Detail Information

Basic Information:


  VIRBase ID:  

HHID00039379

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7c-5p:           ADRB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7c-5p ADRB2
miRBase
Accession/Entrez ID		 MIMAT0000064 154
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADRB2R//ADRBR//B2AR//BAR//BETA2AR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADRB2
chr5:148206691-148206692(+) m6A CDS       24284625//24981863//22608085
chr5:148206721-148206722(+) m6A CDS       24284625//24981863//22608085
chr5:148206760-148206761(+) m6A CDS       24284625//24981863//22608085
chr5:148206958-148206959(+) m6A CDS       24284625//22608085
chr5:148206980-148206981(+) m6A CDS       24284625//22608085
chr5:148207124-148207125(+) m6A CDS       24284625//25456834//24981863//22608085
chr5:148207164-148207165(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr5:148207500-148207501(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207518-148207519(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207532-148207533(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207550-148207551(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207658-148207659(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr5:148207676-148207677(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207683-148207684(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207710-148207711(+) m6A 3'UTR       24981863//22608085
chr5:148208019-148208020(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208043-148208044(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208058-148208059(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208064-148208065(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7c-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Saliva     19627513
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Malignant melanoma cell line (A375)     23056502
Exosome Saliva     23302638
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|Breast milk|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Saliva|Seminal fluid     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
Nucleus HeLa cells     22058130
ADRB2
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7c-5p
6-(Bromomethyl)anthracene-1,4-dione 9995010 Drug resistant
Iodine Green 9956454 Drug resistant
8-Aminoadenosine 96851 Drug resistant
Ethyl phenylpropiolate 91516 Drug resistant
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug resistant
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug resistant
2,5-Dimethyl-1,4-benzoquinone 8718 Drug resistant
4,7-Diphenyl-1,10-phenanthroline 72812 Drug resistant
2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,8,9,11a-octahydro-8-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(Z),6Z,8S*,10E,11aR*))- 71586750 Drug resistant
Phosphotrienin 6913994 Drug resistant
Sulbentine 67686 Drug resistant
Acnistin F 6712173 Drug resistant
3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive
3-Deazauridine 54684286 Drug resistant
Incomptina B 54612584 Drug resistant
Aspiculamycin hcl 54600418 Drug sensitive
Heliangolide 5384466 Drug resistant
Acetylrolandrolide 5384465 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
Crassin, acetate 5355441 Drug resistant
Lovastatin 53232 Drug sensitive
Plumericin 5281545 Drug resistant
Eupachlorin 5281446 Drug resistant
Hookerianamide I 44587245 Drug resistant
Fastigilin B 442241 Drug resistant
Asimicinone 393461 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
4-Azido-2-chloro-3-cyanoquinoline 381915 Drug resistant
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
3-Deazaneplanocin hydrochloride 358176 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
5-(4-Azido-3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine 353605 Drug resistant
Acronycine, 2-nitro 342903 Drug resistant
Predorine 333830 Drug resistant
4-Ethyl-6-methoxy-7-(oxiran-2-ylmethoxy)quinazoline 333565 Drug resistant
Dmask 32465 Drug resistant
2-Chloro-5-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]butyl]benzenesulfonyl fluoride;ethanesulfonic acid 278692 Drug resistant
5-Fluoro-2-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide 25218614 Drug resistant
Hydrazine sulfate 24842 Drug resistant
Drostanolone propionate 224004 Drug resistant
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug resistant
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug resistant
4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Arypurine derivatives 16220246 Drug resistant
4-Oxo-4-[[(13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid 146160078 Drug resistant
N-[3-[(3-Amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1S)-18-[(2S)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide 146156820 Drug resistant
Inosine dialdehyde 135400916 Drug resistant
Abiraterone 132971 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant
Acetylenedicarboxamide 10971 Drug resistant
Marcellomycin 107861 Drug resistant
9-Chloro-2-methylellipticinium acetate, hydrate 10383530 Drug sensitive
Binimetinib 10288191 Drug resistant
6-[4-(1-Cyclohexenyl)-1,3-butadiyn-1-yl]-2(2H)-pyranone 10263039 Drug resistant
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug resistant
Tocladesine 100299 Drug resistant
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug resistant
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug resistant
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug resistant
geldanamycin, n,n'-dimethyl - Drug resistant
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant
propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-propyl- - Drug resistant
bavachyaone - Drug resistant
Methotrexate Derivative - Drug resistant
organosulfur compound - Drug resistant
somatostatin analog in diacetic form mw=1067.2 - Drug resistant
streptorubrin - Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive
pyrazino[1,2-a]benzimidazole, 1,3-diphenyl- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7c-5p
Formaldehyde 712 Drug interaction    RC00000229
Bisphenol A 6623 Drug interaction    RC00000236
Gemcitabine 60750 Drug interaction    RC00000240
Vincristine 5978 Drug interaction    RC00000235
Estradiol 5757 Drug interaction    RC00000234
Prednisolone 5755 Drug interaction    RC00000233
Eloxatine 5310940 Drug interaction    RC00000251
Sirolimus 5284616 Drug interaction    RC00000117
Tretinoin 444795 Drug interaction    RC00000250
Trichostatin A 444732 Drug interaction    RC00000249
Paroxetine 43815 Drug interaction    RC00000239
Metformin 4091 Drug interaction    RC00000232
5-Fluorouracil 3385 Drug interaction    RC00000231
Doxorubicin 31703 Drug interaction    RC00000238
Daunorubicin 30323 Drug interaction    RC00000237
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000230
Anisomycin 253602 Drug interaction    RC00000248
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000252
Nandrolone phenpropionate 229455 Drug interaction    RC00000247
Sorafenib 216239 Drug interaction    RC00000246
Erlotinib 176870 Drug interaction    RC00000245
Docetaxel 148124 Drug interaction    RC00000244
Gefitinib 123631 Drug interaction    RC00000243
Ginsenoside Rh2 119307 Drug interaction    RC00000242
Fulvestrant 104741 Drug interaction    RC00000241
Marine fungal metabolite 1386A - Drug interaction    RC00000258
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000257
CDF(analogues of curcumin) - Drug interaction    RC00000256
Bio-Oss - Drug interaction    RC00000255
Asparaginase Escherichia coli - Drug interaction    RC00000253
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00000254

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7c-5p
Interactor2: ADRB2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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