Basic Information
RNALocate ID: | RLID:11000616 |
RNA Symbol: | hsa-let-7d-5p |
Localization: | Exosome |
RNA Information
RNA Name: | hsa-let-7d-5p |
RNA ID: | miRBase:MIMAT0000065 |
RNA Category: | miRNA |
Species: | Homo sapiens |
Localization Information
PubMed ID: | 22211110 |
Tissue/Cell Line: | Breast milk |
Method: | Next-generation RNA sequencing |
The expression profile of selected miRNAs in breast milk exosomes. Originally published in Int J Biol Sci. Zhou Q, et al, 2012. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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Description: | Distribution and characterization of miRNAs in breast milk exosomes. (A) Distribution of pre-miRNAs. Out of 1,424 pre-miRNAs deposited in miRBase 17.0 (blue circle), 87 (6.11%) pre-miRNAs have been designated as immune-related pre-miRNAs based on annotation in the Pathway Central database (SABiosciences, MD, USA). Immune-related pre-miRNAs (59 of 452, 13.05%) are enriched in breast milk exosomes (red circle). χ2 test: Number of immune-related miRNAs and others detected in breast milk exosomes compared with the total entries in miRBase 17.0. (B) Top ten most highly expressed unique miRNAs. Plot of the unique miRNAs (starting from the miRNA with the highest counts, x-axis) versus their cumulative % of the total counts from 602 unique miRNAs detected in breast milk exosomes for each small RNA library. Values are means ± s.d. The dashed horizontal line at 62.3% represents the level of the top ten unique miRNAs and the % of individual miRNAs is marked by the gray line. (C-E) The expression profile of selected miRNAs in breast milk exosomes. (C) 59 immune-related pre-miRNAs; (D) miR-17-92 cluster and paralogous clusters, and (E) ten well-characterized tissue-specific pre-miRNAs. Data are collected from Figure 2. |
Other Subcellular Localization
RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
RLID:01001219 | Cytoplasm | Nasopharyngeal carcinoma cells | 20498841 |
RLID:01001220 | Cytoplasm | Colon cancer cells | 20864815 |
RLID:01001221 | Cytoplasm | Cell line (HeLa) | 21695135 |
RLID:01001222 | Cytoplasm | HeLa cells | 22058130 |
RLID:01001223 | Cytoplasm | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:01001224 | Mitochondrion | Skeletal muscle myoblasts | 21637849 |
RLID:01001225 | Mitochondrion | Cell line (HEK-293|HeLa) | 22984580 |
RLID:01001226 | Nucleus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:01001227 | Nucleolus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:01001228 | Nucleus | Nasopharyngeal carcinoma cells | 20498841 |
RLID:01001229 | Nucleus | HeLa cells | 22058130 |
RLID:11000611 | Apoptotic body | Human umbilical vein endothelial cells | 19996457 |
RLID:11000612 | Exosome | Human cervical carcinoma cell line (SiHa) | 25760330 |
RLID:11000613 | Exosome | Hetastatic gastric cancer cell line (AZ-P7a) | 20949044 |
RLID:11000614 | Exosome | Breast cancer cell line (MCF-7) | 20976003 |
RLID:11000615 | Exosome | Primary dendritic cells|T cell line (J77) | 21505438 |
RLID:11000617 | Exosome | Epidermal melanocytes (HEMa-LP) | 23056502 |
RLID:11000618 | Exosome | Brain tissue | 23382797 |
RLID:11000619 | Exosome | Plasma | 23663360 |
RLID:11000620 | Exosome | Human mast cell line (HMC-1) | 24009880 |
RLID:11000621 | Exosome | Breast cancer cell lines (MCF-7|MDA-MB-231) | 24468161 |
RLID:11000622 | Microvesicle | Plasma | 23077538 |
RLID:11000623 | Microvesicle | Seminal plasma | 23539611 |
RLID:11000624 | Microvesicle | Follicular fluid | 23666971 |
RLID:11000625 | Microvesicle | Hepatoma cells | 23771658 |
RLID-D:11000004 | Exosome | Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue | |
RLID-D:11000264 | Microvesicle | Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine |
ncRNA Disease Information
Resource | RNA Symbol | Disease | Link |
MNDR | hsa-let-7d-5p | Diffuse large b cell lymphoma | MNDR-E-MI-01210 |
MNDR | hsa-let-7d-5p | Splenic marginal zone lymphoma | MNDR-E-MI-01211 |
MNDR | hsa-let-7d-5p | Oral squamous cell carcinoma | MNDR-E-MI-01212 |
MNDR | hsa-let-7d-5p | Lymphoma | MNDR-E-MI-01213 |
MNDR | hsa-let-7d-5p | Lymphoma non-hodgkin | MNDR-E-MI-01214 |
MNDR | hsa-let-7d-5p | Estrogen-receptor positive breast cancer | MNDR-E-MI-01215 |
MNDR | hsa-let-7d-5p | Estrogen-receptor negative breast cancer | MNDR-E-MI-01216 |
MNDR | hsa-let-7d-5p | Progesterone-receptor positive breast cancer | MNDR-E-MI-01217 |
MNDR | hsa-let-7d-5p | Progesterone-receptor negative breast cancer | MNDR-E-MI-01218 |
MNDR | hsa-let-7d-5p | Her2-receptor positive breast cancer | MNDR-E-MI-01219 |
MNDR | hsa-let-7d-5p | Breast cancer luminal | MNDR-E-MI-01220 |
MNDR | hsa-let-7d-5p | Prostate cancer | MNDR-E-MI-01221 |
MNDR | hsa-let-7d-5p | Gastric cancer | MNDR-E-MI-01222 |
MNDR | hsa-let-7d-5p | Gastric lymphoma | MNDR-E-MI-01223 |
MNDR | hsa-let-7d-5p | Alzheimer disease | MNDR-E-MI-01224 |
MNDR | hsa-let-7d-5p | Dysautonomia familial | MNDR-E-MI-01225 |
MNDR | hsa-let-7d-5p | Seizures | MNDR-E-MI-01226 |
MNDR | hsa-let-7d-5p | Cardiovascular disease | MNDR-E-MI-01227 |
MNDR | hsa-let-7d-5p | Carotid stenosis | MNDR-E-MI-01228 |
MNDR | hsa-let-7d-5p | Lung cancer | MNDR-E-MI-01229 |
MNDR | hsa-let-7d-5p | Metabolic syndrome x | MNDR-E-MI-01230 |
MNDR | hsa-let-7d-5p | Parkinson disease | MNDR-E-MI-01231 |
MNDR | hsa-let-7d-5p | Breast cancer | MNDR-E-MI-01232 |
MNDR | hsa-let-7d-5p | Pancreatic cancer | MNDR-E-MI-01233 |
MNDR | hsa-let-7d-5p | Melanoma | MNDR-E-MI-01234 |
MNDR | hsa-let-7d-5p | Nephroblastoma | MNDR-E-MI-01235 |
MNDR | hsa-let-7d-5p | Colon cancer | MNDR-E-MI-01236 |
MNDR | hsa-let-7d-5p | Ischemic attack transient | MNDR-E-MI-01237 |
MNDR | hsa-let-7d-5p | Multiple sclerosis relapsing-remitting | MNDR-E-MI-01238 |
MNDR | hsa-let-7d-5p | Familial ovarian cancer | MNDR-E-MI-01239 |
MNDR | hsa-let-7d-5p | Prostate adenocarcinoma | MNDR-E-MI-01240 |
MNDR | hsa-let-7d-5p | Carcinoma ductal breast | MNDR-E-MI-01241 |
MNDR | hsa-let-7d-5p | Glioblastoma | MNDR-E-MI-01242 |
MNDR | hsa-let-7d-5p | Glioma | MNDR-E-MI-01243 |
MNDR | hsa-let-7d-5p | Chordoma | MNDR-E-MI-01244 |
MNDR | hsa-let-7d-5p | Amyotrophic lateral sclerosis | MNDR-E-MI-01245 |
MNDR | hsa-let-7d-5p | Osteosarcoma | MNDR-E-MI-01246 |
MNDR | hsa-let-7d-5p | Liposarcoma | MNDR-E-MI-01247 |
MNDR | hsa-let-7d-5p | Meningioma | MNDR-E-MI-01248 |
MNDR | hsa-let-7d-5p | Liver cancer | MNDR-E-MI-01249 |
MNDR | hsa-let-7d-5p | Uterine cancer | MNDR-E-MI-01250 |
MNDR | hsa-let-7d-5p | Cervical adenocarcinoma | MNDR-E-MI-01251 |
MNDR | hsa-let-7d-5p | Lung squamous cell carcinoma | MNDR-E-MI-01252 |
MNDR | hsa-let-7d-5p | Non-small cell lung adenocarcinoma | MNDR-E-MI-01253 |
MNDR | hsa-let-7d-5p | Lung adenocarcinoma | MNDR-E-MI-01254 |
MNDR | hsa-let-7d-5p | Adrenocortical cancer | MNDR-E-MI-01255 |
MNDR | hsa-let-7d-5p | Thyroid carcinoma | MNDR-E-MI-01256 |
MNDR | hsa-let-7d-5p | Tuberculosis | MNDR-E-MI-01257 |
MNDR | hsa-let-7d-5p | Bladder urothelial carcinoma | MNDR-E-MI-01258 |
MNDR | hsa-let-7d-5p | Kidney renal clear cell carcinoma | MNDR-E-MI-01259 |
MNDR | hsa-let-7d-5p | Renal clear cell carcinoma | MNDR-E-MI-01260 |
MNDR | hsa-let-7d-5p | Biliary tract cancer | MNDR-E-MI-01261 |
MNDR | hsa-let-7d-5p | Cholangiocarcinoma | MNDR-E-MI-01262 |
MNDR | hsa-let-7d-5p | Esophageal cancer | MNDR-E-MI-01263 |
MNDR | hsa-let-7d-5p | Lung small cell carcinoma | MNDR-E-MI-01264 |
MNDR | hsa-let-7d-5p | Head and neck squamous cell carcinoma | MNDR-E-MI-01265 |
MNDR | hsa-let-7d-5p | Fibromyalgia | MNDR-E-MI-01266 |
MNDR | hsa-let-7d-5p | Adenoma | MNDR-E-MI-01267 |
MNDR | hsa-let-7d-5p | Breast invasive carcinoma | MNDR-E-MI-01268 |
MNDR | hsa-let-7d-5p | Early hepatocellular carcinoma | MNDR-E-MI-01269 |
MNDR | hsa-let-7d-5p | Familiar ovarian carcinoma | MNDR-E-MI-01270 |
MNDR | hsa-let-7d-5p | B-cell lymphoma | MNDR-E-MI-01271 |
MNDR | hsa-let-7d-5p | Rheumatoid arthritis | MNDR-E-MI-01272 |
MNDR | hsa-let-7d-5p | T-cell leukemia | MNDR-E-MI-01273 |
MNDR | hsa-let-7d-5p | Retinoblastoma | MNDR-E-MI-01274 |
MNDR | hsa-let-7d-5p | Neuroblastoma | MNDR-E-MI-01275 |
MNDR | hsa-let-7d-5p | Hodgkin lymphoma | MNDR-E-MI-01276 |
MNDR | hsa-let-7d-5p | Burkitt lymphoma | MNDR-E-MI-01277 |
MNDR | hsa-let-7d-5p | Tonsil cancer | MNDR-E-MI-01278 |
MNDR | hsa-let-7d-5p | Acute myelocytic leukemia | MNDR-E-MI-01279 |
MNDR | hsa-let-7d-5p | Colorectal cancer | MNDR-E-MI-01280 |
MNDR | hsa-let-7d-5p | Nasopharynx carcinoma | MNDR-E-MI-01281 |
MNDR | hsa-let-7d-5p | Multiple myeloma | MNDR-E-MI-01282 |
MNDR | hsa-let-7d-5p | Nasopharyngeal cancer | MNDR-E-MI-01283 |
MNDR | hsa-let-7d-5p | Prostatic neoplasms | MNDR-E-MI-01284 |
MNDR | hsa-let-7d-5p | Cerebral hemorrhage traumatic | MNDR-E-MI-01285 |
MNDR | hsa-let-7d-5p | Intracranial hemorrhage hypertensive | MNDR-E-MI-01286 |
MNDR | hsa-let-7d-5p | Breast cancer her3+ negative | MNDR-E-MI-01287 |
MNDR | hsa-let-7d-5p | High grade dysplastic nodule | MNDR-E-MI-01288 |
MNDR | hsa-let-7d-5p | Tubulovillous adenoma | MNDR-E-MI-01289 |
RNA Interaction Information
Resource | RNA Symbol | Species | Link | RNALocate ID |
RNAInter | ABT1 | Homo sapiens | RR00027895 |
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