Basic Information:

  VIRBase ID:  

HHID00026714

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-3p:  MIMAT0004584          CASP3:  NM_004346     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-3p	CASP3
miRBase Accession/Entrez ID	MIMAT0004584	836
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CPP32//CPP32B//SCA-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7g-3p	rs1022640944 chr3:52268290    G/A rs1166657040 chr3:52268299    A/G rs1356748432 chr3:52268293    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CASP3	chr4:185563395(-) A-I      intronic chr4:185563394(-) A-I      intronic chr4:185563384(-) A-I      intronic chr4:185563373(-) A-I      intronic chr4:185563404(-) A-I      intronic chr4:185563238(-) A-I      intronic chr4:185563248(-) A-I      intronic chr4:185563256(-) A-I      intronic chr4:185563258(-) A-I      intronic chr4:185563263(-) A-I      intronic chr4:185563366(-) A-I      intronic chr4:185563267(-) A-I      intronic chr4:185563281(-) A-I      intronic chr4:185563282(-) A-I      intronic chr4:185563287(-) A-I      intronic chr4:185558634(-) A-I      intronic chr4:185558588(-) A-I      intronic chr4:185558356(-) A-I      intronic chr4:185564752(-) A-I      intronic chr4:185564777(-) A-I      intronic chr4:185564768(-) A-I      intronic chr4:185564626(-) A-I      intronic chr4:185563358(-) A-I      intronic chr4:185557396(-) A-I      intronic chr4:185563253(-) A-I      intronic chr4:185557349(-) A-I      intronic chr4:185558689(-) A-I      intronic chr4:185558232(-) A-I      intronic chr4:185558615(-) A-I      intronic chr4:185551739(-) A-I      intronic chr4:185558568(-) A-I      intronic chr4:185563319(-) A-I      intronic chr4:185566909(-) A-I      intronic chr4:185566948(-) A-I      intronic chr4:185558311(-) A-I      intronic chr4:185558258(-) A-I      intronic chr4:185558672(-) A-I      intronic chr4:185560238(-) A-I      intronic chr4:185560360(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CASP3	chr4:185570553(-) A-I exon 5'UTR    19478186 chr4:185558311(-) A-G intron -    22484847 chr4:185558672(-) A-G intron -    22484847 chr4:185563358(-) A-G intron -    22484847 chr4:185566794(-) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CASP3	chr4:185549472-185549473(-) m6A 3'UTR       24981863 chr4:185556524-185556525(-) m6A CDS       - chr4:185556542-185556543(-) m6A CDS       - chr4:185559556-185559557(-) m6A CDS       24981863 chr4:185559590-185559591(-) m6A CDS       24981863//27773535 chr4:185559599-185559600(-) m6A CDS       24981863//27773535 chr4:185565779-185565780(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	CASP3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-3p
Interactor2: CASP3

Evidence Support:

Strong-Evidence	Luciferase reporter assay//RT-PCR
Support Database	VIRmiRNA

References:

PMID	21565290	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	B-lymphocyte cells	Interactor2 expression	None
Description	We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).