Detail Information

Basic Information:


  VIRBase ID:  

HHID00038919

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-5p:           ADRB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7a-5p ADRB2
miRBase
Accession/Entrez ID		 MIMAT0000062 154
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADRB2R//ADRBR//B2AR//BAR//BETA2AR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7a-5p
rs1396618771 chr9:94175977    T/C
rs201607747 chr9:94175962    T/A
rs1176612700 chr11:122146575    C/T
rs760725471 chr11:122146573    T/C
rs770465876 chr11:122146569    A/G
rs751394786 chr22:46112764    T/C
rs1362975136 chr11:122146584    A/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADRB2
chr5:148206691-148206692(+) m6A CDS       24284625//24981863//22608085
chr5:148206721-148206722(+) m6A CDS       24284625//24981863//22608085
chr5:148206760-148206761(+) m6A CDS       24284625//24981863//22608085
chr5:148206958-148206959(+) m6A CDS       24284625//22608085
chr5:148206980-148206981(+) m6A CDS       24284625//22608085
chr5:148207124-148207125(+) m6A CDS       24284625//25456834//24981863//22608085
chr5:148207164-148207165(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr5:148207500-148207501(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207518-148207519(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207532-148207533(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207550-148207551(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207658-148207659(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr5:148207676-148207677(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207683-148207684(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207710-148207711(+) m6A 3'UTR       24981863//22608085
chr5:148208019-148208020(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208043-148208044(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208058-148208059(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208064-148208065(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7a-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Endoplasmic reticulum HEK-293 cells     26304123
Exosome Human milk     28688106
Exosome Glioblastoma cells     19011622
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Serum     22427800
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Plasma     24937531
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     19002258
Microvesicle Glioblastoma cells     19011622
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
Polysome Human cervical cancer cell line (HeLa)     25609084
ADRB2
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7a-5p
Heliangolide 5384466 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7a-5p
Curcumin 969516 Drug interaction    RC00000193
Formaldehyde 712 Drug interaction    RC00000173
Cytarabine 6253 Drug interaction    RC00000182
Capecitabine 60953 Drug interaction    RC00000189
Gemcitabine 60750 Drug interaction    RC00000188
Prednisone 5865 Drug interaction    RC00000181
Estradiol 5757 Drug interaction    RC00000180
Eloxatine 5310940 Drug interaction    RC00000195
Imatinib 5291 Drug interaction    RC00000179
Cholecalciferol 5280795 Drug interaction    RC00000194
2-{[2-Ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 46843772 Drug interaction    RC00000199
Tretinoin 444795 Drug interaction    RC00000192
Trichostatin A 444732 Drug interaction    RC00000191
Epirubicin 41867 Drug interaction    RC00000187
Metformin 4091 Drug interaction    RC00000178
Hydroxychloroquine 3652 Drug interaction    RC00000177
Etoposide 36462 Drug interaction    RC00000186
Paclitaxel 36314 Drug interaction    RC00000185
5-Fluorouracil 3385 Drug interaction    RC00000176
Enoxacin 3229 Drug interaction    RC00000175
Doxorubicin 31703 Drug interaction    RC00000184
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000174
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000198
Caudatin 21633059 Drug interaction    RC00000197
Polylysine 162282 Drug interaction    RC00000190
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00000196
Arsenic trioxide 14888 Drug interaction    RC00000183
Trypaflavine - Drug interaction    RC00000206
platinum-based doublet chemotherapy - Drug interaction    RC00000200
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00000201
Aidi injection - Drug interaction    RC00000202
CDF(analogues of curcumin) - Drug interaction    RC00000203
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000204
Marine fungal metabolite 1386A - Drug interaction    RC00000205
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7a-5p
Cisplatin 5702198       25356050
Cisplatin 5702198       29565706
Bortezomib 387447       31063487
Doxorubicin 31703       31188543
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7a-5p
Interactor2: ADRB2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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