d-5p
Interactor2: ADRB2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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