Detail Information

Basic Information:


  VIRBase ID:  

HHID00026643

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-122-5p:           TP53:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-122-5p TP53
miRBase
Accession/Entrez ID		 MIMAT0000421 7157
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BCC7//BMFS5//LFS1//P53//TRP53

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-122-5p
rs1258166649 chr18:58451088    T/C
rs1426570658 chr18:58451093    T/A

RNA Editing:


Resource Symbol Editing Position
Lncediting TP53
    chr17: 7588904
    chr17: 7588877
Resource Symbol Editing Position Change Genetic Region
RADAR TP53
chr17:7574250(-) A-I      intronic
chr17:7573520(-) A-I      intronic
chr17:7573351(-) A-I      intronic
chr17:7573387(-) A-I      intronic
chr17:7573391(-) A-I      intronic
chr17:7573398(-) A-I      intronic
chr17:7573399(-) A-I      intronic
chr17:7573478(-) A-I      intronic
chr17:7574292(-) A-I      intronic
chr17:7574227(-) A-I      intronic
chr17:7573369(-) A-I      intronic
chr17:7575291(-) A-I      intronic
chr17:7575306(-) A-I      intronic
chr17:7575453(-) A-I      intronic
chr17:7576230(-) A-I      intronic
chr17:7576261(-) A-I      intronic
chr17:7576264(-) A-I      intronic
chr17:7576361(-) A-I      intronic
chr17:7587661(-) A-I      intronic
chr17:7576380(-) A-I      intronic
chr17:7576396(-) A-I      intronic
chr17:7576405(-) A-I      intronic
chr17:7576421(-) A-I      intronic
chr17:7586541(-) A-I      intronic
chr17:7575466(-) A-I      intronic
chr17:7575516(-) A-I      intronic
chr17:7575536(-) A-I      intronic
chr17:7575592(-) A-I      intronic
chr17:7575608(-) A-I      intronic
chr17:7576437(-) A-I      intronic
chr17:7583952(-) A-I      intronic
chr17:7574403(-) A-I      intronic
chr17:7574462(-) A-I      intronic
chr17:7574463(-) A-I      intronic
chr17:7574479(-) A-I      intronic
chr17:7574730(-) A-I      intronic
chr17:7574756(-) A-I      intronic
chr17:7574767(-) A-I      intronic
chr17:7574782(-) A-I      intronic
chr17:7574800(-) A-I      intronic
chr17:7574811(-) A-I      intronic
chr17:7574821(-) A-I      intronic
chr17:7574826(-) A-I      intronic
chr17:7588904(-) A-I      intronic
chr17:7588877(-) A-I      intronic
chr17:7587669(-) A-I      intronic
chr17:7587624(-) A-I      intronic
chr17:7587598(-) A-I      intronic
chr17:7587574(-) A-I      intronic
chr17:7587205(-) A-I      intronic
chr17:7583956(-) A-I      intronic
chr17:7587199(-) A-I      intronic
chr17:7575775(-) A-I      intronic
chr17:7575868(-) A-I      intronic
chr17:7575939(-) A-I      intronic
chr17:7576110(-) A-I      intronic
chr17:7576184(-) A-I      intronic
chr17:7573279(-) A-I      intronic
chr17:7573315(-) A-I      intronic
chr17:7573355(-) A-I      intronic
chr17:7586686(-) A-I      intronic
chr17:7573435(-) A-I      intronic
chr17:7574228(-) A-I      intronic
chr17:7574305(-) A-I      intronic
chr17:7572048(-) A-I      3'UTR
chr17:7572107(-) A-I      3'UTR
chr17:7571943(-) A-I      3'UTR
chr17:7571926(-) A-I      3'UTR
chr17:7571944(-) A-I      3'UTR
chr17:7574393(-) A-I      intronic
chr17:7586338(-) A-I      intronic
chr17:7587302(-) A-I      intronic
chr17:7574688(-) A-I      intronic
chr17:7574296(-) A-I      intronic
chr17:7587561(-) A-I      intronic
chr17:7587082(-) A-I      intronic
chr17:7574520(-) A-I      intronic
chr17:7584245(-) A-I      intronic
chr17:7587693(-) A-I      intronic
chr17:7574572(-) A-I      intronic
chr17:7587621(-) A-I      intronic
chr17:7575299(-) A-I      intronic
chr17:7576319(-) A-I      intronic
chr17:7574311(-) A-I      intronic
chr17:7584291(-) A-I      intronic
chr17:7573395(-) A-I      intronic
chr17:7574545(-) A-I      intronic
chr17:7575897(-) A-I      intronic
chr17:7587676(-) A-I      intronic
chr17:7587514(-) A-I      intronic
chr17:7587473(-) A-I      intronic
chr17:7587534(-) A-I      intronic
chr17:7587218(-) A-I      intronic
chr17:7574298(-) A-I      intronic
chr17:7585684(-) A-I      intronic
chr17:7587701(-) A-I      intronic
chr17:7573459(-) A-I      intronic
chr17:7573390(-) A-I      intronic
chr17:7587545(-) A-I      intronic
chr17:7582810(-) A-I      intronic
chr17:7574715(-) A-I      intronic
chr17:7575858(-) A-I      intronic
chr17:7573473(-) A-I      intronic
chr17:7574318(-) A-I      intronic
chr17:7587126(-) A-I      intronic
chr17:7572004(-) A-I      3'UTR
chr17:7574265(-) A-I      intronic
chr17:7587660(-) A-I      intronic
chr17:7571913(-) A-I      3'UTR
chr17:7572141(-) A-I      3'UTR
chr17:7587472(-) A-I      intronic
chr17:7575233(-) A-I      intronic
chr17:7573467(-) A-I      intronic
chr17:7572026(-) A-I      3'UTR
chr17:7587671(-) A-I      intronic
chr17:7587663(-) A-I      intronic
chr17:7573334(-) A-I      intronic
chr17:7587200(-) A-I      intronic
chr17:7574341(-) A-I      intronic
chr17:7575528(-) A-I      intronic
chr17:7574913(-) A-I      intronic
chr17:7575356(-) A-I      intronic
chr17:7574407(-) A-I      intronic
chr17:7587537(-) A-I      intronic
chr17:7575244(-) A-I      intronic
chr17:7576064(-) A-I      intronic
chr17:7587301(-) A-I      intronic
chr17:7587668(-) A-I      intronic
chr17:7586352(-) A-I      intronic
chr17:7574783(-) A-I      intronic
chr17:7574517(-) A-I      intronic
chr17:7573472(-) A-I      intronic
chr17:7575465(-) A-I      intronic
chr17:7573360(-) A-I      intronic
chr17:7587190(-) A-I      intronic
chr17:7575947(-) A-I      intronic
chr17:7587198(-) A-I      intronic
chr17:7576006(-) A-I      intronic
chr17:7587499(-) A-I      intronic
chr17:7574757(-) A-I      intronic
chr17:7582804(-) A-I      intronic
chr17:7582053(-) A-I      intronic
chr17:7574539(-) A-I      intronic
chr17:7574258(-) A-I      intronic
chr17:7573454(-) A-I      intronic
chr17:7574354(-) A-I      intronic
chr17:7574328(-) A-I      intronic
chr17:7573361(-) A-I      intronic
chr17:7576027(-) A-I      intronic
chr17:7587525(-) A-I      intronic
chr17:7587645(-) A-I      intronic
chr17:7575777(-) A-I      intronic
chr17:7574547(-) A-I      intronic
chr17:7571931(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TP53
chr17:7587671(-) A-I intron -    22327324
chr17:7572004(-) A-G exon 3'UTR    22484847
chr17:7572148(-) C-T exon 3'UTR    22484847
chr17:7572154(-) C-T exon 3'UTR    22484847
chr17:7572173(-) C-T exon 3'UTR    22484847
chr17:7573360(-) A-G intron -    22484847
chr17:7573361(-) A-G intron -    22484847
chr17:7574354(-) A-G intron -    22484847
chr17:7574547(-) A-G intron -    22484847
chr17:7587198(-) A-G intron -    22484847
chr17:7587301(-) A-G intron -    22484847
chr17:7587302(-) A-G intron -    22484847
chr17:7587472(-) A-G intron -    22484847
chr17:7587645(-) A-G intron -    22484847
chr17:7587663(-) A-G intron -    22484847
chr17:7587668(-) A-G intron -    22484847
chr17:7587671(-) A-G intron -    22484847
chr17:7587676(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TP53
chr17:7569558-7569559(-) m6A CDS//intron       24981863//27773535
chr17:7571749-7571750(-) m6A 3'UTR//intron       24981863//27773535
chr17:7571942-7571943(-) m6A 3'UTR//intron       27773535
chr17:7572719-7572720(-) m6A 3'UTR//intron       26404942
chr17:7572771-7572772(-) m6A 3'UTR//intron       -
chr17:7572804-7572805(-) m6A 3'UTR//intron       -
chr17:7572843-7572844(-) m6A 3'UTR//intron       -
chr17:7572930-7572931(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7572949-7572950(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7572962-7572963(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7573979-7573980(-) m6A 3'UTR//CDS//intron       27371828
chr17:7576546-7576547(-) m6A 3'UTR//CDS//intron       27371828
chr17:7576650-7576651(-) m6A CDS//intron       24981863//27371828
chr17:7576882-7576883(-) m6A CDS//intron       24981863//27371828//27773536
chr17:7577095-7577096(-) m6A CDS//intron       -
chr17:7578511-7578512(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr17:7579334-7579335(-) m6A CDS//exon//intron       24284625
chr17:7579382-7579383(-) m6A CDS//exon//intron       24284625
chr17:7579516-7579517(-) m6A CDS//exon//intron       24284625//22575960
chr17:7579533-7579534(-) m6A CDS//exon//intron       24284625//22575960
chr17:7579709-7579710(-) m6A 5'UTR//CDS//exon//intron       24284625//22575960
chr17:7579720-7579721(-) m6A 5'UTR//CDS//exon//intron       24284625//22575960
chr17:7579840-7579841(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579850-7579851(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579860-7579861(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579932-7579933(-) m6A 5'UTR//exon//intron       24284625//27371828//27773536
chr17:7580702-7580703(-) m6A 5'UTR//intron       24284625//24981863//27371828//27773536
chr17:7588791-7588792(-) m6A intron       27371828//27773536
chr17:7588861-7588862(-) m6A intron       27371828//27773536
chr17:7588979-7588980(-) m6A intron       24284625//25456834//24981863//27371828//22608085
chr17:7589074-7589075(-) m6A intron       24284625//25456834//24981863//22608085
chr17:7589175-7589176(-) m6A intron       24284625//24981863//27773535//22608085
chr17:7589398-7589399(-) m6A intron       24284625//22608085
chr17:7589550-7589551(-) m6A intron       22608085
chr17:7590754-7590755(-) m6A 5'UTR//exon       24284625//25456834//24981863
chr17:7590831-7590832(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-122-5p
Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Cytoplasm Huh-7 cells     29486652
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Huh-7 cells     26304123
Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950
Exosome B cell line (Raji)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Chronic lymphocytic leukemia cells     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Nucleus Nasopharyngeal carcinoma cells     20498841
Polysome Human cervical cancer cell line (HeLa)     25609084
TP53
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-122-5p
Interactor2: TP53

Evidence Support:


Strong-Evidence RT-qPCR//Western blot
Support Database ViRBase

References:


PMID 31366735 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Huh7 cells Interactor2 expression None
Description In addition, our findings suggest that ADAR1 adopts the cyclin G1 and p53 proteins as downstream molecules of miR122 to reduce the HBV RNA levels. As expected, the ADAR1- and miR-122 mimic transfectants showed decreased cyclin G1 expression with concomitant up-regulation of the p53 protein (Fig. 6A).

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