Basic Information:

  VIRBase ID:  

HHID00038509

  Virus:  

Human alphaherpesvirus 1 (HSV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      NEAT1:  NR_028272          CXCL8:  NM_000584     

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Interactor Information:

	Interactor1	Interactor2
Symbol	NEAT1	CXCL8
miRBase Accession/Entrez ID	283131	3576
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	mRNA
Alias	LINC00084//NCRNA00084//TncRNA//VINC	GCP-1//GCP1//IL8//LECT//LUCT//LYNAP//MDNCF//MONAP//NAF//NAP-1//NAP1//SCYB8

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	NEAT1	chr11: 65206907     chr11: 65206904     chr11: 65206899     chr11: 65206898     chr11: 65206890     chr11: 65206881     chr11: 65207527     chr11: 65207508     chr11: 65215409     chr11: 65215399     chr11: 65215396     chr11: 65217194     chr11: 65215431     chr11: 65208857     chr11: 65208856     chr11: 65208855     chr11: 65208818     chr11: 65208815     chr11: 65208301     chr11: 65208279     chr11: 65208253     chr11: 65208239     chr11: 65208205     chr11: 65208201     chr11: 65208195     chr11: 65215326     chr11: 65215297     chr11: 65214997     chr11: 65214974     chr11: 65214907     chr11: 65214679     chr11: 65214671     chr11: 65214601     chr11: 65188315     chr11: 65188285     chr11: 65208173     chr11: 65208169     chr11: 65208158     chr11: 65208152     chr11: 65188097     chr11: 65188160     chr11: 65208132     chr11: 65208128     chr11: 65208050     chr11: 65207839     chr11: 65207820     chr11: 65207799     chr11: 65207798     chr11: 65207690     chr11: 65208919     chr11: 65207526     chr11: 65207519     chr11: 65207472     chr11: 65207464     chr11: 65207127     chr11: 65207109     chr11: 65207078     chr11: 65207063     chr11: 65207059     chr11: 65207050     chr11: 65207042     chr11: 65208156     chr11: 65207039     chr11: 65207037     chr11: 65207036     chr11: 65207005     chr11: 65207004     chr11: 65207001     chr11: 65206981     chr11: 65208870     chr11: 65208874     chr11: 65207834     chr11: 65208889     chr11: 65208896     chr11: 65208897     chr11: 65208898     chr11: 65208910     chr11: 65208912     chr11: 65210090     chr11: 65210098     chr11: 65210103     chr11: 65210124     chr11: 65210133     chr11: 65210136     chr11: 65210149     chr11: 65210172     chr11: 65210173     chr11: 65210174     chr11: 65210259     chr11: 65206975     chr11: 65206970     chr11: 65206947     chr11: 65206936     chr11: 65208888

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NEAT1	chr11:65207834(+) A-I      ncRNA chr11:65210259(+) A-I      ncRNA chr11:65208050(+) A-I      ncRNA chr11:65208896(+) A-I      ncRNA chr11:65208152(+) A-I      ncRNA chr11:65210149(+) A-I      ncRNA chr11:65208857(+) A-I      ncRNA chr11:65208169(+) A-I      ncRNA chr11:65208279(+) A-I      ncRNA chr11:65208855(+) A-I      ncRNA chr11:65208874(+) A-I      ncRNA chr11:65208132(+) A-I      ncRNA chr11:65208239(+) A-I      ncRNA chr11:65208158(+) A-I      ncRNA chr11:65208201(+) A-I      ncRNA chr11:65208173(+) A-I      ncRNA chr11:65208205(+) A-I      ncRNA chr11:65208195(+) A-I      ncRNA chr11:65208128(+) A-I      ncRNA chr11:65208156(+) A-I      ncRNA chr11:65208301(+) A-I      ncRNA chr11:65208253(+) A-I      ncRNA chr11:65210172(+) A-I      ncRNA chr11:65210098(+) A-I      ncRNA chr11:65207839(+) A-I      ncRNA chr11:65207798(+) A-I      ncRNA chr11:65207820(+) A-I      ncRNA chr11:65210103(+) A-I      ncRNA chr11:65210124(+) A-I      ncRNA chr11:65210173(+) A-I      ncRNA chr11:65208910(+) A-I      ncRNA chr11:65208897(+) A-I      ncRNA chr11:65207799(+) A-I      ncRNA chr11:65208889(+) A-I      ncRNA chr11:65207690(+) A-I      ncRNA chr11:65210174(+) A-I      ncRNA chr11:65210136(+) A-I      ncRNA chr11:65208888(+) A-I      ncRNA chr11:65210133(+) A-I      ncRNA chr11:65208898(+) A-I      ncRNA chr11:65208870(+) A-I      ncRNA chr11:65208856(+) A-I      ncRNA chr11:65210090(+) A-I      ncRNA chr11:65208815(+) A-I      ncRNA chr11:65208912(+) A-I      ncRNA chr11:65208919(+) A-I      ncRNA chr11:65208818(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NEAT1	chr11:65192925(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NEAT1	chr11:65190344-65190345(+) m6A exon       24284625//24209618//24981863//22575960 chr11:65190421-65190422(+) m6A exon       24284625//24209618//24981863//27773535//22575960 chr11:65190436-65190437(+) m6A exon       24284625//24209618//24981863//27773535//22575960 chr11:65190488-65190489(+) m6A exon       24284625//24209618//24981863//22575960 chr11:65190536-65190537(+) m6A exon       24284625//24209618//24981863//22575960 chr11:65190765-65190766(+) m6A exon       24284625//24209618//22575960 chr11:65190779-65190780(+) m6A exon       24284625//24209618//22575960 chr11:65190811-65190812(+) m6A exon       24284625//24209618//22575960 chr11:65190816-65190817(+) m6A exon       24284625//24209618//22575960 chr11:65191038-65191039(+) m6A exon//intron       24284625//24209618//22575960 chr11:65191068-65191069(+) m6A exon//intron       24284625//24209618//24981863//22575960 chr11:65191116-65191117(+) m6A exon       24284625//24209618//24981863//26404942//22575960 chr11:65191140-65191141(+) m6A exon//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr11:65191201-65191202(+) m6A exon//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr11:65191230-65191231(+) m6A exon//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr11:65191413-65191414(+) m6A exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65191457-65191458(+) m6A exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65191465-65191466(+) m6A exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65191512-65191513(+) m6A exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65191846-65191847(+) m6A exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65191878-65191879(+) m6A exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65191931-65191932(+) Cm exon       - chr11:65192060-65192061(+) m6A exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65192271-65192272(+) m6A exon       24284625//24209618//24981863//27773535 chr11:65192277-65192278(+) m6A exon       24284625//24209618//24981863 chr11:65192327-65192328(+) m6A exon       24284625//24209618//24981863//27773535//22575960 chr11:65192365-65192366(+) m6A exon       24284625//24209618//24981863//22575960 chr11:65192453-65192454(+) m1A exon       26863196//26863410 chr11:65192637-65192638(+) m6A exon       24284625//24209618//24981863//27773535 chr11:65192656-65192657(+) m6A exon       24284625//24209618//24981863//27773535 chr11:65192669-65192670(+) m6A exon       24284625//24209618//24981863//27773535 chr11:65192677-65192678(+) m6A exon       24284625//24209618//24981863//27773535 chr11:65192685-65192686(+) m6A exon       24284625//24209618//24981863//27773535 chr11:65192721-65192722(+) m6A exon       24284625//24209618//24981863//27773535 chr11:65192743-65192744(+) m6A exon       24284625//24981863//27773535 chr11:65192775-65192776(+) m6A exon       24284625//24981863//27773535 chr11:65192850-65192851(+) m6A exon       24284625//24981863//22575960 chr11:65192929-65192930(+) m6A exon       24284625//24981863//22575960 chr11:65192993-65192994(+) m6A exon       24981863//22575960 chr11:65193081-65193082(+) m6A exon       26404942//22575960 chr11:65193219-65193220(+) m6A exon//intron       22575960 chr11:65193354-65193355(+) m6A exon//intron       27773535//22575960 chr11:65193441-65193442(+) m6A exon//intron       24981863//26404942//27773535//22575960 chr11:65193453-65193454(+) m6A exon//intron       24981863//26404942//27773535//22575960 chr11:65193479-65193480(+) m6A exon//intron       24981863//26404942//27773535//22575960 chr11:65193484-65193485(+) m6A exon//intron       24981863//26404942//27773535//22575960 chr11:65193559-65193560(+) m6A exon       24981863//26404942//22575960 chr11:65193778-65193779(+) m6A exon       26404942//27773535//22575960 chr11:65193861-65193862(+) m6A exon       26404942//27773535//22575960 chr11:65193913-65193914(+) m6A exon       27773535//22575960 chr11:65194617-65194618(+) m6A exon       24284625//22575960 chr11:65194640-65194641(+) m6A exon       24284625//22575960 chr11:65194705-65194706(+) m6A exon       24284625//22575960 chr11:65194843-65194844(+) m6A exon       24284625//22575960 chr11:65194849-65194850(+) m6A exon       24284625//22575960 chr11:65194862-65194863(+) m6A exon       24284625//22575960 chr11:65195052-65195053(+) m6A exon       24284625//22575960 chr11:65195155-65195156(+) m6A exon       24284625//24981863 chr11:65195240-65195241(+) m6A exon       24284625//24981863 chr11:65195457-65195458(+) m6A exon       22575960 chr11:65195728-65195729(+) m6A exon       22575960 chr11:65195808-65195809(+) m6A exon       22575960 chr11:65195899-65195900(+) m6A exon       22575960 chr11:65195938-65195939(+) m6A exon       22575960 chr11:65196010-65196011(+) m6A exon       22575960 chr11:65196846-65196847(+) m6A exon       22575960 chr11:65196919-65196920(+) m6A exon       22575960 chr11:65197281-65197282(+) m6A exon       24284625 chr11:65197348-65197349(+) m6A exon       24284625//22575960 chr11:65197420-65197421(+) m6A exon       24284625//22575960 chr11:65197507-65197508(+) m6A exon       22575960 chr11:65197546-65197547(+) m6A exon       22575960 chr11:65197670-65197671(+) m6A exon       24284625//22575960 chr11:65197788-65197789(+) m6A exon       24284625 chr11:65203206-65203207(+) m6A exon       22575960 chr11:65203217-65203218(+) m6A exon       22575960 chr11:65203287-65203288(+) m6A exon       22575960 chr11:65203641-65203642(+) m6A exon       24284625//22575960 chr11:65203689-65203690(+) m6A exon       24284625//22575960 chr11:65205409-65205410(+) m6A exon       22575960 chr11:65205615-65205616(+) m6A exon       24284625//22575960 chr11:65205644-65205645(+) m6A exon       22575960 chr11:65205658-65205659(+) m6A exon       22575960 chr11:65207077-65207078(+) m6A exon       24284625//24981863 chr11:65207132-65207133(+) m6A exon       24284625//24981863//27773535 chr11:65207915-65207916(+) m6A exon       24284625//24981863//27773535//22575960 chr11:65207939-65207940(+) m6A exon       24284625//24981863//27773535//22575960 chr11:65207959-65207960(+) m6A exon       24284625//24981863//27773535//22575960 chr11:65207964-65207965(+) m6A exon       24284625//24981863//27773535//22575960 chr11:65207977-65207978(+) m6A exon       24284625//24981863//27773535//22575960 chr11:65208052-65208053(+) m6A exon       24284625//24981863//27773535//22575960 chr11:65208067-65208068(+) Am exon       - chr11:65208114-65208115(+) m6A exon       24284625//24981863//27773535 chr11:65208137-65208138(+) m6A exon       24284625//24981863 chr11:65208375-65208376(+) m6A exon       22575960 chr11:65208427-65208428(+) m6A exon       22575960 chr11:65208472-65208473(+) m6A exon       22575960 chr11:65209566-65209567(+) m6A exon       24284625//24981863//22575960 chr11:65209667-65209668(+) m6A exon       24284625//22575960 chr11:65209722-65209723(+) m6A exon       24284625//22575960 chr11:65209814-65209815(+) m6A exon       24284625//22575960 chr11:65209836-65209837(+) m6A exon       22575960 chr11:65209877-65209878(+) m6A exon       22575960 chr11:65209970-65209971(+) m6A exon       22575960 chr11:65210063-65210064(+) m6A exon       22575960 chr11:65210756-65210757(+) m6A exon       22575960 chr11:65211492-65211493(+) m6A exon       22575960 chr11:65211700-65211701(+) m6A exon       24284625//22575960 chr11:65211732-65211733(+) m6A exon       24284625//22575960 chr11:65211938-65211939(+) m6A exon       22575960 chr11:65212016-65212017(+) m6A exon       24284625//22575960 chr11:65212021-65212022(+) m6A exon       24284625//22575960 chr11:65212035-65212036(+) m6A exon       24284625//22575960 chr11:65212064-65212065(+) m6A exon       24284625//22575960 chr11:65212119-65212120(+) m6A exon       24284625//22575960 chr11:65212212-65212213(+) m6A exon       24284625//22575960 chr11:65212331-65212332(+) Gm exon       - chr11:65212391-65212392(+) m6A exon       22575960 chr11:65212400-65212401(+) m6A exon       22575960 chr11:65212732-65212733(+) m6A exon       22575960 chr11:65212806-65212807(+) m6A exon       22575960 chr11:65212829-65212830(+) m6A exon       22575960
	CXCL8	chr4:74606289-74606290(+) m6A 5'UTR//exon       24981863//26404942 chr4:74606299-74606300(+) m6A 5'UTR//exon       24981863//26404942 chr4:74606324-74606325(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606341-74606342(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606354-74606355(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606373-74606374(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74607286-74607287(+) m6A CDS//exon       27773535 chr4:74607308-74607309(+) m6A CDS//exon       27773535 chr4:74607319-74607320(+) m6A CDS//exon       26404942//27773535 chr4:74607346-74607347(+) m6A CDS//exon       26404942//27773535 chr4:74607367-74607368(+) m6A CDS//exon       26404942//27773535 chr4:74607434-74607435(+) m6A exon//intron       26404942 chr4:74608331-74608332(+) m6A 3'UTR       27773535 chr4:74608370-74608371(+) m6A 3'UTR       27773535 chr4:74608413-74608414(+) m6A 3'UTR       27773535 chr4:74608510-74608511(+) m6A 3'UTR       26404942//27773535 chr4:74608579-74608580(+) m6A 3'UTR       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NEAT1	Chromatin HeLa cells     28536419 Chromatin HeLa-S3 cells|K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Plasma     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Cell line (HeLa)     28484218 Nucleus HeLa cells     28846091 Nucleus Human colon carcinoma-derived cell line (HCT-116)     29345294 Nucleus HeLa cells     31044562 Nucleus Fibroblasts|Lymphoblasts     17270048 Nucleus HeLa cells     19217333 Nucleus Placenta     24280234 Nucleus Colon cancer cells     24393600 Nucleus BJ foreskin fibroblasts     25155612 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Paraspeckles Epithelial adenocarcinoma cell line (HeLa)     19217333 Paraspeckles Cell line (HeLa)     21240286 Paraspeckles HeLa cells     26979837 Paraspeckles VCaP cells     25415230 Paraspeckles in the nucleus Cell line (HCT-116|MCF-7)     27378782
	CXCL8	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	NEAT1	Vincristine 5978 Drug resistant

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	NEAT1	Vincristine 5978 Drug interaction    RC00000026

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	NEAT1	6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119 Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773 1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054 epsilon-Rhodomycinone       99207 Tivozanib       9911830 Zibotentan       9910224 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786 PI-103       9884685 Osi-930       9868037 5Z-7-Oxozeaenol       9863776 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940 Midostaurin       9829523 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577 Asperuloside       84298 Phenformin       8249 Bexarotene       82146 (E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717 Neplanocin A       72968 N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473 (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848 Panobinostat       6918837 Belinostat       6918638 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454 Temsirolimus       6918289 Daporinad       6914657 N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167 Tanespimycin       6505803 Ispinesib mesylate       6450816 Axitinib       6450551 Dacinostat       6445533 Cytarabine       6253 Irinotecan       60838 Gemcitabine       60750 Topotecan       60700 Mitomycin       5746 1-[4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea;hydrochloride       57391096 (2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337 l-685,458       5479543 Artelastochromene       5471310 3-Hexenediamide       5458982 Temozolomide       5394 (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one       5382674 Bleomycin a2       5360373 N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664 Palbociclib       5330286 N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361 1-[4-[Methyl-[2-[(3-Sulfamoylphenyl)amino]pyrimidin-4-Yl]amino]phenyl]-3-[4-(Trifluoromethyloxy)phenyl]urea       5329829 Sunitinib       5329102 Bosutinib       5328940 Vorinostat       5311 Cucurbitacin B       5281316 Bryostatin 1       5280757 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396 Bis(2-hydroxy-1-naphthyl) disulfide       521106 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032 Tubastatin A       49850262 Alectinib       49806720 Shikonin       479503 2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432 (S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate       46907787 3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516 N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454 4-Epi-7-aza-phomopsolide E       45028013 N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660 Tretinoin       444795 Dabrafenib       44462760 Cyclamin       441916 Refametinib       44182295 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid       44137675 Foretinib       42642645 Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640 (2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol       42623900 Artocarpesin       399491 3,5-Dihydroxy-4-methyl-6-(3-methylbut-2-enyl)-6-(2-methylpropanoyl)-2-[[2,4,6-trihydroxy-3-(3-methylbut-2-enyl)-5-(2-methylpropanoyl)phenyl]methyl]cyclohexa-2,4-dien-1-one       391023 3,6-Bis(methylsulfanyl)-1,2,4,5-tetrazine       384504 Kenpaullone       3820 4-Azido-3-chloro-1-methyl-2-quinolone       381911 1-Azido-2-(2-pyridyl)-phenalen-3-one       381904 N-Methyl-bis,3'-(2-nitroimidazol-1H-yl)propylamine       379960 2,3,6-Tribromo-7-chloro-3,7-dimethyloct-1-ene       377930 Etoposide       36462 3-Chloropropyl disulfide       355642 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide       3463933 5-Fluorouracil       3385 Embelin       3218 Digimed       3061 Tamoxifen       2733526 Virosecurinine       267769 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965 2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557 Brucine, dihydro-       251913 Omipalisib       25167777 Ruxolitinib       25126798 Cabozantinib       25102847 Navitoclax       24978538 Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314 Quizartinib       24889392 Ponatinib       24826799 Vismodegib       24776445 4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860 Cudc-101       24756910 Adenine, 9,9'ethylenebis(N,N-dimethyl-       243877 N 4-(2-Phenylbenzothiazole),N'(p-chlorophenyl)thiourea       24202662 Vincaleukoblastine       241903 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719 Olaparib       23725625 Propiophenone, 3-phenyl-3-piperidino-       219163 Nutlin-3       216345 Lenalidomide       216326 Cedronine       183337 Erlotinib       176870 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388 Gsk-690693       16725726 Fedratinib       16722836 Obatoclax mesylate       16681698 N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342 2-[4-(7-Chloroquinoxalin-2-yl)oxyphenoxy]propanoic acid       148183 Docetaxel       148124 1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401 2'-Deoxyuridine       13712 (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062 Luminespib       135539077 (3Z)-3-[[4-(1,2,4-Triazol-1-yl)anilino]methylidene]-1H-indol-2-one       135506564 Iodinin       135441735 Cytallene       135436546 Pac-1       135421197 4-[[5-(Dimethylamino)-2-hydroxy-1H-indol-3-yl]methylideneamino]benzenesulfonamide       135421139 4-[1-(2-Hydroxy-1H-indol-3-yl)ethylideneamino]benzenesulfonamide       135421134 N-[4-[[(Z)-(2-Oxo-1H-indol-3-ylidene)methyl]amino]phenyl]methanesulfonamide       135418262 Osi-027       135398516 Dovitinib       135398510 Akt inhibitor VIII       135398501 Hydroxychloroquine sulfate       12947 Methotrexate       126941 Lestaurtinib       126565 Veliparib       11960529 Uprolide H       11824652 BAY 61-3606 dihydrochloride       11784504 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511 Trametinib       11707110 4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725 Idelalisib       11625818 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559 Serdemetan       11609586 Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964 5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598 Linifanib       11485656 N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430 Ryanodine       11317883 Amuvatinib       11282283 (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667 7-Ethyl-10-hydroxycamptothecin       104842 VX-702       10341154 Benzimidazole-urea, 34       10186269 Afatinib       10184653 Selumetinib       10127622 1,3-Benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile       10109823 N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147 Masitinib       10074640 1,1'-biphenyl, 4,4'bis(thiomethyl)-       - ;1-(6-chloro-1H-benzo[d]imidazol-2-yl)-3-(4-methoxypheny...       - ;2-(3-chloro-4-fluorophenyl)-5-(3-(3,4,5-trimethoxypheny...       - 3-(2,5-dimethoxy-phenylsulfanyl)-1,3-diphenyl-propan-1-one       - 3,3'-di(5,5'-difluoroindolyl)methane       - 4h-cyclopenta[c]thiophen-4-one, 1,3-dichloro-       - ;5,6-dichloro-2-(3-(4-methoxyphenyl)imidazo[1,5-a]pyridi...       - Bleomycin (50 uM)       - Cetuximab       - Cisplatin       - ellipticine, 6-(3-aminopropyl)-, dihydrochloride       - fenakrom blue xr       - Genentech Cpd 10       - hydroxybenzoestra-1,3,5(10),16-tetraen-3-ol       - ICL1100013       - imidazole-5-one deri.       - JW-7-24-1       - KIN001-236       - KIN001-244       - KIN001-260       - KIN001-270       - MPS-1-IN-1       - NPK76-II-72-1       - Nutlin-3a (-)       - QL-X-138       - QL-XI-92       - QL-XII-47       - SB52334       - sjl 778       - THZ-2-102-1       - TL-1-85       - TL-2-105       - VNLG/124       - WZ3105       - XMD13-2       - XMD14-99       - XMD15-27       -

Interaction Network (The top 100 interactions):

Interactor1: NEAT1
Interactor2: CXCL8

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	24507715	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	A549 cells//HeLa TO cells	Interactor2 expression	None
Description	Here we show that nuclear enriched abundant transcript 1 (NEAT1), an essential LncRNA for the formation of nuclear body paraspeckles, is induced by influenza virus and herpes simplex virus infection as well as by Toll-like receptor3-p38 pathway-triggered poly I:C stimulation, resulting in excess formation of paraspeckles.We found that NEAT1 facilitates the expression of antiviral genes including cytokines such as interleukin-8 (IL8).