Detail Information

Basic Information:


  VIRBase ID:  

HHID00026642

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-122-5p:           SLC7A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-122-5p SLC7A1
miRBase
Accession/Entrez ID		 MIMAT0000421 6541
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ATRC1//CAT-1//ERR//HCAT1//REC1L

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-122-5p
rs1258166649 chr18:58451088    T/C
rs1426570658 chr18:58451093    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC7A1
chr13:30165123(-) A-I      intronic
chr13:30162644(-) A-I      intronic
chr13:30150317(-) A-I      intronic
chr13:30164990(-) A-I      intronic
chr13:30150232(-) A-I      intronic
chr13:30150299(-) A-I      intronic
chr13:30162781(-) A-I      intronic
chr13:30134017(-) A-I      intronic
chr13:30162743(-) A-I      intronic
chr13:30150347(-) A-I      intronic
chr13:30150377(-) A-I      intronic
chr13:30162779(-) A-I      intronic
chr13:30150174(-) A-I      intronic
chr13:30148946(-) A-I      intronic
chr13:30150253(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SLC7A1
chr13:30162779(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC7A1
chr13:30083687-30083688(-) m6A 3'UTR       27773535
chr13:30083728-30083729(-) m6A 3'UTR       27773535
chr13:30084103-30084104(-) m6A 3'UTR       25456834//24981863//22608085
chr13:30084118-30084119(-) m6A 3'UTR       25456834//24981863//22608085
chr13:30084167-30084168(-) m6A 3'UTR       24284625//24209618//24981863//22608085
chr13:30084276-30084277(-) m6A 3'UTR       24284625//24981863//22608085
chr13:30084361-30084362(-) m6A 3'UTR       24284625//27773535
chr13:30084559-30084560(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr13:30084714-30084715(-) m6A 3'UTR       24284625//24209618//24981863
chr13:30084771-30084772(-) m6A 3'UTR       24284625//24981863
chr13:30084868-30084869(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30084883-30084884(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30084929-30084930(-) m6A 3'UTR       24284625//24981863//27773535//22575960
chr13:30085005-30085006(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr13:30085043-30085044(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr13:30085069-30085070(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27773536//22575960//22608085
chr13:30085101-30085102(-) m6A 3'UTR       24284625//25456834//27773536//22575960//22608085
chr13:30085108-30085109(-) m6A 3'UTR       24284625//25456834//27773536//22575960//22608085
chr13:30085165-30085166(-) m6A 3'UTR       25456834//27773536//22575960
chr13:30085468-30085469(-) m6A 3'UTR       -
chr13:30085577-30085578(-) m6A 3'UTR       24209618
chr13:30085675-30085676(-) m6A 3'UTR       24284625
chr13:30085703-30085704(-) Cm 3'UTR       -
chr13:30085801-30085802(-) m6A 3'UTR       24284625//27773535
chr13:30085832-30085833(-) m6A 3'UTR       24284625//27773535
chr13:30085916-30085917(-) m6A 3'UTR       24284625//27773535
chr13:30085935-30085936(-) m6A 3'UTR       24284625//27773535
chr13:30086022-30086023(-) m6A 3'UTR       27773535
chr13:30086071-30086072(-) m6A 3'UTR       27773535
chr13:30086317-30086318(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30086362-30086363(-) m6A 3'UTR       24284625//22575960
chr13:30086396-30086397(-) m6A 3'UTR       24284625//22575960
chr13:30087099-30087100(-) m6A 3'UTR       24981863
chr13:30087131-30087132(-) m6A 3'UTR       24284625//24981863
chr13:30087180-30087181(-) m6A 3'UTR       24284625//24981863
chr13:30087223-30087224(-) m6A 3'UTR       24284625//24981863
chr13:30087341-30087342(-) m6A 3'UTR       24284625//27773535
chr13:30087367-30087368(-) m6A 3'UTR       24284625//27773535
chr13:30087622-30087623(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30087765-30087766(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr13:30087779-30087780(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30087786-30087787(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30087871-30087872(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30087878-30087879(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088030-30088031(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088146-30088147(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088180-30088181(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088212-30088213(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088245-30088246(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088265-30088266(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088352-30088353(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088413-30088414(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088522-30088523(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr13:30088561-30088562(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr13:30088629-30088630(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr13:30088648-30088649(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr13:30090315-30090316(-) m6A CDS       24284625//27773535//22575960
chr13:30109978-30109979(-) m6A CDS       27773535
chr13:30110227-30110228(-) m6A CDS       24284625//25456834//24981863
chr13:30110266-30110267(-) m6A CDS       24284625//25456834
chr13:30110332-30110333(-) m6A 5'UTR       24284625
chr13:30127964-30127965(-) m6A 5'UTR       24284625
chr13:30127987-30127988(-) m6A 5'UTR       24284625
chr13:30169797-30169798(-) m6A 5'UTR       24981863
chr13:30169810-30169811(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-122-5p
Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Cytoplasm Huh-7 cells     29486652
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Huh-7 cells     26304123
Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950
Exosome B cell line (Raji)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Chronic lymphocytic leukemia cells     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Nucleus Nasopharyngeal carcinoma cells     20498841
Polysome Human cervical cancer cell line (HeLa)     25609084
SLC7A1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-122-5p
Interactor2: SLC7A1

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR
Support Database VIRmiRNA

References:


PMID 21565290 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Hepatoma cells Interactor2 expression None
Description We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).

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