Basic Information
RNALocate ID: | RLID:11000564 |
RNA Symbol: | hsa-let-7a-5p |
Localization: | Exosome |
RNA Information
RNA Name: | hsa-let-7a |
RNA ID: | miRBase:MIMAT0000062 |
RNA Category: | miRNA |
Species: | Homo sapiens |
Localization Information
PubMed ID: | 24468161 |
Tissue/Cell Line: | Breast cancer cell lines (MCF-7|MDA-MB-231) |
Method: | Microarray|RT-PCR |
Quantitative real-time PCR of miRNAs performed to validate the microarray data. Down-regulation of mir-198 in MCF-Exo and up-regulation of let-7a, mir-328, mir-130a, mir-149, mir-603, and mir-92b from microarray experiments were validated by quantitative PCR analysis (*P < 0.01). Originally published in BMC Cancer. Kruger S, et al, 2014. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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Description: | Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. Data are collected from Figure 3. |
Other Subcellular Localization
RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
RLID:01001185 | Cytoplasm | Nasopharyngeal carcinoma cells | 20498841 |
RLID:01001186 | Cytoplasm | Cell line (HeLa) | 21695135 |
RLID:01001187 | Cytoplasm | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:01001188 | Endoplasmic reticulum | HEK-293 cells | 26304123 |
RLID:01001189 | Mitochondrion | Cell line (HEK-293|HeLa) | 22984580 |
RLID:01001190 | Nucleus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:01001191 | Nucleolus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
RLID:01001192 | Nucleus | Nasopharyngeal carcinoma cells | 20498841 |
RLID:01001193 | Nucleus | Colon adenocarcinoma cells | 20864815 |
RLID:01001194 | Polysome | Human cervical cancer cell line (HeLa) | 25609084 |
RLID:11000554 | Exosome | Human milk | 28688106 |
RLID:11000555 | Exosome | Glioblastoma cells | 19011622 |
RLID:11000556 | Exosome | Hetastatic gastric cancer cell line (AZ-P7a) | 20949044 |
RLID:11000557 | Exosome | Breast cancer cell line (MCF-7) | 20976003 |
RLID:11000558 | Exosome | Primary dendritic cells|T cell line (J77) | 21505438 |
RLID:11000559 | Exosome | Renal cancer cells | 21670082 |
RLID:11000560 | Exosome | Serum | 22427800 |
RLID:11000561 | Exosome | Brain tissue | 23382797 |
RLID:11000562 | Exosome | Plasma | 23663360 |
RLID:11000563 | Exosome | Human mast cell line (HMC-1) | 24009880 |
RLID:11000565 | Exosome | Plasma | 24937531 |
RLID:11000566 | Exosome | Human esophageal cancer cell line (EC9706) | 25184951 |
RLID:11000567 | Microvesicle | Plasma | 19002258 |
RLID:11000568 | Microvesicle | Glioblastoma cells | 19011622 |
RLID:11000569 | Microvesicle | Plasma | 23077538 |
RLID:11000570 | Microvesicle | Seminal plasma | 23539611 |
RLID:11000571 | Microvesicle | Hepatoma cells | 23771658 |
RLID-D:11000001 | Exosome | Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue | |
RLID-D:11000261 | Microvesicle | Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine |
ncRNA Disease Information
Resource | RNA Symbol | Disease | Link |
MNDR | hsa-let-7a-5p | Idiopathic pulmonary fibrosis | MNDR-E-MI-00423 |
MNDR | hsa-let-7a-5p | Splenic marginal zone lymphoma | MNDR-E-MI-00424 |
MNDR | hsa-let-7a-5p | Multiple sclerosis chronic progressive | MNDR-E-MI-00425 |
MNDR | hsa-let-7a-5p | Oral squamous cell carcinoma | MNDR-E-MI-00426 |
MNDR | hsa-let-7a-5p | Large cell neuroendocrine cancer | MNDR-E-MI-00427 |
MNDR | hsa-let-7a-5p | Medulloblastoma | MNDR-E-MI-00428 |
MNDR | hsa-let-7a-5p | B cell lymphoma of malt type | MNDR-E-MI-00429 |
MNDR | hsa-let-7a-5p | Uterine corpus endometrial carcinoma | MNDR-E-MI-00430 |
MNDR | hsa-let-7a-5p | Lymphoma | MNDR-E-MI-00431 |
MNDR | hsa-let-7a-5p | Lymphoma non-hodgkin | MNDR-E-MI-00432 |
MNDR | hsa-let-7a-5p | Estrogen-receptor positive breast cancer | MNDR-E-MI-00433 |
MNDR | hsa-let-7a-5p | Estrogen-receptor negative breast cancer | MNDR-E-MI-00434 |
MNDR | hsa-let-7a-5p | Progesterone-receptor positive breast cancer | MNDR-E-MI-00435 |
MNDR | hsa-let-7a-5p | Progesterone-receptor negative breast cancer | MNDR-E-MI-00436 |
MNDR | hsa-let-7a-5p | Her2-receptor positive breast cancer | MNDR-E-MI-00437 |
MNDR | hsa-let-7a-5p | Breast cancer luminal | MNDR-E-MI-00438 |
MNDR | hsa-let-7a-5p | Precursor cell lymphoblastic leukemia-lymphoma | MNDR-E-MI-00439 |
MNDR | hsa-let-7a-5p | Lupus nephritis | MNDR-E-MI-00440 |
MNDR | hsa-let-7a-5p | Prostate cancer | MNDR-E-MI-00441 |
MNDR | hsa-let-7a-5p | Chronic lymphocytic leukemia | MNDR-E-MI-00442 |
MNDR | hsa-let-7a-5p | Gastric cancer | MNDR-E-MI-00443 |
MNDR | hsa-let-7a-5p | Gastric lymphoma | MNDR-E-MI-00444 |
MNDR | hsa-let-7a-5p | Alzheimer disease | MNDR-E-MI-00445 |
MNDR | hsa-let-7a-5p | Intracranial aneurysm | MNDR-E-MI-00446 |
MNDR | hsa-let-7a-5p | Sarcoma | MNDR-E-MI-00447 |
MNDR | hsa-let-7a-5p | Dysautonomia familial | MNDR-E-MI-00448 |
MNDR | hsa-let-7a-5p | Malaria | MNDR-E-MI-00449 |
MNDR | hsa-let-7a-5p | Leukemia | MNDR-E-MI-00450 |
MNDR | hsa-let-7a-5p | Huntington disease | MNDR-E-MI-00451 |
MNDR | hsa-let-7a-5p | Cardiovascular disease | MNDR-E-MI-00452 |
MNDR | hsa-let-7a-5p | Carotid stenosis | MNDR-E-MI-00453 |
MNDR | hsa-let-7a-5p | Moyamoya disease | MNDR-E-MI-00454 |
MNDR | hsa-let-7a-5p | Uterine leiomyoma | MNDR-E-MI-00455 |
MNDR | hsa-let-7a-5p | Lung cancer | MNDR-E-MI-00456 |
MNDR | hsa-let-7a-5p | Metabolic syndrome x | MNDR-E-MI-00457 |
MNDR | hsa-let-7a-5p | Parkinson disease | MNDR-E-MI-00458 |
MNDR | hsa-let-7a-5p | Niemann-pick disease | MNDR-E-MI-00459 |
MNDR | hsa-let-7a-5p | Colon carcinoma | MNDR-E-MI-00460 |
MNDR | hsa-let-7a-5p | Breast cancer | MNDR-E-MI-00461 |
MNDR | hsa-let-7a-5p | Squamous cell carcinoma | MNDR-E-MI-00462 |
MNDR | hsa-let-7a-5p | Pancreatic cancer | MNDR-E-MI-00463 |
MNDR | hsa-let-7a-5p | Malignant melanoma | MNDR-E-MI-00464 |
MNDR | hsa-let-7a-5p | Lesch-nyhan syndrome | MNDR-E-MI-00465 |
MNDR | hsa-let-7a-5p | Nephroblastoma | MNDR-E-MI-00466 |
MNDR | hsa-let-7a-5p | Colon cancer | MNDR-E-MI-00467 |
MNDR | hsa-let-7a-5p | Colon adenocarcinoma | MNDR-E-MI-00468 |
MNDR | hsa-let-7a-5p | Multiple sclerosis | MNDR-E-MI-00469 |
MNDR | hsa-let-7a-5p | Relapsing-remitting multiple sclerosis | MNDR-E-MI-00470 |
MNDR | hsa-let-7a-5p | Familial ovarian cancer | MNDR-E-MI-00471 |
MNDR | hsa-let-7a-5p | Prostate adenocarcinoma | MNDR-E-MI-00472 |
MNDR | hsa-let-7a-5p | Laryngeal cancer | MNDR-E-MI-00473 |
MNDR | hsa-let-7a-5p | Laryngeal carcinoma | MNDR-E-MI-00474 |
MNDR | hsa-let-7a-5p | Myoma | MNDR-E-MI-00475 |
MNDR | hsa-let-7a-5p | Glioblastoma | MNDR-E-MI-00476 |
MNDR | hsa-let-7a-5p | Glioma | MNDR-E-MI-00477 |
MNDR | hsa-let-7a-5p | Chronic obstructive pulmonary disease | MNDR-E-MI-00478 |
MNDR | hsa-let-7a-5p | Nemaline myopathy | MNDR-E-MI-00479 |
MNDR | hsa-let-7a-5p | Chordoma | MNDR-E-MI-00480 |
MNDR | hsa-let-7a-5p | Lipoma | MNDR-E-MI-00481 |
MNDR | hsa-let-7a-5p | Amyotrophic lateral sclerosis | MNDR-E-MI-00482 |
MNDR | hsa-let-7a-5p | Temporal lobe epilepsy | MNDR-E-MI-00483 |
MNDR | hsa-let-7a-5p | Osteosarcoma | MNDR-E-MI-00484 |
MNDR | hsa-let-7a-5p | Ewing sarcoma | MNDR-E-MI-00485 |
MNDR | hsa-let-7a-5p | Chondrosarcoma | MNDR-E-MI-00486 |
MNDR | hsa-let-7a-5p | Liposarcoma | MNDR-E-MI-00487 |
MNDR | hsa-let-7a-5p | Pancreatic ductal adenocarcinoma | MNDR-E-MI-00488 |
MNDR | hsa-let-7a-5p | Lafora disease | MNDR-E-MI-00489 |
MNDR | hsa-let-7a-5p | Liver cancer | MNDR-E-MI-00490 |
MNDR | hsa-let-7a-5p | Pituitary adenoma | MNDR-E-MI-00491 |
MNDR | hsa-let-7a-5p | Lung squamous cell carcinoma | MNDR-E-MI-00492 |
MNDR | hsa-let-7a-5p | Carcinoma lung non-small-cell | MNDR-E-MI-00493 |
MNDR | hsa-let-7a-5p | Lung adenocarcinoma | MNDR-E-MI-00494 |
MNDR | hsa-let-7a-5p | Adrenocortical cancer | MNDR-E-MI-00495 |
MNDR | hsa-let-7a-5p | Thyroid follicular adenoma and carcinoma | MNDR-E-MI-00496 |
MNDR | hsa-let-7a-5p | Tuberculosis | MNDR-E-MI-00497 |
MNDR | hsa-let-7a-5p | Scleroderma | MNDR-E-MI-00498 |
MNDR | hsa-let-7a-5p | Myasthenia gravis | MNDR-E-MI-00499 |
MNDR | hsa-let-7a-5p | Myasthenia gravis autoimmune experimental | MNDR-E-MI-00500 |
MNDR | hsa-let-7a-5p | Carcinoma renal cell | MNDR-E-MI-00501 |
MNDR | hsa-let-7a-5p | Clear cell renal cell carcinoma | MNDR-E-MI-00502 |
MNDR | hsa-let-7a-5p | Biliary tract cancer | MNDR-E-MI-00503 |
MNDR | hsa-let-7a-5p | Cholangiocarcinoma | MNDR-E-MI-00504 |
MNDR | hsa-let-7a-5p | Esophageal cancer | MNDR-E-MI-00505 |
MNDR | hsa-let-7a-5p | Liver cirrhosis | MNDR-E-MI-00506 |
MNDR | hsa-let-7a-5p | Synovial sarcoma | MNDR-E-MI-00507 |
MNDR | hsa-let-7a-5p | Growth hormone-secreting pituitary adenoma | MNDR-E-MI-00508 |
MNDR | hsa-let-7a-5p | Fibromyalgia | MNDR-E-MI-00509 |
MNDR | hsa-let-7a-5p | Encephalomyelitis | MNDR-E-MI-00510 |
MNDR | hsa-let-7a-5p | Pulmonary arterial hypertension | MNDR-E-MI-00511 |
MNDR | hsa-let-7a-5p | Adenoma | MNDR-E-MI-00512 |
MNDR | hsa-let-7a-5p | Early hepatocellular carcinoma | MNDR-E-MI-00513 |
MNDR | hsa-let-7a-5p | Embryonal cancer | MNDR-E-MI-00514 |
MNDR | hsa-let-7a-5p | Familiar ovarian carcinoma | MNDR-E-MI-00515 |
MNDR | hsa-let-7a-5p | B-cell lymphoma | MNDR-E-MI-00516 |
MNDR | hsa-let-7a-5p | Rheumatoid arthritis | MNDR-E-MI-00517 |
MNDR | hsa-let-7a-5p | T-cell leukemia | MNDR-E-MI-00518 |
MNDR | hsa-let-7a-5p | Malignant pleural mesothelioma | MNDR-E-MI-00519 |
MNDR | hsa-let-7a-5p | Retinoblastoma | MNDR-E-MI-00520 |
MNDR | hsa-let-7a-5p | Neuroblastoma | MNDR-E-MI-00521 |
MNDR | hsa-let-7a-5p | Hodgkin lymphoma | MNDR-E-MI-00522 |
MNDR | hsa-let-7a-5p | Burkitt lymphoma | MNDR-E-MI-00523 |
MNDR | hsa-let-7a-5p | Neuromyelitis optica | MNDR-E-MI-00524 |
MNDR | hsa-let-7a-5p | Acute myeloid leukemia | MNDR-E-MI-00525 |
MNDR | hsa-let-7a-5p | Colorectal cancer | MNDR-E-MI-00526 |
MNDR | hsa-let-7a-5p | Nasopharyngeal carcinoma | MNDR-E-MI-00527 |
MNDR | hsa-let-7a-5p | Nasopharynx carcinoma | MNDR-E-MI-00528 |
MNDR | hsa-let-7a-5p | Multiple myeloma | MNDR-E-MI-00529 |
MNDR | hsa-let-7a-5p | Ovarian epithelial cancer | MNDR-E-MI-00530 |
MNDR | hsa-let-7a-5p | Esophageal squamous cell carcinoma | MNDR-E-MI-00531 |
MNDR | hsa-let-7a-5p | Hamartoma | MNDR-E-MI-00532 |
MNDR | hsa-let-7a-5p | Nasopharyngeal cancer | MNDR-E-MI-00533 |
MNDR | hsa-let-7a-5p | Prostatic neoplasms | MNDR-E-MI-00534 |
MNDR | hsa-let-7a-5p | Sleep deprivation | MNDR-E-MI-00535 |
MNDR | hsa-let-7a-5p | Aids dementia complex | MNDR-E-MI-00536 |
MNDR | hsa-let-7a-5p | Cerebral hemorrhage traumatic | MNDR-E-MI-00537 |
MNDR | hsa-let-7a-5p | Subarachnoid hemorrhage traumatic | MNDR-E-MI-00538 |
MNDR | hsa-let-7a-5p | Intracranial hemorrhage hypertensive | MNDR-E-MI-00539 |
MNDR | hsa-let-7a-5p | Pituitary acth hypersecretion | MNDR-E-MI-00540 |
MNDR | hsa-let-7a-5p | Chronic pain | MNDR-E-MI-00541 |
MNDR | hsa-let-7a-5p | Stroke lacunar | MNDR-E-MI-00542 |
MNDR | hsa-let-7a-5p | Breast cancer her3+ negative | MNDR-E-MI-00543 |
MNDR | hsa-let-7a-5p | High grade dysplastic nodule | MNDR-E-MI-00544 |
MNDR | hsa-let-7a-5p | Malignant cholangiocyte | MNDR-E-MI-00545 |
RNA Interaction Information
Resource | RNA Symbol | Species | Link | RNALocate ID |
RNAInter | ACVR1B | Homo sapiens | RR00038908 |
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