Detail Information

Basic Information:


  VIRBase ID:  

HHID00026715

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:           MYC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7g-3p MYC
miRBase
Accession/Entrez ID		 MIMAT0004584 4609
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bHLHe39//c-Myc//MRTL//MYCC

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7g-3p
rs1022640944 chr3:52268290    G/A
rs1166657040 chr3:52268299    A/G
rs1356748432 chr3:52268293    C/G

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MYC
chr8:128752212(+) C-T intron -    22484847
chr8:128752228(+) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MYC
chr8:128747856-128747857(+) m6A 5'UTR       24284625
chr8:128747998-128747999(+) m6A 5'UTR       24284625
chr8:128748018-128748019(+) m6A 5'UTR       24284625
chr8:128748315-128748316(+) m6A 5'UTR//intron       24284625//24981863
chr8:128748596-128748597(+) Y 5'UTR//intron       26075521
chr8:128748673-128748674(+) m6A 5'UTR//intron       24284625//24981863//26404942//22575960
chr8:128748711-128748712(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748776-128748777(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748798-128748799(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748864-128748865(+) m6A 5'UTR//CDS       24284625//24981863//22575960
chr8:128750539-128750540(+) m6A 5'UTR//CDS       24284625//24981863//26404942//22575960
chr8:128750596-128750597(+) m6A CDS       24284625//24981863//26404942//22575960
chr8:128750761-128750762(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750833-128750834(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750842-128750843(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750874-128750875(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750887-128750888(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750902-128750903(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750980-128750981(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128750995-128750996(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128751142-128751143(+) m6A CDS       24284625//22575960
chr8:128751237-128751238(+) m6A CDS       24284625//22575960
chr8:128752648-128752649(+) m6A CDS       24284625//22575960
chr8:128752750-128752751(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr8:128752836-128752837(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752866-128752867(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752885-128752886(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752886-128752887(+) Cm CDS       -
chr8:128752929-128752930(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752955-128752956(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753040-128753041(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753136-128753137(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753158-128753159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753167-128753168(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753173-128753174(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753179-128753180(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753190-128753191(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753261-128753262(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753316-128753317(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753341-128753342(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753356-128753357(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:128753373-128753374(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7g-3p
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
MYC
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7g-3p
Interactor2: MYC

Evidence Support:


Strong-Evidence IHC//qRT-PCR//Western blot
Support Database VIRmiRNA

References:


[1]PMID 20033209 Target region None
Source VIRmiRNA Interactor1 expression None
Tissue or cell line B-lymphocyte cells Interactor2 expression None
Description Real-time RT-PCR showed the expression of let-7a was increased significantly in A549-let-7a cells-injected group, compared with A549-control cells-injected group and A549 cells-injected group (P < 0.01). In the xenografts of A549-let-7a cells-injected group, a significant depression in tumor weight (P < 0.05) and significant decrease of k-Ras and c-Myc protein were observed (P < 0.01), compared to A549 cells-injected group and A549-control cells-injected group.
[2]PMID 21565290 Target region None
Source VIRmiRNA Interactor1 expression None
Tissue or cell line B-lymphocyte cells Interactor2 expression None
Description We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).

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